Mediator Complex Dependent Regulation of Cardiac Development and Disease

Genomics, Proteomics and Bioinformatics

Volumn 11, Issue 3, 2013, Pages 151-157

  Grueter, Chad E ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Cardiac disease; Development; Mediator complex; Transcription

Indexed keywords

CYCLIN DEPENDENT KINASE 19; CYCLIN DEPENDENT KINASE 8; MEDIATOR COMPLEX; MEDIATOR COMPLEX 12; MEDIATOR COMPLEX 19; MEDIATOR COMPLEX 23; MEDIATOR COMPLEX 25; MEDIATOR COMPLEX 28; MEDIATOR COMPLEX 29; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR BINDING PROTEIN; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

CARDIOVASCULAR DISEASE; GENE MUTATION; HEART; HEART DEVELOPMENT; HEART FUNCTION; HUMAN; METABOLISM; NONHUMAN; PROTEIN FUNCTION; REVIEW;

ANIMALS; CARDIOVASCULAR DISEASES; CELL NUCLEUS; GENE EXPRESSION REGULATION; HEART; HUMANS; MEDIATOR COMPLEX; MUTATION; MYOCARDIUM; RNA, UNTRANSLATED; TRANSCRIPTION, GENETIC;

EID: 84879785584     PISSN: 16720229     EISSN: 22103244     Source Type: Journal    
DOI: 10.1016/j.gpb.2013.05.002     Document Type: Review

References (110)

