Role of σ-factor (orf21) in clavulanic acid production in Streptomyces clavuligerus NRRL3585

Microbiological Research

Volumn 166, Issue 5, 2011, Pages 369-379

  Jnawali, Hum Nath ^a   Liou, Kwangkyoung ^a   Sohng, Jae Kyung ^a  

^a SunMoon University   (South Korea)

Author keywords

Clavulanic acid; Replication; Sigma factor; Streptomyces clavuligerus NRRL3585

Indexed keywords

CLAVULANIC ACID; GROWTH PATTERNS; HYPERPRODUCTION; INSERTIONAL INACTIVATION; OVER-EXPRESSION; REGULATORY GENES; REPLICATION; SIGMA FACTOR; SOLID MEDIUM; STREPTOMYCES CLAVULIGERUS; WILD TYPES; WILD-TYPE CELLS;

BACTERIA; GENE EXPRESSION;

CARBOXYLIC ACIDS;

CLAVULANIC ACID; SIGMA FACTOR;

ANTIBIOTICS; BACTERIUM; GENE EXPRESSION; GROWTH RATE; MOLECULAR ANALYSIS; POLYMERASE CHAIN REACTION; REAL TIME; SPORULATION;

ARTICLE; BACTERIAL SPORE; BIOSYNTHESIS; CHEMISTRY; CULTURE MEDIUM; CYTOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOMYCES;

CLAVULANIC ACID; CULTURE MEDIA; GENE EXPRESSION PROFILING; GENE KNOCKOUT TECHNIQUES; MUTAGENESIS, INSERTIONAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGMA FACTOR; SPORES, BACTERIAL; STREPTOMYCES;

BACTERIA (MICROORGANISMS); STREPTOMYCES CLAVULIGERUS;

EID: 79955931243     PISSN: 09445013     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.micres.2010.07.005     Document Type: Article

References (46)

