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Volumn 469, Issue 7330, 2011, Pages 336-342

Pervasive roles of microRNAs in cardiovascular biology

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; OLIGONUCLEOTIDE;

EID: 78751660177     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09783     Document Type: Review
Times cited : (1046)

References (91)
  • 1
    • 41449086790 scopus 로고    scopus 로고
    • Cardiac plasticity
    • Hill, J. A. & Olson, E. N. Cardiac plasticity. N. Engl. J. Med. 358, 1370-1380 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , pp. 1370-1380
    • Hill, J.A.1    Olson, E.N.2
  • 2
    • 0037134945 scopus 로고    scopus 로고
    • The incidence of congenital heart disease
    • Hoffman, J. I. & Kaplan, S. The incidence of congenital heart disease. J. Am. Coll. Cardiol. 39, 1890-1900 (2002).
    • (2002) J. Am. Coll. Cardiol. , vol.39 , pp. 1890-1900
    • Hoffman, J.I.1    Kaplan, S.2
  • 3
    • 39749191367 scopus 로고    scopus 로고
    • The developmental genetics of congenital heart disease
    • Bruneau, B. G. The developmental genetics of congenital heart disease. Nature 451, 943-948 (2008).
    • (2008) Nature , vol.451 , pp. 943-948
    • Bruneau, B.G.1
  • 4
    • 64249165694 scopus 로고    scopus 로고
    • MicroRNA regulation of cardiovascular development
    • Cordes, K. R. & Srivastava, D. MicroRNA regulation of cardiovascular development. Circ. Res. 104, 724-732 (2009).
    • (2009) Circ. Res. , vol.104 , pp. 724-732
    • Cordes, K.R.1    Srivastava, D.2
  • 6
    • 77649253288 scopus 로고    scopus 로고
    • MicroRNAs add a new dimension to cardiovascular disease
    • Small, E. M., Frost, R. J. & Olson, E. N. MicroRNAs add a new dimension to cardiovascular disease. Circulation 121, 1022-1032 (2010).
    • (2010) Circulation , vol.121 , pp. 1022-1032
    • Small, E.M.1    Frost, R.J.2    Olson, E.N.3
  • 7
    • 34848838292 scopus 로고    scopus 로고
    • MicroRNAs: Powerful new regulators of heart disease and provocative therapeutic targets
    • Van Rooij, E. & Olson, E. N. MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets. J. Clin. Invest. 117, 2369-2376 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 2369-2376
    • Van Rooij, E.1    Olson, E.N.2
  • 8
    • 77951919333 scopus 로고    scopus 로고
    • MicroRNA regulatory networks in cardiovascular development
    • Liu, N. & Olson, E. N. MicroRNA regulatory networks in cardiovascular development. Dev. Cell 18, 510-525 (2010).
    • (2010) Dev. Cell , vol.18 , pp. 510-525
    • Liu, N.1    Olson, E.N.2
  • 9
    • 36248948593 scopus 로고    scopus 로고
    • Altered microRNA expression in human heart disease
    • Ikeda, S. et al. Altered microRNA expression in human heart disease. Physiol. Genomics 31, 367-373 (2007).
    • (2007) Physiol. Genomics , vol.31 , pp. 367-373
    • Ikeda, S.1
  • 10
    • 33845317603 scopus 로고    scopus 로고
    • A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure
    • Van Rooij, E. et al. A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc. Natl Acad. Sci. USA 103, 18255-18260 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 18255-18260
    • Van Rooij, E.1
  • 11
    • 63649096271 scopus 로고    scopus 로고
    • Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support
    • Matkovich, S. J. et al. Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support. Circulation 119, 1263-1271 (2009).
    • (2009) Circulation , vol.119 , pp. 1263-1271
    • Matkovich, S.J.1
  • 12
    • 34547579291 scopus 로고    scopus 로고
    • MicroRNAs in the human heart: A clue to fetal gene reprogramming in heart failure
    • Thum, T. et al. MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure. Circulation 116, 258-267 (2007).
