Role of the highly structured 5′-end region of MDR1 mRNA in P-glycoprotein expression

Biochemical Journal

Volumn 406, Issue 3, 2007, Pages 445-455

  Randle, Rebecca A ^a,b   Raguz, Selina ^a   Higgins, Christopher F ^a,c   Yagüe, Ernesto ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UCB PHARMA   (Belgium)

^c DURHAM UNIVERSITY   (United Kingdom)

Author keywords

Cytotoxic stress; Drug resistance; Eukaryotic initiation factor 4E (EIF4E); mRNA hairpin; mRNA translation

Indexed keywords

CYTOTOXICITY; DRUG PRODUCTS; PROTEINS; STRESS ANALYSIS;

CYTOTOXIC STRESS; DRUG RESISTANCE; EUKARYOTIC INITIATION FACTOR-4E (EIF4E); MRNA HAIRPIN; MRNA TRANSLATION;

RNA;

CYTOTOXIC AGENT; GLYCOPROTEIN P; HYBRID PROTEIN; INITIATION FACTOR 4E BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN KINASE B; REPRESSOR PROTEIN; SMALL INTERFERING RNA;

5' UNTRANSLATED REGION; ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; GENETIC CODE; HUMAN; HUMAN CELL; IN VIVO STUDY; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REPORTER GENE; RNA TRANSLATION; SIGNAL TRANSDUCTION; UPREGULATION;

5' UNTRANSLATED REGIONS; ANTINEOPLASTIC AGENTS; BLOTTING, SOUTHERN; DRUG RESISTANCE; ENZYME INHIBITORS; EUKARYOTIC INITIATION FACTOR-4E; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; K562 CELLS; LUCIFERASES; P-GLYCOPROTEIN; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PROTEIN BIOSYNTHESIS; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EUKARYOTA; MAMMALIA;

EID: 34548716988     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20070235     Document Type: Article

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