C-Jun terminal kinases play an important role in regulating embryonic survival and eye development in vertebrates

Current Molecular Medicine

Volumn 13, Issue 1, 2013, Pages 228-237

  Huang, X Q ^a   Huang, Z X ^a   Li, Z L ^a   Chen, X W ^a   Li, X ^a   Tang, X C ^b   Liu, F Y ^b   Liu, Y ^a   Chen, L ^a   Han, W J ^a   Liu, L ^a   Li, L ^a   Wu, K L ^b   Wu, M X ^b   Liu, X L ^b   Luo, L X ^b   Yu, M B ^b   Liu, Yi Zhi ^b   Liu, Shao Jun ^a   Li, David Wan Cheng ^a,b,d  

^a HUNAN NORMAL UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c Department of Biochemistry and Molecular Biology ^*  (United States)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Cataract; Cell differentiation; Development; JNK1; JNK2; JNK3; Lens; Retina

Indexed keywords

BETA CRYSTALLIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAK; PROTEIN MCL 1; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR SOX2; ANTHRA(1,9 CD)PYRAZOL 6(2H) ONE; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 10; MITOGEN ACTIVATED PROTEIN KINASE 9; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; STRESS ACTIVATED PROTEIN KINASE 1;

ADULT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EYE DEVELOPMENT; FEMALE; FLUORESCENCE MICROSCOPY; GASTRULATION; GOLDFISH; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MICROPHTHALMIA; MOLECULAR CLONING; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VERTEBRATE; WESTERN BLOTTING; ANIMAL; ANIMAL EMBRYO; BLASTULA; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; EYE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUTATION; PRENATAL DEVELOPMENT;

ANIMALS; ANTHRACENES; APOPTOSIS; BLASTULA; EMBRYO, NONMAMMALIAN; ENZYME INHIBITORS; EYE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GOLDFISH; MAP KINASE KINASE 4; MITOGEN-ACTIVATED PROTEIN KINASE 10; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; MUTATION;

EID: 84881324915     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/156652413804486278     Document Type: Article

References (64)

