Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: Negative regulation of secondary metabolism by (p)ppGpp

Microbiology

Volumn 154, Issue 3, 2008, Pages 744-755

  Gomez Escribano, Juan P ^a   Martín, Juan F ^a,b   Hesketh, A ^c   Bibb, M J ^c   Liras, Paloma ^a,b  

^a UNIVERSITY OF LEÓN   (Spain)

^b Institute of Biotechnology INBIOTEC Parque Científico de León   (Spain)

^c JOHN INNES CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CEPHAMYCIN C; CLAVULANIC ACID; TRANSCRIPTION FACTOR RELA; CEPHAMYCIN DERIVATIVE; GUANOSINE 3' DIPHOSPHATE 5' TRIPHOSPHATE; GUANOSINE 3',5' POLYPHOSPHATE SYNTHETASES; GUANOSINE 3',5'-POLYPHOSPHATE SYNTHETASES; LIGASE;

ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM MUTANT; BIOSYNTHESIS; CONTROLLED STUDY; DRUG SYNTHESIS; GENETIC TRANSCRIPTION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN METABOLISM; STREPTOMYCES CLAVULIGERUS; WILD TYPE; BACTERIAL SPORE; DNA SEQUENCE; ENZYMOLOGY; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC COMPLEMENTATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOLECULAR GENETICS; MUTATION; PHYSIOLOGY; STREPTOMYCES; TRANSACTIVATION; TRANSCRIPTION INITIATION SITE;

STREPTOMYCES; STREPTOMYCES CLAVULIGERUS;

BASE SEQUENCE; CEPHAMYCINS; CLAVULANIC ACID; CLONING, MOLECULAR; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC COMPLEMENTATION TEST; GUANOSINE PENTAPHOSPHATE; LIGASES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; MUTATION; SEQUENCE ANALYSIS, DNA; SPORES, BACTERIAL; STREPTOMYCES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION INITIATION SITE;

EID: 42949154408     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.2007/011890-0     Document Type: Article

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