-
1
-
-
0032482940
-
-
Bachmann, B. O., R. Li, and C. A Townsend. 1998. β-Lactam synthetase: A new biosynthetic enzyme. Proc. Natl. Acad. Sci. USA 95: 9082-9086.
-
Bachmann, B. O., R. Li, and C. A Townsend. 1998. β-Lactam synthetase: A new biosynthetic enzyme. Proc. Natl. Acad. Sci. USA 95: 9082-9086.
-
-
-
-
2
-
-
0025755182
-
Isolation of dihydroclavaminic acid, an intermediate in the biosynthesis of clavulanic acid
-
Baldwin, J. E., R. M. Adlington, J. S. Bryans, A. O. Bringhen, J. B. Coates, N. P. Crouch, M. D. Lloyd, C. J. Schofield, S. W. Elson, K. H. Baggaley, R. Cassels, and N. H. Nicholson. 1991. Isolation of dihydroclavaminic acid, an intermediate in the biosynthesis of clavulanic acid. Tetrahedron 47: 4089-4100.
-
(1991)
Tetrahedron
, vol.47
, pp. 4089-4100
-
-
Baldwin, J.E.1
Adlington, R.M.2
Bryans, J.S.3
Bringhen, A.O.4
Coates, J.B.5
Crouch, N.P.6
Lloyd, M.D.7
Schofield, C.J.8
Elson, S.W.9
Baggaley, K.H.10
Cassels, R.11
Nicholson, N.H.12
-
3
-
-
0026645203
-
Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp
-
Bierman, M., R. Logan, K. O'Brien, E. T. Seno, R. N. Rao, and B. E. Schoner. 1992. Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp. Gene 116: 43-49.
-
(1992)
Gene
, vol.116
, pp. 43-49
-
-
Bierman, M.1
Logan, R.2
O'Brien, K.3
Seno, E.T.4
Rao, R.N.5
Schoner, B.E.6
-
4
-
-
0017074284
-
Naturally occurring β-lactamase inhibitors with antibacterial activity
-
Brown, A. G., D. Butterworth, M. Cole, G. Hanscombe, J. D. Hood, C. Reading, and G. N. Rolison. 1976. Naturally occurring β-lactamase inhibitors with antibacterial activity. J. Antibiol. 29: 668-669.
-
(1976)
J. Antibiol
, vol.29
, pp. 668-669
-
-
Brown, A.G.1
Butterworth, D.2
Cole, M.3
Hanscombe, G.4
Hood, J.D.5
Reading, C.6
Rolison, G.N.7
-
5
-
-
0034612342
-
One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
-
Datsenko, K. A. and B. L. Wanner. 2000. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. USA 97: 6640-6645.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 6640-6645
-
-
Datsenko, K.A.1
Wanner, B.L.2
-
6
-
-
0027244494
-
The identification of three new biosynthetic intermediates and one further biosynthetic enzyme in the clavulanic acid pathway
-
Elson, S. W., K. H. Baggaley, M. Davison, M. Fulston, N. H. Nicholson, G. D. Risbridger, and J. W. Tyler. 1993. The identification of three new biosynthetic intermediates and one further biosynthetic enzyme in the clavulanic acid pathway. J. Chem. Soc. Chem. Commun. 1993: 1212-1214.
-
(1993)
J. Chem. Soc. Chem. Commun
, vol.1993
, pp. 1212-1214
-
-
Elson, S.W.1
Baggaley, K.H.2
Davison, M.3
Fulston, M.4
Nicholson, N.H.5
Risbridger, G.D.6
Tyler, J.W.7
-
7
-
-
0020440898
-
Assay of amoxycillin and clavulanic acid, the components Augmentin, in biological fluids with high performance liquid chromatography
-
Foulstone, M. and C. Reading. 1982. Assay of amoxycillin and clavulanic acid, the components Augmentin, in biological fluids with high performance liquid chromatography. Antimicrob. Agents Chemother. 22: 753-762.
