MAP-kinase signaling pathways in T cells

Current Opinion in Immunology

Volumn 13, Issue 3, 2001, Pages 339-345

  Rincon M ^a  

^a UNIVERSITY OF VERMONT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE;

CELL DIFFERENTIATION; CELL MATURATION; ENZYME ACTIVITY; HUMAN; LYMPHOCYTE ACTIVATION; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMOCYTE;

EID: 0035366079     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(00)00224-7     Document Type: Review

References (49)

1. Mitogen-activated protein kinases: Specific messages from ubiquitous messengers
2. Emerging targets for anti-inflammatory therapy
3. Signal transduction by the JNK group of MAP kinases
4. Molecular and cellular events in early thymocyte development
5. The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte
6. Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo
7. Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors
8. Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase
9. Activation of the p38 MAP kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo
10. Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest
11. + T cells to Th1 cells requires MAP kinase JNK2
12. Defective T cell differentiation in the absence of Jnk1
13. JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development
14. Selective requirement for MAP kinase activation in thymocyte differentiation
15. Positive and negative selection invoke distinct signaling pathways
16. Involvement of p21ras distinguishes positive and negative selection in thymocytes
17. + thymocytes
18. Raf regulates positive selection
19. Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes
20. CD3δ couples T-cell receptor signaling to ERK activation and thymocyte positive selection
21. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice
22. Degree of ERK activation influences both positive and negative thymocyte selection
23. + thymocytes
24. + thymocytes
25. + stage requires an active p38 mitogen-activated protein kinase
26. Interferon-γ expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway
27. + T cells
28. The influence of the MAPK pathway on T cell lineage commitment
29. Activation of the extracellular signal-related kinase/mitogen-activated protein kinase pathway discriminates CD4 versus CD8 lineage commitment in the thymus
30. Commitment to the CD4 lineage mediated by extracellular signal-related kinase mitogen-activated protein kinase and Ick signaling
31. T lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin A
32. Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway
33. Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation
34. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
35. JNK is required for effector T-cell function but not for T-cell activation
36. 2 terminal kinase (Jnk) gene expression during T cell activation
37. JNK1 is required for T cell-mediated immunity against Leishmania major infection
38. Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation
39. The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-γ expression
40. Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity
41. p38 mitogen-activated protein kinase regulates human T cell IL-5 synthesis
42. + T cells and Th2 effector cells
43. T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation
44. + T cell cytolytic activity independent of mitogen-activated protein kinase / extracellular regulatory kinase signaling (MAP kinase/ERK)
45. Regulation of Fas ligand expression during activation-induced cell death in T cells by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase
46. Activation of p38 MAP kinase in T cells facilitates the immune response to the influenza virus
47. 2-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1
48. Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT)
49. 2-terminak kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation