메뉴 건너뛰기




Volumn 8, Issue 7, 2013, Pages

A Strong Anti-Inflammatory Signature Revealed by Liver Transcription Profiling of Tmprss6-/- Mice

Author keywords

[No Author keywords available]

Indexed keywords

HEPCIDIN; IRON; LIPOPOLYSACCHARIDE;

EID: 84880782961     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0069694     Document Type: Article
Times cited : (7)

References (39)
  • 1
    • 14544294358 scopus 로고    scopus 로고
    • Modification of iron regulation by the inflammatory response
    • Weiss G, (2005) Modification of iron regulation by the inflammatory response. Best practice & research Clinical haematology 18: 183-201.
    • (2005) Best Practice & Research Clinical Haematology , vol.18 , pp. 183-201
    • Weiss, G.1
  • 2
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, et al. (2004) IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 113: 1271-1276.
    • (2004) J Clin Invest , vol.113 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3    Keller, C.4    Taudorf, S.5
  • 4
    • 43049132128 scopus 로고    scopus 로고
    • A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells
    • Verga Falzacappa MV, Casanovas G, Hentze MW, Muckenthaler MU, (2008) A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells. J Mol Med (Berl) 86: 531-540.
    • (2008) J Mol Med (Berl) , vol.86 , pp. 531-540
    • Verga Falzacappa, M.V.1    Casanovas, G.2    Hentze, M.W.3    Muckenthaler, M.U.4
  • 5
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, et al. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306: 2090-2093.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5
  • 6
    • 77955005442 scopus 로고    scopus 로고
    • Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice
    • De Domenico I, Zhang TY, Koening CL, Branch RW, London N, et al. (2011) Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice. J Clin Invest 120: 2395-2405.
    • (2011) J Clin Invest , vol.120 , pp. 2395-2405
    • De Domenico, I.1    Zhang, T.Y.2    Koening, C.L.3    Branch, R.W.4    London, N.5
  • 7
    • 84862002810 scopus 로고    scopus 로고
    • Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination
    • Qiao B, Sugianto P, Fung E, Del-Castillo-Rueda A, Moran-Jimenez MJ, et al. (2012) Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination. Cell Metab 15: 918-924.
    • (2012) Cell Metab , vol.15 , pp. 918-924
    • Qiao, B.1    Sugianto, P.2    Fung, E.3    Del-Castillo-Rueda, A.4    Moran-Jimenez, M.J.5
  • 8
    • 44449177930 scopus 로고    scopus 로고
    • The serine protease TMPRSS6 is required to sense iron deficiency
    • Du X, She E, Gelbart T, Truksa J, Lee P, et al. (2008) The serine protease TMPRSS6 is required to sense iron deficiency. Science 320: 1088-1092.
    • (2008) Science , vol.320 , pp. 1088-1092
    • Du, X.1    She, E.2    Gelbart, T.3    Truksa, J.4    Lee, P.5
  • 9
    • 54349096688 scopus 로고    scopus 로고
    • Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis
    • Folgueras AR, de Lara FM, Pendas AM, Garabaya C, Rodriguez F, et al. (2008) Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis. Blood 112: 2539-2545.
    • (2008) Blood , vol.112 , pp. 2539-2545
    • Folgueras, A.R.1    de Lara, F.M.2    Pendas, A.M.3    Garabaya, C.4    Rodriguez, F.5
  • 10
    • 42649118442 scopus 로고    scopus 로고
    • Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)
    • Finberg KE, Heeney MM, Campagna DR, Aydinok Y, Pearson HA, et al. (2008) Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). Nat Genet 40: 569-571.
    • (2008) Nat Genet , vol.40 , pp. 569-571
    • Finberg, K.E.1    Heeney, M.M.2    Campagna, D.R.3    Aydinok, Y.4    Pearson, H.A.5
  • 11
    • 79960681867 scopus 로고    scopus 로고
    • Low hepcidin accounts for the proinflammatory status associated with iron deficiency
    • Pagani A, Nai A, Corna G, Bosurgi L, Rovere-Querini P, et al. (2011) Low hepcidin accounts for the proinflammatory status associated with iron deficiency. Blood 118: 736-746.
    • (2011) Blood , vol.118 , pp. 736-746
    • Pagani, A.1    Nai, A.2    Corna, G.3    Bosurgi, L.4    Rovere-Querini, P.5
  • 13
    • 33746768303 scopus 로고    scopus 로고
    • Gentleman R, Carey V, Dudoit S, Irizarry R, Huber W, editors. New York: Springer
    • Smyth GK (2005) Limma: linear models for microarray data.; Gentleman R, Carey V, Dudoit S, Irizarry R, Huber W, editors. New York: Springer.
    • (2005) Limma: Linear models for microarray data
