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Volumn , Issue , 2009, Pages 15-46

The P-Glycoprotein 170: Just a Multidrug Resistance Protein or a Protean Molecule?

Author keywords

ATP binding cassette (ABC) proteins diversified superfamily in living kingdoms; P glycoprotein 170; Tissular, cellular, and organelle expression of P gp 170

Indexed keywords


EID: 84880180369     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470495131.ch1     Document Type: Chapter
Times cited : (7)

References (173)
  • 1
    • 34547734539 scopus 로고    scopus 로고
    • Mechanism of multidrug recognition by MDR1/ABCB1
    • Kimura Y, Morita SY, Matsuo M, and Ueda K. 2007. Mechanism of multidrug recognition by MDR1/ABCB1. Cancer Sci 98: 1303-1310.
    • (2007) Cancer Sci , vol.98 , pp. 1303-1310
    • Kimura, Y.1    Morita, S.Y.2    Matsuo, M.3    Ueda, K.4
  • 2
    • 40949121607 scopus 로고    scopus 로고
    • ABC multidrug transporters: Structure, function and role in chemoresistance
    • Sharom FJ. 2008. ABC multidrug transporters: Structure, function and role in chemoresistance. Pharmacogenomics 9: 105-127.
    • (2008) Pharmacogenomics , vol.9 , pp. 105-127
    • Sharom, F.J.1
  • 3
    • 0035014565 scopus 로고    scopus 로고
    • The ABC of ABCS: A phylogenetic and functional classification of ABC systems in living organisms
    • Dassa E and Bouige P. 2001. The ABC of ABCS: A phylogenetic and functional classification of ABC systems in living organisms. Res Microbiol 152: 211-229.
    • (2001) Res Microbiol , vol.152 , pp. 211-229
    • Dassa, E.1    Bouige, P.2
  • 5
    • 34147214716 scopus 로고    scopus 로고
    • Multiple molecular mechanisms for multidrug resistance transporters
    • Higgins CF. 2007. Multiple molecular mechanisms for multidrug resistance transporters. Nature 446: 749-757.
    • (2007) Nature , vol.446 , pp. 749-757
    • Higgins, C.F.1
  • 6
    • 33645830172 scopus 로고
    • A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
    • Juliano RL and Ling V. 1976. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 455: 152-162.
    • (1976) Biochim Biophys Acta , vol.455 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 7
    • 31844444140 scopus 로고    scopus 로고
    • The molecular basis of multidrug resistance in cancer: The early years of P-glycoprotein research
    • Gottesman MM and Ling V. 2006. The molecular basis of multidrug resistance in cancer: The early years of P-glycoprotein research. FEBS Lett 580: 998-1009.
    • (2006) FEBS Lett , vol.580 , pp. 998-1009
    • Gottesman, M.M.1    Ling, V.2
  • 8
    • 32044453808 scopus 로고    scopus 로고
    • Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux
    • Loo TW and Clarke DM. 2005. Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux. J Membr Biol 206: 173-185.
    • (2005) J Membr Biol , vol.206 , pp. 173-185
    • Loo, T.W.1    Clarke, D.M.2
  • 10
    • 33846568546 scopus 로고    scopus 로고
    • ABCB1 pharmacogenetics: Progress, pitfalls, and promise
    • Chinn LW and Kroetz DL. 2007. ABCB1 pharmacogenetics: Progress, pitfalls, and promise. Clin Pharmacol Ther 81: 265-269.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 265-269
    • Chinn, L.W.1    Kroetz, D.L.2
  • 11
    • 33846215616 scopus 로고    scopus 로고
    • A primer on the mechanics of P-glycoprotein the multidrug transporter
    • Hennessy M and Spiers JP. 2007. A primer on the mechanics of P-glycoprotein the multidrug transporter. Pharmacol Res 55: 1-15.
    • (2007) Pharmacol Res , vol.55 , pp. 1-15
    • Hennessy, M.1    Spiers, J.P.2
  • 13
    • 33751075186 scopus 로고    scopus 로고
    • ABC transporters, neural stem cells and neurogenesis-A different perspective
    • Lin T, Islam O, and Heese K. 2006. ABC transporters, neural stem cells and neurogenesis-A different perspective. Cell Res 16: 857-871.
    • (2006) Cell Res , vol.16 , pp. 857-871
    • Lin, T.1    Islam, O.2    Heese, K.3
  • 14
    • 33749488939 scopus 로고    scopus 로고
    • Human multidrug resistance ABCB and ABCG transporters: Participation in a chemoimmunity defense system
    • Sarkadi B, Homolya L, Szakács G, and Váradi A. 2006. Human multidrug resistance ABCB and ABCG transporters: Participation in a chemoimmunity defense system. Physiol Rev 86: 1179-1236.
    • (2006) Physiol Rev , vol.86 , pp. 1179-1236
    • Sarkadi, B.1    Homolya, L.2    Szakács, G.3    Váradi, A.4
  • 15
    • 33745699234 scopus 로고    scopus 로고
    • Membrane transporters and channels in chemore-sistance and-sensitivity of tumor cells
    • Huang Y and Sadée W. 2006. Membrane transporters and channels in chemore-sistance and-sensitivity of tumor cells. Cancer Lett 239: 168-182.
    • (2006) Cancer Lett , vol.239 , pp. 168-182
    • Huang, Y.1    Sadée, W.2
  • 16
    • 0007544439 scopus 로고    scopus 로고
    • MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine
    • Van Helvoort A, Smith AJ, Sprong H, Fritzsche I, Schinkel AH, Borst P et al. 1996. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell 87: 507-517.
    • (1996) Cell , vol.87 , pp. 507-517
    • Van Helvoort, A.1    Smith, A.J.2    Sprong, H.3    Fritzsche, I.4    Schinkel, A.H.5    Borst, P.6
  • 17
    • 0025191307 scopus 로고
    • Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins
    • Chen CJ, Clark D, Ueda K, Pastan I, Gottesman MM, and Roninson IB. 1990. Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. J Biol Chem 265: 506-514.
    • (1990) J Biol Chem , vol.265 , pp. 506-514
    • Chen, C.J.1    Clark, D.2    Ueda, K.3    Pastan, I.4    Gottesman, M.M.5    Roninson, I.B.6
  • 19
    • 33846023369 scopus 로고    scopus 로고
    • Characterization of gene rearrangement leading to activation of MDR-1
    • Huff LM, Lee J-S, Robey RW, and Fojo T. 2006. Characterization of gene rearrangement leading to activation of MDR-1. JBiol Chem 281: 36501-36509.
    • (2006) JBiol Chem , vol.281 , pp. 36501-36509
    • Huff, L.M.1    Lee, J.-S.2    Robey, R.W.3    Fojo, T.4
  • 20
    • 0027410016 scopus 로고
    • Identification of a functional initiator sequence in the human MDR1 promoter
    • Van Groenigen M, Valentijn LJ, and Baas F. 1993. Identification of a functional initiator sequence in the human MDR1 promoter. Biochim Biophys Acta 1172: 138-146.
    • (1993) Biochim Biophys Acta , vol.1172 , pp. 138-146
    • Van Groenigen, M.1    Valentijn, L.J.2    Baas, F.3
  • 21
    • 29244438188 scopus 로고    scopus 로고
    • Aberrant transcription from an unrelated promoter can result in MDR-1 expression following drug selection in vitro and in relapsed lymphoma samples
    • Huff LM, Wang Z, Iglesias A, Fojo T, and Lee JS. 2005. Aberrant transcription from an unrelated promoter can result in MDR-1 expression following drug selection in vitro and in relapsed lymphoma samples. Cancer Res 65: 11694-11703.
    • (2005) Cancer Res , vol.65 , pp. 11694-11703
    • Huff, L.M.1    Wang, Z.2    Iglesias, A.3    Fojo, T.4    Lee, J.S.5
  • 22
    • 0031844689 scopus 로고    scopus 로고
    • The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein
    • Lutterbach B, Sun D, Schuetz J, and Hiebert SW. 1998. The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein. Mol Cell Biol 18: 3604-3611.
    • (1998) Mol Cell Biol , vol.18 , pp. 3604-3611
    • Lutterbach, B.1    Sun, D.2    Schuetz, J.3    Hiebert, S.W.4
  • 23
    • 34548716988 scopus 로고    scopus 로고
    • Role of the highly structured 5'-end region of MDR1 mRNA in P-glycoprotein expression
    • Randle RA, Raguz S, Higgins CF, and Yagüe E. 2007. Role of the highly structured 5'-end region of MDR1 mRNA in P-glycoprotein expression. Biochem J 406: 445-455.
    • (2007) Biochem J , vol.406 , pp. 445-455
    • Randle, R.A.1    Raguz, S.2    Higgins, C.F.3    Yagüe, E.4
  • 24
    • 0028024166 scopus 로고
    • Prevalence of multidrug resistance related to activation of the mdr1 gene in human sarcoma mutants derived by single-step doxorubicin selection
    • Chen G, Jaffrezou JP, Fleming WH, Duran GE, and Sikic BI. 1994. Prevalence of multidrug resistance related to activation of the mdr1 gene in human sarcoma mutants derived by single-step doxorubicin selection. Cancer Res 54: 4980-4987.
    • (1994) Cancer Res , vol.54 , pp. 4980-4987
    • Chen, G.1    Jaffrezou, J.P.2    Fleming, W.H.3    Duran, G.E.4    Sikic, B.I.5
  • 25
    • 0031865310 scopus 로고    scopus 로고
    • Demethylation of the human MDR1 5' region accompanies activation of P-glycoprotein expression in a HL60 multidrug resistant subline
    • Desiderato L, Davey MW, and Piper AA. 1997. Demethylation of the human MDR1 5' region accompanies activation of P-glycoprotein expression in a HL60 multidrug resistant subline. Somat Cell Mol Genet 23: 391-400.
