-
1
-
-
0036043220
-
The genetic basis of variability in drug responses
-
Roden, D. M. and George, A. L., Jr. The genetic basis of variability in drug responses. Nat. Rev. Drug Discov., 1: 37-44, 2002. (Pubitemid 37361402)
-
(2002)
Nature Reviews Drug Discovery
, vol.1
, Issue.1
, pp. 37-44
-
-
Roden, D.M.1
George Jr., A.L.2
-
2
-
-
0033569516
-
Pharmacogenomics: Translating functional genomics into rational therapeutics
-
Evans, W. E. and Relling, M. V. Pharmacogenomics: translating functional genomics into rational therapeutics. Science, 286: 487-491, 1999.
-
(1999)
Science
, vol.286
, pp. 487-491
-
-
Evans, W.E.1
Relling, M.V.2
-
3
-
-
0023854270
-
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism
-
DOI 10.1038/331442a0
-
Gonzalez, F. J., Skoda, R. C., Kimura, S., Umeno, M., Zanger, U. M., Nebert, D. W., Gelboin, H. V., Hardwick, J. P., and Meyer, U. A. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature, 331: 442-446, 1988. (Pubitemid 18064368)
-
(1988)
Nature
, vol.331
, Issue.6155
, pp. 442-446
-
-
Gonzalez, F.J.1
Skoda, R.C.2
Kimura, S.3
Umeno, M.4
Zanger, U.M.5
Nebert, D.W.6
Gelboin, H.V.7
Hardwick, J.P.8
Meyer, U.A.9
-
4
-
-
0344927562
-
Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
-
Konig, J., Nies, A. T., Cui, Y., Leier, I., and Keppler, D. Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. Biochim. Biophys. Acta, 1461: 377-394, 1999.
-
(1999)
Biochim. Biophys. Acta
, vol.1461
, pp. 377-394
-
-
Konig, J.1
Nies, A.T.2
Cui, Y.3
Leier, I.4
Keppler, D.5
-
5
-
-
0036364467
-
Multidrug resistance in cancer: Role of ATP-dependent transporters
-
Gottesman, M. M., Fojo, T., and Bates, S. E. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat. Rev. Cancer, 2: 48-58, 2002. (Pubitemid 37328807)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.1
, pp. 48-58
-
-
Gottesman, M.M.1
Fojo, T.2
Bates, S.E.3
-
6
-
-
0034674901
-
A family of drug transporters: The multidrug resistance-associated proteins
-
Borst, P., Evers, R., Kool, M., and Wijnholds, J. A family of drug transporters: the multidrug resistance-associated proteins. J. Natl. Cancer Inst., 92: 1295-1302, 2000. (Pubitemid 30662093)
-
(2000)
Journal of the National Cancer Institute
, vol.92
, Issue.16
, pp. 1295-1302
-
-
Borst, P.1
Evers, R.2
Kool, M.3
Wijnholds, J.4
-
7
-
-
85163545088
-
-
United Kingdom: Academic Press
-
Holland, I. B., Cole, S. P. C., Kuchler, K., and Higgins, C. F. ABC Proteins, From Bacteria to Man, pp. 423 - 443. United Kingdom: Academic Press, 2003.
-
(2003)
ABC Proteins, from Bacteria to Man
, pp. 423-443
-
-
Holland, I.B.1
Cole, S.P.C.2
Kuchler, K.3
Higgins, C.F.4
-
8
-
-
0347865941
-
Canalicular multispecific organic anion transporter, ABCC2
-
S. Bröer and C. A. Wagner (eds.), New York: Kluwer Academic/Plenum Publishers
-
Wada, M., Uchiumi, T., and Kuwano, M. Canalicular multispecific organic anion transporter, ABCC2. In: S. Bröer and C. A. Wagner (eds.), Membrane Transport Diseases: Molecular Basis of Inherited Transport Defects. New York: Kluwer Academic/Plenum Publishers, 2003.
