-
1
-
-
0024997935
-
pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-l-lysine
-
Kyriakis J.M., and Avruch J. pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-l-lysine. J. Biol. Chem. 265 (1990) 17355-17363
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 17355-17363
-
-
Kyriakis, J.M.1
Avruch, J.2
-
2
-
-
0035413618
-
MAP kinases
-
Chen Z., Gibson T.B., Robinson F., Silvestro L., Pearson G., Xu B., Wright A., Vanderbilt C., and Cobb M.H. MAP kinases. Chem. Rev. 101 (2001) 2449-2476
-
(2001)
Chem. Rev.
, vol.101
, pp. 2449-2476
-
-
Chen, Z.1
Gibson, T.B.2
Robinson, F.3
Silvestro, L.4
Pearson, G.5
Xu, B.6
Wright, A.7
Vanderbilt, C.8
Cobb, M.H.9
-
3
-
-
0034997845
-
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions
-
Pearson G., Robinson F., Beers Gibson T., Xu B.E., Karandikar M., Berman K., and Cobb M.H. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22 (2001) 153-183
-
(2001)
Endocr. Rev.
, vol.22
, pp. 153-183
-
-
Pearson, G.1
Robinson, F.2
Beers Gibson, T.3
Xu, B.E.4
Karandikar, M.5
Berman, K.6
Cobb, M.H.7
-
5
-
-
3142590478
-
Scaffold proteins in mammalian MAP kinase cascades
-
Yoshioka K. Scaffold proteins in mammalian MAP kinase cascades. J. Biochem. (Tokyo) 135 (2004) 657-661
-
(2004)
J. Biochem. (Tokyo)
, vol.135
, pp. 657-661
-
-
Yoshioka, K.1
-
6
-
-
0026165752
-
Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies
-
Boulton T.G., and Cobb M.H. Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. Cell Regul. 2 (1991) 357-371
-
(1991)
Cell Regul.
, vol.2
, pp. 357-371
-
-
Boulton, T.G.1
Cobb, M.H.2
-
7
-
-
0025823448
-
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
-
Boulton T.G., Nye S.H., Robbins D.J., Ip N.Y., Radziejewska E., Morgenbesser S.D., DePinho R.A., Panayotatos N., Cobb M.H., and Yancopoulos G.D. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 65 (1991) 663-675
-
(1991)
Cell
, vol.65
, pp. 663-675
-
-
Boulton, T.G.1
Nye, S.H.2
Robbins, D.J.3
Ip, N.Y.4
Radziejewska, E.5
Morgenbesser, S.D.6
DePinho, R.A.7
Panayotatos, N.8
Cobb, M.H.9
Yancopoulos, G.D.10
-
8
-
-
0031900740
-
Signal transduction through MAP kinase cascades
-
Lewis T.S., Shapiro P.S., and Ahn N.G. Signal transduction through MAP kinase cascades. Adv. Cancer Res. 74 (1998) 49-139
-
(1998)
Adv. Cancer Res.
, vol.74
, pp. 49-139
-
-
Lewis, T.S.1
Shapiro, P.S.2
Ahn, N.G.3
-
9
-
-
0037400510
-
Mechanisms of regulating the Raf kinase family
-
Chong H., Vikis H.G., and Guan K.L. Mechanisms of regulating the Raf kinase family. Cell. Signal. 15 (2003) 463-469
-
(2003)
Cell. Signal.
, vol.15
, pp. 463-469
-
-
Chong, H.1
Vikis, H.G.2
Guan, K.L.3
-
10
-
-
0040175067
-
Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction
-
Frodin M., and Gammeltoft S. Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction. Mol. Cell. Endocrinol. 151 (1999) 65-77
-
(1999)
Mol. Cell. Endocrinol.
