Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice

Chemico-Biological Interactions

Volumn 203, Issue 1, 2013, Pages 212-216

  Brimijoin, Stephen ^a   Orson, Frank ^b,c,d   Kosten, Thomas R ^b,c,d   Kinsey, Berma ^b,d   Shen, Xiao Yun ^b,d   White, Sarah J ^a,e   Gao, Yang ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b Department of Medicine ^*  (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e MAYO CLINIC   (United States)

Author keywords

Brain cocaine; Locomotor stimulation; Metabolism and distribution; Therapeutic antibody

Indexed keywords

CHOLINESTERASE; COCAINE ANTIBODY; COCAINE HYDROLASE; HYDROLASE; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TRAPPING; ANTIGEN BINDING; COCAINE DEPENDENCE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG SEEKING BEHAVIOR; ENZYME ACTIVITY; ENZYME ANALYSIS; FEMALE; GENE TRANSFER; LOCOMOTION; LOW DRUG DOSE; MALE; METABOLISM; MOUSE; NONHUMAN;

ANIMALS; ANTIBODIES; BRAIN; BUTYRYLCHOLINESTERASE; COCAINE; COCAINE-RELATED DISORDERS; DRUG-SEEKING BEHAVIOR; HUMANS; HYDROLASES; MALE; MICE; MICE, INBRED BALB C; MOTOR ACTIVITY; RATS; RECOMBINANT PROTEINS; VACCINES;

MUS; RATTUS;

EID: 84875807718     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.08.015     Document Type: Conference Paper

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