    • (1997) Somat Cell Mol Genet , vol.23 , pp. 391-400
    • Desiderato, L.1    Davey, M.W.2    Piper, A.A.3
  • 26
    • 0033564370 scopus 로고    scopus 로고
    • Association of 5' CpG demethylation and altered chromatin structure in the promoter region with transcriptional activation of the multidrug resistance 1 gene in human cancer cells
    • Kusaba H, Nakayama M, Harada T, Nomoto M, Kohno K, Kuwano M et al. 1999. Association of 5' CpG demethylation and altered chromatin structure in the promoter region with transcriptional activation of the multidrug resistance 1 gene in human cancer cells. Eur J Biochem 262: 924-932.
    • (1999) Eur J Biochem , vol.262 , pp. 924-932
    • Kusaba, H.1    Nakayama, M.2    Harada, T.3    Nomoto, M.4    Kohno, K.5    Kuwano, M.6
  • 27
    • 0027506202 scopus 로고
    • Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs
    • Chaudhary PM and Roninson IB. 1993. Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs. J Natl Cancer Inst 85: 632-639.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 632-639
    • Chaudhary, P.M.1    Roninson, I.B.2
  • 28
    • 0036710923 scopus 로고    scopus 로고
    • Transcriptional regulators of the human multidrug resistance 1 gene: Recent views
    • Labialle S, Gayet L, Marthinet E, Rigal D, and Baggetto LG. 2002. Transcriptional regulators of the human multidrug resistance 1 gene: Recent views. Biochem Pharmacol 64: 943-948.
    • (2002) Biochem Pharmacol , vol.64 , pp. 943-948
    • Labialle, S.1    Gayet, L.2    Marthinet, E.3    Rigal, D.4    Baggetto, L.G.5
  • 29
    • 0033573850 scopus 로고    scopus 로고
    • Negative regulation of MDR1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr, cells by cross-coupled NF-kappa B/p65 and c-Fos transcription factors and their interaction with the CAAT region
    • Ogretmen B and Safa AR. 1999. Negative regulation of MDR1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr, cells by cross-coupled NF-kappa B/p65 and c-Fos transcription factors and their interaction with the CAAT region. Biochemistry 38: 2189-2199.
    • (1999) Biochemistry , vol.38 , pp. 2189-2199
    • Ogretmen, B.1    Safa, A.R.2
  • 30
    • 0031932166 scopus 로고    scopus 로고
    • Regulation of the MDR1 promoter by cyclic AMP-dependent protein kinase and transcription factor Sp1
    • Rohlff C and Glazer RI. 1998. Regulation of the MDR1 promoter by cyclic AMP-dependent protein kinase and transcription factor Sp1. Int J Oncol 12: 383-386.
    • (1998) Int J Oncol , vol.12 , pp. 383-386
    • Rohlff, C.1    Glazer, R.I.2
  • 31
    • 16944363733 scopus 로고    scopus 로고
    • Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression
    • Bargou RC, Jurchott K, Wagener C, Bergmann S, Metzner S, Bommert K et al. 1997. Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Nat Med 3: 447-450.
    • (1997) Nat Med , vol.3 , pp. 447-450
    • Bargou, R.C.1    Jurchott, K.2    Wagener, C.3    Bergmann, S.4    Metzner, S.5    Bommert, K.6
  • 32
    • 0034635186 scopus 로고    scopus 로고
    • Identification and characterization of the MDR1 promoter-enhancing factor 1 (MEF1) in the multidrug resistant HL60/VCR human acute myeloid leukemia cell line
    • Ogretmen B and Safa AR. 2000. Identification and characterization of the MDR1 promoter-enhancing factor 1 (MEF1) in the multidrug resistant HL60/VCR human acute myeloid leukemia cell line. Biochemistry 39: 194-204.
    • (2000) Biochemistry , vol.39 , pp. 194-204
    • Ogretmen, B.1    Safa, A.R.2
  • 33
    • 0032513246 scopus 로고    scopus 로고
    • Direct involvement of the Y-box binding protein YB-1 in genotoxic stress-induced activation of the human multidrug resistance 1 gene
    • Ohga T, Uchiumi T, Makino Y, Koike K, Wada M, Kuwano M et al. 1998. Direct involvement of the Y-box binding protein YB-1 in genotoxic stress-induced activation of the human multidrug resistance 1 gene. J Biol Chem 273: 5997-6000.
    • (1998) J Biol Chem , vol.273 , pp. 5997-6000
    • Ohga, T.1    Uchiumi, T.2    Makino, Y.3    Koike, K.4    Wada, M.5    Kuwano, M.6
  • 34
    • 0035920197 scopus 로고    scopus 로고
    • Transcriptional repression by p53 through direct binding to a novel DNA element
    • Johnson RA, Ince TA, and Scotto KW. 2001. Transcriptional repression by p53 through direct binding to a novel DNA element. J Biol Chem 276: 27716-27720.
    • (2001) J Biol Chem , vol.276 , pp. 27716-27720
    • Johnson, R.A.1    Ince, T.A.2    Scotto, K.W.3
  • 35
    • 0035883628 scopus 로고    scopus 로고
    • Wild type p53 sensitizes soft tissue sarcoma cells to doxorubicin by down-regulating multidrug resistance-1 expression
    • Zhan M, Yu D, Lang A, Li L, and Pollock RE. 2001. Wild type p53 sensitizes soft tissue sarcoma cells to doxorubicin by down-regulating multidrug resistance-1 expression. Cancer 92: 1556-1566.
    • (2001) Cancer , vol.92 , pp. 1556-1566
    • Zhan, M.1    Yu, D.2    Lang, A.3    Li, L.4    Pollock, R.E.5
  • 36
    • 14244250067 scopus 로고    scopus 로고
    • Transcriptional repression of protein kinase C alpha via Sp1 by wild type p53 is involved in inhibition of multidrug resistance 1 P-glycoprotein phosphorylation
    • Zhan M, Yu D, Liu J, Glazer RI, Hannay J, and Pollock RE. 2005. Transcriptional repression of protein kinase C alpha via Sp1 by wild type p53 is involved in inhibition of multidrug resistance 1 P-glycoprotein phosphorylation. J Biol Chem 280: 4825-4833.
    • (2005) J Biol Chem , vol.280 , pp. 4825-4833
    • Zhan, M.1    Yu, D.2    Liu, J.3    Glazer, R.I.4    Hannay, J.5    Pollock, R.E.6
  • 37
    • 17144410320 scopus 로고    scopus 로고
    • Differential regulation of MDR1 transcription by the p53 family members. Role of the DNA binding domain
    • Johnson RA, Shepard EM, and Scotto KW. 2005. Differential regulation of MDR1 transcription by the p53 family members. Role of the DNA binding domain. J Biol Chem 280: 13213-13219.
    • (2005) J Biol Chem , vol.280 , pp. 13213-13219
    • Johnson, R.A.1    Shepard, E.M.2    Scotto, K.W.3
  • 38
    • 16544395969 scopus 로고    scopus 로고
    • Transcription factor NF-Y regulates mdr1 expression through binding to inverted CCAAT sequence in drug-resistant human squamous carcinoma cells
    • Okamura H, Yoshida K, Sasaki E, Morimoto H, and Haneji T. 2004. Transcription factor NF-Y regulates mdr1 expression through binding to inverted CCAAT sequence in drug-resistant human squamous carcinoma cells. Int J Oncol 25: 1031-1037.
    • (2004) Int J Oncol , vol.25 , pp. 1031-1037
    • Okamura, H.1    Yoshida, K.2    Sasaki, E.3    Morimoto, H.4    Haneji, T.5
  • 39
    • 1842533016 scopus 로고    scopus 로고
    • CCAAT/enhancer-binding protein beta (nuclear factor for interleukin 6) transactivates the human MDR1 gene by interaction with an inverted CCAAT box in human cancer cells
    • Chen GK, Sale S, Tan T, Ermoian RP, and Sikic BI. 2004. CCAAT/enhancer-binding protein beta (nuclear factor for interleukin 6) transactivates the human MDR1 gene by interaction with an inverted CCAAT box in human cancer cells. Mol Pharmacol 65: 906-916.
    • (2004) Mol Pharmacol , vol.65 , pp. 906-916
    • Chen, G.K.1    Sale, S.2    Tan, T.3    Ermoian, R.P.4    Sikic, B.I.5
  • 40
    • 3242670026 scopus 로고    scopus 로고
    • New invMED1 element cis-activates human multidrug-related MDR1 and MVP genes, involving the LRP130 protein
    • Labialle S, Dayan G, Gayet L, Rigal D, Gambrelle J, and Baggetto LG. 2004. New invMED1 element cis-activates human multidrug-related MDR1 and MVP genes, involving the LRP130 protein. Nucleic Acids Res 32: 3864-3876.
    • (2004) Nucleic Acids Res , vol.32 , pp. 3864-3876
    • Labialle, S.1    Dayan, G.2    Gayet, L.3    Rigal, D.4    Gambrelle, J.5    Baggetto, L.G.6
  • 41
    • 0037631339 scopus 로고    scopus 로고
    • MYCN enhances P-gp/MDR1 gene expression in the human metastatic neuroblastoma IGR-N-91 model
    • Blanc E, Goldschneider D, Ferrandis E, Barrois M, Le Roux G, Leonce S et al. 2003. MYCN enhances P-gp/MDR1 gene expression in the human metastatic neuroblastoma IGR-N-91 model. Am J Pathol 163: 321-331.
    • (2003) Am J Pathol , vol.163 , pp. 321-331
    • Blanc, E.1    Goldschneider, D.2    Ferrandis, E.3    Barrois, M.4    Le Roux, G.5    Leonce, S.6
  • 42
    • 28544432478 scopus 로고    scopus 로고
    • Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs
    • Baker EK, Johnstone RW, Zalcberg JR, and El-Osta A. 2005. Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs. Oncogene 24: 8061-8075.
