메뉴 건너뛰기




Volumn 75, Issue 1-2, 1999, Pages 125-133

Biosynthesis and molecular genetics of clavulanic acid

Author keywords

lactam; lactamase; Clavam; Clavulanic acid; Enzyme inhibitor; Streptomyces clavuligerus

Indexed keywords

ARGININE; BETA LACTAM ANTIBIOTIC; CLAVULANIC ACID; PYRUVIC ACID;

EID: 0032980244     PISSN: 00036072     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1001755724055     Document Type: Article
Times cited : (67)

References (43)
  • 1
    • 0028048859 scopus 로고
    • Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis
    • Aidoo KA, Wong A, Alexander DC, Rittammer RAR & Jensen SE (1994) Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis. Gene 147: 41-46
    • (1994) Gene , vol.147 , pp. 41-46
    • Aidoo, K.A.1    Wong, A.2    Alexander, D.C.3    Rar, R.4    Jensen, S.E.5
  • 4
    • 37049073348 scopus 로고
    • Studies on the biosynthesis of clavulanic acid. Part 4. Synthetic routes to the monocyclic β-lactam precursor, proclavaminic acid
    • Baggaley KH, Elson SW, Nicholson NH & Sime JT (1990) Studies on the biosynthesis of clavulanic acid. Part 4. Synthetic routes to the monocyclic β-lactam precursor, proclavaminic acid. J. Chem. Soc. Perkin Trans. I. 1513-1520
    • (1990) J. Chem. Soc. Perkin Trans. I. , vol.1 , pp. 513-1520
    • Baggaley, K.H.1    Elson, S.W.2    Nicholson, N.H.3    Sime, J.T.4
  • 8
    • 24444435523 scopus 로고
    • Clavulanic acid and its salts by fermentation
    • Box SJ (1977) Clavulanic acid and its salts by fermentation. Chem. Abstr. 87: 4031e
    • (1977) Chem. Abstr. , vol.87
    • Box, S.J.1
  • 10
    • 0041460302 scopus 로고
    • Structures of three novel β-lactams isolated from Streptomyces clavuligerus
    • Brown D, Evans JR & Fletton RA (1979) Structures of three novel β-lactams isolated from Streptomyces clavuligerus. J. Chem. Soc., Chem. Commun. 282-283
    • (1979) J. Chem. Soc., Chem. Commun. , pp. 282-283
    • Brown, D.1    Evans, J.R.2    Fletton, R.A.3
  • 11
    • 0030991157 scopus 로고    scopus 로고
    • Probable role of clavaminic acid as the terminal intermediate in the common pathway to clavulanic acid and the antipodal clavam metabolites
    • Egan LA, Busby RW, Iwata-Reuyl D & Townsend CA (1997) Probable role of clavaminic acid as the terminal intermediate in the common pathway to clavulanic acid and the antipodal clavam metabolites. J. Am. Chem. Soc. 119: 2348-2355
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 2348-2355
    • Egan, L.A.1    Busby, R.W.2    Iwata-Reuyl, D.3    Townsend, C.A.4
  • 16
    • 0027769610 scopus 로고
    • Emerging evidence for a shared biosynthetic pathway among clavulanic acid and the structurally diverse clavam metabolites
    • Jane JW, Egan LA & Townsend CA (1993) Emerging evidence for a shared biosynthetic pathway among clavulanic acid and the structurally diverse clavam metabolites. Bioorg. Med. Chem. Lett. 3: 2313-2316
    • (1993) Bioorg. Med. Chem. Lett. , vol.3 , pp. 2313-2316
    • Jane, J.W.1    Egan, L.A.2    Townsend, C.A.3
  • 17
    • 0028899310 scopus 로고
    • Purification and characterization of clavaminate synthase from Streptomyces antibioticus: A multifunctional enzyme of clavam biosynthesis
    • Jane JW, Egan LA & Townsend CA (1995) Purification and characterization of clavaminate synthase from Streptomyces antibioticus: A multifunctional enzyme of clavam biosynthesis. J. Biol. Chem. 270: 5399-5404