, vol.151
, pp. 65-77
-
-
Frodin, M.1
Gammeltoft, S.2
-
11
-
-
17144458301
-
Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice
-
Pages G., Guerin S., Grall D., Bonino F., Smith A., Anjuere F., Auberger P., and Pouyssegur J. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science 286 (1999) 1374-1377
-
(1999)
Science
, vol.286
, pp. 1374-1377
-
-
Pages, G.1
Guerin, S.2
Grall, D.3
Bonino, F.4
Smith, A.5
Anjuere, F.6
Auberger, P.7
Pouyssegur, J.8
-
12
-
-
23444444748
-
ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis
-
Nekrasova T., Shive C., Gao Y., Kawamura K., Guardia R., Landreth G., and Forsthuber T.G. ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis. J. Immunol. 175 (2005) 2374-2380
-
(2005)
J. Immunol.
, vol.175
, pp. 2374-2380
-
-
Nekrasova, T.1
Shive, C.2
Gao, Y.3
Kawamura, K.4
Guardia, R.5
Landreth, G.6
Forsthuber, T.G.7
-
13
-
-
18444381728
-
Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory
-
Mazzucchelli C., Vantaggiato C., Ciamei A., Fasano S., Pakhotin P., Krezel W., Welzl H., Wolfer D.P., Pages G., Valverde O., Marowsky A., Porrazzo A., Orban P.C., Maldonado R., Ehrengruber M.U., Cestari V., Lipp H.P., Chapman P.F., Pouyssegur J., and Brambilla R. Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory. Neuron 34 (2002) 807-820
-
(2002)
Neuron
, vol.34
, pp. 807-820
-
-
Mazzucchelli, C.1
Vantaggiato, C.2
Ciamei, A.3
Fasano, S.4
Pakhotin, P.5
Krezel, W.6
Welzl, H.7
Wolfer, D.P.8
Pages, G.9
Valverde, O.10
Marowsky, A.11
Porrazzo, A.12
Orban, P.C.13
Maldonado, R.14
Ehrengruber, M.U.15
Cestari, V.16
Lipp, H.P.17
Chapman, P.F.18
Pouyssegur, J.19
Brambilla, R.20
more..
-
14
-
-
0035110525
-
Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning
-
Selcher J.C., Nekrasova T., Paylor R., Landreth G.E., and Sweatt J.D. Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning. Learn. Mem. 8 (2001) 11-19
-
(2001)
Learn. Mem.
, vol.8
, pp. 11-19
-
-
Selcher, J.C.1
Nekrasova, T.2
Paylor, R.3
Landreth, G.E.4
Sweatt, J.D.5
-
15
-
-
0036472327
-
Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage
-
Bost F., Caron L., Marchetti I., Dani C., Le Marchand-Brustel Y., and Binetruy B. Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage. Biochem. J. 361 (2002) 621-627
-
(2002)
Biochem. J.
, vol.361
, pp. 621-627
-
-
Bost, F.1
Caron, L.2
Marchetti, I.3
Dani, C.4
Le Marchand-Brustel, Y.5
Binetruy, B.6
-
16
-
-
19944433322
-
The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis
-
Bost F., Aouadi M., Caron L., Even P., Belmonte N., Prot M., Dani C., Hofman P., Pages G., Pouyssegur J., Le Marchand-Brustel Y., and Binetruy B. The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. Diabetes 54 (2005) 402-411
-
(2005)
Diabetes
, vol.54
, pp. 402-411
-
-
Bost, F.1
Aouadi, M.2
Caron, L.3
Even, P.4
Belmonte, N.5
Prot, M.6
Dani, C.7
Hofman, P.8
Pages, G.9
Pouyssegur, J.10
Le Marchand-Brustel, Y.11
Binetruy, B.12
-
17
-
-
0242607637
-
An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development
-
Saba-El-Leil M.K., Vella F.D., Vernay B., Voisin L., Chen L., Labrecque N., Ang S.L., and Meloche S. An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep. 4 (2003) 964-968
-
(2003)
EMBO Rep.
