Association of 5' CpG demethylation and altered chromatin structure in the promoter region with transcriptional activation of the multidrug resistance gene in human cancer cells

European Journal of Biochemistry

Volumn 262, Issue 3, 1999, Pages 924-932

  Kusaba, Hitoshi ^a   Nakayama, Masaharu ^a   Harada, Taishi ^a   Nomoto, Minoru ^b   Kohno, Kimitoshi ^b   Kuwano, Michihiko ^a   Wada, Morimasa ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

DNA methylation; Multidrug resistance 1 gene; P glycoprotein; Promoter; Transcription activation

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DEOXYRIBONUCLEASE; DOXORUBICIN; GLYCOPROTEIN P; MESSENGER RNA; VINCRISTINE;

ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CELL SURVIVAL; CHROMATIN STRUCTURE; CONTROLLED STUDY; DEMETHYLATION; GEL ELECTROPHORESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; METHYLATION; MULTIDRUG RESISTANCE; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

AZACITIDINE; CHROMATIN; CLONE CELLS; DINUCLEOSIDE PHOSPHATES; DNA METHYLATION; DRUG RESISTANCE, NEOPLASM; GENE AMPLIFICATION; GENES, MDR; HUMANS; P-GLYCOPROTEIN; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED;

EID: 0033564370     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00469.x     Document Type: Article

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