Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure

EMBO Journal

Volumn 23, Issue 17, 2004, Pages 3559-3569

  Sano, Motoaki ^a   Wang, Sam C ^a   Shirai, Manabu ^a   Scaglia, Fernando ^a   Xie, Min ^a   Sakai, Satoshi ^a   Tanaka, Toru ^a   Kulkarni, Prathit A ^a   Barger, Philip M ^a   Youker, Keith A ^a   Taffet, George E ^a   Hamamori, Yasuo ^a   Michael, Lloyd H ^a   Craigen, William J ^a   Schneider, Michael D ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Cardiac; Cyclin T; Cyclin dependent kinase 9; Heart failure; Mitochondria

Indexed keywords

CELL PROTEIN; CYCLIN DEPENDENT KINASE 9; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; DISEASE PREDISPOSITION; HEART FAILURE; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 9; CYCLINS; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GENE EXPRESSION; HEART FAILURE, CONGESTIVE; HUMANS; MICE; MYOCARDIUM; MYOCYTES, CARDIAC; NF-E2-RELATED FACTOR 1; NUCLEAR RESPIRATORY FACTOR 1; NUCLEAR RESPIRATORY FACTORS; PROMOTER REGIONS (GENETICS); RATS; RNA POLYMERASE II; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 4644231687     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600351     Document Type: Article

References (41)