    • (2007) Circulation , vol.116 , pp. 258-267
    • Thum, T.1
  • 13
    • 62349141343 scopus 로고    scopus 로고
    • MicroRNA expression in response to murine myocardial infarction: MiR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue
    • Roy, S. et al. MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue. Cardiovasc. Res. 82, 21-29 (2009).
    • (2009) Cardiovasc. Res. , vol.82 , pp. 21-29
    • Roy, S.1
  • 14
    • 51349141401 scopus 로고    scopus 로고
    • Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
    • Van Rooij, E. et al. Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc. Natl Acad. Sci. USA 105, 13027-13032 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 13027-13032
    • Van Rooij, E.1
  • 15
    • 34250172419 scopus 로고    scopus 로고
    • MicroRNA expression signature and antisense-mediated depletion reveal an essential role of microRNA in vascular neointimal lesion formation
    • Ji, R. et al. MicroRNA expression signature and antisense-mediated depletion reveal an essential role of microRNA in vascular neointimal lesion formation. Circ. Res. 100, 1579-1588 (2007).
    • (2007) Circ. Res. , vol.100 , pp. 1579-1588
    • Ji, R.1
  • 16
    • 70349125875 scopus 로고    scopus 로고
    • MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury
    • Xin, M. et al. MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev. 23, 2166-2178 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 2166-2178
    • Xin, M.1
  • 18
    • 55449100829 scopus 로고    scopus 로고
    • Toward microRNA-based therapeutics for heart disease: The sense in antisense
    • Van Rooij, E., Marshall, W. S. & Olson, E. N. Toward microRNA-based therapeutics for heart disease: the sense in antisense. Circ. Res. 103, 919-928 (2008).
    • (2008) Circ. Res. , vol.103 , pp. 919-928
    • Van Rooij, E.1    Marshall, W.S.2    Olson, E.N.3
  • 19
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel, D. P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233 (2009).
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 20
    • 38349169664 scopus 로고    scopus 로고
    • Mechanisms of posttranscriptional regulation by microRNAs: Are the answers in sight?
    • Filipowicz, W., Bhattacharyya, S. N. & Sonenberg, N. Mechanisms of posttranscriptional regulation by microRNAs: are the answers in sight? Nature Rev. Genet. 9, 102-114 (2008).
    • (2008) Nature Rev. Genet. , vol.9 , pp. 102-114
    • Filipowicz, W.1    Bhattacharyya, S.N.2    Sonenberg, N.3
  • 21
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, Biogenesis, Mechanism, and function
    • Bartel, D. P. MicroRNAs: genomics, Biogenesis, Mechanism, And function. Cell 116, 281-297 (2004).
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 22
    • 77950546627 scopus 로고    scopus 로고
    • Intronic microRNAs support their host genes by mediating synergistic and antagonistic regulatory effects
    • Lutter, D., Marr, C., Krumsiek, J., Lang, E. W. & Theis, F. J. Intronic microRNAs support their host genes by mediating synergistic and antagonistic regulatory effects. BMC Genomics 11, 224 (2010).
    • (2010) BMC Genomics , vol.11 , pp. 224
    • Lutter, D.1    Marr, C.2    Krumsiek, J.3    Lang, E.W.4    Theis, F.J.5
  • 23
    • 77953285766 scopus 로고    scopus 로고
    • Intronic miR-301 feedback regulates its host gene, Ska2 A549 cells by targeting MEOX2 to affect ERK/CREB pathways
    • Cao, G. et al. Intronic miR-301 feedback regulates its host gene, Ska2, In A549 cells by targeting MEOX2 to affect ERK/CREB pathways. Biochem. Biophys. Res. Commun. 396, 978-982 (2010).
    • (2010) Biochem. Biophys. Res. Commun. , vol.396 , pp. 978-982
    • Cao, G.1
  • 24
    • 77953780835 scopus 로고    scopus 로고
    • MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis
    • Najafi-Shoushtari, S. H. et al. MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science 328, 1566-1569 (2010).
