Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus

Molecular Microbiology

Volumn 56, Issue 3, 2005, Pages 824-835

  Santamarta, Irene ^a,b   Pérez Redondo, Rosario ^a,b   Lorenzana, Luis M ^b   Martín, Juan F ^a,b   Liras, Paloma ^a,b  

^a UNIVERSITY OF LEÓN   (Spain)

^b Institute of Biotechnology INBIOTEC Parque Científico de León   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYROLACTONE RECEPTOR PROTEIN; CEPHAMYCIN C; CLAVULANIC ACID; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BRP GENE; CCAR GENE; CELL FREE SYSTEM; CHROMATOGRAPHY; GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PURIFICATION; REGULATOR GENE; STRAIN IDENTIFICATION; STREPTOMYCES CLAVULIGERUS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; CEPHAMYCINS; CLAVULANIC ACID; CLONING, MOLECULAR; DNA-BINDING PROTEINS; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; GENE ORDER; GENES, REGULATOR; MOLECULAR SEQUENCE DATA; MUTATION; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; RESPONSE ELEMENTS; STREPTOMYCES; TRANSCRIPTION FACTORS;

EID: 17644368157     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2005.04581.x     Document Type: Article

References (33)

1. Brown, A.G., Butterworth, D., Cole, M., Hanscombe, G., Hood, J.D., Reading, C., and Rolinson, G.N. (1976) Naturally ocurring β-lactamase inhibitors with antibacterial activity. J Antibiot 29: 668-669.
2. Butler, M.J., Takano, E., Bruheim, P., Jovetic, S., Marinelli, F., and Bibb, M.J. (2003) Deletion of scbA enhances antibiotic production in Streptomyces lividans. Appl Microbiol Biotechnol 61: 512-516.
3. Folcher, M., Gaillard, H., Nguyen, L.T., Nguyen, K.T., Lacroix, P., Bamas-Jacques, N., et al. (2001) Pleiotropic functions of a Streptomyces pristinaespiralis autoregulator receptor in development, antibiotic biosynthesis, and expression of a superoxide dismutase. J Biol Chem 276: 44297-44306.
4. Foulstone, M., and Reading, C. (1982) Assay of amoxicillin and clavulanic acid, the components of augmentin, in biological fluid with high-performance liquid chromatography. Antimicrob Agents Chemother 22: 753-762.
5. Fuente, A. de la, Lorenzana, L.M., Martin, J.F., and Liras, P. (2002) Mutants of Streptomyces clavuligerus with disruptions in different genes for clavulanic acid biosynthesis produce large amounts of holomycin: possible cross-regulation of two unrelated secondary metabolic pathways. J Bacteriol 184: 6559-6565.
6. Horinouchi, S., and Beppu, T. (1992) Autoregulatory factors and communication in actinomycetes. Annu Rev Microbiol 46: 377-398.
7. Kawabuchi, M., Hara, Y., Nihira, T., and Yamada, Y. (1997) Production of butyrolactone autoregulators by Streptomyces coelicolor A3(2). FEMS Microbiol Lett 68: 170-173.
8. Kieser, T., Bibb, M.J., Buttner, M.J., Chater, K.F., and Hopwood, D.A. (2000) Practical Streptomyces genetics. Norwich, UK: John Innes Foundation.
9. Kim, H.S., Lee, Y.J., Lee, C.K., Choi, S.U., Yeo, S-H., Hwang, Y. (2004) Cloning and characterization of a gene encoding the γ-butyrolactone autoregulator receptor from Streptomyces clavuligerus. Arch Microbiol 182: 44-50.
10. Kinoshita, H., Tsuji, T., Ipposhi, H., Nihira, T., and Yamada, Y. (1999) Characterization of binding sequences for butyrolactone autoregulator receptors in Streptomycetes. J Bacteriol 181: 5075-5080.
11. Kitani, S., Kinoshita, H., Nihira, T., and Yamada, Y. (1999) In vitro analysis of the butyrolactone autoregulator receptor protein (FarA) of Streptomyces lavendulae FRI-5 reveals that FarA acts as a DNA-binding transcriptional regulator that controls its own synthesis. J Bacteriol 181: 5081-5084.
12. Liras, P. (1999) Biosynthesis and molecular genetics of cephamycins. Cephamycins produced by actinomycetes. Antonie Van Leeuwenhoek 75: 109-124.
13. Martín, J.F., and Liras, P. (1989) Organization and expression of genes involved in the biosynthesis of antibiotics and other secondary metabolites. Annu Rev Microbiol 43:173-206.
