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Volumn 50, Issue 10, 2004, Pages 803-810

Three unlinked gene clusters are involved in clavam metabolite biosynthesis in Streptomyces clavuligerus

Author keywords

Clavams; Clavulanic acid; Gene clusters; Paralogues; Streptomyces

Indexed keywords

ANTIBIOTICS; BIOSYNTHESIS; CHROMOSOMES; ELECTROPHORESIS; GELS; GENES;

EID: 11044239452     PISSN: 00084166     EISSN: None     Source Type: Journal    
DOI: 10.1139/w04-070     Document Type: Article
Times cited : (29)

References (29)
  • 1
    • 0028048859 scopus 로고
    • Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis
    • Aidoo, K.A., Wong, A., Alexander, D.C., Rittammer, R.A., and Jensen, S.E. 1994. Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis. Gene, 147: 41-46.
    • (1994) Gene , vol.147 , pp. 41-46
    • Aidoo, K.A.1    Wong, A.2    Alexander, D.C.3    Rittammer, R.A.4    Jensen, S.E.5
  • 3
    • 0031855642 scopus 로고    scopus 로고
    • Investigation of the Streptomyces clavuligerus cephamycin C gene cluster and its regulation by the CcaR protein
    • Alexander, D.C., and Jensen, S.E. 1998. Investigation of the Streptomyces clavuligerus cephamycin C gene cluster and its regulation by the CcaR protein. J. Bacteriol. 180: 4068-4079.
    • (1998) J. Bacteriol. , vol.180 , pp. 4068-4079
    • Alexander, D.C.1    Jensen, S.E.2
  • 6
    • 0030991157 scopus 로고    scopus 로고
    • Probable role of clavaminic acid as the terminal intermediate in the common pathway to clavulanic acid and the antipodal clavam metabolites
    • Egan, L.A., Busby, R.W., Iwata-Reuyl, D., and Townsend, C.A. 1997. Probable role of clavaminic acid as the terminal intermediate in the common pathway to clavulanic acid and the antipodal clavam metabolites. J. Am. Chem. Soc. 119: 2348-2355.
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 2348-2355
    • Egan, L.A.1    Busby, R.W.2    Iwata-Reuyl, D.3    Townsend, C.A.4
  • 7
    • 0027407781 scopus 로고
    • Pulsed-field gel electrophoresis of Streptomyces lividans DNA
    • Evans, M., and Dyson, P. 1993. Pulsed-field gel electrophoresis of Streptomyces lividans DNA. Trends Genet. 9: 72.
    • (1993) Trends Genet. , vol.9 , pp. 72
    • Evans, M.1    Dyson, P.2
  • 8
    • 0001169379 scopus 로고
    • Streptomyces clavuligerus sp. nov., a β-lactam antibiotic producer
    • Higgens, C.E., and Kastner, R.E. 1971. Streptomyces clavuligerus sp. nov., a β-lactam antibiotic producer. Int. J. Syst. Bacteriol. 21: 326-331.
    • (1971) Int. J. Syst. Bacteriol. , vol.21 , pp. 326-331
    • Higgens, C.E.1    Kastner, R.E.2
  • 9
    • 0028972461 scopus 로고
    • Clavulanic acid biosynthesis in Streptomyces clavuligerus: Gene cloning and characterization
    • Hodgson, J.E., Fosberry, A.P., Rawlinson, N.S., Ross, H.N.M., Neal, R.J., Arnell, J.C. et al. 1995. Clavulanic acid biosynthesis in Streptomyces clavuligerus: gene cloning and characterization. Gene, 166: 49-55.
    • (1995) Gene , vol.166 , pp. 49-55
    • Hodgson, J.E.1    Fosberry, A.P.2    Rawlinson, N.S.3    Ross, H.N.M.4    Neal, R.J.5    Arnell, J.C.6
  • 10
    • 0038561132 scopus 로고    scopus 로고
    • Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis
    • Ikeda, H., Ishikawa, J., Hanamoto, A., Shinose, M., Kikuchi, H., Shiba, T. et al. 2003. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat. Biotechnol. 21: 526-531.
    • (2003) Nat. Biotechnol. , vol.21 , pp. 526-531
    • Ikeda, H.1    Ishikawa, J.2    Hanamoto, A.3    Shinose, M.4    Kikuchi, H.5    Shiba, T.6
  • 11
    • 0034004958 scopus 로고    scopus 로고
    • Enzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerus
