Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression

Nature Medicine

Volumn 3, Issue 4, 1997, Pages 447-450

  Bargou, Ralf C ^a,b   Jürchott, Karsten ^a   Wagener, Christian ^a   Bergmann, Stephan ^a   Metzner, Sylvia ^b   Bommert, Kurt ^a   Mapara, Markus Y ^a,b   Winzer, Klaus Jürgen ^c   Dietel, Manfred ^c   Dörken, Bernd ^a,b   Royer, Hans Dieter ^a,b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN P; TRANSCRIPTION FACTOR;

ARTICLE; BREAST CANCER; CELL CULTURE; CELL NUCLEUS; CLINICAL ARTICLE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MDR 1 GENE; PRIORITY JOURNAL;

MINK CELL FOCUS-FORMING VIRUS;

EID: 16944363733     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0497-447     Document Type: Article

References (20)

1. Gottesman, M.M. & Pastan, I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62, 385-427 (1993).
2. Goldsmith, M.E., Madden, M.J., Morrow, C.S. & Cowan, K.H. A Y-box consensus sequence is required for basal expression of the human multidrug resistance (MDR1) gene. J. Biol. Chem. 268, 5856-5860 (1993).
3. Verelle, P. et al. Clinical relevance of immunohistochemical detection of multidrug resistance P-glycoprotein in breast carcinoma. J. Natl. Cancer Inst. 83, 111-116 (1991).
4. Schneider, J. et al. P-glycoprotein, HER-2/neu and mutant p53 expression in human gynecologic tumors. J. Natl. Cancer Inst. 86, 850-855 (1994).
5. Madden, M.J. et al. Identification of 5′ and 3′ sequences involved in the regulation of transcription of the human MDR1 gene in vivo. J. Biol. Chem. 268, 8209-8297 (1993).
6. van Groeningen, M., Valentijn, L.J. & Baas, F. Identification of a functional initiator sequence in the human MDR1 promoter. Biochim. Biophys. Acta 1172, 138-146 (1993).
7. Wolffe, A.P. Structural and functional properties of the evolutionarily ancient Y-box family of nucleic acid binding proteins. BioEssays 16, 245-251 (1994).
8. Ladomery, M. & Sommerville, J. A role for Y-box proteins in cell proliferation. BioEssays 17, 9-11 (1995).
9. Asakuno, K. et al. Involvement of a DNA binding protein, MDR-NFY/YB-1, in human MDR1 gene expression by actinomycin D. Biochem. Biophys. Res. Commun. 199, 1428-1435 (1994)
10. Gossen, M. & Bujard, H. Tight control of gene expression in mammalian cells by tetracycline responsive promoters. Proc. Natl. Acad. Sci. USA 89, 5547-5551 (1992)
11. Bittl, A., Nap, M., Jäger, W., Cornillie, F. & Lang, N. Immunohistochemical detection of P-glycoprotein on frozen and paraffin-embedded tissue sections of normal and malignant tissues. Anticancer Res. 15, 1007-1014 (1995).
12. Sanfilippo, O., Ronchi, E., De-Marco, C., Di-Fronzo, G. & Silvestrini, R. Expression of P-glycoprotein in breast cancer tissue and in vitro resistance to doxorubicin and vincristine. Eur. J. Cancer 27, 155-158 (1991).
13. Pinedo, H.M. & Giaccone, G. P-glycoprotein - a marker of cancer-cell behavior. New Engl. J. Med. 333, 1417-1419 (1995).
14. Lee, C.H., Bradley, G. & Ling, V. Expression of P-glycoprotein in normal and malignant rat liver cells. Cold Spring Harbor Symp. Quant. Biol. 59, 607-615 (1994).
15. Weinstein, R.S. et al. Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis. Cancer Res. 51, 2720-2726 (1991).
16. Baldini, N. et al. Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome. New Engl. J. Med. 333, 1380-1385 (1995).
17. Spitkovsky, D.D. et al. Tissue restricted expression and chromosomal localization of the YB-1 gene encoding a 42kD nuclear CCAAT binding protein. Nucleic Acids Res. 20, 797-803 (1992)
18. Bargou, R.C. et al. Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice. J. Clin. Invest. 97, 2651-2659 (1996).
19. Grinstein, E., Weinert, I., Pagano, M., Droese, B. & Royer, H.-D. Cell cycle regulation of nuclear factor p92 DNA-binding activity by novel phase-specific inhibitors. J. Biol. Chem. 271, 9215-9222 (1996)
20. Royer, H.-D. et al. Delineation of human papillomavirus type 18 enhancer binding proteins: The intracellular distribution of a novel octamer binding protein p92 is cell cycle regulated. Nucleic Acids Res. 19, 2363-2371 (1991).