Uncoupling protein 2 ablation exacerbates high-salt intake-induced vascular dysfunction

American Journal of Hypertension

Volumn 23, Issue 8, 2010, Pages 822-828

  Ma, Shuangtao ^a   Ma, Liqun ^a   Yang, Dachun ^a   Luo, Zhidan ^a   Hao, Xinzhong ^a   Liu, Daoyan ^a   Zhu, Zhiming ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

blood pressure; high salt diet; hypertension; nitric oxide; reactive oxygen species; uncoupling protein 2; vascular dysfunction

Indexed keywords

ACETYLCHOLINE; GLYCERYL TRINITRATE; NITRIC OXIDE; PHENYLEPHRINE; SUPEROXIDE; UNCOUPLING PROTEIN 2; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2; SALT INTAKE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; BIOAVAILABILITY; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; DIETARY INTAKE; DISEASE EXACERBATION; ENZYME SYNTHESIS; HEART CONTRACTION; HEART MUSCLE RELAXATION; HYPERTENSION; MESENTERIC ARTERY; MESENTERY BLOOD VESSEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALT INTAKE; VASCULAR RESISTANCE; VASODILATATION; WILD TYPE; ADMINISTRATION AND DOSAGE; ANIMAL; C57BL MOUSE; DEFICIENCY; DRUG EFFECTS; METABOLISM; PHARMACOLOGY; VASOCONSTRICTION;

ACETYLCHOLINE; ANIMALS; AORTA; BLOOD PRESSURE; ION CHANNELS; MESENTERIC ARTERIES; MICE; MICE, INBRED C57BL; MITOCHONDRIAL PROTEINS; NITRIC OXIDE; PHENYLEPHRINE; SODIUM CHLORIDE, DIETARY; SUPEROXIDES; VASOCONSTRICTION; VASODILATION;

EID: 77955773056     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1038/ajh.2010.73     Document Type: Article

References (33)