1. Mendis S., Puska P., Norrving B. Global atlas on cardiovascular disease prevention and control 2011, World Health Organization, Switzerland.
2. Go A.S., Mozaffarian D., Roger V.L., Benjamin E.J., Berry J.D., Borden W.B., et al. Heart disease and stroke statistics - 2013 update: a report from the American Heart Association. Circulation 2013, 127:e6-245.
3. Quiat D., Olson E.N. MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment. J Clin Invest 2013, 123:11-18.
4. Wilson P.W., Culleton B.F. Epidemiology of cardiovascular disease in the United States. Am J Kidney Dis 1998, 32:S56-S65.
5. Grundy S.M., Brewer H.B., Cleeman J.I., Smith S.C., Lenfant C., American Heart A., et al. Definition of metabolic syndrome: report of the national heart, lung, and blood institute/American heart association conference on scientific issues related to definition. Circulation 2004, 109:433-438.
6. Alberti K.G., Eckel R.H., Grundy S.M., Zimmet P.Z., Cleeman J.I., Donato K.A., et al. Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; American heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity. Circulation 2009, 120:1640-1645.
7. Flanagan P.M., Kelleher R.J., Sayre M.H., Tschochner H., Kornberg R.D. A mediator required for activation of RNA polymerase II transcription in vitro. Nature 1991, 350:436-438.
8. Maldonado E., Shiekhattar R., Sheldon M., Cho H., Drapkin R., Rickert P., et al. A human RNA polymerase II complex associated with SRB and DNA-repair proteins. Nature 1996, 381:86-89.
9. Thompson C.M., Koleske A.J., Chao D.M., Young R.A. A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast. Cell 1993, 73:1361-1375.
10. Malik S., Roeder R.G. The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet 2010, 11:761-772.
11. Hill J.A., Olson E.N. Cardiac plasticity. N Engl J Med 2008, 358:1370-1380.
12. Spaeth J.M., Kim N.H., Boyer T.G. Mediator and human disease. Semin Cell Dev Biol 2011, 22:776-787.
13. Asturias F.J., Jiang Y.W., Myers L.C., Gustafsson C.M., Kornberg R.D. Conserved structures of mediator and RNA polymerase II holoenzyme. Science 1999, 283:985-987.
14. Myers L.C., Kornberg R.D. Mediator of transcriptional regulation. Annu Rev Biochem 2000, 69:729-749.
15. Hu X., Malik S., Negroiu C.C., Hubbard K., Velalar C.N., Hampton B., et al. A Mediator-responsive form of metazoan RNA polymerase II. Proc Natl Acad Sci U S A 2006, 103:9506-9511.
16. Malik S., Guermah M., Yuan C.X., Wu W., Yamamura S., Roeder R.G. Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Mol Cell Biol 2004, 24:8244-8254.
17. Malik S., Roeder R.G. Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells. Trends Biochem Sci 2000, 25:277-283.
18. Kagey M.H., Newman J.J., Bilodeau S., Zhan Y., Orlando D.A., van Berkum N.L., et al. Mediator and cohesin connect gene expression and chromatin architecture. Nature 2010, 467:430-435.
19. Park S.W., Li G., Lin Y.P., Barrero M.J., Ge K., Roeder R.G., et al. Thyroid hormone-induced juxtaposition of regulatory elements/factors and chromatin remodeling of Crabp1 dependent on MED1/TRAP220. Mol Cell 2005, 19:643-653.
20. Wallberg A.E., Yamamura S., Malik S., Spiegelman B.M., Roeder R.G. Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. Mol Cell 2003, 12:1137-1149.
21. Meyer K.D., Donner A.J., Knuesel M.T., York A.G., Espinosa J.M., Taatjes D.J. Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO J 2008, 27:1447-1457.
22. Lai F., Orom U.A., Cesaroni M., Beringer M., Taatjes D.J., Blobel G.A., et al. Activating RNAs associate with Mediator to enhance chromatin architecture and transcription. Nature 2013, 494:497-501.
23. Thorsen M., Hansen H., Venturi M., Holmberg S., Thon G. Mediator regulates non-coding RNA transcription at fission yeast centromeres. Epigenetics Chromatin 2012, 5:19.
24. Baek H.J., Malik S., Qin J., Roeder R.G. Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s. Mol Cell Biol 2002, 22:2842-2852.
25. Flanagan P.M., Kelleher R.J., Sayre M.H., Tschochner H., Kornberg R.D. A mediator required for activation of RNA polymerase II transcription in vitro. Nature 1991, 350:436-438.
26. Kim Y.J., Bjorklund S., Li Y., Sayre M.H., Kornberg R.D. A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell 1994, 77:599-608.
27. Kuras L., Borggrefe T., Kornberg R.D. Association of the mediator complex with enhancers of active genes. Proc Natl Acad Sci U S A 2003, 100:13887-13891.
28. Malik S., Roeder R.G. Dynamic regulation of pol II transcription by the mammalian Mediator complex. Trends Biochem Sci 2005, 30:256-263.
29. Boyer T.G., Martin M.E., Lees E., Ricciardi R.P., Berk A.J. Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein. Nature 1999, 399:276-279.