-
(1982)
Antimicrob. Agents Chemother
, vol.22
, pp. 753-762
-
-
Foulstone, M.1
Reading, C.2
-
8
-
-
3042791271
-
Lambda red-mediated genetic manipulation of antibiotic producing Streptomyces
-
Gust, B., G. Chandra, D. Jakimowicz, T. Yuqing, C. J. Bruton. and K. F. Chater. 2004. Lambda red-mediated genetic manipulation of antibiotic producing Streptomyces. Adv. Appl. Microbiol. 54: 107-128.
-
(2004)
Adv. Appl. Microbiol
, vol.54
, pp. 107-128
-
-
Gust, B.1
Chandra, G.2
Jakimowicz, D.3
Yuqing, T.4
Bruton, C.J.5
Chater, K.F.6
-
9
-
-
0020959710
-
Studies on transformation of Escherichia coli with plasmids
-
Hanahan, D. 1983. Studies on transformation of Escherichia coli with plasmids. J. Mol. Biol. 166: 557-580.
-
(1983)
J. Mol. Biol
, vol.166
, pp. 557-580
-
-
Hanahan, D.1
-
10
-
-
35348922983
-
Enhancement of clavulanic acid by replicative and integrative expression of ccaR and cas2 in Streptomyces clavuligerus NRRL3585
-
Hung, T. V., S. Malla, B. C. Park, K. Kiou, H. C. Lee, and J. K. Sohng. 2007. Enhancement of clavulanic acid by replicative and integrative expression of ccaR and cas2 in Streptomyces clavuligerus NRRL3585. J. Microbiol. Biotechnol. 17: 1538-1545
-
(2007)
J. Microbiol. Biotechnol
, vol.17
, pp. 1538-1545
-
-
Hung, T.V.1
Malla, S.2
Park, B.C.3
Kiou, K.4
Lee, H.C.5
Sohng, J.K.6
-
11
-
-
33646540765
-
Degradation of clavulanic acid during the cultivation of Slreptomyces clavuligerus; Instability of clavulanic acid by metabolites and proteins from the strain
-
Ishida, K., T. V. Hung, H. C. Lee, K. Liou, C. H. Shin, Y. J. Yoon, and J. K. Sohng. 2006. Degradation of clavulanic acid during the cultivation of Slreptomyces clavuligerus; Instability of clavulanic acid by metabolites and proteins from the strain. J. Microbiol. Biotechnol. 16: 590-596
-
(2006)
J. Microbiol. Biotechnol
, vol.16
, pp. 590-596
-
-
Ishida, K.1
Hung, T.V.2
Lee, H.C.3
Liou, K.4
Shin, C.H.5
Yoon, Y.J.6
Sohng, J.K.7
-
12
-
-
0030700274
-
Manipulation of the physiology of clavulanic acid production in Streptomyces clavuligerus
-
Ives, P. R. and M. E. Bushell. 1997. Manipulation of the physiology of clavulanic acid production in Streptomyces clavuligerus. Microbiology 143: 3573-3579.
-
(1997)
Microbiology
, vol.143
, pp. 3573-3579
-
-
Ives, P.R.1
Bushell, M.E.2
-
13
-
-
0942268844
-
Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene
-
Jensen, S. E., A. Wong, A. Griffin, and B. Barton. 2004. Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene. Antimicrob. Agents Chemother. 48: 514-520.
-
(2004)
Antimicrob. Agents Chemother
, vol.48
, pp. 514-520
-
-
Jensen, S.E.1
Wong, A.2
Griffin, A.3
Barton, B.4
-
14
-
-
0032877650
-
Origin of the β-lactam carbons in clavulanic acid from an unusual thiamine pyrophosphate-mediated reaction
-
Khaleeli, N., R. Li, and C. A. Townsend. 1999. Origin of the β-lactam carbons in clavulanic acid from an unusual thiamine pyrophosphate-mediated reaction. J. Am. Chem. Soc. 121: 9223-9224.
-
(1999)
J. Am. Chem. Soc
, vol.121
, pp. 9223-9224
-
-
Khaleeli, N.1
Li, R.2
Townsend, C.A.3
-
15
-
-
0003869903
-
-
The John Innes Foundation, Norwich
-
Kieser, T., M. J. Bibb, M. J. Butter, K. F. Chater, and D. A. Hopwood. 2000. Practical Streptomyces Genetics. The John Innes Foundation, Norwich.
