Uncoupling protein 2 deficiency mimics the effects of hypoxia and endoplasmic reticulum stress on mitochondria and triggers pseudohypoxic pulmonary vascular remodeling and pulmonary hypertension

Circulation Research

Volumn 113, Issue 2, 2013, Pages 126-136

  Dromparis, Peter ^a   Paulin, Roxane ^a   Sutendra, Gopinath ^a   Qi, Andrew C ^a   Bonnet, Sébastien ^b   Michelakis, Evangelos D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

metabolism; mitochondria; pseudohypoxia; pulmonary hypertension; pulmonary vascular remodeling; uncoupling protein

Indexed keywords

CALCIUM; HISTAMINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOCHONDRIAL ENZYME; REACTIVE OXYGEN METABOLITE; UNCOUPLING PROTEIN 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CITRIC ACID CYCLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PULMONARY ARTERY; PULMONARY HYPERTENSION; SMOOTH MUSCLE FIBER;

METABOLISM; MITOCHONDRIA; PSEUDOHYPOXIA; PULMONARY HYPERTENSION; PULMONARY VASCULAR REMODELING; UNCOUPLING PROTEIN;

ANIMALS; ANOXIA; CELLS, CULTURED; ENDOPLASMIC RETICULUM STRESS; HYPERTENSION, PULMONARY; ION CHANNELS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MOLECULAR MIMICRY; MYOCYTES, SMOOTH MUSCLE; PULMONARY ARTERY; RANDOM ALLOCATION;

EID: 84880569655     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.300699     Document Type: Article

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