-
1
-
-
17144382751
-
Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study
-
Van Gaal L.F., et al. Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet 2005, 365:1389-1397.
-
(2005)
Lancet
, vol.365
, pp. 1389-1397
-
-
Van Gaal, L.F.1
-
2
-
-
32644441249
-
Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial
-
Pi-Sunyer F.X., et al. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. J. Am. Med. Assoc. 2006, 295:761-775.
-
(2006)
J. Am. Med. Assoc.
, vol.295
, pp. 761-775
-
-
Pi-Sunyer, F.X.1
-
3
-
-
27844463517
-
Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia
-
Despres J.P., et al. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N. Engl. J. Med. 2005, 353:2121-2134.
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 2121-2134
-
-
Despres, J.P.1
-
4
-
-
33751001942
-
Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study
-
Scheen A.J., et al. Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study. Lancet 2006, 368:1660-1672.
-
(2006)
Lancet
, vol.368
, pp. 1660-1672
-
-
Scheen, A.J.1
-
5
-
-
36048995288
-
Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials
-
Christensen R., et al. Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials. Lancet 2007, 370:1706-1713.
-
(2007)
Lancet
, vol.370
, pp. 1706-1713
-
-
Christensen, R.1
-
6
-
-
36049006465
-
Depression and anxiety with rimonabant
-
Mitchell P.B., Morris M.J. Depression and anxiety with rimonabant. Lancet 2007, 370:1671-1672.
-
(2007)
Lancet
, vol.370
, pp. 1671-1672
-
-
Mitchell, P.B.1
Morris, M.J.2
-
7
-
-
40749089483
-
Some effects of CB1 antagonists with inverse agonist and neutral biochemical properties
-
Bergman J., et al. Some effects of CB1 antagonists with inverse agonist and neutral biochemical properties. Physiol. Behav. 2008, 93:666-670.
-
(2008)
Physiol. Behav.
, vol.93
, pp. 666-670
-
-
Bergman, J.1
-
8
-
-
57049102251
-
End of the line for cannabinoid receptor 1 as an anti-obesity target?
-
Jones D. End of the line for cannabinoid receptor 1 as an anti-obesity target?. Nat. Rev. Drug Discov. 2008, 7:961-962.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 961-962
-
-
Jones, D.1
-
9
-
-
33846026023
-
Assessing receptor affinity for inverse agonists: Schild and Cheng-Prusoff methods revisited
-
Giraldo J., et al. Assessing receptor affinity for inverse agonists: Schild and Cheng-Prusoff methods revisited. Curr. Drug Targets 2007, 8:197-202.
-
(2007)
Curr. Drug Targets
, vol.8
, pp. 197-202
-
-
Giraldo, J.1
-
10
-
-
0001169515
-
Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins
-
Costa T., Herz A. Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins. Proc. Natl. Acad. Sci. U.S.A. 1989, 86:7321-7325.
-
(1989)
Proc. Natl. Acad. Sci. U.S.A.
, vol.86
, pp. 7321-7325
-
-
Costa, T.1
Herz, A.2
-
11
-
-
1642495639
-
Efficacy as a vector: the relative prevalence and paucity of inverse agonism
-
Kenakin T. Efficacy as a vector: the relative prevalence and paucity of inverse agonism. Mol. Pharmacol. 2004, 65:2-11.
-
(2004)
Mol. Pharmacol.
, vol.65
, pp. 2-11
-
-
Kenakin, T.1
-
12
-
-
34347336422
-
Cannabinoid CB1 receptor inverse agonists and neutral antagonists: effects on food intake, food-reinforced behavior and food aversions
-
Salamone J.D., et al. Cannabinoid CB1 receptor inverse agonists and neutral antagonists: effects on food intake, food-reinforced behavior and food aversions. Physiol. Behav. 2007, 91:383-388.
-
(2007)
Physiol. Behav.
, vol.91
, pp. 383-388
-
-
Salamone, J.D.1
-
13
-
-
54849141400
-
Play an ADAGIO with a STRADIVARIUS: the right patient for CB1 receptor antagonists?
-
Di Marzo V. Play an ADAGIO with a STRADIVARIUS: the right patient for CB1 receptor antagonists?. Nat. Clin. Pract. Cardiovasc. Med. 2008, 5:610-612.
-
(2008)
Nat. Clin. Pract. Cardiovasc. Med.
, vol.5
, pp. 610-612
-
-
Di Marzo, V.1
-
14
-
-
70350347327
-
CB1 antagonists for obesity-what lessons have we learned from rimonabant?
-
Di Marzo V., Despres J.P. CB1 antagonists for obesity-what lessons have we learned from rimonabant?. Nat. Rev. Endocrinol. 2009, 5:633-638.
-
(2009)
Nat. Rev. Endocrinol.
, vol.5
, pp. 633-638
-
-
Di Marzo, V.1
Despres, J.P.2
-
15
-
-
70349128141
-
Cannabinoid-1 receptor inverse agonists: current understanding of mechanism of action and unanswered questions
-
Fong T.M., Heymsfield S.B. Cannabinoid-1 receptor inverse agonists: current understanding of mechanism of action and unanswered questions. Int. J. Obes. (Lond.) 2009, 33:947-955.
-
(2009)
Int. J. Obes. (Lond.)