-
(2003)
Membrane Transport Diseases: Molecular Basis of Inherited Transport Defects
-
-
Wada, M.1
Uchiumi, T.2
Kuwano, M.3
-
9
-
-
0037648903
-
The basic and clinical implications of ABC transporters, Y-box-binding protein-1 (YB-1) and angiogenesis-related factors in human malignancies
-
DOI 10.1111/j.1349-7006.2003.tb01344.x
-
Kuwano, M., Uchiumi, T., Hayakawa, H., Ono, M., Wada, M., Izumi, H., and Kohno, K. The basic and clinical implications of ABC transporters, Y-box-binding protein-1 (YB-1) and angiogenesis-related factors in human malignancies. Cancer Sci., 94: 9-14, 2003. (Pubitemid 36575851)
-
(2003)
Cancer Science
, vol.94
, Issue.1
, pp. 9-14
-
-
Kuwano, M.1
Uchiumi, T.2
Hayakawa, H.3
Ono, M.4
Wada, M.5
Izumi, H.6
Kohno, K.7
-
10
-
-
4243801613
-
Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins
-
DOI 10.1073/pnas.94.8.4028
-
Schinkel, A. H., Mayer, U., Wagenaar, E., Mol, C. A., van Deemter, L., Smit, J. J., van der Valk, M. A., Voordouw, A. C., Spits, H., van Tellingen, O., Zijlmans, J. M., Fibbe, W. E., and Borst, P. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc. Natl. Acad. Sci. USA, 94: 4028-4033, 1997. (Pubitemid 27180493)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.8
, pp. 4028-4033
-
-
Schinkel, A.H.1
Mayer, U.2
Wagenaar, E.3
Mol, C.A.A.M.4
Van Deemter, L.5
Smit, J.J.M.6
Van Der, V.M.A.7
Voordouw, A.C.8
Spits, H.9
Van Tellingen, O.10
Zijlmans, J.M.J.M.11
Fibbe, W.E.12
Borst, P.13
-
12
-
-
0032900953
-
Biochemical, cellular, and pharmacological aspects of the multidrug transporter
-
DOI 10.1146/annurev.pharmtox.39.1.361
-
Ambudkar, S. V., Dey, S., Hrycyna, C. A., Ramachandra, M., Pastan, I., and Gottesman, M. M. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu. Rev. Pharmacol. Toxicol., 39: 361-398, 1999. (Pubitemid 29222564)
-
(1999)
Annual Review of Pharmacology and Toxicology
, vol.39
, pp. 361-398
-
-
Ambudkar, S.V.1
Dey, S.2
Hrycyna, C.A.3
Ramachandra, M.4
Pastan, I.5
Gottesman, M.M.6
-
13
-
-
0342762062
-
The barrier function of CYP3A4 and P-glycoprotein in the small bowel
-
DOI 10.1016/S0169-409X(97)00041-0, PII S0169409X97000410
-
Watkins, P. B. The barrier function of CYP3A4 and P-glycoprotein in the small bowel. Adv. Drug Deliv. Rev., 27: 161-170, 1997. (Pubitemid 27417871)
-
(1997)
Advanced Drug Delivery Reviews
, vol.27
, Issue.2-3
, pp. 161-170
-
-
Watkins, P.B.1
-
14
-
-
0037131893
-
The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans
-
DOI 10.1016/S0169-409X(02)00064-9, PII S0169409X02000649
-
Fromm, M. F. The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans. Adv. Drug Deliv. Rev., 54: 1295-1310, 2002. (Pubitemid 35284254)
-
(2002)
Advanced Drug Delivery Reviews
, vol.54
, Issue.10
, pp. 1295-1310
-
-
Fromm, M.F.1
-
15
-
-
0034088857
-
A gene expression database for the molecular pharmacology of cancer
-
DOI 10.1038/73439
-
Scherf, U., Ross, D. T., Waltham, M., Smith, L. H., Lee, J. K., Tanabe, L., Kohn, K. W., Reinhold, W. C., Myers, T. G., Andrews, D. T., Scudiero, D. A., Eisen, M. B., Sausville, E. A., Pommier, Y., Botstein, D., Brown, P. O., and Weinstein, J. N. A gene expression database for the molecular pharmacology of cancer. Nat. Genet., 24: 236-244, 2000. (Pubitemid 30132190)
-
(2000)
Nature Genetics
, vol.24
, Issue.3
, pp. 236-244
-
-
Scherf, U.1
Ross, D.T.2
Waltham, M.3
Smith, L.H.4
Lee, J.K.5
Tanabe, L.6
Kohn, K.W.7
Reinhold, W.C.8
Myers, T.G.9
Andrews, D.T.10
Scudiero, D.A.11
Eisen, M.B.12
Sausville, E.A.13
Pommier, Y.14
Botstein, D.15
Brown, P.O.16
Weinstein, J.N.17
-
16
-
-
0042132423
-
Expression of a multidrug-resistance gene in human tumors and tissues
-
Fojo, A. T., Ueda, K., Slamon, D. J., Poplack, D. G., Gottesman, M. M., and Pastan, I. Expression of a multidrug-resistance gene in human tumors and tissues. Proc. Natl. Acad. Sci. USA, 84: 265-269, 1987.