    • (2005) Oncogene , vol.24 , pp. 8061-8075
    • Baker, E.K.1    Johnstone, R.W.2    Zalcberg, J.R.3    El-Osta, A.4
  • 44
    • 0035104031 scopus 로고    scopus 로고
    • Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects
    • Cascorbi I, Gerloff T, Johne A, Meisel C, Hoffmeyer S, Schwab M et al. 2001. Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects. Clin Pharmacol Ther 69: 169-174.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 169-174
    • Cascorbi, I.1    Gerloff, T.2    Johne, A.3    Meisel, C.4    Hoffmeyer, S.5    Schwab, M.6
  • 45
    • 34548100791 scopus 로고    scopus 로고
    • Involvement of P-glycoprotein in the release of cytokines from peripheral blood mononuclear cells treated with methotrexate and dexametha-sone
    • Pawlik A, Baśkiewicz-Masiuk M, Machaliiíski B, Safranow K, and Gawroiíska-Szklarz B. 2005. Involvement of P-glycoprotein in the release of cytokines from peripheral blood mononuclear cells treated with methotrexate and dexametha-sone. J Pharm Pharmacol 57: 1421-1425.
    • (2005) J Pharm Pharmacol , vol.57 , pp. 1421-1425
    • Pawlik, A.1    Baśkiewicz-Masiuk, M.2    Machaliiíski, B.3    Safranow, K.4    Gawroiíska-Szklarz, B.5
  • 46
    • 18444404305 scopus 로고    scopus 로고
    • Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors
    • Siegsmund M, Brinkmann U, Scháffeler E, Weirich G, Schwab M, Eichelbaum M et al. 2002. Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors. J Am Soc Nephrol 13: 1847-1854.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1847-1854
    • Siegsmund, M.1    Brinkmann, U.2    Scháffeler, E.3    Weirich, G.4    Schwab, M.5    Eichelbaum, M.6
  • 47
    • 1942467691 scopus 로고    scopus 로고
    • Genetic polymorphism at the 5' regulatory region of multidrug resistance 1 (MDR1) and its association with interindividual variation of expression level in the colon
    • Taniguchi S, Mochida Y, Uchiumi T, Tahira T, Hayashi K, Takagi K et al. 2003. Genetic polymorphism at the 5' regulatory region of multidrug resistance 1 (MDR1) and its association with interindividual variation of expression level in the colon. Mol Cancer Ther 2: 1351-1359.
    • (2003) Mol Cancer Ther , vol.2 , pp. 1351-1359
    • Taniguchi, S.1    Mochida, Y.2    Uchiumi, T.3    Tahira, T.4    Hayashi, K.5    Takagi, K.6
  • 48
    • 0038241171 scopus 로고    scopus 로고
    • Polymorphism in the P-glycoprotein drug transporter MDR1 gene: A possible link between environmental and genetic factors in Parkinson's disease
    • Drozdzik M, Bialecka M, Mysliwiec K, Honczarenko K, Stankiewicz J, and Sych Z. 2003. Polymorphism in the P-glycoprotein drug transporter MDR1 gene: A possible link between environmental and genetic factors in Parkinson's disease. Pharmacogenetics 13: 259-263.
    • (2003) Pharmacogenetics , vol.13 , pp. 259-263
    • Drozdzik, M.1    Bialecka, M.2    Mysliwiec, K.3    Honczarenko, K.4    Stankiewicz, J.5    Sych, Z.6
  • 49
    • 0038323843 scopus 로고    scopus 로고
    • Human MDR1 polymorphism: G2677T/A and C3435T have no effect on MDR1 transport activities
    • Morita N, Yasumori T, and Nakayama K. 2003. Human MDR1 polymorphism: G2677T/A and C3435T have no effect on MDR1 transport activities. Biochem Pharmacol 65: 1843-1852.
    • (2003) Biochem Pharmacol , vol.65 , pp. 1843-1852
    • Morita, N.1    Yasumori, T.2    Nakayama, K.3
  • 50
    • 0041627670 scopus 로고    scopus 로고
    • Polymorphism C3435T of the MDR-1 gene predicts response to preoperative chemotherapy in locally advanced breast cancer
    • Kafka A, Sauer G, Jaeger C, Grundmann R, Kreienberg R, Zeillinger R et al. 2003. Polymorphism C3435T of the MDR-1 gene predicts response to preoperative chemotherapy in locally advanced breast cancer. Int J Oncol 22: 1117-1121.
    • (2003) Int J Oncol , vol.22 , pp. 1117-1121
    • Kafka, A.1    Sauer, G.2    Jaeger, C.3    Grundmann, R.4    Kreienberg, R.5    Zeillinger, R.6
  • 51
    • 40049090206 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in the multidrug resistance gene 1 (ABCB1): Effects on its expression and clinicopathological characteristics in breast cancer patients
    • Vaclavikova R, Nordgard SH, Alnaes GI, Hubackova M, Kubala E, Kodet R et al. 2008. Single nucleotide polymorphisms in the multidrug resistance gene 1 (ABCB1): Effects on its expression and clinicopathological characteristics in breast cancer patients. Pharmacogenet Genomics 18: 263-273.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 263-273
    • Vaclavikova, R.1    Nordgard, S.H.2    Alnaes, G.I.3    Hubackova, M.4    Kubala, E.5    Kodet, R.6
  • 52
    • 34648851348 scopus 로고    scopus 로고
    • ABCB1 genetic polymorphism and risk of upper aerodi-gestive tract cancers among smokers, tobacco chewers and alcoholics in an Indian population
    • Sam SS, Thomas V, Sivagnanam K, Reddy KS, Surianarayanan G, and Chandrasekaran A. 2007. ABCB1 genetic polymorphism and risk of upper aerodi-gestive tract cancers among smokers, tobacco chewers and alcoholics in an Indian population. Pharmacogenet Genomics 17: 861-866.
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 861-866
    • Sam, S.S.1    Thomas, V.2    Sivagnanam, K.3    Reddy, K.S.4    Surianarayanan, G.5    Chandrasekaran, A.6
  • 53
    • 4243098329 scopus 로고    scopus 로고
    • Multidrug resistance gene G1199A polymorphism alters efflux transport activity of P-glycoprotein
    • Woodahl EL, Yang Z, Bui T, Shen DD, and Ho RJ. 2004. Multidrug resistance gene G1199A polymorphism alters efflux transport activity of P-glycoprotein. J Pharmacol Exp Ther 310: 1199-1207.
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 1199-1207
    • Woodahl, E.L.1    Yang, Z.2    Bui, T.3    Shen, D.D.4    Ho, R.J.5
  • 54
    • 10744224230 scopus 로고    scopus 로고
    • Alteration in copy numbers of genes as a mechanism for acquired drug resistance
    • Yasui K, Mihara S, Zhao C, Okamoto H, Saito-Ohara F, Tomida A et al. 2004. Alteration in copy numbers of genes as a mechanism for acquired drug resistance. Cancer Res 64: 1403-1410.
    • (2004) Cancer Res , vol.64 , pp. 1403-1410
    • Yasui, K.1    Mihara, S.2    Zhao, C.3    Okamoto, H.4    Saito-Ohara, F.5    Tomida, A.6
  • 55
    • 33846845118 scopus 로고    scopus 로고
    • Genetic polymorphisms in MDR1 and CYP3A5 and MDR1 haplotype in mainland Chinese Han, Uygur and Kazakh ethnic groups
    • Li D, Zhang GL, Lou YQ, Li Q, Wang X, and Bu XY. 2007. Genetic polymorphisms in MDR1 and CYP3A5 and MDR1 haplotype in mainland Chinese Han, Uygur and Kazakh ethnic groups. J Clin Pharm Ther 32: 89-95.
    • (2007) J Clin Pharm Ther , vol.32 , pp. 89-95
    • Li, D.1    Zhang, G.L.2    Lou, Y.Q.3    Li, Q.4    Wang, X.5    Bu, X.Y.6
  • 57
    • 40549132901 scopus 로고    scopus 로고
    • Influence of ABCB1 genetic polymorphisms on cyclosporine intracellular concentration in transplant recipients
    • Crettol S, Venetz JP, Fontana M, Aubert JD, Ansermot N, Fathi M et al. 2008. Influence of ABCB1 genetic polymorphisms on cyclosporine intracellular concentration in transplant recipients. Pharmacogenet Genomics 18: 307-315.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 307-315
    • Crettol, S.1    Venetz, J.P.2    Fontana, M.3    Aubert, J.D.4    Ansermot, N.5    Fathi, M.6
  • 58
    • 34648857526 scopus 로고    scopus 로고
    • 1199G > A and 2677G > T/A polymorphisms of ABCB1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation
    • Elens L, Capron A, Kerckhove VV, Lerut J, Mourad M, Lison D et al. 2007. 1199G > A and 2677G > T/A polymorphisms of ABCB1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation. Pharmacogenet Genomic 17: 873-883.
    • (2007) Pharmacogenet Genomic , vol.17 , pp. 873-883
    • Elens, L.1    Capron, A.2    Kerckhove, V.V.3    Lerut, J.4    Mourad, M.5    Lison, D.6
  • 59
    • 48949119322 scopus 로고    scopus 로고
    • Pharmacogenomics of importance for paclitaxel chemotherapy
    • Green H. 2008. Pharmacogenomics of importance for paclitaxel chemotherapy. Pharmacogenomics 9: 671-674.
    • (2008) Pharmacogenomics , vol.9 , pp. 671-674
    • Green, H.1
  • 60
    • 0031786405 scopus 로고    scopus 로고
    • A new structural model for P-glycoprotein
    • Jones PM and George AM. 1998. A new structural model for P-glycoprotein. J Membr Biol 166: 133-147.
    • (1998) J Membr Biol , vol.166 , pp. 133-147
    • Jones, P.M.1    George, A.M.2
  • 61
    • 33748644877 scopus 로고    scopus 로고
    • Structure of a bacterial multidrug ABC transporter
    • Dawson RJ and Locher KP. 2006. Structure of a bacterial multidrug ABC transporter. Nature 443: 180-185.
    • (2006) Nature , vol.443 , pp. 180-185
    • Dawson, R.J.1    Locher, K.P.2
  • 62
    • 36849079744 scopus 로고    scopus 로고
    • Evidence for a Sav1866-like architecture for the human multidrug transporter P-glycoprotein
    • Zolnerciks JK, Wooding C, and Linton KJ. 2007. Evidence for a Sav1866-like architecture for the human multidrug transporter P-glycoprotein. FASEB J 21: 3937-3948.