    • (2010) Science , vol.328 , pp. 1566-1569
    • Najafi-Shoushtari, S.H.1
  • 25
    • 77953948708 scopus 로고    scopus 로고
    • Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation
    • Poliseno, L. et al. Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation. Sci. Signal. 3, Ra29 (2010).
    • (2010) Sci. Signal. , vol.3
    • Poliseno, L.1
  • 26
    • 52649167919 scopus 로고    scopus 로고
    • An intronic microRNA silences genes that are functionally antagonistic to its host gene
    • Barik, S. An intronic microRNA silences genes that are functionally antagonistic to its host gene. Nucleic Acids Res. 36, 5232-5241 (2008).
    • (2008) Nucleic Acids Res. , vol.36 , pp. 5232-5241
    • Barik, S.1
  • 27
    • 76749134307 scopus 로고    scopus 로고
    • Many families of C. Elegans microRNAs are not essential for development or viability
    • Alvarez-Saavedra, E. & Horvitz, H. R. Many families of C. Elegans microRNAs are not essential for development or viability. Curr. Biol. 20, 367-373 (2010).
    • (2010) Curr. Biol. , vol.20 , pp. 367-373
    • Alvarez-Saavedra, E.1    Horvitz, H.R.2
  • 28
    • 78049522849 scopus 로고    scopus 로고
    • MicroRNAs: Genetically sensitized worms reveal new secrets
    • Ambros, V. MicroRNAs: genetically sensitized worms reveal new secrets. Curr. Biol. 20, R598-R600 (2010).
    • (2010) Curr. Biol. , vol.20
    • Ambros, V.1
  • 29
    • 77957756295 scopus 로고    scopus 로고
    • Loss of individual microRNAs causes mutant phenotypes in sensitized genetic backgrounds in C. Elegans
    • Brenner, J. L., Jasiewicz, K. L., Fahley, A. F., Kemp, B. J. & Abbott, A. L. Loss of individual microRNAs causes mutant phenotypes in sensitized genetic backgrounds in C. Elegans. Curr. Biol. 20, 1321-1325 (2010).
    • (2010) Curr. Biol. , vol.20 , pp. 1321-1325
    • Brenner, J.L.1    Jasiewicz, K.L.2    Fahley, A.F.3    Kemp, B.J.4    Abbott, A.L.5
  • 30
    • 34147153781 scopus 로고    scopus 로고
    • Dysregulation of cardiogenesis Cardiac conduction, and cell cycle in mice lacking miRNA-1-2
    • Zhao, Y. et al. Dysregulation of cardiogenesis, Cardiac conduction, And cell cycle in mice lacking miRNA-1-2. Cell 129, 303-317 (2007).
    • (2007) Cell , vol.129 , pp. 303-317
    • Zhao, Y.1
  • 31
    • 34147095310 scopus 로고    scopus 로고
    • The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2
    • Yang, B. et al. The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nature Med. 13, 486-491 (2007).
    • (2007) Nature Med. , vol.13 , pp. 486-491
    • Yang, B.1
  • 32
    • 50649111705 scopus 로고    scopus 로고
    • Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart
    • Luo, X. et al. Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart. J. Biol. Chem. 283, 20045-20052 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 20045-20052
    • Luo, X.1
  • 33
    • 77749279797 scopus 로고    scopus 로고
    • Regulation of PI3-kinase/Akt signalling by muscle-enriched microRNA-486
    • Small, E. M. et al. Regulation of PI3-kinase/Akt signalling by muscle-enriched microRNA-486. Proc. Natl Acad. Sci. USA 107, 4218-4223 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 4218-4223
    • Small, E.M.1
  • 34
    • 67349149082 scopus 로고    scopus 로고
    • MicroRNA-145 regulates OCT4 SOX2, and KLF4 and represses pluripotency in human embryonic stem cells
    • Xu, N., Papagiannakopoulos, T., Pan, G., Thomson, J. A. & Kosik, K. S. MicroRNA-145 regulates OCT4, SOX2, And KLF4 and represses pluripotency in human embryonic stem cells. Cell 137, 647-658 (2009).