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 265-269
-
-
Fojo, A.T.1
Ueda, K.2
Slamon, D.J.3
Poplack, D.G.4
Gottesman, M.M.5
Pastan, I.6
-
17
-
-
16944363733
-
Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression
-
DOI 10.1038/nm0497-447
-
Bargou, R. C., Jurchott, K., Wagener, C., Bergmann, S., Metzner, S., Bommert, K., Mapara, M. Y., Winzer, K. J., Dietel, M., Dorken, B., and Royer, H. D. Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Nat. Med., 3: 447-450, 1997. (Pubitemid 27145688)
-
(1997)
Nature Medicine
, vol.3
, Issue.4
, pp. 447-450
-
-
Bargou, R.C.1
Jurchott, K.2
Wagener, C.3
Bergmann, S.4
Metzner, S.5
Bommert, K.6
Mapara, M.Y.7
Winzer, K.-J.8
Dietel, M.9
Dorken, B.10
Royer, H.-D.11
-
18
-
-
0032513246
-
Direct involvement of the Y-box binding protein YB-1 in genotoxic stress-induced activation of the human multidrug resistance 1 gene
-
DOI 10.1074/jbc.273.11.5997
-
Ohga, T., Uchiumi, T., Makino, Y., Koike, K., Wada, M., Kuwano, M., and Kohno, K. Direct involvement of the Y-box binding protein YB-1 in genotoxic stress-induced activation of the human multidrug resistance 1 gene. J. Biol. Chem., 273: 5997-6000, 1998. (Pubitemid 28144673)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.11
, pp. 5997-6000
-
-
Ohga, T.1
Uchiumi, T.2
Makino, Y.3
Koike, K.4
Wada, M.5
Kuwano, M.6
Kohno, K.7
-
19
-
-
0034021716
-
Alu-associated interstitial deletions and chromosomal re-arrangement in 2 human multidrug-resistant cell lines
-
DOI 10.1002/(SICI)1097-0215(20000515)86:4<506::AID
-
Harada, T., Nagayama, J., Kohno, K., Mickley, L. A., Fojo, T., Kuwano, M., and Wada, M. Alu-associated interstitial deletions and chromosomal re-arrangement in 2 human multidrug-resistant cell lines. Int. J. Cancer, 86: 506-511, 2000. (Pubitemid 30249730)
-
(2000)
International Journal of Cancer
, vol.86
, Issue.4
, pp. 506-511
-
-
Harada, T.1
Nagayama, J.2
Kohno, K.3
Mickley, L.A.4
Fojo, T.5
Kuwano, M.6
Wada, M.7
-
20
-
-
0033564370
-
Association of 5' CpG demethylation and altered chromatin structure in the promoter region with transcriptional activation of the multidrug resistance gene in human cancer cells
-
DOI 10.1046/j.1432-1327.1999.00469.x
-
Kusaba, H., Nakayama, M., Harada, T., Nomoto, M., Kohno, K., Kuwano, M., and Wada, M. Association of 5′ CpG demethylation and altered chromatin structure in the promoter region with transcriptional activation of the multidrug resistance 1 gene in human cancer cells. Eur. J. Biochem., 262: 924-932, 1999. (Pubitemid 29291053)
-
(1999)
European Journal of Biochemistry
, vol.262
, Issue.3
, pp. 924-932
-
-
Kusaba, H.1
Nakayama, M.2
Harada, T.3
Nomoto, M.4
Kohno, K.5
Kuwano, M.6
Wada, M.7
-
21
-
-
0032403478
-
Hypomethylation status of CpG sites at the promoter region and overexpression of the human MDR1 gene in acute myeloid leukemias
-
Nakayama, M., Wada, M., Harada, T., Nagayama, J., Kusaba, H., Ohshima, K., Kozuru, M., Komatsu, H., Ueda, R., and Kuwano, M. Hypomethylation status of CpG sites at the promoter region and overexpression of the human MDR1 gene in acute myeloid leukemias. Blood, 92: 4296-4307, 1998. (Pubitemid 28544347)
-
(1998)
Blood
, vol.92
, Issue.11
, pp. 4296-4307
-
-
Nakayama, M.1
Wada, M.2
Harada, T.3
Nagayama, J.4
Kusaba, H.5
Ohshima, K.6
Kozuru, M.7
Komatsu, H.8
Ueda, R.9
Kuwano, M.10
-
22
-
-
0034351878