1. Alexander D., Jensen S.E. Investigation of the Streptomyces clavuligerus cephamycin gene cluster and its regulation by the CcaR. J Bacteriol 1998, 180:4068-4079.
2. Ando M., Yoshimatsu T., Ko C., Converse P.J., Bishai W.R. Deletion of Mycobacterium tuberculosis sigma factor E results in delayed time to death with bacterial persistence in the lungs of aerosol-infected mice. Infect Immun 2003, 71:7170-7172.
3. Aoki H., Sakai H., Kohsaka M., Konomi T., Hosoda J., Nocardicin A. A new monocyclic β-lactam antibiotic. I. Discovery, isolation and characterization. J Antibiot 1976, 29:492-500.
4. Bachmann B.O., Li R., Townsend C.A. β-Lactam synthetase: a new biosynthetic enzyme. Proc Natl Acad Sci USA 1998, 95:9082-9086.
5. Baldwin J.E., Adlington R.M., Bryans J.S., Bringhen A.O., Coates J.B., Crouch N.P., et al. Isolation of dihydroclavaminic acid, an intermediate in the biosynthesis of clavulanic acid. Tetrahedron 1991, 47:4089-4100.
6. Balleza E., Lopez-Bojorquez L.N., Martinez-Antonio A., Resendis-Antonio O., Lozada-Chavez I., Balderas-Martinez Y.I., et al. Regulation by transcription factors in bacteria: beyond description. FEMS Microbiol Rev 2009, 33:133-151.
7. Barik S., Sureka K., Mukherjee P., Basu J., Kundu M. RseA, the SigE specific anti-sigma factor of Mycobacterium tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2 proteolysis. Mol Microbiol 2010, 75:592-606.
8. Borukhova S., Severinov K. Role of the RNA polymerase sigma subunit in transcription initiation. Res Microbiol 2002, 153:557-562.
9. Browning D.F., Busby S.J. The regulation of bacterial transcription initiation. Nat Rev Microbiol 2004, 2:57-65.
10. Cho Y.H., Lee E.J., Ahn B.E., Roe J.H. SigB, an RNA polymerase sigma factor required for osmoprotection and proper differentiation of Streptomyces coelicolor. Mol Microbiol 2001, 42:205-214.
11. Dona V., Rodrigue S., Dainese E., Palu G., Gaudreau L., Manganelli R., et al. Evidence of complex transcriptional, translational and posttranslational regulation of the extracytoplasmic function sigma factor σE in Mycobacterium tuberculosis. J Bacteriol 2008, 190:5963-5971.
12. Elson S.W., Baggaley K.H., Davison M., Fulston M., Nicholson N.H., Risbridger G.D., et al. The identification of three new biosynthetic intermediates and one further biosynthetic enzyme in the clavulanic acid pathway. J Chem Soc Chem Commun 1993, 1212-1214.
13. Garcia-Dominguez M., Martin J.F., Mahro B., Demain A.L., Liras P. Efficient plasmid transformation of the β-lactam producer Streptomyces clavuligerus. Appl Environ Microbiol 1987, 53:1376-1381.
14. Grainger D.C., Busby S.J. Global regulators of transcription in Escherichia coli: mechanisms of action and methods for study. Adv Appl Microbiol 2008, 65:93-113.
15. Gruber T.M., Gross C.A. Multiple sigma subunits and the partitioning of bacterial transcription space. Annu Rev Microbiol 2003, 57:441-466.
16. Haugen S.P., Ross W., Gourse R.L. Advances in bacterial promoter recognition and its control by factors that do not bind DNA. Nat Rev Microbiol 2008, 6:507-519.
17. Homerova D., Sevcikova B., Sprusansky O., Kormanec J. Identification of DNA-binding proteins involved in regulation of expression of the Streptomyces aureofaciens sigF gene, which encodes sporulation sigma factor sigma(F). Microbiology 2000, 146:2919-2928.
18. Jensen S.E., Paradkar A.S., Mosher R.H., Anders C., Beatty P.H., Brumlik M.J., et al. Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus. Antimicrob Agents Chemother 2004, 48:192-202.
19. Jnawali H.N., Oh T.J., Liou K., Park B.C., Sohng J.K. A two-component regulatory system involved in clavulanic acid production. J Antibiot 2008, 61:651-659.
20. Khaleeli N., Li R., Townsend C.A. Origin of the β-lactam carbons in clavulanic acid from an unusual thiamine pyrophosphate-mediated reaction. J Am Chem Soc 1999, 121:9223-9224.
21. Kieser T., Bibb M.J., Buttner M.J., Chater K.F., Hopwood D.A. Practical streptomyces genetics 2000, John Innes Foundation, Norwich.
22. Kim M.S., Hahn M.Y., Cho Y., Cho S.N., Roe J.H. Positive and negative feedback regulatory loops of thiol-oxidative stress response mediated by an unstable isoform of σR in actinomycetes. Mol Microbiol 2009, 73:815-825.
23. Kirstein J., Dougan D.A., Gerth U., Hecker M., Turgay K. The tyrosine kinase McsB is a regulated adaptor protein for ClpCP. EMBO J 2007, 26:2061-2070.
