Platelet-derived growth factor (PDGF) and glial tumorigenesis

Cancer Letters

Volumn 232, Issue 2, 2006, Pages 139-147

  Shih, Alan H ^a   Holland, Eric C ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Central nervous system; Gliomas; Platelet derived growth factor

Indexed keywords

PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR;

ANGIOGENESIS; AUTOCRINE EFFECT; CARCINOGENESIS; CELL DIFFERENTIATION; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM TUMOR; ENZYME ACTIVITY; GENE EXPRESSION; GLIOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SHORT SURVEY; SIGNAL TRANSDUCTION; TUMOR GROWTH;

EID: 31644442040     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.02.002     Document Type: Review

References (57)

1. R. Ross, J. Glomset, B. Kariya, and L. Harker A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro Proc. Natl. Acad. Sci. USA 71 1974 1207 1210
2. C.H. Heldin, and B. Westermark Mechanism of action and in vivo role of platelet-derived growth factor Physiol. Rev. 79 1999 1283 1316
3. R. Dalla-Favera, E.P. Gelmann, R.C. Gallo, and F. Wong-Staal A human onc gene homologous to the transforming gene (v-sis) of simian sarcoma virus Nature 292 1981 31 35
4. L. Fredriksson, H. Li, C. Fieber, X. Li, and U. Eriksson Tissue plasminogen activator is a potent activator of PDGF-CC Eur. Mol. Biol. Org. J. 23 2004 3793 3802
5. P. Lindblom, H. Gerhardt, S. Liebner, A. Abramsson, M. Enge, and M. Hellstrom Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall Genes Dev. 17 2003 1835 1840
6. E. Feyzi, F. Lustig, G. Fager, D. Spillmann, U. Lindahl, and M. Salmivirta Characterization of heparin and heparan sulfate domains binding to the long splice variant of platelet-derived growth factor a chain J. Biol. Chem. 272 1997 5518 5524
7. M.A. Heidaran, J.F. Beeler, J.C. Yu, T. Ishibashi, W.J. LaRochelle, J.H. Pierce, and S.A. Aaronson Differences in substrate specificities of alpha and beta platelet-derived growth factor (PDGF) receptors. Correlation with their ability to mediate PDGF transforming functions J. Biol. Chem. 268 1993 9287 9295
8. R.A. Klinghoffer, P.F. Mueting-Nelsen, A. Faerman, M. Shani, and P. Soriano The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions Mol. Cell 7 2001 343 354
9. H. Ding, L. Roncari, P. Shannon, X. Wu, N. Lau, and J. Karaskova Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas Cancer Res. 61 2001 3826 3836
10. E.C. Holland, J. Celestino, C. Dai, L. Schaefer, R.E. Sawaya, and G.N. Fuller Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice Nat. Genet. 25 2000 55 57
11. V.K. Rajasekhar, A. Viale, N.D. Socci, M. Wiedmann, X. Hu, and E.C. Holland Oncogenic ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes Mol. Cell 12 2003 889 901
12. J. Seoane, H.V. Le, L. Shen, S.A. Anderson, and J. Massague Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation Cell 117 2004 211 223
13. R.M. Wolf, J.J. Wilkes, M.V. Chao, and M.D. Resh Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation J. Neurobiol. 49 2001 62 78
14. M. Valius, and A. Kazlauskas Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal Cell 73 1993 321 334
15. S. Khoshyomn, P.L. Penar, J. Rossi, A. Wells, D.L. Abramson, and A. Bhushan Inhibition of phospholipase C-gamma1 activation blocks glioma cell motility and invasion of fetal rat brain aggregates Neurosurgery 44 1999 568 577 [discussion 577-578]
16. A.B. da Rocha, D.R. Mans, A. Regner, and G. Schwartsmann Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas? Oncologist 7 2002 17 33