14. Martín, J.F., Gutiérrez, S., and Aparicio, J.F. (2000) Secondary metabolites. In: Encyclopedia of Microbiology, Vol. 4. Lederberg, J. (ed.). San Diego, CA: Academic Press, pp. 213-237.
15. Mosher, R.H., Paradkar, A.S., Anders, C., Barton, B., and Jensen, S.E. (1999) Genes specific for the biosynthesis of clavam metabolites antipodal to clavulanic acid are clustered with the gene for clavaminate synthase 1 in Streptomyces clavuligerus. Antimicrob Agents Chemother 43: 1215-1224.
16. Nakano, H., Takehara, E., Nihira, T., and Yamada, Y. (1998) Gene replacement analysis of the Streptomyces virginiae barA gene encoding the butyrolactone autoregulator receptor reveals that BarA acts as a repressor in virginiamycin biosynthesis. J Bacteriol 180: 3317-3322.
17. Ohnishi, Y., Kameyama, S., Onaka, H., and Horinouchi, S. (1999) The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus: identification of a target gene of the A-factor receptor. Mol Microbiol 34: 102-111.
18. Onaka, H., and Horinouchi, S. (1997) DMA-binding activity of the A-factor receptor protein and its recognition DNA sequences. Mol Microbiol 24: 991-1000.
19. Onaka, H., Ando, N., Nihira, T., Yamada, Y., Beppu, T., and Horinouchi, S. (1995) Cloning and characterization of the A-factor receptor gene from Streptomyces griseus. J Bacteriol 177: 6083-6092.
20. Pan, B., Unnikrishnan, I., and LaPorte, D.C. (1996) The binding site of the IcIR repressor protein overlaps the promoter of aceBAK. J Bacteriol 178: 3982-3984.
21. Pérez-Llarena, F.J., Liras, P., Rodríguez-García, A., and Martín, J.F. (1997) A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both β-lactam compounds. J Bacteriol 179: 2053-2059.
22. Recio, E., Colinas, A., Rumbero, A., Aparicio, J.F., and Martín, J.F. (2004) Pl factor, a novel type quorum-sensing inducer elicits pimaricin production in Streptomyces natalensis. J Biol Chem 279: 41586-41593.
23. Romero, J., Liras, P., and Martin, J.F. (1984) Dissociation of cephamycin and clavulanic acid biosynthesis in Streptomyces clavuligerus. Appl Microbiol Biotechnol 20: 318-325.
24. Sambrook, J., Fritsch, E.F., and Maniatis, J. (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
25. Sánchez, L., and Braña, A.F. (1996) Cell density influences antibiotic biosynthesis in Streptomyces clavuligerus. Microbiology 142: 1209-1220.
26. Santamarta, I., Rodríguez-García, A., Pérez-Redondo, R., Martín, J.F., and Liras, P. (2002) CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcl promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus. J Bacteriol 184: 3106-3113.
27. Stratigopoulos, G., Gandecha, A.R., and Cundliffe, E. (2002) Regulation of tylosin production and morphological differentiation in Streptomyces fradiae by TylP, a deduced gamma-butyrolactone receptor. Mol Microbiol 45: 735-744.
28. Takano, E., Chakraburtty, R., Nihira, T., Yamada, Y., and Bibb, M.J. (2001) A complex role for the gamma-butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3(2). Mol Microbiol 41: 1015-1028.
29. Traag, B.A., Kelemen, G.H., and Van Wezel, G.P. (2004) Transcription of the sporulation gene ssgA is activated by the IcIR-type regulator SsgR in a whi-independent manner in Streptomyces coelicolor A3(2). Mol Microbiol 53: 985-1000.
30. Trubetskoy, D.O., Zavalova, L.L., Akopov, S.B., and Nikolaev, L.G. (2002) Purification of proteins specifically binding human endogenous retrovirus K long terminal repeat by affinity elution chromatography. J Chromatogr 976: 95-101.
31. Vining, L.C. (1992) Secondary metabolism, inventive evolution and biochemical diversity. Gene 115: 135-140.
32. Yamazaki, H., Ohnishi, Y., and Horinouchi, S. (2003) Transcriptional switch on of ssgA by A-factor, which is essential for spore septum formation in Streptomyces griseus. J Bacteriol 185: 1273-1283.
33. Zhang, R.G., Kim, Y., Skarina, T., Beasley, S., Laskowski, R., Arrowsmith, C., et al. (2002) Crystal structure of Thermotoga maritima 0065, a member of the IcIR transcriptional factor family. J Biol Chem 277: 19183-19190.