-
MRD1 gene overexpression and altered degree of methylation at the promoter region in bladder cancer during chemotherapeutic treatment
-
Tada, Y., Wada, M., Kuroiwa, K., Kinugawa, N., Harada, T., Nagayama, J., Nakagawa, M., Naito, S., and Kuwano, M. MDR1 gene overexpression and altered degree of methylation at the promoter region in bladder cancer during chemotherapeutic treatment. Clin. Cancer Res., 6: 4618-4627, 2000. (Pubitemid 32110396)
-
(2000)
Clinical Cancer Research
, vol.6
, Issue.12
, pp. 4618-4627
-
-
Tada, Y.1
Wada, M.2
Kuroiwa, K.3
Kinugawa, N.4
Harada, T.5
Nagayama, J.6
Nakagawa, M.7
Naito, S.8
Kuwano, M.9
-
23
-
-
0023447098
-
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
-
Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M. M., Pastan, I., and Willingham, M. C. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc. Natl. Acad. Sci. USA, 84: 7735-7738, 1987.
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 7735-7738
-
-
Thiebaut, F.1
Tsuruo, T.2
Hamada, H.3
Gottesman, M.M.4
Pastan, I.5
Willingham, M.C.6
-
24
-
-
0023889448
-
Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16
-
Sugawara, I., Kataoka, I., Morishita, Y., Hamada, H., Tsuruo, T., Itoyama, S., and Mori, S. Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16. Cancer Res., 48: 1926-1929, 1988.
-
(1988)
Cancer Res.
, vol.48
, pp. 1926-1929
-
-
Sugawara, I.1
Kataoka, I.2
Morishita, Y.3
Hamada, H.4
Tsuruo, T.5
Itoyama, S.6
Mori, S.7
-
25
-
-
0000712439
-
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
-
DOI 10.1073/pnas.86.2.695
-
Cordon-Cardo, C., O'Brien, J. P., Casals, D., Rittman-Grauer, L., Biedler, J. L., Melamed, M. R., and Bertino, J. R. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc. Natl. Acad. Sci. USA, 86: 695-698, 1989. (Pubitemid 19037807)
-
(1989)
Proceedings of the National Academy of Sciences of the United States of America
, vol.86
, Issue.2
, pp. 695-698
-
-
Cordon-Cardo, C.1
O'Brien, J.P.2
Casals, D.3
Rittman-Grauer, L.4
Biedler, J.L.5
Melamed, M.R.6
Bertino, J.R.7
-
26
-
-
0025071180
-
Expression of the multidrug resistance gene product (P-Glycoprotein) in human normal and tumor tissues
-
Cordon-Cardo, C., O'Brien, J. P., Boccia, J., Casals, D., Bertino, J. R., and Melamed, M. R. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. J. Histochem. Cytochem., 38: 1277-1287, 1990. (Pubitemid 20266126)
-
(1990)
Journal of Histochemistry and Cytochemistry
, vol.38
, Issue.9
, pp. 1277-1287
-
-
Cordon-Cardo, C.1
O'Brien, J.P.2
Boccia, J.3
Casals, D.4
Bertino, J.R.5
Melamed, M.R.6
-
27
-
-
0029916534
-
P-glycoprotein: A major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans
-
DOI 10.1073/pnas.93.9.4001
-
Schuetz, E. G., Schinkel, A. H., Relling, M. V., and Schuetz, J. D. P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P 4503A in mice and humans. Proc. Natl. Acad. Sci. USA, 93: 4001-4005, 1996. (Pubitemid 26144235)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.9
, pp. 4001-4005
-
-
Schuetz, E.G.1
Schinkel, A.H.2
Relling, M.V.3
Schuetz, J.D.4
-
28
-
-
0032754284
-
The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin
-
Greiner, B., Eichelbaum, M., Fritz, P., Kreichgauer, H. P., von Richter, O., Zundler, J., and Kroemer, H. K. The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin. J. Clin. Invest., 104: 147-153, 1999.