    • (2007) FASEB J , vol.21 , pp. 3937-3948
    • Zolnerciks, J.K.1    Wooding, C.2    Linton, K.J.3
  • 63
    • 0037424343 scopus 로고    scopus 로고
    • Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding
    • Rosenberg MF, Kamis AB, Callaghan R, Higgins CF, and Ford RC. 2003. Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding. J Biol Chem 278: 8294-8299.
    • (2003) J Biol Chem , vol.278 , pp. 8294-8299
    • Rosenberg, M.F.1    Kamis, A.B.2    Callaghan, R.3    Higgins, C.F.4    Ford, R.C.5
  • 64
    • 13244292479 scopus 로고    scopus 로고
    • Threedimensional structure of P-glycoprotein: The transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state
    • Rosenberg MF, Callaghan R, Modok S, Higgins CF, and Ford RC. 2005. Threedimensional structure of P-glycoprotein: The transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state. J Biol Chem 280: 2857-2862.
    • (2005) J Biol Chem , vol.280 , pp. 2857-2862
    • Rosenberg, M.F.1    Callaghan, R.2    Modok, S.3    Higgins, C.F.4    Ford, R.C.5
  • 65
    • 33646029725 scopus 로고    scopus 로고
    • Predicting the three-dimensional structure of human P-glycoprotein in absence of ATP by computational techniques embodying crosslinking data: Insight into the mechanism of ligand migration and binding sites
    • Vandevuer S, Van Bambeke F, Tulkens PM, and Prévost M. 2006. Predicting the three-dimensional structure of human P-glycoprotein in absence of ATP by computational techniques embodying crosslinking data: Insight into the mechanism of ligand migration and binding sites. Proteins 63: 466-478.
    • (2006) Proteins , vol.63 , pp. 466-478
    • Vandevuer, S.1    Van Bambeke, F.2    Tulkens, P.M.3    Prévost, M.4
  • 66
    • 41949129746 scopus 로고    scopus 로고
    • Nucleotide-induced structural changes in P. glycoprotein observed by electron microscopy
    • Lee JY, Urbatsch IL, Senior AE, and Wilkens S. 2008. Nucleotide-induced structural changes in P. glycoprotein observed by electron microscopy. J Biol Chem 283: 5769-5779.
    • (2008) J Biol Chem , vol.283 , pp. 5769-5779
    • Lee, J.Y.1    Urbatsch, I.L.2    Senior, A.E.3    Wilkens, S.4
  • 67
    • 33745008903 scopus 로고    scopus 로고
    • Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket
    • Loo TW, Bartlett MC, and Clarke DM. 2006. Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket. Biochem J 396: 537-545.
    • (2006) Biochem J , vol.396 , pp. 537-545
    • Loo, T.W.1    Bartlett, M.C.2    Clarke, D.M.3
  • 68
    • 33749985062 scopus 로고    scopus 로고
    • Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket
    • Loo TW, Bartlett MC, and Clarke DM. 2006. Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket. Biochem J 399: 351-359.
    • (2006) Biochem J , vol.399 , pp. 351-359
    • Loo, T.W.1    Bartlett, M.C.2    Clarke, D.M.3
  • 69
    • 34548507482 scopus 로고    scopus 로고
    • Residue G346 in transmembrane segment six is involved in inter-domain communication in P-glycoprotein
    • Storm J, O'Mara ML, Crowley EH, Peall J, Tieleman DP, Kerr ID et al. 2007. Residue G346 in transmembrane segment six is involved in inter-domain communication in P-glycoprotein. Biochemistry 46: 9899-9910.
    • (2007) Biochemistry , vol.46 , pp. 9899-9910
    • Storm, J.1    O'Mara, M.L.2    Crowley, E.H.3    Peall, J.4    Tieleman, D.P.5    Kerr, I.D.6
  • 70
    • 0025231578 scopus 로고
    • Characterization of a membrane-associated protein kinase of multidrug-resistant HL60 cells which phosphorylates P-glycoprotein
    • Staats J, Marquardt D, and Center MS. 1990. Characterization of a membrane-associated protein kinase of multidrug-resistant HL60 cells which phosphorylates P-glycoprotein. J Biol Chem 265: 4084-4090.
    • (1990) J Biol Chem , vol.265 , pp. 4084-4090
    • Staats, J.1    Marquardt, D.2    Center, M.S.3
  • 71
    • 0032858682 scopus 로고    scopus 로고
    • Lack of modulation of MDR1 gene expression by dominant inhibition of cAMP-dependent protein kinase in doxorubicin-resistant MCF-7 breast cancer cells
    • Parissenti AM, Gannon BR, Villeneuve DJ, Kirwan-rhude AF, Chadderton A, and Gluck S. 1999. Lack of modulation of MDR1 gene expression by dominant inhibition of cAMP-dependent protein kinase in doxorubicin-resistant MCF-7 breast cancer cells. Int J Cancer 82: 893-900.
    • (1999) Int J Cancer , vol.82 , pp. 893-900
    • Parissenti, A.M.1    Gannon, B.R.2    Villeneuve, D.J.3    Kirwan-Rhude, A.F.4    Chadderton, A.5    Gluck, S.6
  • 72
    • 0030027552 scopus 로고    scopus 로고
    • Partial reversal of multidrug resistance in human breast cancer cells by an N-myristoylated protein kinase C-alpha pseudosubstrate peptide
    • Gupta KP, Ward NE, Gravitt KR, Bergman PJ, and O'Brian CA. 1996. Partial reversal of multidrug resistance in human breast cancer cells by an N-myristoylated protein kinase C-alpha pseudosubstrate peptide. J Biol Chem 271: 2102-2111.
    • (1996) J Biol Chem , vol.271 , pp. 2102-2111
    • Gupta, K.P.1    Ward, N.E.2    Gravitt, K.R.3    Bergman, P.J.4    O'Brian, C.A.5
  • 73
    • 0031805276 scopus 로고    scopus 로고
    • Differential expression and activity of phosphatases and protein kinases in adriamycin sensitive and resistant human breast cancer MCF-7 cells
    • Ratsaninghe D, Phang JM, and Yeh GC. 1998. Differential expression and activity of phosphatases and protein kinases in adriamycin sensitive and resistant human breast cancer MCF-7 cells. Int J Oncol 13: 79-84.
    • (1998) Int J Oncol , vol.13 , pp. 79-84
    • Ratsaninghe, D.1    Phang, J.M.2    Yeh, G.C.3
  • 74
    • 32144449462 scopus 로고    scopus 로고
    • Therapeutic significance of ectophosphatase inhibitors in reversal of multi-drug resistance
    • Kannan S. 2006. Therapeutic significance of ectophosphatase inhibitors in reversal of multi-drug resistance. Med Hypotheses 66: 1041-1042.
    • (2006) Med Hypotheses , vol.66 , pp. 1041-1042
    • Kannan, S.1
  • 75
    • 0028818853 scopus 로고
    • Circumvention of P-glycoprotein-mediated multiple drug resistance by phosphorylation modulators is independent of protein kinases
    • Smith CD and Zilfou JT. 1995. Circumvention of P-glycoprotein-mediated multiple drug resistance by phosphorylation modulators is independent of protein kinases. J Biol Chem 270: 28145-28152.
    • (1995) J Biol Chem , vol.270 , pp. 28145-28152
    • Smith, C.D.1    Zilfou, J.T.2
  • 76
    • 0032750335 scopus 로고    scopus 로고
    • Mechanism of inhibition of P-glycoprotein-mediated drug transport by protein kinase C blockers
    • Castro AF, Horton JK, Vanoye CG, and Altenberg GA. 1999. Mechanism of inhibition of P-glycoprotein-mediated drug transport by protein kinase C blockers. Biochem Pharmacol 58: 1723-1733.
    • (1999) Biochem Pharmacol , vol.58 , pp. 1723-1733
    • Castro, A.F.1    Horton, J.K.2    Vanoye, C.G.3    Altenberg, G.A.4
  • 77
    • 0032868409 scopus 로고    scopus 로고
    • Differential phosphorylation of sites in the linker region of P-glycoprotein by protein kinase C isozymes alpha, beta I, beta II, gamma, delta, epsilon, eta, and zeta
    • Sachs CW, Chambers TC, and Fine RL. 1999. Differential phosphorylation of sites in the linker region of P-glycoprotein by protein kinase C isozymes alpha, beta I, beta II, gamma, delta, epsilon, eta, and zeta. Biochem Pharmacol 58: 1587-1592.
    • (1999) Biochem Pharmacol , vol.58 , pp. 1587-1592
    • Sachs, C.W.1    Chambers, T.C.2    Fine, R.L.3
  • 78
    • 0030800860 scopus 로고    scopus 로고
    • Phosphorylation site mutations in the human multidrug transporter modulate its drug-stimulated ATPase activity
    • Szabó K, Bakos E, Welker E, Müller M, Goodfellow HR, Higgins CF et al. 1997. Phosphorylation site mutations in the human multidrug transporter modulate its drug-stimulated ATPase activity. JBiol Chem 272: 23165-23171.
    • (1997) JBiol Chem , vol.272 , pp. 23165-23171
    • Szabó, K.1    Bakos, E.2    Welker, E.3    Müller, M.4    Goodfellow, H.R.5    Higgins, C.F.6
  • 79
    • 0028107948 scopus 로고
    • Modulation of P-glycoprotein by protein kinase C alpha in a baculovirus expression system
    • Ahmad S, Safa AR, and Glazer RI. 1994. Modulation of P-glycoprotein by protein kinase C alpha in a baculovirus expression system. Biochemistry 33: 10313-10318.
    • (1994) Biochemistry , vol.33 , pp. 10313-10318
    • Ahmad, S.1    Safa, A.R.2    Glazer, R.I.3
  • 80
    • 27944493145 scopus 로고    scopus 로고
    • Differential phosphorylation patterns of P-glycoprotein reconstituted into a proteoliposome system: Insight into additional unconventional phosphorylation sites
    • Lelong-Rebel IH and Cardarelli CO. 2005. Differential phosphorylation patterns of P-glycoprotein reconstituted into a proteoliposome system: Insight into additional unconventional phosphorylation sites. Anticancer Res 25: 3925-3935.