17. M.L. Vignais, H.B. Sadowski, D. Watling, N.C. Rogers, and M. Gilman Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins Mol. Cell Biol. 16 1996 1759 1769
18. A. Bonni, Y. Sun, M. Nadal-Vicens, A. Bhatt, D.A. Frank, and I. Rozovsky Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway Science 278 1997 477 483
19. C. Dai, Y. Lyustikman, A.H. Shih, X. Hu, G.N. Fuller, M. Rosenblum, and E.C. Holland The characteristics of astrocytomas and oligodendrogliomas are caused by two distinct and interchangeable signaling formats Neoplasia 7 2005 397 406
20. H.J. Yeh, K.G. Ruit, Y.X. Wang, W.C. Parks, W.D. Snider, and T.F. Deuel PDGF A-chain gene is expressed by mammalian neurons during development and in maturity Cell 64 1991 209 216
21. M. Sasahara, J.W. Fries, E.W. Raines, A.M. Gown, L.E. Westrum, and M.P. Frosch PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model Cell 64 1991 217 227
22. M. Sasahara, S. Amano, H. Sato, J.G. Yang, Y. Hayase, and M. Kaneko Normal developing rat brain expresses a platelet-derived growth factor B chain (c-sis) mRNA truncated at the 5′ end Oncogene 16 1998 1571 1578
23. F. Rorsman, P. Leveen, and C. Betsholtz Platelet-derived growth factor (PDGF) A-chain mRNA heterogeneity generated by the use of alternative promoters and alternative polyadenylation sites Growth Factors 7 1992 241 251
24. P. Horvath, A. Suganuma, M. Inaba, Y.B. Pan, and K.C. Gupta Multiple elements in the 5′ untranslated region down-regulate c-sis messenger RNA translation Cell Growth Differ. 6 1995 1103 1110
25. N.P. Pringle, H.S. Mudhar, E.J. Collarini, and W.D. Richardson PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage Development 115 1992 535 551
26. M. Fruttiger, L. Karlsson, A.C. Hall, A. Abramsson, A.R. Calver, and H. Bostrom Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice Development 126 1999 457 467
27. A.R. Calver, A.C. Hall, W.P. Yu, F.S. Walsh, J.K. Heath, C. Betsholtz, and W.D. Richardson Oligodendrocyte population dynamics and the role of PDGF in vivo Neuron 20 1998 869 882
28. R.A. Klinghoffer, T.G. Hamilton, R. Hoch, and P. Soriano An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development Dev. Cell 2 2002 103 113
29. P. Leveen, M. Pekny, S. Gebre-Medhin, B. Swolin, E. Larsson, and C. Betsholtz Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities Genes Dev. 8 1994 1875 1887
30. R. Cao, E. Brakenhielm, R. Pawliuk, D. Wariaro, M.J. Post, and E. Wahlberg Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2 Nat. Med. 9 2003 604 613
31. P. Kleihues, and W.K. Cavenee World Health Organization Classification of Tumours: Pathology and Genetics: Tumours of the Nervous System second ed. 2000 WHO Publications Centre USA Albany
32. Y. Zhu, and L.F. Parada The molecular and genetic basis of neurological tumours Nat. Rev. Cancer 2 2002 616 626
33. L.M. DeAngelis Brain tumors N. Engl. J. Med. 344 2001 114 123
34. M. Nister, T.A. Libermann, C. Betsholtz, M. Pettersson, L. Claesson-Welsh, and C.H. Heldin Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines Cancer Res. 48 1988 3910 3918
35. M. Hermanson, K. Funa, M. Hartman, L. Claesson-Welsh, C.H. Heldin, B. Westermark, and M. Nister Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops Cancer Res. 52 1992 3213 3219
36. F. Di Rocco, R.S. Corroll, J. Zhang, and P.M. Black Platelet-derived growth factor and its receptor expression in human oligodendrogliomas Neurosurgery 42 1998 341 346
37. M. Varela, S.M. Ranuncolo, A. Morand, J. Lastiri, E.B. De Kier Joffe, L.I. Puricelli, and M.G. Pallotta EGF-R and PDGF-R, but not bcl-2, overexpression predict overall survival in patients with low-grade astrocytomas J. Surg. Oncol. 86 2004 34 40