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 147-153
-
-
Greiner, B.1
Eichelbaum, M.2
Fritz, P.3
Kreichgauer, H.P.4
Von Richter, O.5
Zundler, J.6
Kroemer, H.K.7
-
29
-
-
0030838009
-
The multidrug-resistance P-glycoprotein (Pgp, MDR1) is an early marker of blood-brain barrier development in the microvessels of the developing human brain
-
DOI 10.1007/s004180050159
-
Schumacher, U. and Mollgard, K. The multidrug-resistance P-glycoprotein (Pgp, MDR1) is an early marker of blood-brain barrier development in the microvessels of the developing human brain. Histochem. Cell. Biol., 108: 179-182, 1997. (Pubitemid 27362344)
-
(1997)
Histochemistry and Cell Biology
, vol.108
, Issue.2
, pp. 179-182
-
-
Schumacher, U.1
Mollgard, K.2
-
30
-
-
0033616684
-
Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood- cerebrospinal-fluid drug-permeability barrier
-
DOI 10.1073/pnas.96.7.3900
-
Rao, V. V., Dahlheimer, J. L., Bardgett, M. E., Snyder, A. Z., Finch, R. A., Sartorelli, A. C., and Piwnica-Worms, D. Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier. Proc. Natl. Acad. Sci. USA, 96: 3900-3905, 1999. (Pubitemid 29169008)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.7
, pp. 3900-3905
-
-
Rao, V.V.1
Dahlheimer, J.L.2
Bardgett, M.E.3
Snyder, A.Z.4
Finch, R.A.5
Sartorelli, A.C.6
Piwnica-Worms, D.7
-
31
-
-
0024576304
-
Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein
-
Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M. M., Pastan, I., and Willingham, M. C. Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein. J. Histochem. Cytochem., 37: 159-164, 1989. (Pubitemid 19039163)
-
(1989)
Journal of Histochemistry and Cytochemistry
, vol.37
, Issue.2
, pp. 159-164
-
-
Thiebaut, F.1
Tsuruo, T.2
Hamada, H.3
Gottesman, M.M.4
Pastan, I.5
Willingham, M.C.6
-
32
-
-
0034046035
-
Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas
-
Hinoshita, E., Uchiumi, T., Taguchi, K., Kinukawa, N., Tsuneyoshi, M., Maehara, Y., Sugimachi, K., and Kuwano, M. Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas. Clin. Cancer Res., 6: 2401-2407, 2000. (Pubitemid 30399208)
-
(2000)
Clinical Cancer Research
, vol.6
, Issue.6
, pp. 2401-2407
-
-
Hinoshita, E.1
Uchiumi, T.2
Taguchi, K.-I.3
Kinukawa, N.4
Tsuneyoshi, M.5
Maehara, Y.6
Sugimachi, K.7
Kuwano, M.8
-
33
-
-
0041668155
-
Min/+ mice
-
DOI 10.1093/carcin/bgg073
-
Mochida, Y., Taguchi, K., Taniguchi, S., Tsuneyoshi, M., Kuwano, H., Tsuzuki, T., Kuwano, M., and Wada, M. The role of P-glycoprotein in intestinal tumorigenesis: disruption of mdr1a suppresses polyp formation in ApcMin/+ mice. Carcinogenesis, 24: 1219-1224, 2003. (Pubitemid 36927062)
-
(2003)
Carcinogenesis
, vol.24
, Issue.7
, pp. 1219-1224
-
-
Mochida, Y.1
Taguchi, K.-I.2
Taniguchi, S.3
Tsuneyoshi, M.4
Kuwano, H.5
Tsuzuki, T.6
Kuwano, M.7
Wada, M.8
-
34
-
-
0037373889
-
Min/+ mice
-
Yamada, T., Mori, Y., Hayashi, R., Takada, M., Ino, Y., Naishiro, Y., Kondo, T., and Hirohashi, S. Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+mice. Cancer Res., 63: 895-901, 2003. (Pubitemid 36278415)