    • Smyth, G.K.1
  • 14
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang da W, Sherman BT, Lempicki RA, (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57.
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • da Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 15
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
    • da Huang W, Sherman BT, Lempicki RA, (2009) Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic acids research 37: 1-13.
    • (2009) Nucleic Acids Research , vol.37 , pp. 1-13
    • da Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 16
    • 77951942707 scopus 로고    scopus 로고
    • GOSemSim: an R package for measuring semantic similarity among GO terms and gene products
    • Yu G, Li F, Qin Y, Bo X, Wu Y, et al. (2010) GOSemSim: an R package for measuring semantic similarity among GO terms and gene products. Bioinformatics 26: 976-978.
    • (2010) Bioinformatics , vol.26 , pp. 976-978
    • Yu, G.1    Li, F.2    Qin, Y.3    Bo, X.4    Wu, Y.5
  • 18
    • 84871857327 scopus 로고    scopus 로고
    • Molecular Network Analysis of Diseases and Drugs in KEGG
    • Kanehisa M, (2013) Molecular Network Analysis of Diseases and Drugs in KEGG. Methods in molecular biology 939: 263-275.
    • (2013) Methods in Molecular Biology , vol.939 , pp. 263-275
    • Kanehisa, M.1
  • 19
    • 0036081355 scopus 로고    scopus 로고
    • Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
    • Edgar R, Domrachev M, Lash AE, (2002) Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acid Research 30: 207-210.
    • (2002) Nucleic Acid Research , vol.30 , pp. 207-210
    • Edgar, R.1    Domrachev, M.2    Lash, A.E.3
  • 21
  • 22
    • 70350613915 scopus 로고    scopus 로고
    • Control of iron homeostasis by an iron-regulated ubiquitin ligase
    • Vashisht AA, Zumbrennen KB, Huang X, Powers DN, Durazo A, et al. (2009) Control of iron homeostasis by an iron-regulated ubiquitin ligase. Science 326: 718-721.
    • (2009) Science , vol.326 , pp. 718-721
    • Vashisht, A.A.1    Zumbrennen, K.B.2    Huang, X.3    Powers, D.N.4    Durazo, A.5
  • 23
    • 70350576223 scopus 로고    scopus 로고
    • An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis
    • Salahudeen AA, Thompson JW, Ruiz JC, Ma HW, Kinch LN, et al. (2009) An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis. Science 326: 722-726.
    • (2009) Science , vol.326 , pp. 722-726
    • Salahudeen, A.A.1    Thompson, J.W.2    Ruiz, J.C.3    Ma, H.W.4    Kinch, L.N.5
  • 24
    • 27644530602 scopus 로고    scopus 로고
    • LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia
    • Qin H, Wilson CA, Lee SJ, Zhao X, Benveniste EN, (2005) LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia. Blood 106: 3114-3122.
    • (2005) Blood , vol.106 , pp. 3114-3122
    • Qin, H.1    Wilson, C.A.2    Lee, S.J.3    Zhao, X.4    Benveniste, E.N.5
  • 25
    • 70349644493 scopus 로고    scopus 로고
    • Global transcriptional response to Hfe deficiency and dietary iron overload in mouse liver and duodenum
    • Rodriguez A, Luukkaala T, Fleming RE, Britton RS, Bacon BR, et al. (2009) Global transcriptional response to Hfe deficiency and dietary iron overload in mouse liver and duodenum. PLoS One 4: e7212.
    • (2009) PLoS One , vol.4
    • Rodriguez, A.1    Luukkaala, T.2    Fleming, R.E.3    Britton, R.S.4    Bacon, B.R.5
  • 26
    • 41349106987 scopus 로고    scopus 로고
    • Autocrine formation of hepcidin induces iron retention in human monocytes
    • Theurl I, Theurl M, Seifert M, Mair S, Nairz M, et al. (2008) Autocrine formation of hepcidin induces iron retention in human monocytes. Blood 111: 2392-2399.
    • (2008) Blood , vol.111 , pp. 2392-2399
    • Theurl, I.1    Theurl, M.2    Seifert, M.3    Mair, S.4    Nairz, M.5
  • 27
    • 2442426523 scopus 로고    scopus 로고
    • An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice
    • Roy CN, Custodio AO, de Graaf J, Schneider S, Akpan I, et al. (2004) An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Nat Genet 36: 481-485.
    • (2004) Nat Genet , vol.36 , pp. 481-485
    • Roy, C.N.1    Custodio, A.O.2    de Graaf, J.3    Schneider, S.4    Akpan, I.5
  • 28
    • 33644876815 scopus 로고    scopus 로고
    • A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
    • Wang RH, Li C, Xu X, Zheng Y, Xiao C, et al. (2005) A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab 2: 399-409.
