Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 2, 2002, Pages 710-716

  Sun, Hong ^a,b,c,d   Shen, Maryann L ^a,b,c,d   Pang, Yuan Ping ^a,b,c,d   Lockridge, Oksana ^a,b,c,d   Brimijoin, Stephen ^a,b,c,d  

^a Molecular Neuroscience Program   (United States)

^b Department of Molecular Pharmacology and Experimental Therapeutics ^*  (United States)

^c MAYO CLINIC CANCER CENTER   (United States)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOIC ACID; CHOLINESTERASE; COCAINE; HYDROLASE; RECOMBINANT A328W Y332A BUTYRYLCHOLINESTERASE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DETOXIFICATION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG INTOXICATION; DRUG METABOLISM; ENZYME ENGINEERING; ENZYME KINETICS; MALE; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; RAT; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; BUTYRYLCHOLINESTERASE; COCAINE; HALF-LIFE; HUMANS; MASS SPECTROMETRY; METABOLIC CLEARANCE RATE; MUTAGENESIS; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; TISSUE DISTRIBUTION;

EID: 0036073873     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.302.2.710     Document Type: Article

References (34)

1. Association of tetramers of human butyrylcholinesterase is mediated by conserved aromatic residues of the carboxy terminus
2. Structure of the gene for human butyrylcholinesterase. Evidence for a single copy
3. Kinetics and rat locomotor activity following cocaine and lidocaine administration
4. The presence of cocaine and benzoylecgonine in rat cerebrospinal fluid after the intravenous administration of cocaine
5. Butyrylcholinesterase accelerates cocaine metabolism: In vitro and in vivo effects in nonhuman primates and humans
6. Attenuation of cocaine-induced locomotor activity by butyrylcholinesterase
7. Correlation of saliva cocaine levels with plasma levels and with pharmacologic effects after intravenous cocaine administration in human subjects
8. Enhancing cocaine metabolism with butyrylcholinesterase as a treatment strategy
9. Association between life-threatening cocaine toxicity and plasma cholinesterase activity
10. Administration of purified human plasma cholinesterase protects against cocaine toxicity in mice
11. The management of cocaine-associated myocardial ischemia
12. Determination of cocaine in human urine, plasma and red blood cells by gas-liquid chromatography
13. The mammalian gene of acetylcholinesterase-associated collagen
14. Antibody-catalyzed degradation of cocaine
15. Crystal structure of a bacterial cocaine esterase
16. Acute effects of cocaine on spontaneous and discriminative motor functions: Relation to route of administration and pharmacokinetics
17. Pharmacokinetic-pharmacodynamic modeling of the psychomotor stimulant effect of cocaine after intravenous administration: Timing performance deficits
18. Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse
19. Cocaine detoxification by human plasma butyrylcholinesterase
20. Effects of cocaine and cocaine metabolites on cerebral arteries in vitro
21. Therapeutic use of butyrylcholinesterase for cocaine intoxication
22. Disposition and metabolism of [3H] cocaine in acutely and chronically treated monkeys
23. Sensitive and specific high-performance liquid chromatographic assay with ultraviolet detection for the determination of cocaine and its metabolites in rat plasma
24. Cocaine and alcohol interactions in the rat: Contribution of cocaine metabolites to the pharmacological effects
25. Role of oligosaccharides in the pharmacokinetics of tissue-derived and genetically engineered cholinesterases
26. A validated stable isotope dilution liquid chromatography tandem mass spectrometry assay for the trace analysis of cocaine and its major metabolites in plasma
27. N-Demethylation of cocaine in the rat and in isolated rat hepatocytes: Comparison with aminopyrine demethylation
28. Hydrolysis of cocaine in human plasma by cholinesterase
29. Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase: Engineering effective butyrylcholinesterase mutants for cocaine detoxification
30. Re-engineering butyrylcholinesterase as a cocaine hydrolase
31. Simultaneous pharmacokinetic modeling of cocaine and its metabolites, norcocaine and benzoylecgonine, after intravenous and oral administration in rats
32. Death caused by recreational cocaine use
33. An improved cocaine hydrolase: The A328Y mutant of human butyrylcholinesterase is 4-fold more efficient