SCOPUS 정보 검색 플랫폼

Volumn 10, Issue 10, 2002, Pages 3197-3212

Synthesis and biological activity of a novel class of pyridazine analogues as non-competitive reversible inhibitors of protein tyrosine phosphatase 1B (PTP1B)

(8) Liljebris, Charlotta a Martinsson, Jessica a Tedenborg, Lars a Williams, Meredith a Barker, Emma b Duffy, James E S b Nygren, Alf a James, Stephen a

a BIOVITRUM AB (Sweden)

b BioFocus DPI (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 2 (4 ISOPROPYLPHENYL) 2,3 DIHYDRO 6H THIOPYRANO[3,4 C]PYRIDAZINE 4 CARBONITRILE; ENZYME INHIBITOR; INSULIN; INSULIN RECEPTOR; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE; PYRANO[3,4 C]PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG; VANADATE SODIUM; PROTEIN TYROSINE PHOSPHATASE 1B; PYRIDAZINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MUSCLE FIBER CULTURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; ANIMAL; BINDING SITE; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; HYDROPHOBICITY; IC 50; INSULIN RESISTANCE; KINETICS; METABOLISM; PHOSPHORYLATION; PROTEIN BINDING; RAT; SYNTHESIS;

ANIMALS; BINDING SITES; CELL LINE; CELL MEMBRANE PERMEABILITY; ENZYME INHIBITORS; HYDROPHOBICITY; INHIBITORY CONCENTRATION 50; INSULIN; INSULIN RESISTANCE; KINETICS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-TYROSINE-PHOSPHATASE; PYRIDAZINES; RATS; RECEPTOR, INSULIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036336284 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/S0968-0896(02)00176-1 Document Type: Article

Times cited : (64)

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