38. N.A. Lokker, C.M. Sullivan, S.J. Hollenbach, M.A. Israel, and N.A. Giese Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors Cancer Res. 62 2002 3729 3735
39. K.H. Plate, G. Breier, C.L. Farrell, and W. Risau Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas Lab. Invest. 67 1992 529 534
40. M. Maxwell, S.P. Naber, H.J. Wolfe, T. Galanopoulos, E.T. Hedley-Whyte, P.M. Black, and H.N. Antoniades Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance J. Clin. Invest. 86 1990 131 140
41. L.K. Shawver, D.P. Schwartz, E. Mann, H. Chen, J. Tsai, and L. Chu Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(trifluoromethyl)-phenyl]5-methylisoxazole-4-carboxamide Clin. Cancer Res. 3 1997 1167 1177
42. J.R. Shapiro Genetics of nervous system tumors Hematol. Oncol. Clin. North Am. 15 2001 961 977
43. T.P. Fleming, A. Saxena, W.C. Clark, J.T. Robertson, E.H. Oldfield, S.A. Aaronson, and I.U. Ali Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors Cancer Res. 52 1992 4550 4553
44. J.S. Smith, X.Y. Wang, J. Qian, S.M. Hosek, B.W. Scheithauer, R.B. Jenkins, and C.D. James Amplification of the platelet-derived growth factor receptor-A (PDGFRA) gene occurs in oligodendrogliomas with grade IV anaplastic features J. Neuropathol. Exp. Neurol. 59 2000 495 503
45. T. Kumabe, Y. Sohma, T. Kayama, T. Yoshimoto, and T. Yamamoto Amplification of alpha-platelet-derived growth factor receptor gene lacking an exon coding for a portion of the extracellular region in a primary brain tumor of glial origin Oncogene 7 1992 627 633
46. I.D. Clarke, and P.B. Dirks A human brain tumor-derived PDGFR-alpha deletion mutant is transforming Oncogene 22 2003 722 733
47. L. Uhrbom, G. Hesselager, M. Nister, and B. Westermark Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus Cancer Res. 58 1998 5275 5279
48. C. Dai, J.C. Celestino, Y. Okada, D.N. Louis, G.N. Fuller, and E.C. Holland PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo Genes Dev. 15 2001 1913 1925
49. G. Hesselager, L. Uhrbom, B. Westermark, and M. Nister Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model Cancer Res. 63 2003 4305 4309
50. T. Kilic, J.A. Alberta, P.R. Zdunek, M. Acar, P. Iannarelli, and T. O'Reilly Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class Cancer Res. 60 2000 5143 5150
51. I.R. Radford Imatinib. Novartis Curr. Opin. Investig. Drugs 3 2002 492 499
52. H. Colognato, S. Ramachandrappa, I.M. Olsen, and C. ffrench-Constant Integrins direct Src family kinases to regulate distinct phases of oligodendrocyte development J. Cell Biol. 167 2004 365 375
53. P. Guo, B. Hu, W. Gu, L. Xu, D. Wang, and H.J. Huang Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment Am. J. Pathol. 162 2003 1083 1093
54. C.H. Heldin, K. Rubin, K. Pietras, and A. Ostman High interstitial fluid pressure - an obstacle in cancer therapy Nat. Rev. Cancer 4 2004 806 813
55. K. Pietras, T. Sjoblom, K. Rubin, C.H. Heldin, and A. Ostman PDGF receptors as cancer drug targets Cancer Cell 3 2003 439 443
56. A.H. Shih, C. Dai, X. Hu, M.K. Rosenblum, J.A. Koutcher, and E.C. Holland Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis Cancer Res. 64 2004 4783 4789
57. S. Heller, L. Scheibenpflug, B. Westermark, and M. Nister PFGF B mRNA variants in human tumors with similarity to the v-sis oncogene: expression of cellular PDGF B protein is associated with exon 1 divergence, but not with a 3′UTR splice variant Int. J. Cancer 85 2000 211 222