Activation of insulin receptors by lagerstroemin

Journal of Pharmacological Sciences

Volumn 93, Issue 1, 2003, Pages 69-73

  Hattori, Katsuji ^a   Sukenobu, Naoe ^a   Sasaki, Tomo ^a   Takasuga, Shunsuke ^a   Hayashi, Takeo ^a   Kasai, Ryoji ^a   Yamasaki, Kazuo ^a   Hazeki, Osamu ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Glucose transport; Insulin; Lagerstroemin; Lipolysis; Mitogen activated protein kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CYTOCHALASIN B; GLUCOSE; GLYCEROL; INSULIN; INSULIN RECEPTOR; ISOPRENALINE; LAGERSTROEMIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PLANT EXTRACT; TRYPSIN; TYROSINE; UNCLASSIFIED DRUG; WORTMANNIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; BETA CHAIN; CHO CELL; DIGESTION; DOSE RESPONSE; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EXTRACELLULAR SPACE; GLUCOSE TRANSPORT; HUMAN; LIPOLYSIS; LYTHRACEAE; NONHUMAN; RAT;

ADIPOCYTES; ANIMALS; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROLYZABLE TANNINS; INSULIN; LAGERSTROEMIA; MALE; PLANT LEAVES; RATS; RATS, WISTAR; RECEPTOR, INSULIN; TANNINS;

EID: 0141955261     PISSN: 13478613     EISSN: None     Source Type: Journal    
DOI: 10.1254/jphs.93.69     Document Type: Article

References (14)

1. Kakuda T, Sakane I, Takihara T, Ozaki Y, Takeuchi H, Kuroyanagi M. Hypoglycemic effect of extracts from Lagerstroemia speciosa L. leaves in genetically diabetic KK-AY mice. Biosci Biotechnol Biochem. 1996;60:204-208.
2. Liu F, Ki J, Li Y, Liu X, Li J, Chen X. An extract of Lagerstroemia speciosa L. has insulin-like glucose uptake-stimulatory and adipocyte differentiation-inhibitory activities in 3T3-L1 cells. J Nutr. 2001;131:2242-2247.
3. Murakami C, Myoga K, Kasai R, et al. Screening of plant constituents for effect on glucose transport activity in Ehrlich ascites tumours cells. Chem Pharm Bull (Tokyo). 1993;41:2129-2131.
4. Tommasi ND, Simone FD, Cirino G, Cicara C, Pizza C. Hypoglycemic effects of sesquiterpene glycosides and polyhydroxylated triterpenoids of Eriobotrya japonica. Planta Med. 1991;57:414-416.
5. Hayashi T, Maruyama H, Kasai R, et al. Ellagitannins from Lagerstroemia speciosa as activators of glucose transport in fat cells. Planta Med. 2002;68:173-175.
6. Okada T, Kawano Y, Sakakibara T, Hazeki O, Ui M. Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes: Studies with a selective inhibitor wortmannin. J Biol Chem. 1994;269:3568-3573.
7. Takasuga S, Katada T, Ui M, Hazeki O. Enhancement by adenosine of insulin-induced activation of phosphoinositide 3-kinase and protein kinase B in rat adipocytes. J Biol Chem. 1999;274:19545-19550.
8. White MF, Kahn CR. The insulin signaling system. J Biol Chem. 1994;269:1-4.
9. Green A, Olefsky JM. Evidence for insulin-induced internalization and degradation of insulin receptors in rat adipocytes. Proc Natl Acad Sci USA. 1982;79:427-431.
10. Kono T, Barham FW. Insulin-like effects of trypsin on fat cells: Localization of the metabolic steps and the cellular site affected by the enzyme. J Biol Chem. 1971;246:6204-6209.
11. Green A. The insulin-like effect of sodium vanadate on adipocyte glucose transport is mediated at a post-insulin-receptor level. Biochem J. 1986;238:663-669.
12. Duckworth BC, Cantley LC. Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin: Dependence on signal strength. J Biol Chem. 1997;272:27665-27670.
13. Takeda H, Matozaki T, Takada T, et al. PI 3-kinase γ and protein kinase C-ζ mediate RAS-independent activation of MAP kinase by a Gi protein-coupled receptor. EMBO J. 1999;18:386-395.
14. Kosuge S, Maekawa T, Saito C, Tanaka T, Kouno I, Ohtsuki K. Biochemical characterization of galloyl pedunculagin (ellagitannin) as a selective inhibitor of the β-regulatory subunit of A-kinase in vitro. J Biochem. 2001;129:403-409.