    • (1995) J. Biol. Chem. , vol.270 , pp. 5399-5404
    • Jane, J.W.1    Egan, L.A.2    Townsend, C.A.3
  • 18
    • 0001590160 scopus 로고
    • Extending the β-lactam biosynthetic gene cluster in Streptomyces clavuligerus
    • Baltz RH, Hegeman GD & Skatrud PL (Eds) American Society for Microbiology, Washington, DC
    • Jensen SE, Alexander DC, Paradkar AS & Aidoo KA (1993) Extending the β-lactam biosynthetic gene cluster in Streptomyces clavuligerus, p. 169-176. In: Baltz RH, Hegeman GD & Skatrud PL (Eds) Industrial Microorganisms: Basic and Applied Molecular Genetics. American Society for Microbiology, Washington, DC
    • (1993) Industrial Microorganisms: Basic and Applied Molecular Genetics , pp. 169-176
    • Jensen, S.E.1    Alexander, D.C.2    Paradkar, A.S.3    Aidoo, K.A.4
  • 21
    • 24444458898 scopus 로고
    • Clavulanic acid production by Streptomyces katsurahamanus
    • Kitano K, Kintaka K & Katamoto K (1979) Clavulanic acid production by Streptomyces katsurahamanus. Chem. Abstr. 90: 119758b
    • (1979) Chem. Abstr. , vol.90
    • Kitano, K.1    Kintaka, K.2    Katamoto, K.3
  • 22
    • 0027052392 scopus 로고
    • Two isozymes of clavaminate synthase central to clavulanic acid formation: Cloning and sequencing of both genes from Streptomyces clavuligerus
    • Marsh NE, Chang MD-T & Townsend CA (1992) Two isozymes of clavaminate synthase central to clavulanic acid formation: cloning and sequencing of both genes from Streptomyces clavuligerus. Biochemistry 31: 1268-12657
    • (1992) Biochemistry , vol.31 , pp. 1268-12657
    • Marsh, N.E.1    Chang, M.D.-T.2    Townsend, C.A.3
  • 24
    • 0022632338 scopus 로고
    • Clavamycins, new clavam antibiotics from two variants of Streptomyces hygroscopicus. II. Isolation and structures of clavamycins A, B and C from Streptomyces hygroscopicus NRRL 15846 and of clavamycin D, e and F from Streptomyces hygroscopicus NRRL 15879
    • Naegeli HU, Loosli HR & Nussbaumer A (1986) Clavamycins, new clavam antibiotics from two variants of Streptomyces hygroscopicus. II. Isolation and structures of clavamycins A, B and C from Streptomyces hygroscopicus NRRL 15846 and of clavamycin D, E and F from Streptomyces hygroscopicus NRRL 15879. J. Antibiot. 39: 516-524
    • (1986) J. Antibiot. , vol.39 , pp. 516-524
    • Naegeli, H.U.1    Loosli, H.R.2    Nussbaumer, A.3
  • 27
    • 0031891879 scopus 로고    scopus 로고
    • A pathway-specific transcriptional activator regulates late steps of clavulanic acid biosynthesis in Streptomyces clavuligerus
    • Paradkar AS, Aidoo KA & Jensen SE (1998) A pathway-specific transcriptional activator regulates late steps of clavulanic acid biosynthesis in Streptomyces clavuligerus. Mol. Microbiol. 27: 831-843
    • (1998) Mol. Microbiol. , vol.27 , pp. 831-843
    • Paradkar, A.S.1    Aidoo, K.A.2    Jensen, S.E.3
  • 28
    • 0030954966 scopus 로고    scopus 로고
    • A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: Amplification results in overproduction of both beta-lactam compounds
    • Perez-Llarena F, Liras P, Rodríguez-García A & Martín JF (1997) A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds. J. Bacteriol. 179: 2053-2059
    • (1997) J. Bacteriol. , vol.179 , pp. 2053-2059
    • Perez-Llarena, F.1    Liras, P.2    Rodríguez-García, A.3    Martín, J.F.4
  • 31
    • 0020632185 scopus 로고
    • Ro-22-5417, a new clavam antibiotic from Streptomyces clavuligerus. I. Discovery and biological activity