    • (2005) Anticancer Res , vol.25 , pp. 3925-3935
    • Lelong-Rebel, I.H.1    Cardarelli, C.O.2
  • 81
    • 4544254316 scopus 로고    scopus 로고
    • Processing mutations located throughout the human multidrug resistance P-glycoprotein disrupt interactions between the nucleotide binding domains
    • Loo TW, Bartlett MC, and Clarke DM. 2004. Processing mutations located throughout the human multidrug resistance P-glycoprotein disrupt interactions between the nucleotide binding domains. J Biol Chem 279: 38395-38401.
    • (2004) J Biol Chem , vol.279 , pp. 38395-38401
    • Loo, T.W.1    Bartlett, M.C.2    Clarke, D.M.3
  • 82
    • 0028127183 scopus 로고
    • Prolonged association of temperature-sensitive mutants of human P-glycoprotein with calnexin during biogenesis
    • Loo TW and Clarke DM. 1994. Prolonged association of temperature-sensitive mutants of human P-glycoprotein with calnexin during biogenesis. J Biol Chem 269: 28683-28689.
    • (1994) J Biol Chem , vol.269 , pp. 28683-28689
    • Loo, T.W.1    Clarke, D.M.2
  • 83
    • 0029099301 scopus 로고
    • P-glycoprotein. Associations between domains and between domains and molecular chaperones
    • Loo TW and Clarke DM. 1995. P-glycoprotein. Associations between domains and between domains and molecular chaperones. J Biol Chem 270: 21839-21844.
    • (1995) J Biol Chem , vol.270 , pp. 21839-21844
    • Loo, T.W.1    Clarke, D.M.2
  • 84
    • 0028901907 scopus 로고
    • Inhibition of N--inked glycosylation of P-glycoprotein by tunicamy-cin results in a reduced multidrug resistance phenotype
    • Kramer R, Weber TK, Arceci R, Ramchurren N, Kastrinakis WV, Steele G, Jr. et al. 1995. Inhibition of N--inked glycosylation of P-glycoprotein by tunicamy-cin results in a reduced multidrug resistance phenotype. Br J Cancer 71: 670-675.
    • (1995) Br J Cancer , vol.71 , pp. 670-675
    • Kramer, R.1    Weber, T.K.2    Arceci, R.3    Ramchurren, N.4    Kastrinakis, W.V.5    Steele Jr., G.6
  • 85
    • 4944242078 scopus 로고    scopus 로고
    • Regulation of the stability of P-glycoprotein by ubiquitination
    • Zhang Z, Wu JY, Hait WN, and Yang JM. 2004. Regulation of the stability of P-glycoprotein by ubiquitination. Mol Pharmacol 66: 395-403.
    • (2004) Mol Pharmacol , vol.66 , pp. 395-403
    • Zhang, Z.1    Wu, J.Y.2    Hait, W.N.3    Yang, J.M.4
  • 86
    • 0034142125 scopus 로고    scopus 로고
    • Functional characterization of glycosylation-deficient human P-glycoprotein using a vaccinia virus expression system
    • Gribar JJ, Ramachandra M, Hrycyna CA, Dey S, and Ambudkar SV. 2000. Functional characterization of glycosylation-deficient human P-glycoprotein using a vaccinia virus expression system. J Membr Biol 173: 203-214.
    • (2000) J Membr Biol , vol.173 , pp. 203-214
    • Gribar, J.J.1    Ramachandra, M.2    Hrycyna, C.A.3    Dey, S.4    Ambudkar, S.V.5
  • 87
    • 0035298436 scopus 로고    scopus 로고
    • Purification and characterization of N-glycosylation mutant mouse and human P-glycoproteins expressed in Pichia pastoris cells
    • Urbatsch IL, Wilke-Mounts S, Gimi K, and Senior AE. 2001. Purification and characterization of N-glycosylation mutant mouse and human P-glycoproteins expressed in Pichia pastoris cells. Arch Biochem Biophys 388: 171-177.
    • (2001) Arch Biochem Biophys , vol.388 , pp. 171-177
    • Urbatsch, I.L.1    Wilke-Mounts, S.2    Gimi, K.3    Senior, A.E.4
  • 88
    • 34547852327 scopus 로고    scopus 로고
    • Distinct N-glycan glycosylation of P-glycoprotein isolated from the human uterine sarcoma cell line MES-SA/Dx5
    • Greer DA and Ivey S. 2007. Distinct N-glycan glycosylation of P-glycoprotein isolated from the human uterine sarcoma cell line MES-SA/Dx5. Biochim Biophys Acta 1770: 1275-1282.
    • (2007) Biochim Biophys Acta , vol.1770 , pp. 1275-1282
    • Greer, D.A.1    Ivey, S.2
  • 89
    • 33750619876 scopus 로고    scopus 로고
    • Posttranslational protein modifications: Current implications for cancer detection, prevention, and therapeutics
    • Krueger KE and Srivastava S. 2006. Posttranslational protein modifications: Current implications for cancer detection, prevention, and therapeutics. Mol Cell Proteomics 5: 1799-1810.
    • (2006) Mol Cell Proteomics , vol.5 , pp. 1799-1810
    • Krueger, K.E.1    Srivastava, S.2
  • 91
    • 0242552872 scopus 로고    scopus 로고
    • Importance of P-glycoprotein for drug disposition in humans
    • Fromm MF. 2003. Importance of P-glycoprotein for drug disposition in humans. Eur J Clin Invest 33: 6-9.
    • (2003) Eur J Clin Invest , vol.33 , pp. 6-9
    • Fromm, M.F.1
  • 92
    • 33747838842 scopus 로고    scopus 로고
    • The role of the transporter P-glycoprotein for disposition and effects of centrally acting drugs and for the pathogenesis of CNS diseases
    • Thuerauf N and Fromm MF. 2006. The role of the transporter P-glycoprotein for disposition and effects of centrally acting drugs and for the pathogenesis of CNS diseases. Eur Arch Psychiatry Clin Neurosci 256: 281-286.
    • (2006) Eur Arch Psychiatry Clin Neurosci , vol.256 , pp. 281-286
    • Thuerauf, N.1    Fromm, M.F.2
  • 93
    • 21544438456 scopus 로고    scopus 로고
    • A bitter melon extract inhibits the P-glycoprotein activity in intestinal Caco-2 cells: Monoglyceride as an active compound
    • Konishi T, Satsu H, Hatsugai Y, Aizawa K, Inakuma T, Nagata S et al. 2004. A bitter melon extract inhibits the P-glycoprotein activity in intestinal Caco-2 cells: Monoglyceride as an active compound. Biofactors 22: 71-74.
    • (2004) Biofactors , vol.22 , pp. 71-74
    • Konishi, T.1    Satsu, H.2    Hatsugai, Y.3    Aizawa, K.4    Inakuma, T.5    Nagata, S.6
  • 94
    • 17544368685 scopus 로고    scopus 로고
    • Multidrug resistance proteins: Role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
    • Leslie EM, Deeley RG, and Cole SP. 2005. Multidrug resistance proteins: Role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol 204: 216-237.
    • (2005) Toxicol Appl Pharmacol , vol.204 , pp. 216-237
    • Leslie, E.M.1    Deeley, R.G.2    Cole, S.P.3
  • 95
    • 3242785620 scopus 로고    scopus 로고
    • Importance of P-glycoprotein at blood-tissue barriers
    • Fromm MF. 2004. Importance of P-glycoprotein at blood-tissue barriers. Trends Pharmacol Sci 25: 423-429.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 423-429
    • Fromm, M.F.1
  • 96
    • 33748949567 scopus 로고    scopus 로고
    • In situ localization of P-glycoprotein (ABCB1) in human and rat brain
    • Bendayan R, Ronaldson PT, Gingras D, and Bendayan M. 2006. In situ localization of P-glycoprotein (ABCB1) in human and rat brain. J Histochem Cytochem 54: 1159-1167.
    • (2006) J Histochem Cytochem , vol.54 , pp. 1159-1167
    • Bendayan, R.1    Ronaldson, P.T.2    Gingras, D.3    Bendayan, M.4
  • 97
    • 35448949586 scopus 로고    scopus 로고
    • Mini review on molecular modeling of P-glycoprotein (Pgp)
    • Ha SN, Hochman J, and Sheridan RP. 2007. Mini review on molecular modeling of P-glycoprotein (Pgp). Curr Top Med Chem 7: 1525-1529.
    • (2007) Curr Top Med Chem , vol.7 , pp. 1525-1529
    • Ha, S.N.1    Hochman, J.2    Sheridan, R.P.3
  • 98
    • 0036074018 scopus 로고    scopus 로고
    • Mammalian ABC transporters in health and disease
    • Borst P and Elferink RO. 2002. Mammalian ABC transporters in health and disease. Annu Rev Biochem 71: 537-592.
    • (2002) Annu Rev Biochem , vol.71 , pp. 537-592
    • Borst, P.1    Elferink, R.O.2
  • 99
    • 19944425121 scopus 로고    scopus 로고
    • The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: Evaluation using the MDR1A/1B knockout mouse model
    • Doran A, Obach RS, Smith BJ, Hosea NA, Becker S, Callegari E et al. 2005. The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: Evaluation using the MDR1A/1B knockout mouse model. Drug Metab Dispos 33: 165-174.
    • (2005) Drug Metab Dispos , vol.33 , pp. 165-174
    • Doran, A.1    Obach, R.S.2    Smith, B.J.3    Hosea, N.A.4    Becker, S.5    Callegari, E.6
  • 100
    • 0347623323 scopus 로고    scopus 로고
    • Clinical relevance of P-glycoprotein in drug therapy
    • Lin JH and Yamazaki M. 2003. Clinical relevance of P-glycoprotein in drug therapy. Drug Metab Rev 35: 417-454.
    • (2003) Drug Metab Rev , vol.35 , pp. 417-454
    • Lin, J.H.1    Yamazaki, M.2
  • 102
  • 103
    • 0025799513 scopus 로고
    • Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells
    • Chaudhary PM and Roninson IB. 1991. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 66: 85-94.
