Identification of novel orally available small molecule insulin mimetics

Journal of Pharmacology and Experimental Therapeutics

Volumn 323, Issue 2, 2007, Pages 579-585

  Lin, Bo ^a   Li, Zhitao ^b   Park, Kaapjoo ^b   Deng, Liu ^b   Pai, Ashok ^c,d   Zhong, Ling ^c,d   Pirrung, Michael C ^b   Webster, Nicholas J G ^a,c,d  

^a VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,5 DIHYDROXY 3 (7 BENZYLOXY 1H INDOL 3 YL) [1,4]BENZOQUINONE; 2,5 DIHYDROXY 3 [2 (1,1 DIMETHYLALLYL) 1H INDOL 3 YL] [1,4]BENZOQUINONE; 2,5 DIHYDROXY 3 [7 (3 METHYL BUT 2 ENYL) 1H INDOL 3 YL] [1,4]BENZOQUINONE; INSULIN; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; NORASTERRIQUINONE B1; ORAL ANTIDIABETIC AGENT; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG SPECIFICITY; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; HYPOGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; LIPOGENESIS; MITOGENESIS; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

3T3-L1 CELLS; ADMINISTRATION, ORAL; ANIMALS; BENZOQUINONES; CHO CELLS; CRICETINAE; CRICETULUS; HYPOGLYCEMIC AGENTS; INSULIN; MICE; MICE, INBRED C57BL; NIH 3T3 CELLS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTOR, INSULIN;

EID: 35549002671     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.126102     Document Type: Article

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