1. Pearson G, Robinson F, Beers Gibson T, et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 2001; 22: 153-183.
2. Rincon M. MAP-kinase signaling pathways in T cells. Curr Opin Immunol 2001; 13: 339-345.
3. Schaeffer HJ, Weber MJ. Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol Cell Biol 1999; 19: 2435-2444.
4. Kyriakis JM, Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 2001; 81: 807-869.
5. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 2000; 103: 239-252.
6. Weston CR, Davis RJ. The JNK signal transduction pathway. Curr Opin Genet Dev 2002; 12: 14-21.
7. Han J, Ulevitch RJ. Emerging targets for anti-inflammatory therapy. Nat Cell Biol 1999; 1: E39-E40.
8. Franklin RA, McCubrey JA. Kinases: positive and negative regulators of apoptosis. Leukemia 2000; 14: 2019-2034.
9. Xia Z, Dickens M, Raingeaud J, et al. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995; 270: 1326-1331.
10. Ballif BA, Blenis J. Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals. Cell Growth Differ 2001; 12: 397-408.
11. Yang DD, Kuan CY, Whitmarsh AJ, et al. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 1997; 389: 865-870.
12. Yang DD, Conze D, Whitmarsh AJ, et al. Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. Immunity 1998; 9: 575-585.
13. Dong C, Yang DD, Wysk M, et al. Defective T cell differentiation in the absence of Jnk1. Science 1998; 282: 2092-2095.
14. Sabapathy K, Hu Y, Kallunki T, et al. JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development. Curr Biol 1999; 9: 116-125.
15. Sabapathy K, Jochum W, Hochedlinger K, et al. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech Dev 1999; 89: 115-124.
16. Kuan CY, Yang DD, Samanta Roy DR, et al. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 1999; 22: 667-676.
17. Fu H, Ma H, Zheng C, et al. Molecular cloning and differential expression patterns of the regulatory subunit B’ of PP-2A in goldfish, Carassius auratus. Sci China Ser C-Life Sci 2009; 52: 724-732.
18. Ma HL, Peng YL, Gong L, et al. The goldfish SG2NA gene encodes two alpha-type regulatory subunits for PP-2A and displays distinct developmental expression pattern. Gene Regul & Syst Biol 2009; 3: 115-129.
19. Zhao J-Q, S-S Xie, W-B Liu, et al. Molecular cloning of the genes encoding the PR55/B/ regulatory subunits for PP-2A and analysis of their functions in regulating development of goldfish, Carassius auratus. Gene Regul & Syst Biol 2010; 4: 135-148.
20. Liu WB, Yan Q, Liu FY, et al. Protein Serine/ThreoninePhosphotase-1 is Essential in Governing Normal Development of Vertebrate Eye. Curr Mol Med 2012; 12: 1361-1371.
21. Mao YW, Xiang H, Wang J, Korsmeyer S, Reddan J, Li DW.Human bcl-2 gene attenuates the ability of rabbit lens epithelial cells against H2O2-induced apoptosis through down-regulation of the alpha B-crystallin gene. J Biol Chem 2001; 276: 43435-43445.
22. Deng M, Chen P, Liu F, et al. The p53-Bak ApoptoticSignaling Axis Plays An Essential Role in Regulating Differentiation of the Ocular Lens. Curr Mol Med 2012; 12: 901-916.
23. Liu FY, Tang XC, Deng M, et al. The tumor suppressor p53directly regulates c-Maf and Prox-1 to control lens differentiation. Curr Mol Med 2012; 12: 917-928.
24. Li DW-C, Liu J-P, Mao YW, et al. Calcium-ActivatedRAF/MEK/ERK pathway mediates p53-dependent apoptosis and is abrogated by B-crystallin through Inhibition of Ras Activation. Mol Biol Cell 2005; 16: 4437-4453.
25. Mausouri A, Hallonet M, Gruss P. Pax genes and their rolesin cell differentiation an development. Curr Opin Cell Biol 1996; 8: 851-7.
26. Zhang G, Chu W, Hu S, et al. Identification and analysis ofmuscle-related protein isoforms expressed in the white muscle of the mandarin fish (Siniperca chuatsi). Mar Biotechnol (NY) 2011; 13: 151-162.
27. Ding F, Chu W, Cui P, et al. EST-based identification ofgenes expressed in skeletal muscle of the mandarin fish (Siniperca chuatsi). Genomics Proteomics Bioinformatics 2011; 9: 30-36.
28. Haines L, Neyt C, Gautier P, et al. Met and Hgf signalingcontrols hypaxial muscle and lateral line development in the zebrafish. Development 2004; 131: 4857-4869.
29. Kamachi Y, Uchikawa M, Tanouchi A, et al. Pax6 and SOX2form a co-DNA-binding partner complex that regulates initiation of lens development. Genes & Dev 2001; 15: 1272-1286.
30. Hill RE, Favor J, Hogan BL, et al. Mouse small eye resultsfrom mutations in a paired- like homeobox-containing gene. Nature 1991; 354: 522-525.
31. Glaser T, Walton DS, Maas RL. Genomic structure,evolutionary conservation and aniridia mutations in the human PAX6 gene. Nat Genet 1992; 2: 232-239.
32. Czerny T, Schaffner G, Busslinger M. DNA sequencerecognition by Pax proteins: bipartite structure of the paired domain and its binding site. Genes Dev 1993; 7: 2048-2061.
33. Carriere C, Plaza S, Martin P, et al. Characterization of quailPax-6 (Pax-QNR) proteins expressed in the neuroretina. Mol Cell Biol 1993; 13: 7257-7266.
34. Epstein JA, Glaser T, Cai J, et al. Two independent andinteractive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing. Genes Dev 1994; 8: 2022-2034.