, vol.33
, pp. 947-955
-
-
Fong, T.M.1
Heymsfield, S.B.2
-
16
-
-
58149138840
-
Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain?
-
Kunos G., et al. Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain?. Trends Pharmacol. Sci. 2009, 30:1-7.
-
(2009)
Trends Pharmacol. Sci.
, vol.30
, pp. 1-7
-
-
Kunos, G.1
-
17
-
-
48149101434
-
The endocannabinoid system in obesity and type 2 diabetes
-
Di Marzo V. The endocannabinoid system in obesity and type 2 diabetes. Diabetologia 2008, 51:1356-1367.
-
(2008)
Diabetologia
, vol.51
, pp. 1356-1367
-
-
Di Marzo, V.1
-
18
-
-
75749126604
-
Signal transduction of the CB1 cannabinoid receptor
-
Turu G., Hunyady L. Signal transduction of the CB1 cannabinoid receptor. J. Mol. Endocrinol. 2010, 44:75-85.
-
(2010)
J. Mol. Endocrinol.
, vol.44
, pp. 75-85
-
-
Turu, G.1
Hunyady, L.2
-
19
-
-
68949209293
-
The current status and future perspectives of studies of cannabinoid receptor 1 antagonists as anti-obesity agents
-
Lee H.K., et al. The current status and future perspectives of studies of cannabinoid receptor 1 antagonists as anti-obesity agents. Curr. Top. Med. Chem. 2009, 9:482-503.
-
(2009)
Curr. Top. Med. Chem.
, vol.9
, pp. 482-503
-
-
Lee, H.K.1
-
20
-
-
24044539957
-
Allosteric modulation of the cannabinoid CB1 receptor
-
Price M.R., et al. Allosteric modulation of the cannabinoid CB1 receptor. Mol. Pharmacol. 2005, 68:1484-1495.
-
(2005)
Mol. Pharmacol.
, vol.68
, pp. 1484-1495
-
-
Price, M.R.1
-
21
-
-
33745127060
-
The two-state dimer receptor model: a general model for receptor dimers
-
Franco R., et al. The two-state dimer receptor model: a general model for receptor dimers. Mol. Pharmacol. 2006, 69:1905-1912.
-
(2006)
Mol. Pharmacol.
, vol.69
, pp. 1905-1912
-
-
Franco, R.1
-
22
-
-
73049085563
-
The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways
-
Rovira X., et al. The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways. Trends Pharmacol. Sci. 2010, 31:15-21.
-
(2010)
Trends Pharmacol. Sci.
, vol.31
, pp. 15-21
-
-
Rovira, X.1
-
23
-
-
36148944785
-
When a G protein-coupled receptor does not couple to a G protein
-
Sun Y., et al. When a G protein-coupled receptor does not couple to a G protein. Mol. Biosyst. 2007, 3:849-854.
-
(2007)
Mol. Biosyst.
, vol.3
, pp. 849-854
-
-
Sun, Y.1
-
24
-
-
66849093630
-
Evidence for distinct antagonist-revealed functional states of 5-hydroxytryptamine(2A) receptor homodimers
-
Brea J., et al. Evidence for distinct antagonist-revealed functional states of 5-hydroxytryptamine(2A) receptor homodimers. Mol. Pharmacol. 2009, 75:1380-1391.
-
(2009)
Mol. Pharmacol.
, vol.75
, pp. 1380-1391
-
-
Brea, J.1
-
25
-
-
69649097791
-
'7TM receptor allostery: putting numbers to shapeshifting proteins
-
Kenakin T.P. '7TM receptor allostery: putting numbers to shapeshifting proteins. Trends Pharmacol. Sci. 2009, 30:460-469.
-
(2009)
Trends Pharmacol. Sci.
, vol.30
, pp. 460-469
-
-
Kenakin, T.P.1
-
26
-
-
68249113457
-
Cellular assays as portals to seven-transmembrane receptor-based drug discovery
-
Kenakin T.P. Cellular assays as portals to seven-transmembrane receptor-based drug discovery. Nat. Rev. Drug Discov. 2009, 8:617-626.
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 617-626
-
-
Kenakin, T.P.1
-
27
-
-
0028950255
-
The two-state model of receptor activation
-
Leff P. The two-state model of receptor activation. Trends Pharmacol. Sci. 1995, 16:89-97.
-
(1995)
Trends Pharmacol. Sci.
, vol.16
, pp. 89-97
-
-
Leff, P.1
-
28
-
-
55849117700
-
CB(1) receptor antagonism: biological basis for metabolic effects
-
Di Marzo V. CB(1) receptor antagonism: biological basis for metabolic effects. Drug Discov. Today 2008, 13:1026-1041.
-
(2008)
Drug Discov. Today
, vol.13
, pp. 1026-1041
-
-
Di Marzo, V.1
-
29
-
-
77649234756
-
How to improve R&D productivity: the pharmaceutical industry's grand challenge
-
Paul S.M., et al. How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nat. Rev. Drug Discov. 2010, 9:203-214.
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 203-214
-
-
Paul, S.M.1
-
30
-
-
0347985770
-
Agonist induction, conformational selection, and mutant receptors
-
Giraldo J. Agonist induction, conformational selection, and mutant receptors. FEBS Lett. 2004, 556:13-18.
-
(2004)
FEBS Lett.
, vol.556
, pp. 13-18
-
-
Giraldo, J.1
|