Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 31, Issue 10, 2011, Pages 2278-2286

  Nishioka, Kinue ^a   Nishida, Motohiro ^a   Ariyoshi, Marina ^a   Jian, Zhong ^c   Saiki, Shota ^a   Hirano, Mayumi ^b   Nakaya, Michio ^a   Sato, Yoji ^d   Kita, Satomi ^c   Iwamoto, Takahiro ^c   Hirano, Katsuya ^b   Inoue, Ryuji ^c   Kurose, Hitoshi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c FUKUOKA UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

angiotensin II; diacylglycerol; phosphodiesterase; phosphorylation; transient receptor potential canonical

Indexed keywords

ANGIOTENSIN II; CALCIUM; CILOSTAZOL; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIACYLGLYCEROL; PHOSPHODIESTERASE; PHOSPHODIESTERASE III; TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL 7;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; THORACIC AORTA; VASOCONSTRICTION;

ANGIOTENSIN II; ANIMALS; AORTA, THORACIC; CALCIUM SIGNALING; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIGLYCERIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; MALE; MICE; MUSCLE, SMOOTH, VASCULAR; MUTATION; MYOCYTES, SMOOTH MUSCLE; PHOSPHODIESTERASE 3 INHIBITORS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RATS, SPRAGUE-DAWLEY; RHO GTP-BINDING PROTEINS; TETRAZOLES; TRANSFECTION; TRPC CATION CHANNELS; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 80052964149     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.110.221010     Document Type: Article

References (41)