-
(2000)
Practical Streptomyces Genetics
-
-
Kieser, T.1
Bibb, M.J.2
Butter, M.J.3
Chater, K.F.4
Hopwood, D.A.5
-
16
-
-
0026575735
-
Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector
-
MacNeil, D. J., K. M. Gewain, C. L. Ruby, G. Dezeny, P. H. Gibbons, and T. MacNeil. 1992. Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector. Gene 111: 61-68.
-
(1992)
Gene
, vol.111
, pp. 61-68
-
-
MacNeil, D.J.1
Gewain, K.M.2
Ruby, C.L.3
Dezeny, G.4
Gibbons, P.H.5
MacNeil, T.6
-
17
-
-
0027052392
-
Two isozymes of clavaminate synthase central to clavulanic acid formation: Cloning and sequencing of both genes from Streptomyces clavuligerus
-
Marsh, E. N., M. D. Chang, and C. A. Townsend. 1992. Two isozymes of clavaminate synthase central to clavulanic acid formation: Cloning and sequencing of both genes from Streptomyces clavuligerus. Biochemistry 31: 12648-12657.
-
(1992)
Biochemistry
, vol.31
, pp. 12648-12657
-
-
Marsh, E.N.1
Chang, M.D.2
Townsend, C.A.3
-
18
-
-
0036260378
-
The clavulanic acid biosynthetic cluster of Streptomyces clavuligerus: Genetic organization of the region upstream of the car gene
-
Mellado, E., L. M. Lorenzana, M. Rodríguez-Sáiz, B. Díez, P. Liras, and J. L. Barredo. 2002. The clavulanic acid biosynthetic cluster of Streptomyces clavuligerus: Genetic organization of the region upstream of the car gene. Microbiology 148: 1427-1438.
-
(2002)
Microbiology
, vol.148
, pp. 1427-1438
-
-
Mellado, E.1
Lorenzana, L.M.2
Rodríguez-Sáiz, M.3
Díez, B.4
Liras, P.5
Barredo, J.L.6
-
19
-
-
0028282879
-
Evidence that the immediate biosynthetic precursor of clavulanic acid is its N-aldchyde analog
-
Nicholson, N. H., K. H. Baggaley, R. Cassels, M. Davison, S. W. Elson, M. Fulston, J. W. Tyler, and S. R. Woroniecki. 1994. Evidence that the immediate biosynthetic precursor of clavulanic acid is its N-aldchyde analog. J. Chem. Soc. Chem. Commun. 1994: 1281-1282.
-
(1994)
J. Chem. Soc. Chem. Commun
, vol.1994
, pp. 1281-1282
-
-
Nicholson, N.H.1
Baggaley, K.H.2
Cassels, R.3
Davison, M.4
Elson, S.W.5
Fulston, M.6
Tyler, J.W.7
Woroniecki, S.R.8
-
20
-
-
0028275089
-
On the evolution of arginases and related enzymes
-
Ouzounis, C. A. and N. C. Kyrpides. 1994. On the evolution of arginases and related enzymes. J. Mol. Evol. 39: 101-104.
-
(1994)
J. Mol. Evol
, vol.39
, pp. 101-104
-
-
Ouzounis, C.A.1
Kyrpides, N.C.2
-
21
-
-
0031891879
-
A pathway-specific transcriptional activator regulates late steps of clavulanic acid biosynthesis in Streptomyces clavuligerus
-
Paradkar, A. S., K. A. Aidoo, and S. E. Jensen. 1998. A pathway-specific transcriptional activator regulates late steps of clavulanic acid biosynthesis in Streptomyces clavuligerus. Mol. Microbiol. 27: 831-843.
-
(1998)
Mol. Microbiol
, vol.27
, pp. 831-843
-
-
Paradkar, A.S.1
Aidoo, K.A.2
Jensen, S.E.3
-
22
-
-
0035347174
-
Applications of gene replacement technology to Streptomyces clavuligerus strain development for clavulanic acid production
-
Paradkar, A. S., R. H. Mosher, C. Anders, A. Griffin, J. Griffin, C. Hughes, P. Greaves, B. Barton, and S. E. Jensen. 2001. Applications of gene replacement technology to Streptomyces clavuligerus strain development for clavulanic acid production. Appl. Environ. Microbiol. 67: 2292-2297.