    • (2005) Cell Metab , vol.2 , pp. 399-409
    • Wang, R.H.1    Li, C.2    Xu, X.3    Zheng, Y.4    Xiao, C.5
  • 29
    • 78751598932 scopus 로고    scopus 로고
    • Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis
    • Lakhal S, Schodel J, Townsend AR, Pugh CW, Ratcliffe PJ, et al. (2011) Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis. J Biol Chem 286: 4090-4097.
    • (2011) J Biol Chem , vol.286 , pp. 4090-4097
    • Lakhal, S.1    Schodel, J.2    Townsend, A.R.3    Pugh, C.W.4    Ratcliffe, P.J.5
  • 30
    • 84861380376 scopus 로고    scopus 로고
    • Matriptase-2 (TMPRSS6) is directly up-regulated by hypoxia inducible factor-1: identification of a hypoxia-responsive element in the TMPRSS6 promoter region
    • Maurer E, Gutschow M, Stirnberg M, (2012) Matriptase-2 (TMPRSS6) is directly up-regulated by hypoxia inducible factor-1: identification of a hypoxia-responsive element in the TMPRSS6 promoter region. Biol Chem 393: 535-540.
    • (2012) Biol Chem , vol.393 , pp. 535-540
    • Maurer, E.1    Gutschow, M.2    Stirnberg, M.3
  • 31
    • 77952573858 scopus 로고    scopus 로고
    • Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis
    • Finberg KE, Whittlesey RL, Fleming MD, Andrews NC, (2010) Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis. Blood 115: 3817-3826.
    • (2010) Blood , vol.115 , pp. 3817-3826
    • Finberg, K.E.1    Whittlesey, R.L.2    Fleming, M.D.3    Andrews, N.C.4
  • 32
    • 33646076196 scopus 로고    scopus 로고
    • GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation
    • Xu J, Kimball TR, Lorenz JN, Brown DA, Bauskin AR, et al. (2006) GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circ Res 98: 342-350.
    • (2006) Circ Res , vol.98 , pp. 342-350
    • Xu, J.1    Kimball, T.R.2    Lorenz, J.N.3    Brown, D.A.4    Bauskin, A.R.5
  • 33
    • 79955703474 scopus 로고    scopus 로고
    • GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice
    • Kempf T, Zarbock A, Widera C, Butz S, Stadtmann A, et al. (2011) GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med 17: 581-588.
    • (2011) Nat Med , vol.17 , pp. 581-588
    • Kempf, T.1    Zarbock, A.2    Widera, C.3    Butz, S.4    Stadtmann, A.5
  • 34
    • 34948904750 scopus 로고    scopus 로고
    • High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
    • Tanno T, Bhanu NV, Oneal PA, Goh SH, Staker P, et al. (2007) High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med 13: 1096-1101.
    • (2007) Nat Med , vol.13 , pp. 1096-1101
    • Tanno, T.1    Bhanu, N.V.2    Oneal, P.A.3    Goh, S.H.4    Staker, P.5
  • 35
    • 84880835660 scopus 로고    scopus 로고
    • The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice
    • Casanovas G, Vujic Spasic M, Casu C, Rivella S, Strelau J, et al. (2012) The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice. Haematologica.
    • (2012) Haematologica
    • Casanovas, G.1    Vujic Spasic, M.2    Casu, C.3    Rivella, S.4    Strelau, J.5
  • 36
    • 33646547951 scopus 로고    scopus 로고
    • Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4
    • Gilchrist M, Thorsson V, Li B, Rust AG, Korb M, et al. (2006) Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4. Nature 441: 173-178.
    • (2006) Nature , vol.441 , pp. 173-178
    • Gilchrist, M.1    Thorsson, V.2    Li, B.3    Rust, A.G.4    Korb, M.5
  • 37
    • 0038369998 scopus 로고    scopus 로고
    • A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells
    • Kang Y, Chen CR, Massague J, (2003) A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell 11: 915-926.
    • (2003) Mol Cell , vol.11 , pp. 915-926
    • Kang, Y.1    Chen, C.R.2    Massague, J.3
  • 38
    • 0032572723 scopus 로고    scopus 로고
    • Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
    • Zhang Y, Feng XH, Derynck R, (1998) Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature 394: 909-913.
    • (1998) Nature , vol.394 , pp. 909-913
    • Zhang, Y.1    Feng, X.H.2    Derynck, R.3
  • 39
    • 70349494083 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis
    • Corradini E, Garuti C, Montosi G, Ventura P, Andriopoulos B Jr, et al. (2009) Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis. Gastroenterology 137: 1489-1497.
    • (2009) Gastroenterology , vol.137 , pp. 1489-1497
    • Corradini, E.1    Garuti, C.2    Montosi, G.3    Ventura, P.4    Andriopoulos Jr., B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.