1. Johnson PC. The myogenic response and the microcirculation. Microvasc Res. 1977;13:1-18.
2. 2+-dependent regulation of vascular tone. J Anesth. 2007;21: 220-231. (Pubitemid 46692015)
3. Berridge MJ. Inositol trisphosphate and calcium signalling. Nature. 1993; 361:315-325. (Pubitemid 23041621)
4. Putney JW Jr. Capacitative calcium entry revisited. Cell Calcium 1990; 11:611-624.
5. Leung FP, Yung LM, Yao X, Laher I, Huang Y. Store-operated calcium entry in vascular smooth muscle. Brit J Pharmacol. 2008;153:846-857. (Pubitemid 351328924)
6. Nishizuka Y. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 1995;9:484-496.
7. 2+-permeable cation channel. Circ Res. 2001;88:325-332. (Pubitemid 32173757)
8. Welsh DG, Morielli AD, Nelson MT, Brayden JE. Transient receptor potential channels regulate myogenic tone of resistance arteries. Circ Res. 2002;90:248-250. (Pubitemid 34633924)
9. -/- mice. Mol Cell Biol. 2005;25: 6980-6989. (Pubitemid 41105898)
10. Kimura Y, Tani T, Kanbe T, Watanabe K. Effect of cilostazol on platelet aggregation and experimental thrombosis. Arzneimittelforschung. 1985; 35(7A):1144-1149. (Pubitemid 15030828)
11. Kambayashi J, Liu Y, Sun B, Shakur Y, Yoshitake M, Czerwiec F. Cilostazol as a unique antithrombotic agent. Curr Pharm Des. 2003;9: 2289-2302. (Pubitemid 37236353)
12. Dawson DL, Cutler BS, Meissner MH, Strandness DE, Jr. Cilostazol has beneficial effects in treatment of intermittent claudication: results from a multicenter, randomized, prospective, double-blind trial. Circulation. 1998;98:678-686. (Pubitemid 28387495)
13. Tanaka T, Ishikawa T, Hagiwara M, Onoda K, Itoh H, Hidaka H. Effects of cilostazol, a selective cAMP phosphodiesterase inhibitor on the contraction of vascular smooth muscle. Pharmacology. 1988;36:313-320.
14. i and force in middle cerebral artery of the rabbit. Brit J Pharmacol. 1998;123: 869-878. (Pubitemid 28085387)
15. Adelstein RS, Conti MA, Hathaway DR, Klee CB. Phosphorylation of smooth muscle myosin light chain kinase by the catalytic subunit of adenosine 3': 5'-monophosphate-dependent protein kinase. J Biol Chem. 1978;253:8347-8350. (Pubitemid 9082534)
16. q-dependent PLC-/31 activity by PKG and PKA is mediated by phosphorylation of RGS4 and GRK2. Am J Physiol Cell Physiol. 2007;292: C200-C208. (Pubitemid 46127309)
17. Heximer SP, Knutsen RH, Sun X, Kaltenbronn KM, Rhee MH, Peng N, Oliveira-dos-Santos A, Penninger JM, Muslin AJ, Steinberg TH, Wyss JM, Mecham RP, Blumer KJ. Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest. 2003;111: 445-452. (Pubitemid 36228001)
18. Harris DM, Cohn HI, Pesant S, Eckhart AD. GPCR signalling in hypertension: role of GRKs. Clin Sci (Lond). 2008;115:79-89.
19. Montell C, Rubin GM. Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototrans-duction. Neuron. 1989;2:1313-1323.
20. Nishida M, Hara Y, Yoshida T, Inoue R, Mori Y. TRP channels: molecular diversity and physiological function. Microcirculation. 2006; 13:535-550. (Pubitemid 44446634)
21. Hofmann T, Schaefer M, Schultz G, Gudermann T. Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci USA. 2002;99:7461-7466. (Pubitemid 34568713)
22. Lucas P, Ukhanov K, Leinders-Zufall T, Zufall F. A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron. 2003;40: 551-561. (Pubitemid 37494704)
23. Onohara N, Nishida M, Inoue R, Kobayashi H, Sumimoto H, Sato Y, Mori Y, Nagao T, Kurose H. TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy. EMBO J. 2006;25: 5305-5316. (Pubitemid 44764140)
24. 2+ Entry in purinergically stimulated aorta smooth muscle cells. Circ Res. 2007;101:1030-1038. (Pubitemid 350084980)
25. 2+ exchanger type-1 in vascular smooth muscle. Nat Med. 2004;10:1193-1199. (Pubitemid 39540435)
26. 2+ entry and proliferation of prostate cancer epithelial cells. Cancer Res. 2006;66:2038-2047.
27. Trebak M, Hempel N, Wedel BJ, Smyth JT, Bird GS, Putney JW, Jr. Negative regulation of TRPC3 channels by protein kinase C-mediated phosphorylation of serine 712. Mol Pharmacol. 2005;67:558-563. (Pubitemid 40216749)
28. Kwan HY, Huang Y, Yao X. Protein kinase C can inhibit TRPC3 channels indirectly via stimulating protein kinase G. J Cell Physiol. 2006;207:315-321.
29. Kwan HY, Huang Y, Yao X. Regulation of canonical transient receptor potential isoform 3 (TRPC3) channel by protein kinase G. Proc Natl Acad Sci USA. 2004;101:2625-2630. (Pubitemid 38269361)
30. Takahashi S, Lin H, Geshi N, Mori Y, Kawarabayashi Y, Takami N, Mori MX, Honda A, Inoue R. Nitric oxide-cGMP-protein kinase G pathway negatively regulates vascular transient receptor potential channel TRPC6. J Physiol. 2008;586:4209-4223.
31. 2+ entry-mediated translo-cation and activation of PLCγ2 in B lymphocytes. EMBO J. 2003;22: 4677-4688. (Pubitemid 37162904)
32. 12/13 signaling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis. EMBO J. 2008;27:3104-3115.
33. Bi D, Nishimura J, Niiro N, Hirano K, Kanaide H. Contractile properties of the cultured vascular smooth muscle cells: the crucial role played by RhoA in the regulation of contractility. Circ Res. 2005;96:890-897. (Pubitemid 40604973)
34. 2+ permeable nonselective cation channels in vascular smooth muscle: a physiologic perspective. J Car-diovasc Electrophysiol. 2002;13:493-501.
35. Inoue R, Jensen LJ, Shi J, Morita H, Nishida M, Honda A, Ito Y. Transient receptor potential channels in cardiovascular function and disease. Circ Res. 2006;99:119-131. (Pubitemid 44297035)
36. Schwede F, Maronde E, Genieser H, Jastorff B. Cyclicnucleotide analogs as biochemical tools and prospective drugs. Pharmacol Ther. 2000;87: 199-226.
37. 69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition. J Biol Chem. 2010;285:13244-13253.
38. 2+ signaling microdomains: platforms for the assembly and regulation of TRPC channels. Trends Pharmacol Sci. 2006;27:25-32. (Pubitemid 43063121)
39. 2+ sensitivity in vascular smooth muscle. J Smooth Muscle Res. 2004;40:219-236. (Pubitemid 40372154)
40. 2+ entry induces RhoA activation and resultant endothelial cell shape change in response to thrombin. J Biol Chem. 2007;282:7833-7843. (Pubitemid 47093600)
41. Nakamura K, Ikomi F, Ohhashi T. Cilostazol, an inhibitor of type 3 phosphodiesterase, produces endothelium-independent vasodilation in pressurized rabbit cerebral penetrating arterioles. J Vasc Res. 2006;43: 86-94. (Pubitemid 41832710)