30. Fondell J.D., Ge H., Roeder R.G. Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. Proc Natl Acad Sci U S A 1996, 93:8329-8333.
31. Naar A.M., Beaurang P.A., Zhou S., Abraham S., Solomon W., Tjian R. Composite co-activator ARC mediates chromatin-directed transcriptional activation. Nature 1999, 398:828-832.
32. Rachez C., Lemon B.D., Suldan Z., Bromleigh V., Gamble M., Naar A.M., et al. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature 1999, 398:824-828.
33. Bourbon H.M., Aguilera A., Ansari A.Z., Asturias F.J., Berk A.J., Bjorklund S., et al. A unified nomenclature for protein subunits of Mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell 2004, 14:553-557.
34. Elmlund H., Baraznenok V., Lindahl M., Samuelsen C.O., Koeck P.J., Holmberg S., et al. The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II. Proc Natl Acad Sci U S A 2006, 103:15788-15793.
35. Akoulitchev S., Chuikov S., Reinberg D. TFIIH is negatively regulated by cdk8-containing mediator complexes. Nature 2000, 407:102-106.
36. Sato S., Tomomori-Sato C., Parmely T.J., Florens L., Zybailov B., Swanson S.K., et al. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Mol Cell 2004, 14:685-691.
37. Taatjes D.J. The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends Biochem Sci 2010, 35:315-322.
38. Ebmeier C.C., Taatjes D.J. Activator-Mediator binding regulates Mediator-cofactor interactions. Proc Natl Acad Sci U S A 2010, 107:11283-11288.
39. Fukasawa R., Tsutsui T., Hirose Y., Tanaka A., Ohkuma Y. Mediator CDK subunits are platforms for interactions with various chromatin regulatory complexes. J Biochem 2012, 152:241-249.
40. Persaud S.D., Huang W.H., Park S.W., Wei L.N. Gene repressive activity of RIP140 through direct interaction with CDK8. Mol Endocrinol 2011, 25:1689-1698.
41. Donner A.J., Ebmeier C.C., Taatjes D.J., Espinosa J.M. CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nat Struct Mol Biol 2010, 17:194-201.
42. Furumoto T., Tanaka A., Ito M., Malik S., Hirose Y., Hanaoka F., et al. A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation. Genes Cells 2007, 12:119-132.
43. Boube M., Joulia L., Cribbs D.L., Bourbon H.M. Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man. Cell 2002, 110:143-151.
44. Casamassimi A., Napoli C. Mediator complexes and eukaryotic transcription regulation: an overview. Biochimie 2007, 89:1439-1446.
45. Conaway R.C., Conaway J.W. Function and regulation of the Mediator complex. Curr Opin Genet Dev 2011, 21:225-230.
46. Galbraith M.D., Donner A.J., Espinosa J.M. CDK8: a positive regulator of transcription. Transcription 2010, 1:4-12.
47. Hentges K.E. The Mediator complex: crucial functions in transcription with links to development and disease. Semin Cell Dev Biol 2011, 22:728.
48. Kornberg R.D. Mediator and the mechanism of transcriptional activation. Trends Biochem Sci 2005, 30:235-239.
49. Zhu Y., Qi C., Jain S., Le Beau M.M., Espinosa R., Atkins G.B., et al. Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. Proc Natl Acad Sci U S A 1999, 96:10848-10853.
50. Matsumoto K., Yu S., Jia Y., Ahmed M.R., Viswakarma N., Sarkar J., et al. Critical role for transcription coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein/TRAP220 in liver regeneration and PPARalpha ligand-induced liver tumor development. J Biol Chem 2007, 282:17053-17060.
51. Huang S., Holzel M., Knijnenburg T., Schlicker A., Roepman P., McDermott U., et al. MED12 controls the response to multiple cancer drugs through regulation of TGF-beta receptor signaling. Cell 2012, 151:937-950.
52. Zhang H., Jiang H., Wang W., Gong J., Zhang L., Chen Z., et al. Expression of Med19 in bladder cancer tissues and its role on bladder cancer cell growth. Urol Oncol 2012, 30:920-927.
53. Yang X., Zhao M., Xia M., Liu Y.T., Yan J., Ji H.B., et al. Selective requirement for Mediator MED23 in Ras-active lung cancer. Proc Natl Acad Sci U S A 2012, 109:E2813-E2822.
54. Yoon N.K., Maresh E.L., Elshimali Y., Li A., Horvath S., Seligson D.B., et al. Elevated MED28 expression predicts poor outcome in women with breast cancer. BMC Cancer 2010, 10:335.
55. Kuuselo R., Savinainen K., Sandstrom S., Autio R., Kallioniemi A. MED29, a component of the mediator complex, possesses both oncogenic and tumor suppressive characteristics in pancreatic cancer. Int J Cancer 2011, 129:2553-2565.
56. Xu W., Ji J.Y. Dysregulation of CDK8 and Cyclin C in tumorigenesis. J Genet Genomics 2011, 38:439-452.
57. Firestein R., Bass A.J., Kim S.Y., Dunn I.F., Silver S.J., Guney I., et al. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature 2008, 455:547-551.