    • (1991) Cell , vol.66 , pp. 85-94
    • Chaudhary, P.M.1    Roninson, I.B.2
  • 104
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean M, Fojo T, and Bates S. 2005. Tumour stem cells and drug resistance. Nat Rev Cancer 5: 275-284.
    • (2005) Nat Rev Cancer , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 105
    • 0024279163 scopus 로고
    • The multidrug transporter, a double-edged sword
    • Gottesman MM and Pastan I. 1988. The multidrug transporter, a double-edged sword. J Biol Chem 263: 12163-12166.
    • (1988) J Biol Chem , vol.263 , pp. 12163-12166
    • Gottesman, M.M.1    Pastan, I.2
  • 106
    • 35348878723 scopus 로고    scopus 로고
    • Retroviral integration site analysis and the fate of transduced clones in an MDR1 gene therapy protocol targeting metastatic breast cancer
    • Mitsuhashi J, Tsukahara S, Suzuki R, Oh-hara Y, Nishi S, Hosoyama H et al. 2007. Retroviral integration site analysis and the fate of transduced clones in an MDR1 gene therapy protocol targeting metastatic breast cancer. Hum Gene Ther 18: 895-906.
    • (2007) Hum Gene Ther , vol.18 , pp. 895-906
    • Mitsuhashi, J.1    Tsukahara, S.2    Suzuki, R.3    Oh-Hara, Y.4    Nishi, S.5    Hosoyama, H.6
  • 107
    • 21244452807 scopus 로고    scopus 로고
    • Characterization of ABC transporter ABCB1 expressed in human neural stem/ progenitor cells
    • Islam MO, Kanemura Y, Tajria J, Mori H, Kobayashi S, Shofuda T et al. 2005. Characterization of ABC transporter ABCB1 expressed in human neural stem/ progenitor cells. FEBS Lett 579: 3473-3480.
    • (2005) FEBS Lett , vol.579 , pp. 3473-3480
    • Islam, M.O.1    Kanemura, Y.2    Tajria, J.3    Mori, H.4    Kobayashi, S.5    Shofuda, T.6
  • 110
    • 37249070862 scopus 로고    scopus 로고
    • Combined treatment of P-gp-positive L1210/VCR cells by verapamil and all-trans retinoic acid induces down-regulation of P-glycoprotein expression and transport activity
    • Sulová Z, Macejová D, Seres M, Sedlák J, Brtko J, and Breier A. 2008. Combined treatment of P-gp-positive L1210/VCR cells by verapamil and all-trans retinoic acid induces down-regulation of P-glycoprotein expression and transport activity. Toxicol In Vitro 22: 96-105.
    • (2008) Toxicol In Vitro , vol.22 , pp. 96-105
    • Sulová, Z.1    Macejová, D.2    Seres, M.3    Sedlák, J.4    Brtko, J.5    Breier, A.6
  • 111
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • Gottesman MM, Fojo T, and Bates SE. 2002. Multidrug resistance in cancer: Role of ATP-dependent transporters. Nat Rev Cancer 2: 48-58.
    • (2002) Nat Rev Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 112
    • 0026524781 scopus 로고
    • Overexpression of the MDR1 gene and P-glycoprotein in human hepatocellular carcinoma
    • Huang CC, Wu MC, Xu GW, Li DZ, Cheng H, Tu ZX et al. 1992. Overexpression of the MDR1 gene and P-glycoprotein in human hepatocellular carcinoma. J Natl Cancer Inst 84: 262-264.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 262-264
    • Huang, C.C.1    Wu, M.C.2    Xu, G.W.3    Li, D.Z.4    Cheng, H.5    Tu, Z.X.6
  • 113
    • 0027298544 scopus 로고
    • Constitutive expression of multidrug resistance in human colorectal tumours and cell lines
    • Kramer R, Weber TK, Morse B, Arceci R, Staniunas R, Steele G, Jr. et al. 1993. Constitutive expression of multidrug resistance in human colorectal tumours and cell lines. Br J Cancer 67: 959-968.
    • (1993) Br J Cancer , vol.67 , pp. 959-968
    • Kramer, R.1    Weber, T.K.2    Morse, B.3    Arceci, R.4    Staniunas, R.5    Steele Jr., G.6
  • 117
    • 0031760987 scopus 로고    scopus 로고
    • Confocal scanning microspectrofluorometry reveals specific anthracyline accumulation in cytoplasmic organelles of multidrug-resistant cancer cells
    • Belhoussine R, Morjani H, Millot JM, Sharonov S, and Manfait M. 1998. Confocal scanning microspectrofluorometry reveals specific anthracyline accumulation in cytoplasmic organelles of multidrug-resistant cancer cells. J Histochem Cytochem 46: 1369-1376.
    • (1998) J Histochem Cytochem , vol.46 , pp. 1369-1376
    • Belhoussine, R.1    Morjani, H.2    Millot, J.M.3    Sharonov, S.4    Manfait, M.5
  • 118
    • 0034104453 scopus 로고    scopus 로고
    • Resistance mechanisms associated with altered intracellular distribution of anticancer agents
    • Larsen AK, Escargueil AE, and Skladanowski A. 2000. Resistance mechanisms associated with altered intracellular distribution of anticancer agents. Pharmacol Ther 85: 217-229.
    • (2000) Pharmacol Ther , vol.85 , pp. 217-229
    • Larsen, A.K.1    Escargueil, A.E.2    Skladanowski, A.3
  • 119
    • 0033986713 scopus 로고    scopus 로고
    • Determination of intracellular organelles implicated in daunorubicin cytoplasmic sequestration in multidrug-resistant MCF-7 cells using fluorescence microscopy image analysis
    • Bour-Dill C, Gramain MP, Merlin JL, Marchal S, and Guillemin F. 2000. Determination of intracellular organelles implicated in daunorubicin cytoplasmic sequestration in multidrug-resistant MCF-7 cells using fluorescence microscopy image analysis. Cytometry 39: 16-25.
    • (2000) Cytometry , vol.39 , pp. 16-25
    • Bour-Dill, C.1    Gramain, M.P.2    Merlin, J.L.3    Marchal, S.4    Guillemin, F.5
  • 120
    • 0034002720 scopus 로고    scopus 로고
    • Regulation of cellular glutathione modulates nuclear accumulation of daunoru-bicin in human MCF7 cells overexpressing multidrug resistance associated protein
    • Benderra Z, Trussardi A, Morjani H, Villa AM, Doglia SM, and Manfait M. 2000. Regulation of cellular glutathione modulates nuclear accumulation of daunoru-bicin in human MCF7 cells overexpressing multidrug resistance associated protein. Eur J Cancer 36: 428-434.
    • (2000) Eur J Cancer , vol.36 , pp. 428-434
    • Benderra, Z.1    Trussardi, A.2    Morjani, H.3    Villa, A.M.4    Doglia, S.M.5    Manfait, M.6
  • 121
    • 0029037727 scopus 로고
    • Intracellular localization, vesicular accumulation and kinetics of daunorubicin in sensitive and multidrug-resistant gastric carcinoma EPG85-257 cells
    • Seidel A, Hasmann M, Loser R, Bunge A, Schaefer B, Herzig I et al. 1995. Intracellular localization, vesicular accumulation and kinetics of daunorubicin in sensitive and multidrug-resistant gastric carcinoma EPG85-257 cells. Virchows Arch 426: 249-256.
    • (1995) Virchows Arch , vol.426 , pp. 249-256
    • Seidel, A.1    Hasmann, M.2    Loser, R.3    Bunge, A.4    Schaefer, B.5    Herzig, I.6
  • 122
    • 0029939371 scopus 로고    scopus 로고
    • Defective pH regulation of acidic compartments in human breast cancer cells (MCF-7) is normalized in adriamycin-resistant cells (MCF-7adr)
    • Schindler M, Grabski S, Hoff E, and Simon SM. 1996. Defective pH regulation of acidic compartments in human breast cancer cells (MCF-7) is normalized in adriamycin-resistant cells (MCF-7adr). Biochemistry 35: 2811-2817.
    • (1996) Biochemistry , vol.35 , pp. 2811-2817
    • Schindler, M.1    Grabski, S.2    Hoff, E.3    Simon, S.M.4
  • 123
    • 0025812024 scopus 로고
    • Secretion of lysosomal enzymes by drug-sensitive and multiple drug-resistant cells
    • Warren L, Jardillier JC, and Ordentlich P. 1991. Secretion of lysosomal enzymes by drug-sensitive and multiple drug-resistant cells. Cancer Res 51: 1996-2001.
    • (1991) Cancer Res , vol.51 , pp. 1996-2001
    • Warren, L.1    Jardillier, J.C.2    Ordentlich, P.3
  • 125
    • 0035066434 scopus 로고    scopus 로고
    • Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukemia
    • Ferrao P, Sincock P, Cole S, and Ashman L. 2001. Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukemia. Leuk Res 25: 395-405.
    • (2001) Leuk Res , vol.25 , pp. 395-405
    • Ferrao, P.1    Sincock, P.2    Cole, S.3    Ashman, L.4
  • 126
    • 0033303510 scopus 로고    scopus 로고
    • P-glycoprotein subcellular localization and cell morphotype in MDR1 gene-transfected human osteosarcoma cells
    • Maraldi NM, Zini N, Santi S, Scotlandi K, Serra M, and Baldini N. 1999. P-glycoprotein subcellular localization and cell morphotype in MDR1 gene-transfected human osteosarcoma cells. Biol Cell 91: 17-28.
    • (1999) Biol Cell , vol.91 , pp. 17-28
    • Maraldi, N.M.1    Zini, N.2    Santi, S.3    Scotlandi, K.4    Serra, M.5    Baldini, N.6
  • 127
  • 128
    • 1242274510 scopus 로고    scopus 로고
    • Dynamic and intracellular trafficking of P-glycoprotein-EGFP fusion protein: Implications in multidrug resistance in cancer
    • Fu D, Bebawy M, Kable EPW, and Roufogalis BD. 2004. Dynamic and intracellular trafficking of P-glycoprotein-EGFP fusion protein: Implications in multidrug resistance in cancer. Int J Cancer 109: 174-181.