-
(2003)
Cancer Research
, vol.63
, Issue.5
, pp. 895-901
-
-
Yamada, T.1
Mori, Y.2
Hayashi, R.3
Takada, M.4
Ino, Y.5
Naishiro, Y.6
Kondo, T.7
Hirohashi, S.8
-
35
-
-
0034724324
-
Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P- glycoprotein expression and activity in vivo
-
DOI 10.1073/pnas.050585397
-
Hoffmeyer, S., Burk, O., von Richter, O., Arnold, H. P., Brockmoller, J., Johne, A., Cascorbi, I., Gerloff, T., Roots, I., Eichelbaum, M., and Brinkmann, U. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc. Natl. Acad. Sci. USA, 97: 3473-3478, 2000. (Pubitemid 30183327)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.7
, pp. 3473-3478
-
-
Hoffmeyer, S.1
Burk, O.2
Von Richter, O.3
Arnold, H.P.4
Brockmoller, J.5
Johne, A.6
Cascorbi, I.7
Gerloff, T.8
Roots, I.9
Eichelbaum, M.10
Brinkmann, U.11
-
36
-
-
0035103009
-
Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects
-
DOI 10.1097/00008571-200103000-00008
-
Ito, S., Ieiri, I., Tanabe, M., Suzuki, A., Higuchi, S., and Otsubo, K. Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects. Pharmacogenetics, 11: 175-184, 2001. (Pubitemid 32216128)
-
(2001)
Pharmacogenetics
, vol.11
, Issue.2
, pp. 175-184
-
-
Ito, S.1
Ieiri, I.2
Tanabe, M.3
Suzuki, A.4
Higuchi, S.5
Otsubo, K.6
-
37
-
-
0025191307
-
Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins
-
Chen, C. J., Clark, D., Ueda, K., Pastan, I., Gottesman, M. M., and Roninson, I. B. Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. J. Biol. Chem., 265: 506-514, 1990.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 506-514
-
-
Chen, C.J.1
Clark, D.2
Ueda, K.3
Pastan, I.4
Gottesman, M.M.5
Roninson, I.B.6
-
38
-
-
0031612929
-
Recommendations for a nomenclature system for human gene mutations
-
Antonarakis, S. E. Recommendations for a nomenclature system for human gene mutations. Nomenclature Working Group. Hum. Mutat., 11: 1-3, 1998. (Pubitemid 128679142)
-
(1998)
Human Mutation
, vol.11
, Issue.1
, pp. 1-3
-
-
Antonarakis, S.E.1
Ashburner, M.2
Auerbach, A.D.3
Beaudet, A.L.4
Beckmann, J.S.5
Beutler, E.6
Cooper, D.N.7
Cotton, R.G.H.8
Den, D.J.T.9
Desnick, R.J.10
Eng, C.11
Fasman, K.H.12
Goldman, D.13
Hayashi, K.14
Hutchinson, F.15
Kazazian Jr., H.H.16
Keen, J.17
King, M.-C.18
Lehvaslaiho, H.19
McAlpine, P.J.20
McKusick, V.21
Motulski, A.G.22
Povey, S.23
Schorderet, D.F.24
Scriver, C.R.25
Shows Jr., T.B.26
Supertifurga, A.27
Tay, A.H.N.28
Tsui, L.-C.29
Valle, D.30
Vihinen, M.31
more..
-
39
-
-
0029964835
-
A novel method for real time quantitative RT-PCR
-
Gibson, U. E., Heid, C. A., and Williams, P. M. A novel method for real time quantitative RT-PCR. Genome Res., 6: 995-1001, 1996. (Pubitemid 26388092)
-
(1996)
Genome Research
, vol.6
, Issue.10
, pp. 995-1001
-
-
Gibson, U.E.M.1
Heid, C.A.2
Williams, P.M.3
-
40
-
-
0025730640
-
A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
-
Andrews, N. C. and Faller, D. V. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res., 19: 2499, 1991.