58. Zhou H., Spaeth J.M., Kim N.H., Xu X., Friez M.J., Schwartz C.E., et al. MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling. Proc Natl Acad Sci U S A 2012, 109:19763-19768.
59. Kaufmann R., Straussberg R., Mandel H., Fattal-Valevski A., Ben-Zeev B., Naamati A., et al. Infantile cerebral and cerebellar atrophy is associated with a mutation in the MED17 subunit of the transcription preinitiation mediator complex. Am J Hum Genet 2010, 87:667-670.
60. Hashimoto S., Boissel S., Zarhrate M., Rio M., Munnich A., Egly J.M., et al. MED23 mutation links intellectual disability to dysregulation of immediate early gene expression. Science 2011, 333:1161-1163.
61. Leal A., Huehne K., Bauer F., Sticht H., Berger P., Suter U., et al. Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models. Neurogenetics 2009, 10:275-287.
62. Mukhopadhyay A., Kramer J.M., Merkx G., Lugtenberg D., Smeets D.F., Oortveld M.A., et al. CDK19 is disrupted in a female patient with bilateral congenital retinal folds, microcephaly and mild mental retardation. Hum Genet 2010, 128:281-291.
63. Ueberham U., Hessel A., Arendt T. Cyclin C expression is involved in the pathogenesis of Alzheimer's disease. Neurobiol Aging 2003, 24:427-435.
64. Borik S., Simon A.J., Nevo-Caspi Y., Mishali D., Amariglio N., Rechavi G., et al. Increased RNA editing in children with cyanotic congenital heart disease. Intensive Care Med 2011, 37:1664-1671.
65. Boutry-Kryza N., Labalme A., Till M., Schluth-Bolard C., Langue J., Turleau C., et al. An 800kb deletion at 17q23.2 including the MED13 (THRAP1) gene, revealed by aCGH in a patient with a SMC 17p. Am J Med Genet A 2012, 158A:400-405.
66. Asadollahi R., Oneda B., Sheth F., Azzarello-Burri S., Baldinger R., Joset P., et al. Dosage changes of MED13L further delineate its role in congenital heart defects and intellectual disability. Eur J Hum Genet 2013, 10.1038/ejhg.2013.17.
67. Muncke N., Jung C., Rudiger H., Ulmer H., Roeth R., Hubert A., et al. Missense mutations and gene interruption in PROSIT240, a novel TRAP240-like gene, in patients with congenital heart defect (transposition of the great arteries). Circulation 2003, 108:2843-2850.
68. Bradshaw E.A., Martin G.R. Screening for critical congenital heart disease: advancing detection in the newborn. Curr Opin Pediatr 2012, 24:603-608.
69. Hoffman J.I., Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol 2002, 39:1890-1900.
70. Chen C.P., Chen Y.Y., Chern S.R., Wu P.S., Su J.W., Chen Y.T., et al. Prenatal diagnosis and molecular cytogenetic characterization of de novo partial trisomy 12q (12q24.21->qter) and partial monosomy 6q (6q27->qter) associated with coarctation of the aorta, ventriculomegaly and thickened nuchal fold. Gene 2013, 516:138-142.
71. Paz N., Levanon E.Y., Amariglio N., Heimberger A.B., Ram Z., Constantini S., et al. Altered adenosine-to-inosine RNA editing in human cancer. Genome Res 2007, 17:1586-1595.
72. Ito M., Roeder R.G. The TRAP/SMCC/Mediator complex and thyroid hormone receptor function. Trends Endocrinol Metab 2001, 12:127-134.
73. Loncle N., Boube M., Joulia L., Boschiero C., Werner M., Cribbs D.L., et al. Distinct roles for Mediator Cdk8 module subunits in Drosophila development. EMBO J 2007, 26:1045-1054.
74. Chen W., Zhang X., Birsoy K., Roeder R.G. A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism. Proc Natl Acad Sci U S A 2010, 107:10196-10201.
75. Rocha P.P., Scholze M., Bleiss W., Schrewe H. Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling. Development 2010, 137:2723-2731.
76. Ge K., Guermah M., Yuan C.X., Ito M., Wallberg A.E., Spiegelman B.M., et al. Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature 2002, 417:563-567.
77. Ito M., Yuan C.X., Okano H.J., Darnell R.B., Roeder R.G. Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. Mol Cell 2000, 5:683-693.
78. Grueter C.E., van Rooij E., Johnson B.A., DeLeon S.M., Sutherland L.B., Qi X., et al. A cardiac microRNA governs systemic energy homeostasis by regulation of MED13. Cell 2012, 149:671-683.
79. Krebs P., Fan W., Chen Y.H., Tobita K., Downes M.R., Wood M.R., et al. Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet. Proc Natl Acad Sci U S A 2011, 108:19678-19682.
80. Westerling T., Kuuluvainen E., Makela T.P. Cdk8 is essential for preimplantation mouse development. Mol Cell Biol 2007, 27:6177-6182.
81. Riehle C., Abel E.D. PGC-1 proteins and heart failure. Trends Cardiovasc Med 2012, 22:98-105.
82. Yuan C.X., Ito M., Fondell J.D., Fu Z.Y., Roeder R.G. The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc Natl Acad Sci U S A 1998, 95:7939-7944.
