The probable cell of origin of NF1- and PDGF-Driven glioblastomas

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Hambardzumyan, Dolores ^a   Cheng, Yu Kang ^b,c,d   Haeno, Hiroshi ^b   Holland, Eric C ^c   Michor, Franziska ^b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLATELET DERIVED GROWTH FACTOR; NEUROFIBROMIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CARCINOGENESIS; CELL DIVISION; CELL TYPE; CONTROLLED STUDY; GENE; GENE MUTATION; GENE OVEREXPRESSION; GENE TRANSFER; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VIVO STUDY; MATHEMATICAL MODEL; MOUSE; NF1 GENE; NONHUMAN; PDGF GENE; PREDICTION; PROTEIN EXPRESSION; SUBVENTRICULAR ZONE; VALIDATION STUDY; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; BRAIN; BRAIN TUMOR; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY; MUTATION; PATHOLOGY; STEM CELL; THEORETICAL MODEL; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

MUS;

ANIMALS; BRAIN; BRAIN NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, NEUROFIBROMATOSIS 1; GLIOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; MODELS, GENETIC; MODELS, THEORETICAL; MUTATION; NEUROFIBROMIN 1; PLATELET-DERIVED GROWTH FACTOR; STEM CELLS;

EID: 80052559874     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024454     Document Type: Article

References (47)