-
(1991)
Nucleic Acids Res.
, vol.19
, pp. 2499
-
-
Andrews, N.C.1
Faller, D.V.2
-
41
-
-
0032562677
-
The role of an inverted CCAAT element in transcriptional activation of the human DNA topoisomerase IIα gene by heat shock
-
DOI 10.1074/jbc.273.17.10550
-
Furukawa, M., Uchiumi, T., Nomoto, M., Takano, H., Morimoto, R. I., Naito, S., Kuwano, M., and Kohno, K. The role of an inverted CCAAT element in transcriptional activation of the human DNA topoisomerase IIα gene by heat shock. J. Biol. Chem., 273: 10550-10555, 1998. (Pubitemid 28227666)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.17
, pp. 10550-10555
-
-
Furukawa, M.1
Uchiumi, T.2
Nomoto, M.3
Takano, H.4
Morimoto, R.I.5
Naito, S.6
Kuwano, M.7
Kohno, K.8
-
42
-
-
0034997034
-
Expression of P-glycoprotein in human placenta: Relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene
-
Tanabe, M., Ieiri, I., Nagata, N., Inoue, K., Ito, S., Kanamori, Y., Takahashi, M., Kurata, Y., Kigawa, J., Higuchi, S., Terakawa, N., and Otsubo, K. Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene. J. Pharmacol. Exp. Ther., 297: 1137-1143, 2001. (Pubitemid 32472514)
-
(2001)
Journal of Pharmacology and Experimental Therapeutics
, vol.297
, Issue.3
, pp. 1137-1143
-
-
Tanabe, M.1
Ieiri, I.2
Nagata, N.3
Inoue, K.4
Ito, S.5
Kanamori, Y.6
Takahashi, M.7
Kurata, Y.8
Kigawa, J.9
Higuchi, S.10
Terakawa, N.11
Otsubo, K.12
-
43
-
-
3042772026
-
Identification of functionally variant MDR1 alleles among European Americans and African Americans
-
DOI 10.1067/mcp.2001.117412
-
Kim, R. B., Leake, B. F., Choo, E. F., Dresser, G. K., Kubba, S. V., Schwarz, U. I., Taylor, A., Xie, H. G., McKinsey, J., Zhou, S., Lan, L. B., Schuetz, J. D., Schuetz, E. G., and Wilkinson, G. R. Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin. Pharmacol. Ther., 70: 189-199, 2001. (Pubitemid 32777772)
-
(2001)
Clinical Pharmacology and Therapeutics
, vol.70
, Issue.2
, pp. 189-199
-
-
Kim, R.B.1
Leake, B.F.2
Choo, E.F.3
Dresser, G.K.4
Kubba, S.V.5
Schwarz, U.I.6
Taylor, A.7
Xie, H.-G.8
McKinsey, J.9
Zhou, S.10
Lan, L.-B.11
Schuetz, J.D.12
Schuetz, E.G.13
Wilkinson, G.R.14
-
44
-
-
0036803396
-
Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677: Functional relevance to pharmacokinetics of digoxin
-
DOI 10.1023/A:1020433422259
-
Horinouchi, M., Sakaeda, T., Nakamura, T., Morita, Y., Tamura, T., Aoyama, N., Kasuga, M., and Okumura, K. Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677: functional relevance to pharmacokinetics of digoxin. Pharm. Res., 19: 1581-1585, 2002. (Pubitemid 35266567)
-
(2002)
Pharmaceutical Research
, vol.19
, Issue.10
, pp. 1581-1585
-
-
Horinouchi, M.1
Sakaeda, T.2
Nakamura, T.3
Morita, Y.4
Tamura, T.5
Aoyama, N.6
Kasuga, M.7
Okumura, K.8
-
45
-
-
0036224114
-
Effect of the mutation (C3435t) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects
-
DOI 10.1067/mcp.2002.122055
-
Nakamura, T., Sakaeda, T., Horinouchi, M., Tamura, T., Aoyama, N., Shirakawa, T., Matsuo, M., Kasuga, M., and Okumura, K. Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects. Clin. Pharmacol. Ther., 71: 297-303, 2002. (Pubitemid 34311459)
-
(2002)
Clinical Pharmacology and Therapeutics
, vol.71
, Issue.4
, pp. 297-303
-
-
Nakamura, T.1
Sakaeda, T.2
Horinouchi, M.3
Tamura, T.4
Aoyama, N.5
Shirakawa, T.6
Matsuo, M.7
Kasuga, M.8
Okumura, K.9
-
46
-
-
0036667953
-
C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation
-
Goto, M., Masuda, S., Saito, H., Uemoto, S., Kiuchi, T., Tanaka, K., and Inui, K. C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation. Pharmacogenetics, 12: 451- 457, 2002.
