Preparation and in vivo characterization of a cocaine hydrolase engineered from human butyrylcholinesterase for metabolizing cocaine

Biochemical Journal

Volumn 453, Issue 3, 2013, Pages 447-454

  Xue, Liu ^a   Hou, Shurong ^a   Tong, Min ^a   Fang, Lei ^a   Chen, Xiabin ^a   Jin, Zhenyu ^a   Tai, Hsin Hsiung ^a   Zheng, Fang ^a   Zhan, Chang Guo ^a  

^a University of Kentucky   (United States)

Author keywords

Butyrylcholinesterase; Drug abuse; Protein drug; Protein production; Stable cell line

Indexed keywords

CHOLINESTERASE; COCAINE; COCAINE HYDROLASE; HYDROLASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG CLEARANCE; DRUG METABOLISM; ENZYME STABILITY; FEMALE; HYPERACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LENTIVIRINAE; LOCOMOTION; MALE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; PRODUCTIVITY; PROTEIN EXPRESSION; RAT; SCALE UP; SUBSTANCE ABUSE; ANIMAL; CELL LINE; CHO CELL; COCAINE DEPENDENCE; DRUG EFFECT; GENETICS; HAMSTER; HUMAN; METABOLISM; METHODOLOGY; MOTOR ACTIVITY; MOUSE; PROTEIN ENGINEERING; SPRAGUE DAWLEY RAT;

ANIMALS; BUTYRYLCHOLINESTERASE; CELL LINE; CHO CELLS; COCAINE; COCAINE-RELATED DISORDERS; CRICETINAE; FEMALE; HUMANS; MALE; MICE; MOTOR ACTIVITY; PROTEIN ENGINEERING; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84880048875     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130549     Document Type: Article

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