    • (2004) Int J Cancer , vol.109 , pp. 174-181
    • Fu, D.1    Bebawy, M.2    Kable, E.P.W.3    Roufogalis, B.D.4
  • 129
    • 0029163141 scopus 로고
    • Differential effects of verapamil and quinine on the reversal of doxorubicin resistance in a human leukemia cell line
    • Bennis S, Ichas F, and Robert J. 1995. Differential effects of verapamil and quinine on the reversal of doxorubicin resistance in a human leukemia cell line. Int J Cancer 62: 283-290.
    • (1995) Int J Cancer , vol.62 , pp. 283-290
    • Bennis, S.1    Ichas, F.2    Robert, J.3
  • 130
    • 0041968944 scopus 로고    scopus 로고
    • Subcellular localization and activity of multidrug resistance proteins
    • Rajagopal A and Simon SM. 2003. Subcellular localization and activity of multidrug resistance proteins. Mol Biol Cell 14: 3389-3399.
    • (2003) Mol Biol Cell , vol.14 , pp. 3389-3399
    • Rajagopal, A.1    Simon, S.M.2
  • 131
    • 0034283968 scopus 로고    scopus 로고
    • Identification of the subcellular localization of daunorubicin in multidrug-resistant K562 cell line
    • Gong Y, Wang Y, Chen F, Han J, Miao J et al. 2000. Identification of the subcellular localization of daunorubicin in multidrug-resistant K562 cell line. Leuk Res 24: 769-774.
    • (2000) Leuk Res , vol.24 , pp. 769-774
    • Gong, Y.1    Wang, Y.2    Chen, F.3    Han, J.4    Miao, J.5
  • 133
    • 33751520985 scopus 로고    scopus 로고
    • P-gp localization in mitochondria and its functional characterization in multiple drug-resistant cell lines
    • Solazzo M, Fantappiè O, Lasagna N, Sassoli C, Nosi D, and Mazzanti R. 2006. P-gp localization in mitochondria and its functional characterization in multiple drug-resistant cell lines. Exp Cell Res 312: 4070-4078.
    • (2006) Exp Cell Res , vol.312 , pp. 4070-4078
    • Solazzo, M.1    Fantappiè, O.2    Lasagna, N.3    Sassoli, C.4    Nosi, D.5    Mazzanti, R.6
  • 134
    • 34547425303 scopus 로고    scopus 로고
    • P-Glycoprotein is not present in mitochondrial membranes
    • Paterson JK and Gottesman MM. 2007. P-Glycoprotein is not present in mitochondrial membranes. Exp Cell Res 313: 3100-3105.
    • (2007) Exp Cell Res , vol.313 , pp. 3100-3105
    • Paterson, J.K.1    Gottesman, M.M.2
  • 135
    • 0013095102 scopus 로고    scopus 로고
    • MDR1 genotype-related pharmacokinetics and pharmacodynamics
    • Sakaeda T, Nakamura T, and Okumura K. 2002. MDR1 genotype-related pharmacokinetics and pharmacodynamics. Biol Pharm Bull 25: 1391-1400.
    • (2002) Biol Pharm Bull , vol.25 , pp. 1391-1400
    • Sakaeda, T.1    Nakamura, T.2    Okumura, K.3
  • 137
    • 33947417310 scopus 로고    scopus 로고
    • Shedding light on drug transport: Structure and function of the P-glycoprotein multidrug transporter (ABCB1)
    • Sharom FJ. 2006. Shedding light on drug transport: Structure and function of the P-glycoprotein multidrug transporter (ABCB1). Biochem Cell Biol 84: 979-992.
    • (2006) Biochem Cell Biol , vol.84 , pp. 979-992
    • Sharom, F.J.1
  • 138
    • 33846794508 scopus 로고    scopus 로고
    • About a switch: How P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work
    • Sauna ZE and Ambudkar SV. 2007. About a switch: How P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work. Mol Cancer Ther 6: 13-23.
    • (2007) Mol Cancer Ther , vol.6 , pp. 13-23
    • Sauna, Z.E.1    Ambudkar, S.V.2
  • 139
    • 0030921564 scopus 로고    scopus 로고
    • The functional purification of P-glycoprotein is dependent on maintenance of a lipid-protein interface
    • Callaghan R, Berridge G, Ferry DR, and Higgins CF. 1997. The functional purification of P-glycoprotein is dependent on maintenance of a lipid-protein interface. Biochim Biophys Acta 1328: 109-124.
    • (1997) Biochim Biophys Acta , vol.1328 , pp. 109-124
    • Callaghan, R.1    Berridge, G.2    Ferry, D.R.3    Higgins, C.F.4
  • 140
    • 33644840984 scopus 로고    scopus 로고
    • The power of the pump: Mechanisms of action of P-glycoprotein (ABCB1)
    • Ambudkar SV, Kim IW, and Sauna ZE. 2006. The power of the pump: Mechanisms of action of P-glycoprotein (ABCB1). Eur J Pharm Sci 27: 392-400.
    • (2006) Eur J Pharm Sci , vol.27 , pp. 392-400
    • Ambudkar, S.V.1    Kim, I.W.2    Sauna, Z.E.3
  • 141
    • 0030868612 scopus 로고    scopus 로고
    • Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein
    • Ambudkar SV, Cardarelli CO, Pashinsky I, and Stein WD. 1997. Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein. J Biol Chem 272: 21160-21166.
    • (1997) J Biol Chem , vol.272 , pp. 21160-21166
    • Ambudkar, S.V.1    Cardarelli, C.O.2    Pashinsky, I.3    Stein, W.D.4
  • 142
    • 0032523818 scopus 로고    scopus 로고
    • Stoichiometry of coupling of rhodamine 123 transport to ATP hydrolysis by P-glycoprotein
    • Shapiro AB and Ling V. 1998. Stoichiometry of coupling of rhodamine 123 transport to ATP hydrolysis by P-glycoprotein. Eur J Biochem 254: 189-193.
    • (1998) Eur J Biochem , vol.254 , pp. 189-193
    • Shapiro, A.B.1    Ling, V.2
  • 143
    • 25444460555 scopus 로고    scopus 로고
    • Involvement of the "occluded nucleotide conformation" of P-glycoprotein in the catalytic pathway
    • Tombline G, Muharemagic A, White LB, and Senior AE. 2005. Involvement of the "occluded nucleotide conformation" of P-glycoprotein in the catalytic pathway. Biochemistry 44: 12879-12886.
    • (2005) Biochemistry , vol.44 , pp. 12879-12886
    • Tombline, G.1    Muharemagic, A.2    White, L.B.3    Senior, A.E.4
  • 144
    • 0028285002 scopus 로고
    • Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates
    • Stein WD, Cardarelli C, Pastan I, and Gottesman MM. 1994. Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates. Mol Pharmacol 45: 763-772.
    • (1994) Mol Pharmacol , vol.45 , pp. 763-772
    • Stein, W.D.1    Cardarelli, C.2    Pastan, I.3    Gottesman, M.M.4
  • 145
    • 0033602840 scopus 로고    scopus 로고
    • The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter
    • Romsicki Y and Sharom FJ. 1999. The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter. Biochemistry 38: 6887-6896.
    • (1999) Biochemistry , vol.38 , pp. 6887-6896
    • Romsicki, Y.1    Sharom, F.J.2
  • 146
    • 0037424343 scopus 로고    scopus 로고
    • Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding
    • Rosenberg MF, Kamis AB, Callaghan R, Higgins CF, and Ford RC. 2003. Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding. J Biol Chem 278: 8294-8299.
    • (2003) J Biol Chem , vol.278 , pp. 8294-8299
    • Rosenberg, M.F.1    Kamis, A.B.2    Callaghan, R.3    Higgins, C.F.4    Ford, R.C.5
  • 147
    • 33846215616 scopus 로고    scopus 로고
    • A primer on the mechanics of P-glycoprotein the multidrug transporter
    • Hennessy M and Spiers JP. 2007. A primer on the mechanics of P-glycoprotein the multidrug transporter. Pharmacol Res 55: 1-15.
    • (2007) Pharmacol Res , vol.55 , pp. 1-15
    • Hennessy, M.1    Spiers, J.P.2
  • 148
    • 0032523929 scopus 로고    scopus 로고
    • Transport of LDS-751 from the cytoplasmic leaflet of the plasma membrane by the rhodamine-123-selective site of P-glycoprotein
    • Shapiro AB and Ling V. 1998. Transport of LDS-751 from the cytoplasmic leaflet of the plasma membrane by the rhodamine-123-selective site of P-glycoprotein. Eur J Biochem 254: 181-188.
    • (1998) Eur J Biochem , vol.254 , pp. 181-188
    • Shapiro, A.B.1    Ling, V.2
  • 149
  • 150
    • 0027363563 scopus 로고
    • Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
    • Smit JJM, Schinkel AH, Oude Elferink RPJ, Groen AK, Wagenaar E, van Deemter L et al. 1993. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 75: 451-462.
    • (1993) Cell , vol.75 , pp. 451-462
    • Smit, J.J.M.1    Schinkel, A.H.2    Oude Elferink, R.P.J.3    Groen, A.K.4    Wagenaar, E.5    Van Deemter, L.6
  • 151
    • 0035849506 scopus 로고    scopus 로고
    • Phospholipid flippase activity of the reconstituted P-glycoprotein multidrug transporter
    • Romsicki Y and Sharom FJ. 2001. Phospholipid flippase activity of the reconstituted P-glycoprotein multidrug transporter. Biochemistry 40: 6937-6947.
    • (2001) Biochemistry , vol.40 , pp. 6937-6947
    • Romsicki, Y.1    Sharom, F.J.2
  • 152
    • 33646573706 scopus 로고    scopus 로고
    • Localization of multidrug transporter substrates within model membranes
    • Siarheyeva A, Lopez JJ, and Glaubitz C. 2006. Localization of multidrug transporter substrates within model membranes. Biochemistry 45: 6203-6211.
