MPTP-induced parkinsonism in minipigs: A behavioral, biochemical, and histological study

Neurotoxicology and Teratology

Volumn 21, Issue 2, 1999, Pages 169-175

  Mikkelsen, M ^a   MOller A ^b   Jensen, L H ^b   Pedersen, A ^a   Harajehi, J Berg ^a   Pakkenberg, H ^a  

^a Mental Health Services CPH   (Denmark)

^b NEUROSEARCH A S   (Denmark)

Author keywords

Behavior; Biochemistry; Histology; Minipig; MPTP

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 3,4 DIHYDROXYPHENYLACETIC ACID; DOPAMINE; HOMOVANILLIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN REGION; CONTROLLED STUDY; DOPAMINE METABOLISM; HISTOLOGY; MUSCLE RIGIDITY; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; SWINE; SYMPTOM; TISSUE INJURY;

ANIMALIA;

EID: 0033031162     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0892-0362(98)00037-3     Document Type: Article

References (29)

1. Ballard P.A., Tetrud J.W., Langston J.W. Permanent human parkinsonism due to l-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP). Seven cases Neurology. 35:1985;949-956.
2. Burns R.S., Chiueh C.C., Markey S.O., Ebert M.H., Jacobowitz D.M., Kopin I.J. A primate model of parkinsonism. Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Proc. Natl. Acad. Sci. USA. 80:1983;4546-4550.
3. Burns R.S., Markey S.P., Phillips J.M., Chiueh C.C. The neurotoxicity of l-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the monkey and man. Can. J. Neurol. Sci. 11:1984;166-168.
4. Chadi G., Møller A., Rosén L., Janson A.M., Agnati L.A., Goldstein M., Ögren S.O., Pettersson R.F., Fuxe K. Protective actions of human recombinant basic Fibroblast Growth Factor on MPTP lesioned in nigrostriatal dopamine neurons after intraventricular infusion. Exp. Brain Res. 97:1993;145-158.
5. Chiueh C.C., Burns R.S., Markey S.P., Jacobowitz D.M., Kopin I.J. Primate model of parkinsonsism. Selective lesion of nigrostriatal neurons by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine produces an extrapyramidal syndrome in rhesus monkeys Life Sci. 36:1985;213-218.
6. Davis G.C., Williams A.D., Markey S.P., Ebert M.H., Caine E.D., Reichert C.M., Kopin I.J. Chronic Parkinsonism secondary to intravenous injection of meperidine analogues. Psychiatr. Res. 1:1979;249-254.
7. Douglas W.R. Of pigs and men in research. A review of applications and analogies of the pig, Sus crofa, in human medical research Space Life Sci. 3:1972;226-234.
8. Forno, L. S.; DeLanney, L. E.; Irwin, I.; Langston, J. W.: Similarities and differences between MPTP-induced parkinsonism and Parkinson's disease. Neuropathologic considerations. In: Narabayashi, H.; Nagatsu, T.; Yanagisawa, N.; Mizuno, Y., eds. Advances in neurology. New York: Raven Press Ltd.; 1993; 60:600-608.
9. Freeman T.B., Brandeis L., Pearson J., Noonan R.A. Ontogeny of mesencephalic tyrosine hydroxylase immunoreactive neurons on the brain of the farm pig. Soc. Neurosci. Abstr. 12:1986;1223.
10. Hallman H., Olson L., Jonsson G. Neurotoxicity of the meperidine analogue N-methyl-4-phenyl-1,2,2,6-tetrahydropyridine on brain catecholamine neurons in the mouse. Eur. J. Pharmacol. 979:1984;133-136.
11. Heikkila R.E., Manzino L., Cabbat F.S., Duvoisin R.C. Protection against the dopaminergic neurotoxicity of 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine by monoamine oxidase inhibitors. Nature. 311:1984;467-469.
12. Huffaker T.K., Boss B.D., Morgan A.S., Neff N.T., Strecker R.E., Spence M.S., Miao R. Xenografting of fetal pig ventral mesencephalon corrects motor asymmetry in the rat model of Parkinson's disease. Exp. Brain Res. 77:1989;329-336.