, vol.4
, pp. 964-968
-
-
Saba-El-Leil, M.K.1
Vella, F.D.2
Vernay, B.3
Voisin, L.4
Chen, L.5
Labrecque, N.6
Ang, S.L.7
Meloche, S.8
-
18
-
-
10744228332
-
Essential role for ERK2 mitogen-activated protein kinase in placental development
-
Hatano N., Mori Y., Oh-hora M., Kosugi A., Fujikawa T., Nakai N., Niwa H., Miyazaki J., Hamaoka T., and Ogata M. Essential role for ERK2 mitogen-activated protein kinase in placental development. Genes Cells 8 (2003) 847-856
-
(2003)
Genes Cells
, vol.8
, pp. 847-856
-
-
Hatano, N.1
Mori, Y.2
Oh-hora, M.3
Kosugi, A.4
Fujikawa, T.5
Nakai, N.6
Niwa, H.7
Miyazaki, J.8
Hamaoka, T.9
Ogata, M.10
-
19
-
-
0242300107
-
Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation
-
Yao Y., Li W., Wu J., Germann U.A., Su M.S., Kuida K., and Boucher D.M. Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation. Proc. Natl. Acad. Sci. USA 100 (2003) 12759-12764
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 12759-12764
-
-
Yao, Y.1
Li, W.2
Wu, J.3
Germann, U.A.4
Su, M.S.5
Kuida, K.6
Boucher, D.M.7
-
20
-
-
26644459229
-
The role of erk1 and erk2 in multiple stages of T cell development
-
Fischer A.M., Katayama C.D., Pages G., Pouyssegur J., and Hedrick S.M. The role of erk1 and erk2 in multiple stages of T cell development. Immunity 23 (2005) 431-443
-
(2005)
Immunity
, vol.23
, pp. 431-443
-
-
Fischer, A.M.1
Katayama, C.D.2
Pages, G.3
Pouyssegur, J.4
Hedrick, S.M.5
-
21
-
-
0028329953
-
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
-
Derijard B., Hibi M., Wu I.H., Barrett T., Su B., Deng T., Karin M., and Davis R.J. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76 (1994) 1025-1037
-
(1994)
Cell
, vol.76
, pp. 1025-1037
-
-
Derijard, B.1
Hibi, M.2
Wu, I.H.3
Barrett, T.4
Su, B.5
Deng, T.6
Karin, M.7
Davis, R.J.8
-
22
-
-
0028229012
-
The stress-activated protein kinase subfamily of c-Jun kinases
-
Kyriakis J.M., Banerjee P., Nikolakaki E., Dai T., Rubie E.A., Ahmad M.F., Avruch J., and Woodgett J.R. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369 (1994) 156-160
-
(1994)
Nature
, vol.369
, pp. 156-160
-
-
Kyriakis, J.M.1
Banerjee, P.2
Nikolakaki, E.3
Dai, T.4
Rubie, E.A.5
Ahmad, M.F.6
Avruch, J.7
Woodgett, J.R.8
-
23
-
-
0035066383
-
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
-
Kyriakis J.M., and Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81 (2001) 807-869
-
(2001)
Physiol. Rev.
