Molecular and functional alterations in a mouse cardiac model of friedreich ataxia: Activation of the integrated stress response, eIF2α phosphorylation, and the induction of downstream targets

American Journal of Pathology

Volumn 183, Issue 3, 2013, Pages 745-757

  Huang, Michael Li Hsuan ^a   Sivagurunathan, Sutharshani ^a   Ting, Samantha ^a   Jansson, Patric J ^a   Austin, Christopher J D ^a   Kelly, Matthew ^b,c   Semsarian, Christopher ^b,c,d   Zhang, Daohai ^a   Richardson, Des R ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c CENTENARY INSTITUTE   (Australia)

^d ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CREATINE KINASE MM; FRATAXIN; INITIATION FACTOR 2ALPHA;

AMINO ACID SYNTHESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; BIOSYNTHESIS; CARDIOMYOPATHY; CONTROLLED STUDY; FEMALE; FRIEDREICH ATAXIA; HEART FUNCTION; HEART VENTRICLE HYPERTROPHY; HISTOPATHOLOGY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; UPREGULATION;

ACTIVATING TRANSCRIPTION FACTOR 4; AMINO ACIDS; ANIMALS; APOPTOSIS; AUTOPHAGY; CARDIOMEGALY; DISEASE MODELS, ANIMAL; EUKARYOTIC INITIATION FACTOR-2; FEMALE; FRIEDREICH ATAXIA; GENE EXPRESSION PROFILING; HEART FUNCTION TESTS; HUMANS; IRON-BINDING PROTEINS; MALE; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MYOCARDIUM; MYOCYTES, CARDIAC; PHENOTYPE; PHOSPHORYLATION; PROTEIN KINASES; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL;

EID: 84880074199     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2013.05.032     Document Type: Article

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