13. Irwin I., DeLanney L.E., Forno L.S., Finnegan K.T., Di Monte D.A., Langston J.W. The evolution of nigrostriatal neurochemical changes in the MPTP-treated squirrel monkey. Brain Res. 531:1990;42-252.
14. Janson A.M., Møller A. Total number and mean volume of neurons and glia in substantia nigra after protection by chronic nicotine treatment in male rats partially hemitransected at the meso-diencephalic junction. Neuroscience. 57:1993;931-941.
15. Johannessen J.N., Chiueh C.C., Bacon J.P., Garick N.A., Burns R.S., Weise V.K., Kopin I.J., Parisi J.E., Markey S.P. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the dog. Effect of Pargyline Pretreatment. J. Neurochem. 53:1989;582-589.
16. Langston J.W., Ballard P., Tetrud J.W., Irwin I. Chronic Parkinsonism in humans due to a product of meperidine-Analog synthesis. Science. 219:1983;979-980.
17. Langston J.W., Forno L.S., Rebert C., Irwin I. Selective nigral toxicity after administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in squirrel monkey. Brain Res. 292:1984;390-394.
18. Langston J.W., Irwin I. MPTP. Current concepts and controversies Clin. Neuropharmacol. 6:1986;485-507.
19. Østergaard K., Holm I.E., Zimmer J. Tyrosine hydroxylase and acetylcholinesterase in the domestic pig mesencephalon. An immunocytochemical and histochemical study J. Comp. Neurol. 322:1992;149-166.
20. Pakkenberg B., Gundersen H.J.G. Total number of neurons and glia cells in human brain nuclei estimated by way of the disector and the fractionator. J. Microsc. 150:1988;1-20.
21. Pakkenberg B., Evans S.M., Møller A., Braendgaard H., Gundersen H.J.G. Total number of neurons in human neocortex related to age and sex estimated by way of optical disectors. Acta Stereol. 8:1989;251-256.
22. Pakkenberg B., Møller A., Dam A.M., Gundersen H.J.G., Pakkenberg H. The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's Disease estimated unbiasedly with a stereological method. J. Neurol. Neurosurg. Psychiat. 54:1991;30-33.
23. Ricaurte G.A., Langston J.W., DeLanney L.E., Irwin I., Peroutka S.J., Forno I.S. Fate of nigrostriatal neurons in young mature mice given 1-methyl-4-Phenyl-1,2,3,6-tetrahydropyridine. A neurochemical and morphological reassessment Brain Res. 376:1986;117-124.
24. Schneider J.S., Yuwiler A., Markham C.H. Production of a Parkinson-like syndrome in the cat with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Behavior, histology and biochemistry Exp. Neurol. 91:1986;293-307.
25. Schneider J.S., Markham C.H. Neurotoxic effects of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the cat. Tyrosine hydroxylase immunohistochemistry. Brain Res. 373:1986;258-267.
26. Schneider J.S. Effects of age on GM1 ganglioside-induced recovery of concentrations of dopamine in the striatum in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice. Neuropharmacology. 31:1992;185-192.
27. Sterio D.C. The unbiased estimation of number and sizes of arbitrary particles using the disector. J. Microsc. 134:1984;127-136.
28. Trétiakoff, C.: Contribution a l'etude de l'anatomie pathologique du locus niger de saemmering - avec quelgue deductions relatives a la pathogénie des troubles du tonus musculaire et de la maladie de Parkinson. Thèse pour le doctorat en Médecine; Paris, 1919: 1-124.
29. Wilson J.S., Turner B.H., Morrow G.D., Hartman P.J. MPTP produces a mosaic-like pattern of terminal degeneration in the caudate nucleus of dog. Brain Res. 423:1984;329-332.