    • Pruess DL & Kellett m (1983) Ro-22-5417, a new clavam antibiotic from Streptomyces clavuligerus. I. Discovery and biological activity. J. Antibiot. 36: 208-212
    • (1983) J. Antibiot. , vol.36 , pp. 208-212
    • Pruess, D.L.1    Kellett, M.2
  • 32
    • 0022535425 scopus 로고
    • Utilization of ornithine and arginine as specific precursors of clavulanic acid
    • Romero J, Liras P & Martin JF (1986) Utilization of ornithine and arginine as specific precursors of clavulanic acid. Appl. Environ. Microbiol. 52: 892-897
    • (1986) Appl. Environ. Microbiol. , vol.52 , pp. 892-897
    • Romero, J.1    Liras, P.2    Martin, J.F.3
  • 33
    • 0026093197 scopus 로고
    • Elucidation of the order of oxidations and identification of an intermediate in the multistep clavaminate synthase reaction
    • Salowe SP, Krol WJ, Iwata-Reuyl D & Townsend CA (1991) Elucidation of the order of oxidations and identification of an intermediate in the multistep clavaminate synthase reaction. Biochemistry 30: 2281-2292
    • (1991) Biochemistry , vol.30 , pp. 2281-2292
    • Salowe, S.P.1    Krol, W.J.2    Iwata-Reuyl, D.3    Townsend, C.A.4
  • 34
    • 0025337148 scopus 로고
    • Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: An unusual oxidative enzyme in natural product biosynthesis
    • Salowe SP, Marsh EN & Townsend CA (1990) Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis. Biochemistry 29: 6499-6508
    • (1990) Biochemistry , vol.29 , pp. 6499-6508
    • Salowe, S.P.1    Marsh, E.N.2    Townsend, C.A.3
  • 35
    • 84943868811 scopus 로고
    • Clavulanic acid
    • Sanraku-Ocean Co. Ltd. (1981) Clavulanic acid. Chem Abstr 94: 137803z
    • (1981) Chem Abstr , vol.94
  • 36
    • 24444437960 scopus 로고
    • Antitumor and antifungus G0069C substance production by Streptomyces species
    • JP 61, 268, 685
    • Seki C, Den K, Marunaka T, Miyake Y, Minami Y Kajitani A & Ishida N (1987) Antitumor and antifungus G0069C substance production by Streptomyces species. JP 61, 268, 685. Chem. Abstr. 106: 194774f
    • (1987) Chem. Abstr. , vol.106
    • Seki, C.1    Den, K.2    Marunaka, T.3    Miyake, Y.4    Minami, Y.5    Kajitani, A.6    Ishida, N.7
  • 40
    • 0019417121 scopus 로고
    • Ein neues antifungisches β-lactam antibioticum der clavam-reihe
    • Wanning M, Zahner H, Krone B & Zeeck A (1981) Ein neues antifungisches β-lactam antibioticum der clavam-reihe. Tetrahedron Lett. 22: 2539-2540
    • (1981) Tetrahedron Lett. , vol.22 , pp. 2539-2540
    • Wanning, M.1    Zahner, H.2    Krone, B.3    Zeeck, A.4
  • 41
    • 0027289141 scopus 로고
    • The biosynthetic genes for clavulanic acid and cephamycin production occur as a 'super-cluster' in three Streptomyces
    • Ward JM & Hodgson JE (1993) The biosynthetic genes for clavulanic acid and cephamycin production occur as a 'super-cluster' in three Streptomyces. FEMS Microbiol. Lett. 110: 239-242
    • (1993) FEMS Microbiol. Lett. , vol.110 , pp. 239-242
    • Ward, J.M.1    Hodgson, J.E.2
  • 42
    • 0030929313 scopus 로고    scopus 로고
    • A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold
    • Wietzorrek A & Bibb M (1997) A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold. Mol. Microbiol. 25: 1181-1184
    • (1997) Mol. Microbiol. , vol.25 , pp. 1181-1184
    • Wietzorrek, A.1    Bibb, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.