, vol.81
, pp. 807-869
-
-
Kyriakis, J.M.1
Avruch, J.2
-
24
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
Davis R.J. Signal transduction by the JNK group of MAP kinases. Cell 103 (2000) 239-252
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.J.1
-
25
-
-
0031453248
-
The JUN kinase/stress-activated protein kinase pathway is required for epidermal growth factor stimulation of growth of human A549 lung carcinoma cells
-
Bost F., McKay R., Dean N., and Mercola D. The JUN kinase/stress-activated protein kinase pathway is required for epidermal growth factor stimulation of growth of human A549 lung carcinoma cells. J. Biol. Chem. 272 (1997) 33422-33429
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 33422-33429
-
-
Bost, F.1
McKay, R.2
Dean, N.3
Mercola, D.4
-
26
-
-
0032509479
-
Defective T cell differentiation in the absence of Jnk1
-
Dong C., Yang D.D., Wysk M., Whitmarsh A.J., Davis R.J., and Flavell R.A. Defective T cell differentiation in the absence of Jnk1. Science 282 (1998) 2092-2095
-
(1998)
Science
, vol.282
, pp. 2092-2095
-
-
Dong, C.1
Yang, D.D.2
Wysk, M.3
Whitmarsh, A.J.4
Davis, R.J.5
Flavell, R.A.6
-
27
-
-
0034604093
-
JNK is required for effector T-cell function but not for T-cell activation
-
Dong C., Yang D.D., Tournier C., Whitmarsh A.J., Xu J., Davis R.J., and Flavell R.A. JNK is required for effector T-cell function but not for T-cell activation. Nature 405 (2000) 91-94
-
(2000)
Nature
, vol.405
, pp. 91-94
-
-
Dong, C.1
Yang, D.D.2
Tournier, C.3
Whitmarsh, A.J.4
Xu, J.5
Davis, R.J.6
Flavell, R.A.7
-
28
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J., Tuncman G., Chang L., Gorgun C.Z., Uysal K.T., Maeda K., Karin M., and Hotamisligil G.S. A central role for JNK in obesity and insulin resistance. Nature 420 (2002) 333-336
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Gorgun, C.Z.4
Uysal, K.T.5
Maeda, K.6
Karin, M.7
Hotamisligil, G.S.8
-
29
-
-
33644813043
-
JNK1 but not JNK2 promotes the development of steatohepatitis in mice
-
Schattenberg J.M., Singh R., Wang Y., Lefkowitch J.H., Rigoli R.M., Scherer P.E., and Czaja M.J. JNK1 but not JNK2 promotes the development of steatohepatitis in mice. Hepatology 43 (2006) 163-172
-
(2006)
Hepatology
, vol.43
, pp. 163-172
-
-
Schattenberg, J.M.1
Singh, R.2
Wang, Y.3
Lefkowitch, J.H.4
Rigoli, R.M.5
Scherer, P.E.6
Czaja, M.J.7
-
30
-
-
0032724021
-
Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2
-
Sabapathy K., Jochum W., Hochedlinger K., Chang L., Karin M., and Wagner E.F. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech. Dev. 89 (1999) 115-124
-
(1999)
Mech. Dev.
, vol.89
, pp. 115-124
-
-
Sabapathy, K.1
Jochum, W.2
Hochedlinger, K.3
Chang, L.4
Karin, M.5
Wagner, E.F.6
-
31
-
-
0032191173
-
Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2
-
Yang D.D., Conze D., Whitmarsh A.J., Barrett T., Davis R.J., Rincon M., and Flavell R.A. Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. Immunity 9 (1998) 575-585
-
(1998)
Immunity
, vol.9
, pp. 575-585
-
-
Yang, D.D.1
Conze, D.2
Whitmarsh, A.J.3
Barrett, T.4
Davis, R.J.5
Rincon, M.6
Flavell, R.A.7
-
32
-
-
21044453408
-
Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes
-
(Epub 2005)
-
Jaeschke A., Rincon M., Doran B., Reilly J., Neuberg D., Greiner D.L., Shultz L.D., Rossini A.A., Flavell R.A., and Davis R.J. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proc. Natl. Acad. Sci. USA 102 (2005) 6931-6935 (Epub 2005)
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 6931-6935
-
-
Jaeschke, A.1
Rincon, M.2
Doran, B.3
Reilly, J.4
Neuberg, D.5
Greiner, D.L.6
Shultz, L.D.7
Rossini, A.A.8
Flavell, R.A.9
Davis, R.J.10
-
33
-
-
0030780804
-
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
-
Yang D.D., Kuan C.Y., Whitmarsh A.J., Rincon M., Zheng T.S., Davis R.J., Rakic P., and Flavell R.A. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389 (1997) 865-870
-
(1997)
Nature
, vol.389
, pp. 865-870
-
-
Yang, D.D.1
Kuan, C.Y.2
Whitmarsh, A.J.3
Rincon, M.4
