Relationship between subjective effects of cocaine and dopamine transporter occupancy

Nature

Volumn 386, Issue 6627, 1997, Pages 827-830

  Volkow, N D ^a,b   Wang, G J ^a   Fischman, M W ^c   Foltint, R W ^c   Fowler, J S ^a   Abumrad, N N ^d   Vitkun, S ^b   Logan, J ^a   Gatley, S J ^a   Pappas, N ^a   Hitzemann, R ^b   Shea, C E ^a  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c Columbia University ^*  (United States)

^d Northshore University Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE;

ARTICLE; BRAIN LEVEL; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; DRUG ABUSE; DRUG DEPENDENCE; HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

EID: 0030995126     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/386827a0     Document Type: Article

References (24)

1. Ritz, M. C., Lamb, R. J., Goldberg, S. R. & Kuhar, M. J. Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science 237, 1219-1223 (1987).
2. Koob, G. F. & Bloom, F. E. Cellular and molecular mechanism of drug dependence. Science 242, 715-723 (1988).
3. 3H] cocaine binding sites in caudate-putamen. J. Pharmacol. Exp. Ther. 251, 131-141 (1989).
4. Giros, B., Jaber, M., Jones, S. R., Wightman, R. M. & Caron, M. G. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379, 606-612 (1996).
5. Fowler, J. et al. Mapping cocaine-binding sites in human and baboon brain in vivo. Synapse 4, 371-377 (1989).
6. Pogun, S., Scheffel, U. & Kuhar, M. J. Cocaine displaces 3H-WIN 35,248 binding to dopamine uptake sites in vivo more rapidly than mazindol or GBR 12,909. Eur. J. Pharmacol. 198, 203-205 (1991).
7. Gatley, S. J. et al. Displacement of RTI-55 from the dopamine transporter by cocaine. Eur. J. Pharmacol. 296, 145-151 (1996).
8. 11C] raclopride binding in the brain: model simulations and kinetic analysis of PET data. J. Cereb. Blood Flow Metab. 14, 995-1010 (1994).
9. Nestler, E. J. Molecular mechanisms of drug addiction. J. Neurosci. 12, 2439-2450 (1992).
10. Volkow, N. D. et al. Temporal relationships between the pharmacokinetics of methylphenidate in the human brain and its behavioral and cardiovascular effects. Psychopharmacology 123, 26-33 (1996).
11. Fischman, M. W. & Foltin, R. W. Utility of subjective-effects measurements in assessing abuse liability of drugs in humans. Br. J. Addiction 86, 1563-1570 (1991).
12. Fischman, M. W. in Testing for Abuse Liability of Drugs in Humans, NIDA Research Monographs Vol. 92 (eds Fischman, M. W. & Mello, N. H.) 211-230 (Government Printing Office, Washington DC, 1989).
13. Pettit, H. O. & Justice, J. B. Effect of dose in cocaine self-administration behavior and dopamine levels in the nucleus accumbens. Brain Res. 539, 94-102 (1991).
14. Balster, R. L. & Schuster, C. R. Fixed interval schedule of cocaine reinforcement: effect of dose and infusion duration. J. Exp. Anal. Behav. 20, 119-129 (1973).
15. Stathis, M. et al. Rate of binding of various inhibitors at the dopamine transporter in vivo. Psychopharmacology 119, 376-384 (1995).
16. Verbey, K. & Gold, M. S. From coca leaves to crack: the effects of dose and routes of administration in abuse liability. Psychiatr. Ann. 18, 513-520 (1988).
17. Rothman, R. B. High affinity dopamine reuptake inhibitors as potential cocaine antagonists: a strategy for drug development. Life Sci. 46, 17-21 (1990).
18. Pettit, H. O., Ettenberg, A., Bloom, F. E. & Koob, G. F. Destruction of dopamine in the nucleus accumbens selectively attentuates cocaine but not heroin self-administration in rats. Psychopharmacology 84, 167-173 (1984).
19. Pontieri, F. E., Tanda, G., Orzi, F. & Di Chiara, G. Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs. Nature 382, 255-257 (1996).
20. Izenwasser, S., Werling, L. L. & Cox, B. M. Comparison of the effects of cocaine and other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex. Brain Res. 520, 303-309 (1990).
21. Javaid, J. I., Fischman, M. W., Schuster, C. R., Dekirmenjiian, H. & Davis, J. M. Cocaine plasma concentration: relation to physiological and subjective effects in human. Science 202, 227-228 (1978).
22. Gatley, S. J. et al. A model for estimating dopamine transporter occupancy and subsequent increases in synaptic dopamine using positron emission tomography and carbon-11 labeled cocaine. Biochem. Pharmacol. 51, 43-52 (1997).
23. Volkow, N. D. et al. Carbon-11-cocaine binding compared at sub-pharmacological and pharmacological doses: a PET study. J. Nucl. Med. 36, 1289-1297 (1995).
24. 11C-methyl]-(1)-cocaine PET studies in human subjects. J. Cereb. Blood Flow Metab. 10, 740-747 (1990).