1. Adams JW, Pagel AL, Means CK, Oksenberg D, Armstrong RC, Brown JH (2000) Cardiomyocyte apoptosis induced by Galphaq signaling is mediated by permeability transition pore formation and activation of the mitochondrial death pathway. Circ Res 87: 1180-1187
2. Adams JW, Sakata Y, Davis MG, Sah VP, Wang YB, Liggett SB, Chien KR, Brown JH, Dorn GW (1998) Enhanced G alpha q signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. Proc Natl Acad Sci USA 95: 10140-10145
3. Ahn SH, Kim M, Buratowski S (2004) Phosphorylation of serine 2 within the RNA polymerase II C-terminal domain couples transcription and 3′ end processing. Mol Cell 13: 67-76
4. Barboric M, Nissen RM, Kanazawa S, Jabrane-Ferrat N, Peterlin BM (2001) NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II. Mol Cell 8: 327-337
5. Czubryt MP, McAnally J, Fishman GI, Olson EN (2003) Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) and mitochondrial function by MEF2 and HDAC5. Proc Natl Acad Sci USA 100: 1711-1716
6. Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 116: 205-219
7. de Falco G, Bagella L, Claudio PP, De Luca A, Fu Y, Calabretta B, Sala A, Giordano A (2000) Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation. Oncogene 19: 373-379
8. Eberhardy SR, Farnham PJ (2002) Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter. J Biol Chem 277: 40156-40162
9. Falkenberg M, Gaspari M, Rantanen A, Trifunovic A, Larsson NG, Gustafsson CM (2002) Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. Nat Genet 31: 289-294
10. Fujinaga K, Irwin D, Huang Y, Taube R, Kurosu T, Peterlin BM (2004) Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element. Mol Cell Biol 24: 787-795
11. Graham BH, Waymire KG, Cottrell B, Trounce IA, MacGregor GR, Wallace DC (1997) A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator. Nat Genet 16: 226-234
12. Handschin C, Rhee J, Lin J, Tarr PT, Spiegelman BM (2003) An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. Proc Natl Acad Sci USA 100: 7111-7116
13. Hansson A, Hance N, Dufour E, Rantanen A, Hultenby K, Clayton DA, Wibom R, Larsson NG (2004) A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts. Proc Natl Acad Sci USA 101: 3136-3141
14. He TC, Zhou SB, daCosta LT, Yu J, Kinzler KW, Vogelstein B (1998) A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 95: 2509-2514
15. Hirota H, Chen J, Betz UA, Rajewsky K, Gu Y, Ross Jr J, Muller W, Chien KR (1999) Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell 97: 189-198
16. Howes AL, Arthur JF, Zhang T, Miyamoto S, Adams JW, Dorn IG, Woodcock EA, Brown JH (2003) Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion. J Biol Chem 278: 40343-40351
17. Izumi H, Ohta R, Nagatani G, Ise T, Nakayama Y, Nomoto M, Kohno K (2003) p300/CBP-associated factor (P/CAF) interacts with nuclear respiratory factor-1 to regulate the UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-3 gene. Biochem J 373: 713-722
18. Kelly DP, Scarpulla RC (2004) Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev 18: 357-368
19. Kirshenbaum LA, de Moissac D (1997) The bcl-2 gene product prevents programmed cell death of ventricular myocytes. Circulation 96: 1580-1585
20. Komarnitsky P, Cho EJ, Buratowski S (2000) Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription. Genes Dev 14: 2452-2460
21. Kwak YT, Ivanov D, Guo J, Nee E, Gaynor RB (1999) Role of the human and murine cyclin T proteins in regulating HIV-1 tat-activation. J Mol Biol 288: 57-69
22. Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros DM, Kelly DP (2000) Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest 106: 847-856
23. Lehman JJ, Kelly DP (2002) Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart. Clin Exp Pharmacol Physiol 29: 339-345
24. Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ, Yoshimura MP, Berger C, Chan PH, Wallace DC, Epstein CJ (1995) Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet 11: 376-381.
25. Lis JT, Mason P, Peng J, Price DH, Werner J (2000) P-TEFb kinase recruitment and function at heat shock loci. Genes Dev 14: 792-803
26. Litingtung Y, Lawler AM, Sebald SM, Lee E, Gearhart JD, Westphal H, Corden JL (1999) Growth retardation and neonatal lethality in mice with a homozygous deletion in the C-terminal domain of RNA polymerase II. Mol Gen Genet 261: 100-105
27. Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, Lania L, Bensaude O (2003) MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner. Mol Cell Biol 23: 4859-4869
28. Oh H, Wang SC, Prahash A, Sano M, Moravec CS, Taffet GE, Michael LH, Youker KA, Entman ML, Schneider MD (2003) Telomere attrition and Chk2 activation in human heart failure. Proc Natl Acad Sci USA 100: 5378-5383
29. Olson EN, Schneider MD (2003) Sizing up the heart: development redux in disease. Genes Dev 17: 1937-1956
30. Orphanides G, Reinberg D (2002) A unified theory of gene expression. Cell 108: 439-451
31. Pokholok DK, Hannett NM, Young RA (2002) Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo. Mol Cell 9: 799-809
32. Price DH (2000) P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II. Mol Cell Biol 20: 2629-2634
33. Rossi DJ, Londesborough A, Korsisaari N, Pihlak A, Lehtonen E, Henkemeyer M, Makela TP (2001) Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Matl. EMBO J 20: 2844-2856
34. Sakata Y, Hoit BD, Liggett SB, Walsh RA, Dorn G (1998) Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice. Circulation 97: 1488-1495
35. Sano M, Abdellatif M, Oh H, Xie M, Bagella L, Giordano A, Michael LH, DeMayo FJ, Schneider MD (2002) Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy. Nat Med 8: 1310-1317
36. Shariat SF, Desai S, Song W, Khan T, Zhao J, Nguyen C, Foster BA, Greenberg N, Spencer DM, Slawin KM (2001) Adenovirus-mediated transfer of inducible caspases: a novel 'death switch' gene therapeutic approach to prostate cancer. Cancer Res 61: 2562-2571
37. Shilatifard A, Conaway RC, Conaway JW (2003) The RNA polymerase II elongation complex. Annu Rev Biochem 72: 693-715
38. Shim EY, Walker AK, Shi Y, Blackwell TK (2002) CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo. Genes Dev 16: 2135-2146
39. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM (1999) Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98: 115-124
40. Yik JH, Chen R, Nishimura R, Jennings JL, Link AJ, Zhou Q (2003) Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA. Mol Cell 12: 971-982
41. Zhang F, Barboric M, Blackwell TK, Peterlin BM (2003) A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb. Genes Dev 17: 748-758