Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-a signaling in the heart

Circulation Research

Volumn 106, Issue 12, 2010, Pages 1849-1860

  Kinoshita, Hideyuki ^a   Kuwahara, Koichiro ^a   Nishida, Motohiro ^b   Jian, Zhong ^c,e   Rong, Xianglu ^a   Kiyonaka, Shigeki ^d   Kuwabara, Yoshihiro ^a   Kurose, Hitoshi ^b   Inoue, Ryuji ^c   Mori, Yasuo ^d   Li, Yuhao ^a   Nakagawa, Yasuaki ^a   Usami, Satoru ^a   Fujiwara, Masataka ^a   Yamada, Yuko ^a   Minami, Takeya ^a   Ueshima, Kenji ^a   Nakao, Kazuwa ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c FUKUOKA UNIVERSITY   (Japan)

^d KYOTO UNIVERSITY   (Japan)

^e XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

calcium; hypertrophy; ion channels; natriuretic peptides

Indexed keywords

ANGIOTENSIN II; ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; BTP 2; CALCINEURIN; CALCIUM CHANNEL; CALCIUM ION; CYCLIC GMP DEPENDENT PROTEIN KINASE; GUANYLATE CYCLASE; GUANYLYL CYCLASE A; NITRENDIPINE; THREONINE; TRANSCRIPTION FACTOR NFAT; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL AFFECTING AGENT; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL STRAIN HEK293; CONTROLLED STUDY; DISEASE EXACERBATION; EMBRYO; ENZYME INHIBITION; GENE OVEREXPRESSION; HEART HYPERTROPHY; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR POTENTIAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANILIDES; ANIMALS; ATRIAL NATRIURETIC FACTOR; CALCIUM CHANNELS; CELLS, CULTURED; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DISEASE MODELS, ANIMAL; HUMANS; HYPERTROPHY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MYOCARDIUM; MYOCYTES, CARDIAC; NATRIURETIC PEPTIDE, BRAIN; NFATC TRANSCRIPTION FACTORS; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, ATRIAL NATRIURETIC FACTOR; SIGNAL TRANSDUCTION; THIADIAZOLES; TRPC CATION CHANNELS;

EID: 77954214838     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.208314     Document Type: Article

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