1. Lima NK, Lima FB, dos Santos EA, Okamoto MM, Sumida DH, Hell NS, Furukawa LN, Heimann JC. Effect of lifelong high-or low-salt intake on blood pressure, left ventricular mass and plasma insulin in Wistar rats. Am J Med Sci 2006; 331: 309-314.
2. Santos SF, Vieira LM, Moura RS. Effect of high-salt intake on blood pressure and vascular reactivity of diabetic rats. Braz J Med Biol Res 1995; 28:889-894
3. dos Santos L, Gonçalves MV, Vassallo DV, Oliveira EM, Rossoni LV. Effects of high sodium intake diet on the vascular reactivity to phenylephrine on rat isolated caudal and renal vascular beds: Endothelial modulation. Life Sci 2006; 78: 2272-2279.
4. Weinberger MH. Salt sensitivity as a predictor of hypertension. Am J Hypertens 1991; 4:615S-616S.
5. Tian N, Gannon AW, Khalil RA, Manning RD Jr. Mechanisms of salt-sensitive hypertension: role of renal medullary inducible nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol 2003; 284:R372-R379.
6. Banday AA, Muhammad AB, Fazili FR, Lokhandwala M. Mechanisms of oxidative stress-induced increase in salt sensitivity and development of hypertension in Sprague-Dawley rats. Hypertension 2007; 49:664-671.
7. Wang Y, Chen AF, Wang DH. Enhanced oxidative stress in kidneys of salt-sensitive hypertension: role of sensory nerves. Am J Physiol Heart Circ Physiol 2006; 291:H3136-H3143.
8. Tian N, Moore RS, Braddy S, Rose RA, Gu JW, Hughson MD, Manning RD Jr. Interactions between oxidative stress and inflammation in salt-sensitive hypertension. Am J Physiol Heart Circ Physiol 2007; 293:H3388-H3395.
9. nd, Cason GW, Curry TS, Manning RD Jr. Superoxide dismutase and oxidative stress in Dahl salt-sensitive and-resistant rats. Am J Physiol Regul Integr Comp Physiol 2002; 283:R732-R738.
10. Carlström M, Brown RD, Sällström J, Larsson E, Zilmer M, Zabihi S, Eriksson UJ, Persson AE. SOD1 deficiency causes salt sensitivity and aggravates hypertension in hydronephrosis. Am J Physiol Regul Integr Comp Physiol 2009; 297:R82-R92.
11. Johansen JS, Harris AK, Rychly DJ, Ergul A. Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. Cardiovasc Diabetol 2005; 4:5.
12. Taniyama Y, Griendling KK. Reactive oxygen species in the vasculature: molecular and cellular mechanisms. Hypertension 2003; 42:1075-1081.
13. Puddu P, Puddu GM, Cravero E, De Pascalis S, Muscari A. The putative role of mitochondrial dysfunction in hypertension. Clin Exp Hypertens 2007; 29: 427-434.
14. Krauss S, Zhang CY, Lowell BB. The mitochondrial uncoupling-protein homologues. Nat Rev Mol Cell Biol 2005; 6:248-261.
15. Ji Q, Ikegami H, Fujisawa T, Kawabata Y, Ono M, Nishino M, Ohishi M, Katsuya T, Rakugi H, Ogihara T. A common polymorphism of uncoupling protein 2 gene is associated with hypertension. J Hypertens 2004; 22:97-102.
16. de Cavanagh EM, Toblli JE, Ferder L, Piotrkowski B, Stella I, Inserra F. Renal mitochondrial dysfunction in spontaneously hypertensive rats is attenuated by losartan but not by amlodipine. Am J Physiol Regul Integr Comp Physiol 2006; 290:R1616-R1625.
17. Pi J, Bai Y, Daniel KW, Liu D, Lyght O, Edelstein D, Brownlee M, Corkey BE, Collins S. Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic β-cell function. Endocrinology 2009; 150:3040-3048.
18. Lee KU, Lee IK, Han J, Song DK, Kim YM, Song HS, Kim HS, Lee WJ, Koh EH, Song KH, Han SM, Kim MS, Park IS, Park JY. Effects of recombinant adenovirus-mediated uncoupling protein 2 overexpression on endothelial function and apoptosis. Circ Res 2005; 96:1200-1207.
19. Zhu Z, Zhu S, Liu D, Cao T, Wang L, Tepel M. Thiazide-like diuretics attenuate agonist-induced vasoconstriction by calcium desensitization linked to Rho kinase. Hypertension 2005; 45:233-239.
20. Liu D, Yang D, He H, Chen X, Cao T, Feng X, Ma L, Luo Z, Wang L, Yan Z, Zhu Z, Tepel M. Increased transient receptor potential canonical type 3 channels in vasculature from hypertensive rats. Hypertension 2009; 53:70-76.
21. Zhu J, Huang T, Lombard JH. Effect of high-salt diet on vascular relaxation and oxidative stress in mesenteric resistance arteries. J Vasc Res 2007; 44:382-390.
22. Esterbauer H, Schneitler C, Oberkofler H, Ebenbichler C, Paulweber B, Sandhofer F, Ladurner G, Hell E, Strosberg AD, Patsch JR, Krempler F, Patsch W. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Nat Genet 2001; 28:178-183.
23. Srivastava N, Prakash J, Lakhan R, Agarwal CG, Pant DC, Mittal B. A common polymorphism in the promoter of UCP2 is associated with obesity and hyperinsulenemia in northern Indians. Mol Cell Biochem 2010; 337:293-298.
24. Krempler F, Esterbauer H, Weitgasser R, Ebenbichler C, Patsch JR, Miller K, Xie M, Linnemayr V, Oberkofler H, Patsch W. A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans. Diabetes 2002; 51:3331-3335.
25. Sesti G, Cardellini M, Marini MA, Frontoni S, D'Adamo M, Del Guerra S, Lauro D, De Nicolais P, Sbraccia P, Del Prato S, Gambardella S, Federici M, Marchetti P, Lauro R. A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects. Diabetes 2003; 52:1280-1283.
26. Palmer BR, Devereaux CL, Dhamrait SS, Mocatta TJ, Pilbrow A P, Frampton CM, Skelton L, Yandle TG, Winterbourn CC, Richards AM, Montgomery HE, Cameron VA. The common G-866A polymorphism of the UCP2 gene and survival in diabetic patients following myocardial infarction. Cardiovasc Diabetol 2009; 8:31.
27. Faraci FM. Reactive oxygen species: influence on cerebral vascular tone. J Appl Physiol 2006; 100:739-743.
28. Touyz RM. Reactive oxygen species in vascular biology: role in arterial hypertension. Expert Rev Cardiovasc Ther 2003; 1:91-106.
29. Brand MD, Esteves TC. Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab 2005; 2:85-93.
30. Chaudhuri G, Cuevas J, Buga GM, Ignarro LJ. NO is more important than PGI2 in maintaining low vascular tone in feto-placental vessels. Am J Physiol 1993; 265:H2036-H2043.
31. Guzik TJ, West NE, Pillai R, Taggart D P, Channon KM. Nitric oxide modulates superoxide release and peroxynitrite formation in human blood vessels. Hypertension 2002; 39:1088-1094.
32. Weber DS, Lombard JH. Elevated salt intake impairs dilation of rat skeletal muscle resistance arteries via ANG II suppression. Am J Physiol Heart Circ Physiol 2000; 278:H500-H506.
33. Weber DS, Lombard JH. Angiotensin II AT1 receptors preserve vasodilator reactivity in skeletal muscle resistance arteries. Am J Physiol Heart Circ Physiol 2001; 280:H2196-H2202.