1. Holland EC, (2001) Gliomagenesis: genetic alterations and mouse models. Nat Rev Genet 2: 120-129.
2. Stiles CD, Rowitch DH, (2008) Glioma stem cells: a midterm exam. Neuron 58: 832-846.
3. Temple S, Alvarez-Buylla A, (1999) Stem cells in the adult mammalian central nervous system. Curr Opin Neurobiol 9: 135-141.
4. Kondo T, Raff M, (2000) Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science 289: 1754-1757.
5. Buffo A, Rite I, Tripathi P, Lepier A, Colak D, et al. (2008) Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain. Proc Natl Acad Sci U S A 105: 3581-3586.
6. Pardal R, Molofsky AV, He S, Morrison SJ, (2005) Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors. Cold Spring Harb Symp Quant Biol 70: 177-185.
7. Phillips HS, Kharbanda S, Chen R, Forrest WF, Soriano RH, et al. (2006) Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9: 157-173.
8. Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, et al. (2010) Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17: 98-110.
9. Brennan C, Momota H, Hambardzumyan D, Ozawa T, Tandon A, et al. (2009) Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PLoS One 4: e7752.
10. Albers AC, Gutmann DH, (2009) Gliomas in patients with neurofibromatosis type 1. Expert Rev Neurother 9: 535-539.
11. The Cancer Genome Atlas Project (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455: 1061-1068.
12. Llaguno SA, Chen J, Kwon CH, Jackson EL, Li Y, et al. (2009) Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell 15: 45-56.
13. Liu C, Sage JC, Miller MR, Verhaak RG, Hippenmeyer S, et al. (2011) Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma. Cell.
14. Joseph NM, Mosher JT, Buchstaller J, Snider P, McKeever PE, et al. (2008) The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell 13: 129-140.
15. Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, et al. (2009) Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc Natl Acad Sci U S A 106: 2712-2716.
16. Dai C, Celestino JC, Okada Y, Louis DN, Fuller GN, et al. (2001) PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev 15: 1913-1925.
17. Assanah M, Lochhead R, Ogden A, Bruce J, Goldman J, et al. (2006) Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses. J Neurosci 26: 6781-6790.
18. Hambardzumyan D, Amankulor NM, Helmy KY, Becher OJ, Holland EC, (2009) Modeling Adult Gliomas Using RCAS/t-va Technology. Transl Oncol 2: 89-95.
19. Lindberg N, Kastemar M, Olofsson T, Smits A, Uhrbom L, (2009) Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma. Oncogene 28: 2266-2275.
20. Persson AI, Petritsch C, Swartling FJ, Itsara M, Sim FJ, et al. (2010) Non-stem cell origin for oligodendroglioma. Cancer Cell 18: 669-682.
21. Visvader JE, (2011) Cells of origin in cancer. Nature 469: 314-322.
22. Fialkow PJ, Faguet GB, Jacobson RJ, Vaidya K, Murphy S, (1981) Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell. Blood 58: 916-919.
23. Griffin JD, Lowenberg B, (1986) Clonogenic cells in acute myeloblastic leukemia. Blood 68: 1185-1195.
24. Chow LM, Endersby R, Zhu X, Rankin S, Qu C, et al. (2011) Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain. Cancer Cell 19: 305-316.
25. Tomlinson IP, Bodmer WF, (1995) Failure of programmed cell death and differentiation as causes of tumors: some simple mathematical models. Proc Natl Acad Sci U S A 92: 11130-11134.
26. Johnston MD, Edwards CM, Bodmer WF, Maini PK, Chapman SJ, (2007) Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer. Proc Natl Acad Sci U S A 104: 4008-4013.
27. Mirzadeh Z, Merkle FT, Soriano-Navarro M, Garcia-Verdugo JM, Alvarez-Buylla A, (2008) Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain. Cell Stem Cell 3: 265-278.
28. Moran PAP, (1962) The statistical processes of evolutionary theory Oxford Clarendon Press.
29. Ivanchuk SM, Mondal S, Dirks PB, Rutka JT, (2001) The INK4A/ARF locus: role in cell cycle control and apoptosis and implications for glioma growth. J Neurooncol 51: 219-229.
30. Vousden KH, Lu X, (2002) Live or let die: the cell's response to p53. Nat Rev Cancer 2: 594-604.
31. Sherr CJ, McCormick F, (2002) The RB and p53 pathways in cancer. Cancer Cell 2: 103-112.
32. Zhu Y, Harada T, Liu L, Lush ME, Guignard F, et al. (2005) Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation. Development 132: 5577-5588.
33. Zhu Y, Guignard F, Zhao D, Liu L, Burns DK, et al. (2005) Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 8: 119-130.
34. Assanah MC, Bruce JN, Suzuki SO, Chen A, Goldman JE, et al. (2009) PDGF stimulates the massive expansion of glial progenitors in the neonatal forebrain. Glia 57: 1835-1847.
35. Simons BD, Clevers H, (2011) Strategies for homeostatic stem cell self-renewal in adult tissues. Cell 145: 851-862.
36. Watt FM, Hogan BL, (2000) Out of Eden: stem cells and their niches. Science 287: 1427-1430.
37. Morrison SJ, Shah NM, Anderson DJ, (1997) Regulatory mechanisms in stem cell biology. Cell 88: 287-298.
38. Potten CS, Loeffler M, (1990) Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 110: 1001-1020.
39. Kosodo Y, Roper K, Haubensak W, Marzesco AM, Corbeil D, et al. (2004) Asymmetric distribution of the apical plasma membrane during neurogenic divisions of mammalian neuroepithelial cells. EMBO J 23: 2314-2324.
40. Huttner WB, Brand M, (1997) Asymmetric division and polarity of neuroepithelial cells. Curr Opin Neurobiol 7: 29-39.
41. Zhang R, Zhang Z, Zhang C, Zhang L, Robin A, et al. (2004) Stroke transiently increases subventricular zone cell division from asymmetric to symmetric and increases neuronal differentiation in the adult rat. J Neurosci 24: 5810-5815.
42. Boucher K, Yakovlev AY, Mayer-Proschel M, Noble M, (1999) A stochastic model of temporally regulated generation of oligodendrocytes in cell culture. Math Biosci 159: 47-78.
43. Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, et al. (2002) Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 1: 269-277.
44. Jackson EL, Garcia-Verdugo JM, Gil-Perotin S, Roy M, Quinones-Hinojosa A, et al. (2006) PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling. Neuron 51: 187-199.
45. Araten DJ, Golde DW, Zhang RH, Thaler HT, Gargiulo L, et al. (2005) A quantitative measurement of the human somatic mutation rate. Cancer Res 65: 8111-8117.
46. Oller AR, Rastogi P, Morgenthaler S, Thilly WG, (1989) A statistical model to estimate variance in long term-low dose mutation assays: testing of the model in a human lymphoblastoid mutation assay. Mutat Res 216: 149-161.
47. Franklin KBJ, Paxinos G, (1997) The Mouse Brain in Steriotaxic Coordinates.