Gain-of-function mutations in transient receptor potential C6 (TRPC6) activate extracellular signal-regulated kinases 1/2 (ERK1/2)

Journal of Biological Chemistry

Volumn 288, Issue 25, 2013, Pages 18407-18420

  Chiluiza, David ^a,b   Krishna, Sneha ^a   Schumacher, Valérie A ^b,c   Schlöndorff, Johannes ^a,b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXTRACELLULAR SIGNAL-REGULATED KINASE; PARACRINE; SIGNALING EVENTS; SIGNALING PATHWAYS; TRANSIENT RECEPTOR POTENTIALS;

CHEMICAL ACTIVATION;

PIGMENTS;

CALCINEURIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALMODULIN; CARBACHOL; CYCLIC AMP DEPENDENT PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CANONICAL TRANSIENT RECEPTOR POTENTIAL 6 GENE; CONTROLLED STUDY; ENZYME ACTIVATION; FOCAL GLOMERULOSCLEROSIS; GAIN OF FUNCTION MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PARACRINE SIGNALING; PODOCYTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

CALCIUM; EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR); FOCAL SEGMENTAL GLOMERULOSCLEROSIS; KIDNEY; PROTEIN KINASE A (PKA); TRP CHANNELS;

ANIMALS; BENZYLAMINES; CALCINEURIN; CALMODULIN; CELL LINE; ENZYME ACTIVATION; ENZYME INHIBITORS; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; ISOQUINOLINES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUTATION; PHOSPHORYLATION; PODOCYTES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SULFONAMIDES; TRPC CATION CHANNELS;

EID: 84880072570     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.463059     Document Type: Article

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