Zheng, T.S.5
Davis, R.J.6
Rakic, P.7
Flavell, R.A.8
-
34
-
-
0033118607
-
The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
-
Kuan C.Y., Yang D.D., Samanta Roy D.R., Davis R.J., Rakic P., and Flavell R.A. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22 (1999) 667-676
-
(1999)
Neuron
, vol.22
, pp. 667-676
-
-
Kuan, C.Y.1
Yang, D.D.2
Samanta Roy, D.R.3
Davis, R.J.4
Rakic, P.5
Flavell, R.A.6
-
35
-
-
0034607702
-
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
-
Tournier C., Hess P., Yang D.D., Xu J., Turner T.K., Nimnual A., Bar-Sagi D., Jones S.N., Flavell R.A., and Davis R.J. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288 (2000) 870-874
-
(2000)
Science
, vol.288
, pp. 870-874
-
-
Tournier, C.1
Hess, P.2
Yang, D.D.3
Xu, J.4
Turner, T.K.5
Nimnual, A.6
Bar-Sagi, D.7
Jones, S.N.8
Flavell, R.A.9
Davis, R.J.10
-
36
-
-
0027936755
-
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
-
Han J., Lee J.D., Bibbs L., and Ulevitch R.J. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265 (1994) 808-811
-
(1994)
Science
, vol.265
, pp. 808-811
-
-
Han, J.1
Lee, J.D.2
Bibbs, L.3
Ulevitch, R.J.4
-
37
-
-
0027424403
-
Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14
-
Han J., Lee J.D., Tobias P.S., and Ulevitch R.J. Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14. J. Biol. Chem. 268 (1993) 25009-25014
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 25009-25014
-
-
Han, J.1
Lee, J.D.2
Tobias, P.S.3
Ulevitch, R.J.4
-
38
-
-
0029982565
-
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)
-
Jiang Y., Chen C., Li Z., Guo W., Gegner J.A., Lin S., and Han J. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J. Biol. Chem. 271 (1996) 17920-17926
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 17920-17926
-
-
Jiang, Y.1
Chen, C.2
Li, Z.3
Guo, W.4
Gegner, J.A.5
Lin, S.6
Han, J.7
-
39
-
-
0029911710
-
ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation
-
Lechner C., Zahalka M.A., Giot J.F., Moller N.P., and Ullrich A. ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation. Proc. Natl. Acad. Sci. USA 93 (1996) 4355-4359
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 4355-4359
-
-
Lechner, C.1
Zahalka, M.A.2
Giot, J.F.3
Moller, N.P.4
Ullrich, A.5
-
40
-
-
0030581626
-
The primary structure of p38 gamma: a new member of p38 group of MAP kinases
-
Li Z., Jiang Y., Ulevitch R.J., and Han J. The primary structure of p38 gamma: a new member of p38 group of MAP kinases. Biochem. Biophys. Res. Commun. 228 (1996) 334-340
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.228
, pp. 334-340
-
-
Li, Z.1
Jiang, Y.2
Ulevitch, R.J.3
Han, J.4
-
41
-
-
0030828701
-
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta
-
Jiang Y., Gram H., Zhao M., New L., Gu J., Feng L., Di Padova F., Ulevitch R.J., and Han J. Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta. J. Biol. Chem. 272 (1997) 30122-30128
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 30122-30128
-
-
Jiang, Y.1
Gram, H.2
Zhao, M.3
New, L.4
Gu, J.5
Feng, L.6
Di Padova, F.7
Ulevitch, R.J.8
Han, J.9
-
42
-
-
0031587929
-
Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles
-
Kumar S., McDonnell P.C., Gum R.J., Hand A.T., Lee J.C., and Young P.R. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem. Biophys. Res. Commun. 235 (1997) 533-538
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.235
, pp. 533-538
-
-
Kumar, S.1
McDonnell, P.C.2
Gum, R.J.3
Hand, A.T.4
Lee, J.C.5
Young, P.R.6
-
43
-
-
0031916832
-
Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6
-
Enslen H., Raingeaud J., and Davis R.J. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J. Biol. Chem. 273 (1998) 1741-1748
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 1741-1748
-
-
Enslen, H.1
Raingeaud, J.2
Davis, R.J.3
-
44
-
-
0029020282
-
Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification
-
Hanks S.K., and Hunter T. Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J. 9 (1995) 576-596
-
(1995)
FASEB J.
