Effect of the insulin mimetic L-783,281 on intracellular [Ca2+] and insulin secretion from pancreatic β-cells

Diabetes

Volumn 51, Issue SUPPL., 2002, Pages

  Roper, Michael G ^a   Qian, Wei Jun ^a   Zhang, Bei B ^b   Kulkarni, Rohit N ^c   Ronald Kahn, C ^c   Kennedy, Robert T ^a  

^a University of Florida ^*  (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; INSULIN DERIVATIVE; L 767827; NORASTERRIQUINONE B1; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; THAPSIGARGIN; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL ISOLATION; CHO CELL; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EXOCYTOSIS; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

EID: 0036310723     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.2007.s43     Document Type: Conference Paper

References (39)

1. Discovery of a small molecule insulin mimetic with antidiabetic activity in mice
2. A novel insulin mimetic without a proliferative effect on vascular smooth muscle cells
3. Evidence for presence of insulin receptors in rat islets of Langerhans
4. Expression S48 of insulin receptor mRNA and insulin receptor substrate-1 in pancreatic islet β-cells
5. Glucose-induced insulin receptor tyrosine phosphorylation in insulin-secreting beta-cells
6. Glucose- and insulin-induced phosphorylation of the insulin receptor and its primary substrates IRS-1 and IRS-2 in rat pancreatic islets
7. Insulin mediates glucose-stimulated phosphorylation of PHAS-I by pancreatic beta cells: An insulin-receptor mechanism for autoregulation of protein synthesis by translation
8. Identification of phosphatidylinositol 3,4,5-trisphosphate in pancreatic islets and insulin-secreting beta-cells
9. Disruption of IRS-2 causes type 2 diabetes in mice
10. Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signaling
11. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory β-cell hyperplasia
12. Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways
13. 2+ homeostasis, and insulin expression and secretion
14. 2+ stores in insulin-stimulated insulin secretion in β-cells
15. 2+ uptake in β-cells
16. 972→Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic β cells
17. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured β-cell lines
18. Insulin-stimulated insulin secretion in single pancreatic beta cells
19. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
20. Pyridine nucleotides in pancreatic islets during inhibition of insulin release by exogenous insulin
21. Evidence for a feedback inhibition of insulin on insulin secretion in the isolated, perfused canine pancreas
22. Inhibition of insulin secretion by exogenous insulin in normal man as demonstrated by C-peptide assay
23. Evidence for an insulin-induced inhibition of insulin release by isolated islets of Langerhans
24. 2+ and secretion
25. Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene
26. Association between 5-hydroxytryptamine release and insulin secretion
27. Comparison of amperometric methods for detection of exocytosis from single pancreatic betacells of different species
28. A fluorimetric and amperometric study of calcium and secretion in isolated mouse pancreatic beta-cells
29. Amperometric detection of quantal secretion from patch-clamped rat pancreatic beta-cells
30. Bevelled carbon-fiber ultramicroelectrodes
31. Amperometric monitoring of chemical secretions from individual pancreatic beta-cells
32. Chemical and physiological characterization of fluo-4 Ca(2+)-indicator dyes
33. 2+ indicators with greatly improved fluorescence properties
34. Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps
35. 2+-ATPases in muscle and heart
36. Deconstructing type 2 diabetes
37. Insulin begets insulin
38. Insulin secretion: Feed-forward control of insulin biosynthesis?
39. Perspective: The insulin signaling system: A common link in the pathogenesis of type 2 diabetes