-
(2002)
Pharmacogenetics
, vol.12
, pp. 451-457
-
-
Goto, M.1
Masuda, S.2
Saito, H.3
Uemoto, S.4
Kiuchi, T.5
Tanaka, K.6
Inui, K.7
-
47
-
-
0038106665
-
Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs
-
DOI 10.1517/phgs.4.4.397.22747
-
Sakaeda, T., Nakamura, T., and Okumura, K. Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs. Pharmacogenomics, 4: 397-410, 2003. (Pubitemid 36857176)
-
(2003)
Pharmacogenomics
, vol.4
, Issue.4
, pp. 397-410
-
-
Sakaeda, T.1
Nakamura, T.2
Okumura, K.3
-
48
-
-
0034972150
-
A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans
-
DOI 10.1038/88911
-
Esterbauer, H., Schneitler, C., Oberkofler, H., Ebenbichler, C., Paulweber, B., Sandhofer, F., Ladurner, G., Hell, E., Strosberg, A. D., Patsch, J. R., Krempler, F., and Patsch, W. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Nat. Genet., 28: 178-183, 2001. (Pubitemid 32538066)
-
(2001)
Nature Genetics
, vol.28
, Issue.2
, pp. 178-183
-
-
Esterbauer, H.1
Schneitler, C.2
Oberkofler, H.3
Ebenbichler, C.4
Paulweber, B.5
Sandhofer, F.6
Ladurner, G.7
Hell, E.8
Strosberg, A.D.9
Patsch, J.R.10
Krempler, F.11
Patsch, W.12
-
49
-
-
0029983767
-
Stable transfection of the p-glycoprotein promoter reproduces the endogenous overexpression phenotype: The role of MED-1
-
Ince, T. A. and Scotto, K. W. Stable transfection of the P-glycoprotein promoter reproduces the endogenous overexpression phenotype: the role of MED-1. Cancer Res., 56: 2021-2024, 1996. (Pubitemid 26119901)
-
(1996)
Cancer Research
, vol.56
, Issue.9
, pp. 2021-2024
-
-
Ince, T.A.1
Scotto, K.W.2
-
50
-
-
0036710923
-
Transcriptional regulators of the human multidrug resistance 1 gene: Recent views
-
DOI 10.1016/S0006-2952(02)01156-5, PII S0006295202011565
-
Labialle, S., Gayet, L., Marthinet, E., Rigal, D., and Baggetto, L. G. Transcriptional regulators of the human multidrug resistance 1 gene: recent views. Biochem. Pharmacol., 64: 943-948, 2002. (Pubitemid 35232268)
-
(2002)
Biochemical Pharmacology
, vol.64
, Issue.5-6
, pp. 943-948
-
-
Labialle, S.1
Gayet, L.2
Marthinet, E.3
Rigal, D.4
Baggetto, L.G.5
-
51
-
-
0032969236
-
Methylation analysis of the human multidrug resistance 1 gene in normal and leukemic hematopoietic cells
-
Fryxell, K. B., McGee, S. B., Simoneaux, D. K., Willman, C. L., and Cornwell, M. M. Methylation analysis of the human multidrug resistance 1 gene in normal and leukemic hematopoietic cells. Leukemia, 13: 910-917, 1999. (Pubitemid 29292142)
-
(1999)
Leukemia
, vol.13
, Issue.6
, pp. 910-917
-
-
Fryxell, K.B.1
McGee, S.B.2
Simoneaux, D.K.3
Willman, C.L.4
Cornwell, M.M.5
|