35. Halder G, Callaerts P, Gehring WJ. Induction of ectopic eyesby targeted expression of the eyeless gene in Drosophila. Science 1995; 267: 1788-1792.
36. Cong T, Stoykova A. Trim 11 modulates the function ofneurogenic transcription factor Pax6 through ubiquitin-proteosome system. Genes Dev 2008; 22: 1972-1986.
37. Yan Q, Liu WB, Qin J, et al. Protein Phosphatase-1dephosphorylates Pax-6, a transcription factor controlling brain and eye development. J Biol Chem 2007; 282: 13954-13965.
38. Yan Q, Gong L, Deng M, et al. Sumoylation activates thetranscriptional activity of Pax- 6, an important transcription factor for eye and brain development. Proc Natl Acad Sci USA 2010; 107: 21034-21039.
39. Zhang YX, Kong CZ, Wang LH, et al. Ursolic acid overcomesBcl-2-mediated resistance to apoptosis in prostate cancer cells involving activation of JNK-induced Bcl- 2 phosphorylation and degradation. J Cell Biochem 2010; 109: 764-773.
40. Seki E, Brenner DA, Karin M. A liver full of JNK: signaling inregulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology 2012; 143: 307-320.
41. Tsuruta F, Sunayama J, Mori Y, et al. JNK promotes Baxtranslocation to mitochondria through phosphorylation of 14- 3-3 proteins. EMBO J 2004; 23: 1889-18899.
42. Donovan N, Becker EB, Konishi Y, Bonni A. JNKphosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery. J Biol Chem 2002; 277: 40944-40949.
43. Becker EB, Howell J, Kodama Y, Barker PA, Bonni A.Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis. J Neurosci 2004; 24: 8762-8770.
44. Chang L, Kamata H, Solinas G, et al. The E3 ubiquitin ligaseitch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 2006; 124: 601-613.
45. Kodama Y, Taura K, Miura K, et al. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF- induced hepatocyte apoptosis. Gastroenterology 2009; 136: 1423-1434.
46. Qin J, Chen HG, Yan Q, et al. Protein phosphatase-2A is atarget of epigallocatechin-3- gallate and modulates the p53- Bak apoptotic pathway. Cancer Res 2008; 68: 4150-4162.
47. Schwabe RF, Bradham CA, Uehara T, et al. c-Jun-N-terminalkinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology 2003; 37: 824-832.
48. Wagner AJ, Kokontis JM, Hay N. Myc-mediated apoptosisrequires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. Genes Dev 1994; 8: 2817-2830.
49. Maeda T, Hanna AN, Sim AB, et al. GADD45 regulates G2/Marrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure. J Invest Dermatol 2002; 119: 22-26.
50. Salvador JM, Hollander MC, Nguyen AT, et al. Mice lackingthe p53-effector gene Gadd45a develop a lupus-like syndrome. Immunity 2002; 16: 499-508.
51. Smith ML, Chen IT, Zhan Q, et al. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science 1994; 266: 1376-1380.
52. Wigle JT, Chowdhury K, Gruss P, Oliver G. Prox1 function iscrucial for mouse lens-fibre elongation. Nat Genet 1999; 21: 318-322.
53. Furuta Y, Hogan BL. BMP4 is essential for lens induction inthe mouse embryo. Genes & Dev 1998; 12: 3764-3775.
54. Weston CR, Wong A, Hall JP, et al. JNK initiates a cytokinecascade that causes Pax2 expression and closure of the optic fissure. Genes Dev 2003; 17: 1271-1280.
55. Ventura JJ, Kennedy NJ, Lamb J, Flavell RA, Davis RJ. JNKis essential for the regulation of AP-1 by tumor necrosis factor. Mol Cell Biol 2003; 23: 2871-2882.
56. Piatigorsky J. Lens crystallins. Innovation associated withchanges in gene regulation. J Biol Chem 1992; 267: 4277-4280.
57. Tomarev SI, Duncan MK, Roth HJ, Cvekl A, Piatigorsky J.Convergent evolution of crystallin gene regulation in squid and chicken: The AP-1/ARE connection. J Mol Evol 1993; 39: 134-143.
58. McDermott JB, Cvekl A, Piatigorsky J. A complex enhancerof the chicken beta A3/A1-crystallin gene depends on an AP- 1-CRE element for activity. Invest Ophthalmol Vis Sci 1997; 38: 951-959.
59. Klok EJ, van Genesen ST, Civil A, Schoenmakers JG,Lubsen NH. Regulation of expression within a gene family. The case of the rat gammaB- and gammaD-crystallin promoters. J Biol Chem 1988; 273: 17206-17215.
60. Ilagan JG, Cvekl A, Kantorow M, Piatigorsky J, Sax CM.Regulation of alphaA-crystallin gene expression. Lens specificity achieved through the differential placement of similar transcriptional control elements in mouse and chicken. J Biol Chem 1999; 274: 19973-19978.
61. Li W-C, Wang G-M, Wang R-R, Spector A. The redox activecomponents H2O2 and N- acetyl-L-cysteine regulate expression of c-jun and c-fos in lens systems. Exp Eye Res 1994; 59: 179-190.
62. Mikkola I, Bruun JA, Bjorkoy G, Holm T, Johansen T.Phosphorylation of the transactivation domain of Pax6 by extracellular signal-regulated kinase and p38 mitogenactivated protein kinase. J Biol Chem 1999; 274: 15115-15126.
63. Faber SC, Dimanlig P, Makarenkova HP, Shirke S, Ko K,Lang RA. Fgf receptor signaling plays a role in lens induction. Development 2001; 128: 4425-4438.
64. Faber SC, Robinson M, Makarenkova HP, Lang RA. Bmpsignaling is required for development of primary lens fiber cells. Development 2002; 129: 3727-3737.