-
(2001)
Appl. Environ. Microbiol
, vol.67
, pp. 2292-2297
-
-
Paradkar, A.S.1
Mosher, R.H.2
Anders, C.3
Griffin, A.4
Griffin, J.5
Hughes, C.6
Greaves, P.7
Barton, B.8
Jensen, S.E.9
-
23
-
-
0030954966
-
A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: Amplification results in overproduction of both beta-lactam compounds
-
Pérez-Llarena, F. J., P. Liras, A. Rodríguez-García, and J. F. Martin. 1997. A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: Amplification results in overproduction of both beta-lactam compounds. J. Bacteriol. 179: 2053-2059.
-
(1997)
J. Bacteriol
, vol.179
, pp. 2053-2059
-
-
Pérez-Llarena, F.J.1
Liras, P.2
Rodríguez-García, A.3
Martin, J.F.4
-
24
-
-
0032510817
-
The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene
-
Pérez-Redondo, R., A. Rodriguez-García, J. F. Martin, and P. Liras. 1998. The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene. Gene 211: 311-321.
-
(1998)
Gene
, vol.211
, pp. 311-321
-
-
Pérez-Redondo, R.1
Rodriguez-García, A.2
Martin, J.F.3
Liras, P.4
-
25
-
-
0345440126
-
Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: Evidence for two different genes in formation of the C3 unit
-
Pérez-Redondo, R., A. Rodríguez-García, J. F. Martín, and P. Liras. 1999. Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: Evidence for two different genes in formation of the C3 unit. J. Bacteriol. 181: 6922-6928.
-
(1999)
J. Bacteriol
, vol.181
, pp. 6922-6928
-
-
Pérez-Redondo, R.1
Rodríguez-García, A.2
Martín, J.F.3
Liras, P.4
-
26
-
-
0002903456
-
Parameters of growth and analysis of growth data
-
Blackwell, Oxford, U.K
-
Pirt, S. J. 1975. Parameters of growth and analysis of growth data, pp. 4-14. In: Principles of Microbe and Cell Cultivation. Blackwell, Oxford, U.K.
-
(1975)
Principles of Microbe and Cell Cultivation
, pp. 4-14
-
-
Pirt, S.J.1
-
27
-
-
0030070070
-
A rapid formaldehyde assay using purpald reagent: Application under periodation conditions
-
Quesenberry, M. S. and Y. C. Lee. 1996. A rapid formaldehyde assay using purpald reagent: Application under periodation conditions. Anal. Biochem. 234: 50-55.
-
(1996)
Anal. Biochem
, vol.234
, pp. 50-55
-
-
Quesenberry, M.S.1
Lee, Y.C.2
-
28
-
-
0021685685
-
Dissociation of cephamycin and clavulanic acid biosynthesis in Streptomyces clavuligerus
-
Romero, J. P. Liras, and J. F. Martin. 1984. Dissociation of cephamycin and clavulanic acid biosynthesis in Streptomyces clavuligerus. Appl. Microbiol. Biotechnol. 20: 318-325.
-
(1984)
Appl. Microbiol. Biotechnol
, vol.20
, pp. 318-325
-
-
Romero, J.1
Liras, P.2
Martin, J.F.3
-
29
-
-
12144251669
-
Stringent factor regulates antibiotics production and morphological differentiation of Streptomyces clavuligerus
-
Ryu, Y. G., W. Jin, J. Y Kim, J. Y. Kim, S. H. Lee, and K. J. Lee. 2004. Stringent factor regulates antibiotics production and morphological differentiation of Streptomyces clavuligerus. J. Microbiol. Biotechnol. 14: 1170-1175.
-
(2004)
J. Microbiol. Biotechnol
, vol.14
, pp. 1170-1175
-
-
Ryu, Y.G.1
Jin, W.2
Kim, J.Y.3
Kim, J.Y.4
Lee, S.H.5
Lee, K.J.6
-
30
-
-
0025337148
-
Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: An unusual oxidative enzyme in natural product biosynthesis
-
Salowe, S. P., E. N. Marsh, and C. A. Townsend. 1990. Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: An unusual oxidative enzyme in natural product biosynthesis. Biochemistry 29: 6499-6508.