, vol.9
, pp. 576-596
-
-
Hanks, S.K.1
Hunter, T.2
-
45
-
-
19644367000
-
Activation and signaling of the p38 MAP kinase pathway
-
Zarubin T., and Han J. Activation and signaling of the p38 MAP kinase pathway. Cell Res. 15 (2005) 11-18
-
(2005)
Cell Res.
, vol.15
, pp. 11-18
-
-
Zarubin, T.1
Han, J.2
-
46
-
-
0034697904
-
Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis
-
Tamura K., Sudo T., Senftleben U., Dadak A.M., Johnson R., and Karin M. Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102 (2000) 221-231
-
(2000)
Cell
, vol.102
, pp. 221-231
-
-
Tamura, K.1
Sudo, T.2
Senftleben, U.3
Dadak, A.M.4
Johnson, R.5
Karin, M.6
-
47
-
-
0034641614
-
Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis
-
Mudgett J.S., Ding J., Guh-Siesel L., Chartrain N.A., Yang L., Gopal S., and Shen M.M. Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc. Natl. Acad. Sci. USA 97 (2000) 10454-10459
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 10454-10459
-
-
Mudgett, J.S.1
Ding, J.2
Guh-Siesel, L.3
Chartrain, N.A.4
Yang, L.5
Gopal, S.6
Shen, M.M.7
-
48
-
-
0034610981
-
Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells
-
Allen M., Svensson L., Roach M., Hambor J., McNeish J., and Gabel C.A. Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells. J. Exp. Med. 191 (2000) 859-870
-
(2000)
J. Exp. Med.
, vol.191
, pp. 859-870
-
-
Allen, M.1
Svensson, L.2
Roach, M.3
Hambor, J.4
McNeish, J.5
Gabel, C.A.6
-
49
-
-
0033622470
-
Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development
-
Adams R.H., Porras A., Alonso G., Jones M., Vintersten K., Panelli S., Valladares A., Perez L., Klein R., and Nebreda A.R. Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol. Cell 6 (2000) 109-116
-
(2000)
Mol. Cell
, vol.6
, pp. 109-116
-
-
Adams, R.H.1
Porras, A.2
Alonso, G.3
Jones, M.4
Vintersten, K.5
Panelli, S.6
Valladares, A.7
Perez, L.8
Klein, R.9
Nebreda, A.R.10
-
50
-
-
20444496117
-
Regulation of vertebrate myotome development by the p38 MAP kinase-MEF2 signaling pathway
-
de Angelis L., Zhao J., Andreucci J.J., Olson E.N., Cossu G., and McDermott J.C. Regulation of vertebrate myotome development by the p38 MAP kinase-MEF2 signaling pathway. Dev. Biol. 283 (2005) 171-179
-
(2005)
Dev. Biol.
, vol.283
, pp. 171-179
-
-
de Angelis, L.1
Zhao, J.2
Andreucci, J.J.3
Olson, E.N.4
Cossu, G.5
McDermott, J.C.6
-
51
-
-
23144441633
-
p38 mitogen-activated protein kinase (MAPK) first regulates filamentous actin at the 8-16-cell stage during preimplantation development
-
Paliga A.J., Natale D.R., and Watson A.J. p38 mitogen-activated protein kinase (MAPK) first regulates filamentous actin at the 8-16-cell stage during preimplantation development. Biol. Cell. 97 (2005) 629-640
-
(2005)
Biol. Cell.
