Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: New link between hypoxia signaling and iron homeostasis

Journal of Biological Chemistry

Volumn 286, Issue 6, 2011, Pages 4090-4097

  Lakhal, Samira ^a   Schödel, Johannes ^a   Townsend, Alain R M ^b   Pugh, Christopher W ^a   Ratcliffe, Peter J ^a   Mole, David R ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEINS; HEPATIC CELLS; HEPATOCYTES; HEPCIDIN; HYPOXIA-INDUCIBLE FACTORS; IRON DEFICIENCY; IRON HOMEOSTASIS; MOLECULAR LINKS; OXYGEN-SENSING; RECEPTOR COMPLEX; SERINE PROTEINASE; TRANSMEMBRANES; TYPE II; UP-REGULATION;

AMINO ACIDS; CELL CULTURE; CELL MEMBRANES; MOLECULAR OXYGEN; PROTEINS; SIGNALING;

PHYSIOLOGY;

HEMOJUVELIN; HEPCIDIN; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; IRON; MATRIPTASE; MATRIPTASE 2; MEMBRANE PROTEIN; SERINE PROTEINASE; TRANSMEMBRANE SERINE PROTEINASE TMPRSS6; UNCLASSIFIED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BONE MORPHOGENETIC PROTEIN; ENDOTHELIAL PAS DOMAIN CONTAINING PROTEIN 1; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; HFE PROTEIN, HUMAN; HIF1A PROTEIN, HUMAN; HLA ANTIGEN CLASS 1; OXYGEN; TMPRSS6 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE MUTATION; HOMEOSTASIS; HUMAN; HUMAN CELL; OXYGEN SENSING; PRIORITY JOURNAL; PROTEIN CLEAVAGE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION; UPREGULATION; CELL HYPOXIA; CELL LINE; CELL MEMBRANE; ENZYMOLOGY; GENETICS; IRON DEFICIENCY ANEMIA; METABOLISM; MUTATION; PHYSIOLOGY;

ANEMIA, IRON-DEFICIENCY; ANTIMICROBIAL CATIONIC PEPTIDES; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BONE MORPHOGENETIC PROTEINS; CELL HYPOXIA; CELL LINE; CELL MEMBRANE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HOMEOSTASIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IRON; MEMBRANE PROTEINS; MUTATION; OXYGEN; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 78751598932     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.173096     Document Type: Article

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