Wild-type and A328W mutant human butyrylcholinesterase tetramers expressed in Chinese hamster ovary cells have a 16-hour half-life in the circulation and protect mice from cocaine toxicity

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 2, 2002, Pages 751-758

  Duysen, Ellen G ^a   Bartels, Cynthia F ^a   Lockridge, Oksana ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINESTERASE; COCAINE; DIMER; MONOMER; RECOMBINANT ENZYME; TETRAMER;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHO CELL; CIRCULATION; CONTROLLED STUDY; DRUG EFFECT; DRUG HALF LIFE; ENZYME MECHANISM; GEL ELECTROPHORESIS; HUMAN; HYDROLYSIS; INTOXICATION; LOCOMOTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BASE SEQUENCE; BUTYRYLCHOLINESTERASE; CHO CELLS; COCAINE; CRICETINAE; HALF-LIFE; HUMANS; KINETICS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 0036070598     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.033746     Document Type: Article

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