, vol.97
, pp. 629-640
-
-
Paliga, A.J.1
Natale, D.R.2
Watson, A.J.3
-
52
-
-
33746325064
-
P38MAPK activity commits embryonic stem cells to either neurogenesis or cardiomyogenesis
-
Aouadi M., Bost F., Caron L., Laurent K., Le Marchand Brustel Y., and Binetruy B. P38MAPK activity commits embryonic stem cells to either neurogenesis or cardiomyogenesis. Stem Cells 24 (2006) 1399-1406
-
(2006)
Stem Cells
, vol.24
, pp. 1399-1406
-
-
Aouadi, M.1
Bost, F.2
Caron, L.3
Laurent, K.4
Le Marchand Brustel, Y.5
Binetruy, B.6
-
53
-
-
33644751833
-
Inhibition of p38MAPK increases adipogenesis from embryonic to adult stages
-
Aouadi M., Laurent K., Prot M., Le Marchand-Brustel Y., Binetruy B., and Bost F. Inhibition of p38MAPK increases adipogenesis from embryonic to adult stages. Diabetes 55 (2006) 281-289
-
(2006)
Diabetes
, vol.55
, pp. 281-289
-
-
Aouadi, M.1
Laurent, K.2
Prot, M.3
Le Marchand-Brustel, Y.4
Binetruy, B.5
Bost, F.6
-
54
-
-
27944461325
-
Generation and characterization of p38beta (MAPK11) gene-targeted mice
-
Beardmore V.A., Hinton H.J., Eftychi C., Apostolaki M., Armaka M., Darragh J., McIlrath J., Carr J.M., Armit L.J., Clacher C., Malone L., Kollias G., and Arthur J.S. Generation and characterization of p38beta (MAPK11) gene-targeted mice. Mol. Cell. Biol. 25 (2005) 10454-10464
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 10454-10464
-
-
Beardmore, V.A.1
Hinton, H.J.2
Eftychi, C.3
Apostolaki, M.4
Armaka, M.5
Darragh, J.6
McIlrath, J.7
Carr, J.M.8
Armit, L.J.9
Clacher, C.10
Malone, L.11
Kollias, G.12
Arthur, J.S.13
-
55
-
-
20244365497
-
p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP
-
Sabio G., Arthur J.S., Kuma Y., Peggie M., Carr J., Murray-Tait V., Centeno F., Goedert M., Morrice N.A., and Cuenda A. p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. EMBO J. 24 (2005) 1134-1145
-
(2005)
EMBO J.
, vol.24
, pp. 1134-1145
-
-
Sabio, G.1
Arthur, J.S.2
Kuma, Y.3
Peggie, M.4
Carr, J.5
Murray-Tait, V.6
Centeno, F.7
Goedert, M.8
Morrice, N.A.9
Cuenda, A.10
-
56
-
-
0030694387
-
BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C
-
Kato Y., Kravchenko V.V., Tapping R.I., Han J., Ulevitch R.J., and Lee J.D. BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. EMBO J. 16 (1997) 7054-7066
-
(1997)
EMBO J.
, vol.16
, pp. 7054-7066
-
-
Kato, Y.1
Kravchenko, V.V.2
Tapping, R.I.3
Han, J.4
Ulevitch, R.J.5
Lee, J.D.6
-
57
-
-
0032531881
-
Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor
-
Kato Y., Tapping R.I., Huang S., Watson M.H., Ulevitch R.J., and Lee J.D. Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. Nature 395 (1998) 713-716
-
(1998)
Nature
, vol.395
, pp. 713-716
-
-
Kato, Y.1
Tapping, R.I.2
Huang, S.3
Watson, M.H.4
Ulevitch, R.J.5
Lee, J.D.6
-
58
-
-
0033579552
-
MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway
-
Chao T.H., Hayashi M., Tapping R.I., Kato Y., and Lee J.D. MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway. J. Biol. Chem. 274 (1999) 36035-36038
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 36035-36038
-
-
Chao, T.H.1
Hayashi, M.2
Tapping, R.I.3
Kato, Y.4
Lee, J.D.5
-
59
-
-
0034769309
-
Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells
-