83. Zhu Y., Qi C., Jain S., Rao M.S., Reddy J.K. Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J Biol Chem 1997, 272:25500-25506.
84. Crawford S.E., Qi C., Misra P., Stellmach V., Rao M.S., Engel J.D., et al. Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. J Biol Chem 2002, 277:3585-3592.
85. Zhu Y.J., Crawford S.E., Stellmach V., Dwivedi R.S., Rao M.S., Gonzalez F.J., et al. Coactivator PRIP, the peroxisome proliferator-activated receptor-interacting protein, is a modulator of placental, cardiac, hepatic, and embryonic development. J Biol Chem 2003, 278:1986-1990.
86. Landles C., Chalk S., Steel J.H., Rosewell I., Spencer-Dene B., Lalani el N., et al. The thyroid hormone receptor-associated protein TRAP220 is required at distinct embryonic stages in placental, cardiac, and hepatic development. Mol Endocrinol 2003, 17:2418-2435.
87. Bai L., Jia Y., Viswakarma N., Huang J., Vluggens A., Wolins N.E., et al. Transcription coactivator mediator subunit MED1 is required for the development of fatty liver in the mouse. Hepatology 2011, 53:1164-1174.
88. Lee N.K., Sowa H., Hinoi E., Ferron M., Ahn J.D., Confavreux C., et al. Endocrine regulation of energy metabolism by the skeleton. Cell 2007, 130:456-469.
89. Bostrom P., Wu J., Jedrychowski M.P., Korde A., Ye L., Lo J.C., et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012, 481:463-468.
90. Carvajal K., Moreno-Sanchez R. Heart metabolic disturbances in cardiovascular diseases. Arch Med Res 2003, 34:89-99.
91. Huss J.M., Kelly D.P. Nuclear receptor signaling and cardiac energetics. Circ Res 2004, 95:568-578.
92. Rider O.J., Francis J.M., Ali M.K., Holloway C., Pegg T., Robson M.D., et al. Effects of catecholamine stress on diastolic function and myocardial energetics in obesity. Circulation 2012, 125:1511-1519.
93. Shao W., Espenshade P.J. Expanding roles for SREBP in metabolism. Cell Metab 2012, 16:414-419.
94. Zhao X., Feng D., Wang Q., Abdulla A., Xie X.J., Zhou J., et al. Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J Clin Invest 2012, 122:2417-2427.
95. Taubert S., Van Gilst M.R., Hansen M., Yamamoto K.R. A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Genes Dev 2006, 20:1137-1149.
96. Wang W., Huang L., Huang Y., Yin J.W., Berk A.J., Friedman J.M., et al. Mediator MED23 links insulin signaling to the adipogenesis transcription cascade. Dev Cell 2009, 16:764-771.
97. Yin J.W., Liang Y., Park J.Y., Chen D.R., Yao X., Xiao Q., et al. The mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation. Genes Dev 2012, 26:2192-2205.
98. Conaway R.C., Conaway J.W. The Mediator complex and transcription elongation. Biochim Biophys Acta 2013, 1829:69-75.
99. Takahashi H., Parmely T.J., Sato S., Tomomori-Sato C., Banks C.A., Kong S.E., et al. Human mediator subunit MED26 functions as a docking site for transcription elongation factors. Cell 2011, 146:92-104.
100. Wang W., Yao X., Huang Y., Hu X.M., Liu R.Z., Hou D.M., et al. Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb. Transcription 2013, 4:39-51.
101. Sano M., Abdellatif M., Oh H., Xie M., Bagella L., Giordano A., et al. Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy. Nat Med 2002, 8:1310-1317.
102. Sano M., Wang S.C., Shirai M., Scaglia F., Xie M., Sakai S., et al. Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure. EMBO J 2004, 23:3559-3569.
103. Yang F., Vought B.W., Satterlee J.S., Walker A.K., Jim Sun Z.Y., Watts J.L., et al. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature 2006, 442:700-704.
104. Lee T.I., Young R.A. Transcriptional regulation and its misregulation in disease. Cell 2013, 152:1237-1251.
105. Small E.M., Olson E.N. Pervasive roles of microRNAs in cardiovascular biology. Nature 2011, 469:336-342.
106. Carrer M., Liu N., Grueter C.E., Williams A.H., Frisard M.I., Hulver M.W., et al. Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*. Proc Natl Acad Sci U S A 2012, 109:15330-15335.
107. Mouillet J.F., Chu T., Nelson D.M., Mishima T., Sadovsky Y. MiR-205 silences MED1 in hypoxic primary human trophoblasts. FASEB J 2010, 24:2030-2039.
108. van Rooij E., Sutherland L.B., Qi X., Richardson J.A., Hill J., Olson E.N. Control of stress-dependent cardiac growth and gene expression by a microRNA. Science 2007, 316:575-579.
109. Huszar J.M., Payne C.J. MicroRNA 146 (Mir146) modulates spermatogonial differentiation by retinoic acid in mice. Biol Reprod 2013, 88:15.
110. Montgomery R.L., Hullinger T.G., Semus H.M., Dickinson B.A., Seto A.G., Lynch J.M., et al. Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure. Circulation 2011, 124:1537-1547.