24. Lee E.J., Karoonuthaisiri N., Kim H.S., Park J.H., Cha C.J., Kao C.M., et al. A master regulator sigmaB governs osmotic and oxidative response as well as differentiation via a network of sigma factors in Streptomyces coelicolor. Mol Microbiol 2005, 57:1252-1264.
25. Li R., Townsend C.A. Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus. Metab Eng 2006, 8:240-252.
26. Liras P., Rodri{dotless}guez-Garcia A. Clavulanic acid, a beta-lactamase inhibitor: biosynthesis and molecular genetics. Appl Microbiol Biotechnol 2000, 54:467-475.
27. Lonetto M.A., Brown K.L., Rudd K.E., Buttner M.J. Analysis of the Streptomyces coelicolor sigE gene reveals the existence of a subfamily of eubacterial RNA polymerase factors involved in the regulation of extracytoplasmic functions. Proc Natl Acad Sci USA 1994, 91:7573-7577.
28. Madduri K., Hutchinson C.R. Functional characterization and transcriptional analysis of the dnrR1 locus, which controls daunorubicin biosynthesis in Streptomyces peucetius. J Bacteriol 1995, 177:1208-1215.
29. Marsh E.N., Chang M.D., Townsend C.A. Two isozymes of clavaminate synthase central to clavulanic acid formation: cloning and sequencing of both genes from Streptomyces clavuligerus. Biochemistry 1992, 31:12648-12657.
30. McLeod S.M., Johnson R.C. Control of transcription by nucleoid proteins. Curr Opin Microbiol 2001, 4:152-159.
31. Nicholson N.H., Baggaley K.H., Cassels R., Davison M., Elson S.W., Fulston M., et al. Evidence that the immediate biosynthetic precursor of clavulanic acid is its N-aldehyde analog. J Chem Soc Chem Commun 1994, 1281-1282.
32. Paget M.S., Helmann J.D. The sigma70 family of sigma factors. Genome Biol 2003, 4. 203.201-6.
33. Pan Q., Garsin D.A., Losick R. Self-reinforcing activation of a cell-specific transcription by proteolysis of an anti-sigma factor in B. subtilis. Mol Cell 2001, 8:873-878.
34. Paradkar A.S., Aidoo K.A., Jensen S.E. A pathway-specific transcriptional activator regulates late steps of clavulanic acid biosynthesis in Streptomyces clavuligerus. Mol Microbiol 1998, 27:831-843.
35. Pérez-Redondo R., Rodríguez-García A., Martín J.F., Liras P. Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: evidence for two different genes in formation of the C3 unit. J Bacteriol 1999, 181:6922-6928.
36. Pérez-Redondo R., Rodríguez-García A., Martín J.F., Liras P. The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene. Gene 1998, 211:311-321.
37. Raman S., Song T., Puyang X., Bardarov S., Jacobs W.R., Husson R.N. The alternative sigma factor SigH regulates major components of oxidative and heat stress responses in Mycobacterium tuberculosis. J Bacteriol 2001, 183:6119-6125.
38. Salowe S.P., Marsh E.N., Townsend C.A. Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis. Biochemistry 1990, 29:6499-6508.
39. Sambrook J., Russell D.W. Molecular cloning: a laboratory manual 2001, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. 3rd ed.
40. Sevcikova B., Benada O., Kofronova O., Kormanec J. Stress-response sigma factor sigma(H) is essential for morphological differentiation of Streptomyces coelicolor A3(2). Arch Microbiol 2001, 177:98-106.
41. Sthapit B., Oh T.J., Lamichhane R., Liou K.K., Lee H.C., Kim C.G., et al. Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus. FEBS Lett 2004, 566:201-206.
42. Tan H., Yang H., Tian Y., Wu W., Whatling C.A., Chamberlin L.C., et al. The Streptomyces coelicolor sporulation-specific sigma WhiG form of RNA polymerase transcribes a gene encoding a ProX-like protein that is dispensable for sporulation. Gene 1998, 212:137-146.
43. Valentine B.P., Bailey C.R., Doherty A., Morris J., Elson S.W., Baggaley K.H., et al. Evidence that arginine is a later metabolic intermediate than ornithine in the biosynthesis of clavulanic acid by Streptomyces clavuligerus. J Chem Soc Chem Commun 1993, 1210-1211.
44. Viollier P.H., Kelemen G.H., Dale G.E., Nguyen K.T., Buttner M.J., Thompson C.J. Specialized osmotic stress response systems involve multiple SigB-like sigma factors in Streptomyces coelicolor. Mol Microbiol 2003, 47:699-714.
45. Viollier P.H., Weihofen A., Folcher M., Thompson C.J. Post-transcriptional regulation of the Streptomyces coelicolor stress responsive sigma factor, SigH, involves translational control, proteolytic processing, and an anti-sigma factor homolog. J Mol Biol 2003, 325:637-649.
46. Young B.A., Gruber T.M., Gross C.A. Views of transcription initiation. Cell 2002, 109:417-420.