Dinev D., Jordan B.W., Neufeld B., Lee J.D., Lindemann D., Rapp U.R., and Ludwig S. Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells. EMBO Rep 2 (2001) 829-834
-
(2001)
EMBO Rep
, vol.2
, pp. 829-834
-
-
Dinev, D.1
Jordan, B.W.2
Neufeld, B.3
Lee, J.D.4
Lindemann, D.5
Rapp, U.R.6
Ludwig, S.7
-
60
-
-
0038491472
-
ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons
-
Liu L., Cavanaugh J.E., Wang Y., Sakagami H., Mao Z., and Xia Z. ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons. Proc. Natl. Acad. Sci. USA 100 (2003) 8532-8537
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 8532-8537
-
-
Liu, L.1
Cavanaugh, J.E.2
Wang, Y.3
Sakagami, H.4
Mao, Z.5
Xia, Z.6
-
61
-
-
2142659374
-
Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure
-
Hayashi M., Kim S.W., Imanaka-Yoshida K., Yoshida T., Abel E.D., Eliceiri B., Yang Y., Ulevitch R.J., and Lee J.D. Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. J. Clin. Invest. 113 (2004) 1138-1148
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 1138-1148
-
-
Hayashi, M.1
Kim, S.W.2
Imanaka-Yoshida, K.3
Yoshida, T.4
Abel, E.D.5
Eliceiri, B.6
Yang, Y.7
Ulevitch, R.J.8
Lee, J.D.9
-
62
-
-
12444285810
-
Role of the BMK1/ERK5 signaling pathway: lessons from knockout mice
-
(Epub 2004)
-
Hayashi M., and Lee J.D. Role of the BMK1/ERK5 signaling pathway: lessons from knockout mice. J. Mol. Med. 82 (2004) 800-808 (Epub 2004)
-
(2004)
J. Mol. Med.
, vol.82
, pp. 800-808
-
-
Hayashi, M.1
Lee, J.D.2
-
63
-
-
0037047109
-
Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects
-
Regan C.P., Li W., Boucher D.M., Spatz S., Su M.S., and Kuida K. Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects. Proc. Natl. Acad. Sci. USA 99 (2002) 9248-9253
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 9248-9253
-
-
Regan, C.P.1
Li, W.2
Boucher, D.M.3
Spatz, S.4
Su, M.S.5
Kuida, K.6
-
64
-
-
0037044718
-
ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression
-
Sohn S.J., Sarvis B.K., Cado D., and Winoto A. ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression. J. Biol. Chem. 277 (2002) 43344-43351
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 43344-43351
-
-
Sohn, S.J.1
Sarvis, B.K.2
Cado, D.3
Winoto, A.4
-
65
-
-
0037380693
-
Single-dose pharmacokinetics and pharmacodynamics of RWJ 67657, a specific p38 mitogen-activated protein kinase inhibitor: a first-in-human study
-
Parasrampuria D.A., de Boer P., Desai-Krieger D., Chow A.T., and Jones C.R. Single-dose pharmacokinetics and pharmacodynamics of RWJ 67657, a specific p38 mitogen-activated protein kinase inhibitor: a first-in-human study. J. Clin. Pharmacol. 43 (2003) 406-413
-
(2003)
J. Clin. Pharmacol.
, vol.43
, pp. 406-413
-
-
Parasrampuria, D.A.1
de Boer, P.2
Desai-Krieger, D.3
Chow, A.T.4
Jones, C.R.5
-
66
-
-
0142183227
-
p38 mitogen-activated protein kinase inhibitors for the treatment of chronic cardiovascular disease
-
Behr T.M., Berova M., Doe C.P., Ju H., Angermann C.E., Boehm J., and Willette R.N. p38 mitogen-activated protein kinase inhibitors for the treatment of chronic cardiovascular disease. Curr. Opin. Investig. Drugs 4 (2003) 1059-1064
-
(2003)
Curr. Opin. Investig. Drugs
, vol.4
, pp. 1059-1064
-
-
Behr, T.M.1
Berova, M.2
Doe, C.P.3
Ju, H.4
Angermann, C.E.5
Boehm, J.6
Willette, R.N.7
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