    • (2006) Biochemistry , vol.45 , pp. 6203-6211
    • Siarheyeva, A.1    Lopez, J.J.2    Glaubitz, C.3
  • 153
    • 0030977145 scopus 로고    scopus 로고
    • Phosphatidylcholine and phosphatidylethanolamine behave as substrates of the human MDR1 P-glycoprotein
    • Bosch I, Dunussi-Joannopoulos K, Wu RL, Furlong ST, and Croop J. 1997. Phosphatidylcholine and phosphatidylethanolamine behave as substrates of the human MDR1 P-glycoprotein. Biochemistry 36: 5685-5694.
    • (1997) Biochemistry , vol.36 , pp. 5685-5694
    • Bosch, I.1    Dunussi-Joannopoulos, K.2    Wu, R.L.3    Furlong, S.T.4    Croop, J.5
  • 155
    • 25144443228 scopus 로고    scopus 로고
    • Cellular lipidomics
    • Van Meer G. 2005. Cellular lipidomics. EMBO J 24: 3159-3165.
    • (2005) EMBO J , vol.24 , pp. 3159-3165
    • Van Meer, G.1
  • 157
    • 0033548572 scopus 로고    scopus 로고
    • Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol
    • Luker GD, Nilsson KR, Covey DF, and Piwnica-Worms D. 1999. Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol. J Biol Chem 274: 6979-6991.
    • (1999) J Biol Chem , vol.274 , pp. 6979-6991
    • Luker, G.D.1    Nilsson, K.R.2    Covey, D.F.3    Piwnica-Worms, D.4
  • 158
    • 0036678454 scopus 로고    scopus 로고
    • The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane
    • Garrigues A, Escargueil AE, and Orlowski S. 2002. The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane. Proc Natl Acad Sci USA 99: 10347-10352.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10347-10352
    • Garrigues, A.1    Escargueil, A.E.2    Orlowski, S.3
  • 159
    • 17644405457 scopus 로고    scopus 로고
    • Isolated rafts from adriamycin-resistant P388 cells contain functional ATPases and provide an easy test system for P-glycoprotein-related activities
    • Bucher K, Besse CA, Kamau SW, Wunderli-Allenspach H, and Krämer SD. 2005. Isolated rafts from adriamycin-resistant P388 cells contain functional ATPases and provide an easy test system for P-glycoprotein-related activities. Pharm Res 22: 449-457.
    • (2005) Pharm Res , vol.22 , pp. 449-457
    • Bucher, K.1    Besse, C.A.2    Kamau, S.W.3    Wunderli-Allenspach, H.4    Krämer, S.D.5
  • 160
    • 5444271640 scopus 로고    scopus 로고
    • Raft and cytoskeleton associations of an ABC transporter: P-glycoprotein
    • Basco Z, Nagy H, Goda K, Bene L, Fenyvesi F, Matkó J et al. 2004. Raft and cytoskeleton associations of an ABC transporter: P-glycoprotein. Cytometry A 61: 105-116.
    • (2004) Cytometry A , vol.61 , pp. 105-116
    • Basco, Z.1    Nagy, H.2    Goda, K.3    Bene, L.4    Fenyvesi, F.5    Matkó, J.6
  • 161
    • 13844266481 scopus 로고    scopus 로고
    • Decrease of P-glycoprotein activity in K562/Adr cells by MbCD and filipin and lack of effect induced by cholesterol oxidase indicate that this transporter is not located in rafts
    • Reungpatthanaphong P, Marbeuf-Gueye C, Le Moyec L, Salerno M, and Garnier-Suillerot A. 2004. Decrease of P-glycoprotein activity in K562/Adr cells by MbCD and filipin and lack of effect induced by cholesterol oxidase indicate that this transporter is not located in rafts. J Bioenerg Biomembr 36: 533-543.
    • (2004) J Bioenerg Biomembr , vol.36 , pp. 533-543
    • Reungpatthanaphong, P.1    Marbeuf-Gueye, C.2    Le Moyec, L.3    Salerno, M.4    Garnier-Suillerot, A.5
  • 162
    • 16644374081 scopus 로고    scopus 로고
    • P-glycoprotein retains function when reconstituted into a sphingolipid-and cholesterol-rich environment
    • Modok S, Heyward C, and Callaghan R. 2004. P-glycoprotein retains function when reconstituted into a sphingolipid-and cholesterol-rich environment. J Lipid Res 45: 1910-1918.
    • (2004) J Lipid Res , vol.45 , pp. 1910-1918
    • Modok, S.1    Heyward, C.2    Callaghan, R.3
  • 163
    • 26244460702 scopus 로고    scopus 로고
    • P-Glycoprotein is localized in interme-diate-density membrane microdomains distinct from classical lipid rafts and cave-olar domains
    • Radeva G, Perabo J, and Sharom FJ. 2005. P-Glycoprotein is localized in interme-diate-density membrane microdomains distinct from classical lipid rafts and cave-olar domains. FEBS J 272: 4924-4937.
    • (2005) FEBS J , vol.272 , pp. 4924-4937
    • Radeva, G.1    Perabo, J.2    Sharom, F.J.3
  • 164
    • 0033958086 scopus 로고    scopus 로고
    • Multiple physiological functions for multidrug transporter P-glycoprotein?
    • Johnstone RW, Ruefli AA, and Smyth MJ. 2000. Multiple physiological functions for multidrug transporter P-glycoprotein? Trends Biochem Sci 25: 1-6.
    • (2000) Trends Biochem Sci , vol.25 , pp. 1-6
    • Johnstone, R.W.1    Ruefli, A.A.2    Smyth, M.J.3
  • 165
    • 0030964625 scopus 로고    scopus 로고
    • Human MDR 1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts
    • Robinson LJ, Roberts WK, Ling TT, Lamming D, Sternberg SS, and Roepe PD. 1997. Human MDR 1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts. Biochemistry 36: 11169-11178.
    • (1997) Biochemistry , vol.36 , pp. 11169-11178
    • Robinson, L.J.1    Roberts, W.K.2    Ling, T.T.3    Lamming, D.4    Sternberg, S.S.5    Roepe, P.D.6
  • 166
    • 0036849351 scopus 로고    scopus 로고
    • P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation
    • Ruefli AA, Tainton KM, Darcy PK, Smyth MJ, and Johnstone RW. 2002. P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation. Cell Death Differ 9: 1266-1272.
    • (2002) Cell Death Differ , vol.9 , pp. 1266-1272
    • Ruefli, A.A.1    Tainton, K.M.2    Darcy, P.K.3    Smyth, M.J.4    Johnstone, R.W.5
  • 167
    • 12344336357 scopus 로고    scopus 로고
    • P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway
    • Turzanski J, Grundy M, Shang S, Russell N, and Pallis M. 2005. P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway. Exp Hematol 33: 62-72.
    • (2005) Exp Hematol , vol.33 , pp. 62-72
    • Turzanski, J.1    Grundy, M.2    Shang, S.3    Russell, N.4    Pallis, M.5
  • 168
    • 38849103854 scopus 로고    scopus 로고
    • A new apoptosis inhibitor, CIAPIN1 (cytokine-induced apoptosis inhibitor 1), mediates multidrug resistance in leukemia cells by regulating MDR-1, Bcl-2, and Bax
    • Li X, Hong L, Zhao Y, Jin H, Fan R, Du R, Xia L, Luo G, and Fan D. 2007. A new apoptosis inhibitor, CIAPIN1 (cytokine-induced apoptosis inhibitor 1), mediates multidrug resistance in leukemia cells by regulating MDR-1, Bcl-2, and Bax. Biochem Cell Biol 85: 741-750.
    • (2007) Biochem Cell Biol , vol.85 , pp. 741-750
    • Li, X.1    Hong, L.2    Zhao, Y.3    Jin, H.4    Fan, R.5    Du, R.6    Xia, L.7    Luo, G.8    Fan, D.9
  • 169
    • 34250365663 scopus 로고    scopus 로고
    • P-glycoprotein mediates celecoxib-induced apoptosis in multiple drug-resistant cell lines
    • Fantappiè O, Solazzo M, Lasagna N, Platini F, Tessitore L, and Mazzanti R. 2007. P-glycoprotein mediates celecoxib-induced apoptosis in multiple drug-resistant cell lines. Cancer Res 67: 4915-4923.
    • (2007) Cancer Res , vol.67 , pp. 4915-4923
    • Fantappiè, O.1    Solazzo, M.2    Lasagna, N.3    Platini, F.4    Tessitore, L.5    Mazzanti, R.6
  • 170
    • 34347383964 scopus 로고    scopus 로고
    • Phospho Akt mediates multidrug resistance of gastric cancer cells through regulation of P-gp, Bcl-2 and Bax
    • Han Z, Hong L, Han Y, Wu K, Han S, Shen H et al. 2007. Phospho Akt mediates multidrug resistance of gastric cancer cells through regulation of P-gp, Bcl-2 and Bax. J Exp Clin Cancer Res 26: 261-268.
    • (2007) J Exp Clin Cancer Res , vol.26 , pp. 261-268
    • Han, Z.1    Hong, L.2    Han, Y.3    Wu, K.4    Han, S.5    Shen, H.6
  • 171
    • 34249742090 scopus 로고    scopus 로고
    • Expression of adenosine triphosphate-binding cassette (ABC) drug transporters in peripheral blood cells: Relevance for physiology and pharmacotherapy
    • Köck K, Grube M, Jedlitschky G, Oevermann L, Siegmund W, Ritter CA et al. 2007. Expression of adenosine triphosphate-binding cassette (ABC) drug transporters in peripheral blood cells: Relevance for physiology and pharmacotherapy. Clin Pharmacokine 46: 449-470.
    • (2007) Clin Pharmacokine , vol.46 , pp. 449-470
    • Köck, K.1    Grube, M.2    Jedlitschky, G.3    Oevermann, L.4    Siegmund, W.5    Ritter, C.A.6
  • 172
    • 0032499681 scopus 로고    scopus 로고
    • A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels
    • Randolph GJ, Beaulieu S, Pope M, Sugawara I, Hoffman L, Steinman RM et al. 1998. A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels. Proc Natl Acad Sci USA 95: 6924-6929.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6924-6929
    • Randolph, G.J.1    Beaulieu, S.2    Pope, M.3    Sugawara, I.4    Hoffman, L.5    Steinman, R.M.6


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