    • Jensen, S.E., Elder, K.J., Aidoo, K.A., and Paradkar, A.S. 2000. Enzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerus. Antimicrob. Agents Chemother. 44: 720-726.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 720-726
    • Jensen, S.E.1    Elder, K.J.2    Aidoo, K.A.3    Paradkar, A.S.4
  • 12
    • 0032980244 scopus 로고    scopus 로고
    • Biosynthesis and molecular genetics of clavulanic acid
    • Jensen, S.E., and Paradkar, A.S. 1999. Biosynthesis and molecular genetics of clavulanic acid. Antonie Leeuwenhoek, 75: 125-133.
    • (1999) Antonie Leeuwenhoek , vol.75 , pp. 125-133
    • Jensen, S.E.1    Paradkar, A.S.2
  • 14
    • 0942268844 scopus 로고    scopus 로고
    • Streptomyces clavuligerus has a second copy of the gene encoding proclavaminate amidinohydrolase
    • Jensen, S.E., Wong, A., Griffin, A., and Barton, B. 2004b. Streptomyces clavuligerus has a second copy of the gene encoding proclavaminate amidinohydrolase. Antimicrob. Agents Chemother. 48: 514-520.
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 514-520
    • Jensen, S.E.1    Wong, A.2    Griffin, A.3    Barton, B.4
  • 16
    • 0033933826 scopus 로고    scopus 로고
    • Expansion of the clavulanic acid gene cluster: Identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus
    • Li, R., Khaleeli, N., and Townsend, C.A. 2000. Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus. J. Bacteriol. 182: 4087-4095.
    • (2000) J. Bacteriol. , vol.182 , pp. 4087-4095
    • Li, R.1    Khaleeli, N.2    Townsend, C.A.3
  • 17
    • 0033792721 scopus 로고    scopus 로고
    • Clavulanic acid, a beta-lactamase inhibitor: Biosynthesis and molecular genetics
    • Liras, P., and Rodríguez-García, A. 2000. Clavulanic acid, a beta-lactamase inhibitor: biosynthesis and molecular genetics. Appl. Microbiol. Biotechnol. 54: 467-475.
    • (2000) Appl. Microbiol. Biotechnol. , vol.54 , pp. 467-475
    • Liras, P.1    Rodríguez-García, A.2
  • 18
    • 0036260378 scopus 로고    scopus 로고
    • The clavulanic acid biosynthetic cluster of Streptomyces clavuligerus: Genetic organization of the region upstream of the car gene
    • Mellado, E., Lorenzana, L.M., Rodríguez-Sáiz, M., Díez, B., Liras, P., and Barredo, J.L. 2002. The clavulanic acid biosynthetic cluster of Streptomyces clavuligerus: genetic organization of the region upstream of the car gene. Microbiology, 148: 1427-1438.
    • (2002) Microbiology , vol.148 , pp. 1427-1438
    • Mellado, E.1    Lorenzana, L.M.2    Rodríguez-Sáiz, M.3    Díez, B.4    Liras, P.5    Barredo, J.L.6
  • 19
    • 0032931680 scopus 로고    scopus 로고
    • Genes specific for the biosynthesis of clavam metabolites antipodal to clavulanic acid are clustered with the gene for clavaminate synthase 1 in Streptomyces clavuligerus
    • Mosher, R.H., Paradkar, A.S., Anders, C., Barton, B., and Jensen, S.E. 1999. Genes specific for the biosynthesis of clavam metabolites antipodal to clavulanic acid are clustered with the gene for clavaminate synthase 1 in Streptomyces clavuligerus. Antimicrob. Agents Chemother. 43: 1215-1224.
    • (1999) Antimicrob. Agents Chemother. , vol.43 , pp. 1215-1224
    • Mosher, R.H.1    Paradkar, A.S.2    Anders, C.3    Barton, B.4    Jensen, S.E.5
  • 20
    • 0029135041 scopus 로고
    • Giant linear plasmids of beta-lactam antibiotic producing Streptomyces
    • Netolitzky, D.J., Wu, X., Jensen, S.E., and Roy, K.L. 1995. Giant linear plasmids of beta-lactam antibiotic producing Streptomyces. FEMS Microbiol. Lett. 131: 27-34.
    • (1995) FEMS Microbiol. Lett. , vol.131 , pp. 27-34
    • Netolitzky, D.J.1    Wu, X.2    Jensen, S.E.3    Roy, K.L.4
  • 21
    • 0035834039 scopus 로고    scopus 로고
    • Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites
    • Ōmura, S., Ikeda, H., Ishikawa, J., Hanamoto, A., Takahashi, C., Shinose, M. et al. 2001. Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc. Natl. Acad. Sci. USA, 98: 12 215-12 220.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12215-12220
    • Omura, S.1    Ikeda, H.2    Ishikawa, J.3    Hanamoto, A.4    Takahashi, C.5    Shinose, M.6
  • 22
    • 0030954966 scopus 로고    scopus 로고
    • A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: Amplification results in overproduction of both beta-lactam compounds
    • Pérez-Llarena, F.J., Liras, P., Rodríguez-García, A., and Martín, J.F. 1997. A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds. J. Bacteriol. 179: 2053-2059.
    • (1997) J. Bacteriol. , vol.179 , pp. 2053-2059
    • Pérez-Llarena, F.J.1    Liras, P.2    Rodríguez-García, A.3    Martín, J.F.4
  • 23
    • 0032510817 scopus 로고    scopus 로고
    • The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene
    • Pérez-Redondo, R., Rodríguez-García, A., Martín, J.F., and Liras, P. 1998. The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene. Gene, 211: 311-321.
    • (1998) Gene , vol.211 , pp. 311-321
    • Pérez-Redondo, R.1    Rodríguez-García, A.2    Martín, J.F.3    Liras, P.4
  • 24
    • 0345440126 scopus 로고    scopus 로고
    • Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: Evidence for two different genes in formation of the C3 unit
    • Pérez-Redondo, R., Rodríguez-García, A., Martín, J.F., and Liras, P. 1999. Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: evidence for two different genes in formation of the C3 unit. J. Bacteriol. 181: 6922-6928.
    • (1999) J. Bacteriol. , vol.181 , pp. 6922-6928
    • Pérez-Redondo, R.1    Rodríguez-García, A.2    Martín, J.F.3    Liras, P.4
  • 26
    • 4444277108 scopus 로고    scopus 로고
    • The paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerus
    • Tahlan, K., Anders, C., and Jensen, S.E. 2004a. The paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerus. J. Bacteriol. 186: 6286-6297.
    • (2004) J. Bacteriol. , vol.186 , pp. 6286-6297
    • Tahlan, K.1    Anders, C.2    Jensen, S.E.3
  • 27
    • 1442300124 scopus 로고    scopus 로고
    • Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam biosynthesis in Streptomyces clavuligerus
    • Tahlan, K., Ung Park, H., Wong, A., Beatty, PH., and Jensen, S.E. 2004b. Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam biosynthesis in Streptomyces clavuligerus. Antimicrob. Agents Chemother. 48: 930-939.
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 930-939
    • Tahlan, K.1    Ung Park, H.2    Wong, A.3    Beatty, P.H.4    Jensen, S.E.5
  • 28
    • 0027289141 scopus 로고
    • The biosynthetic genes for clavulanic acid and cephamycin production occur as a 'super-cluster' in three Streptomyces
    • Ward, J.M., and Hodgson, J.E. 1993. The biosynthetic genes for clavulanic acid and cephamycin production occur as a 'super-cluster' in three Streptomyces. FEMS Microbiol. Lett. 110: 239-242.
    • (1993) FEMS Microbiol. Lett. , vol.110 , pp. 239-242
    • Ward, J.M.1    Hodgson, J.E.2
  • 29
    • 0027392412 scopus 로고
    • Complete nucleotide sequence of a linear plasmid from Streptomyces clavuligerus and characterization of its RNA transcripts
    • Wu, X., and Roy, K.L. 1993. Complete nucleotide sequence of a linear plasmid from Streptomyces clavuligerus and characterization of its RNA transcripts. J. Bacteriol. 175: 37-52.
    • (1993) J. Bacteriol. , vol.175 , pp. 37-52
    • Wu, X.1    Roy, K.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.