-
(1990)
Biochemistry
, vol.29
, pp. 6499-6508
-
-
Salowe, S.P.1
Marsh, E.N.2
Townsend, C.A.3
-
31
-
-
0026093197
-
Elucidation of the order of oxidations and identification of an intermediate in the multistep clavaminate synthase reaction
-
Salowe, S. P., W. J. Krol, D. Iwata-Reuyl, and C. A. Townsend. 1991. Elucidation of the order of oxidations and identification of an intermediate in the multistep clavaminate synthase reaction. Biochemistry 30: 2281-2292.
-
(1991)
Biochemistry
, vol.30
, pp. 2281-2292
-
-
Salowe, S.P.1
Krol, W.J.2
Iwata-Reuyl, D.3
Townsend, C.A.4
-
32
-
-
0004136246
-
-
3rd Ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y
-
Sambrook, J., E. F. Fritsch, and T. Maniatis. 2001. Molecular Cloning: A Laboratory Manual, 3rd Ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
-
(2001)
Molecular Cloning: A Laboratory Manual
-
-
Sambrook, J.1
Fritsch, E.F.2
Maniatis, T.3
-
33
-
-
33846829556
-
Optimization of nutritional requirements and feeding strategies for clavulanic acid production by Streptomyces clavuligerus
-
Saudagar, P. S. and R. S. Singhal. 2007. Optimization of nutritional requirements and feeding strategies for clavulanic acid production by Streptomyces clavuligerus. Bioresour. Technol. 98: 2010-2017.
-
(2007)
Bioresour. Technol
, vol.98
, pp. 2010-2017
-
-
Saudagar, P.S.1
Singhal, R.S.2
-
34
-
-
4444277108
-
The paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerus
-
Tahlan, K., C. Anders, and S. E. Jensen. 2004. The paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerus. J. Bacteriol. 186: 6286-6297.
-
(2004)
J. Bacteriol
, vol.186
, pp. 6286-6297
-
-
Tahlan, K.1
Anders, C.2
Jensen, S.E.3
-
35
-
-
0027181592
-
Evidence that arginine is a later melabolic intermediate than ornithine in the biosynthLsis of clavulanic acid by Streptomyces clavuligerus
-
Valentine, B. P., C. R. Bailey, A. Doherty, J. Morris, S. W. Elson, K. H. Baggaley, and N. H. Nicholson. 1993. Evidence that arginine is a later melabolic intermediate than ornithine in the biosynthLsis of clavulanic acid by Streptomyces clavuligerus. J. Chem. Soc. Chem. Commun. 1993: 1210-1211.
-
(1993)
J. Chem. Soc. Chem. Commun
, vol.1993
, pp. 1210-1211
-
-
Valentine, B.P.1
Bailey, C.R.2
Doherty, A.3
Morris, J.4
Elson, S.W.5
Baggaley, K.H.6
Nicholson, N.H.7
-
36
-
-
0024419124
-
Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Succharopolyspora erythraea (Streptomyces erythreus)
-
Vara, J., M. lewandowska-Skarbek, Y. G. Wang, S. Donadio, and C. R. Hutchinson. 1989. Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Succharopolyspora erythraea (Streptomyces erythreus). J. Bacteriol. 171: 5872-5881.
-
(1989)
J. Bacteriol
, vol.171
, pp. 5872-5881
-
-
Vara, J.1
lewandowska-Skarbek, M.2
Wang, Y.G.3
Donadio, S.4
Hutchinson, C.R.5
-
37
-
-
0029004673
-
Identification, cloning, sequencing, and overexpression of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis
-
Wu, T. K., R. W. Busby, T. A. Houston, D. B. McIlwaine, L. A. Egan, and C. A. Townsend. 1995. Identification, cloning, sequencing, and overexpression of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis. J. Bacteriol. 177: 3714-3720.
-
(1995)
J. Bacteriol
, vol.177
, pp. 3714-3720
-
-
Wu, T.K.1
Busby, R.W.2
Houston, T.A.3
McIlwaine, D.B.4
Egan, L.A.5
Townsend, C.A.6
|