    • (2009) Cell , vol.137 , pp. 647-658
    • Xu, N.1    Papagiannakopoulos, T.2    Pan, G.3    Thomson, J.A.4    Kosik, K.S.5
  • 35
    • 35348914716 scopus 로고    scopus 로고
    • Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430
    • Choi, W. Y., Giraldez, A. J. & Schier, A. F. Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430. Science 318, 271-274 (2007).
    • (2007) Science , vol.318 , pp. 271-274
    • Choi, W.Y.1    Giraldez, A.J.2    Schier, A.F.3
  • 36
    • 34347381752 scopus 로고    scopus 로고
    • Novel approaches for gene-specific interference via manipulating actions of microRNAs: Examination on the pacemaker channel genes HCN2 and HCN4
    • Xiao, J. et al. Novel approaches for gene-specific interference via manipulating actions of microRNAs: examination on the pacemaker channel genes HCN2 and HCN4. J. Cell. Physiol. 212, 285-292 (2007).
    • (2007) J. Cell. Physiol. , vol.212 , pp. 285-292
    • Xiao, J.1
  • 37
    • 67651087321 scopus 로고    scopus 로고
    • Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications
    • Brown, B. D. & Naldini, L. Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications. Nature Rev. Genet. 10, 578-585 (2009).
    • (2009) Nature Rev. Genet. , vol.10 , pp. 578-585
    • Brown, B.D.1    Naldini, L.2
  • 38
    • 34548316982 scopus 로고    scopus 로고
    • MicroRNA sponges: Competitive inhibitors of small RNAs in mammalian cells
    • Ebert, M. S., Neilson, J. R. & Sharp, P. A. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nature Methods 4, 721-726 (2007).
    • (2007) Nature Methods , vol.4 , pp. 721-726
    • Ebert, M.S.1    Neilson, J.R.2    Sharp, P.A.3
  • 39
    • 41149147013 scopus 로고    scopus 로고
    • Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure
    • Chen, J. F. et al. Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc. Natl Acad. Sci. USA 105, 2111-2116 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 2111-2116
    • Chen, J.F.1
  • 40
    • 77952885217 scopus 로고    scopus 로고
    • MicroRNAs are necessary for vascular smooth muscle growth Differentiation, and function
    • Albinsson, S. et al. MicroRNAs are necessary for vascular smooth muscle growth, Differentiation, And function. Arterioscler. Thromb. Vasc. Biol. 30, 1118-1126 (2010).
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , pp. 1118-1126
    • Albinsson, S.1
  • 41
    • 70349254444 scopus 로고    scopus 로고
    • Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure
    • Rao, P. K. et al. Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ. Res. 105, 585-594 (2009). Deep sequencing showed that the 18 most abundant cardiac miRNAs account for more than 90% of all miRNAs in the heart.
    • (2009) Circ. Res. , vol.105 , pp. 585-594
    • Rao, P.K.1
  • 42
    • 36849060584 scopus 로고    scopus 로고
    • Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue Lineage and differentiation state
    • Brown, B. D. et al. Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, Lineage and differentiation state. Nature Biotechnol. 25, 1457-1467 (2007).
    • (2007) Nature Biotechnol. , vol.25 , pp. 1457-1467
    • Brown, B.D.1
  • 43
    • 38049156025 scopus 로고    scopus 로고
    • An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133
    • Liu, N. et al. An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133. Proc. Natl Acad. Sci. USA 104, 20844-20849 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 20844-20849
    • Liu, N.1
  • 44
    • 22444437609 scopus 로고    scopus 로고
    • Serum response factor regulates a musclespecific microRNA that targets Hand2 during cardiogenesis
    • Zhao, Y., Samal, E. & Srivastava, D. Serum response factor regulates a musclespecific microRNA that targets Hand2 during cardiogenesis. Nature 436, 214-220 (2005).
    • (2005) Nature , vol.436 , pp. 214-220
    • Zhao, Y.1    Samal, E.2    Srivastava, D.3
  • 45
    • 39749140336 scopus 로고    scopus 로고
    • MicroRNA regulation of cell lineages in mouse and human embryonic stem cells
    • Ivey, K. N. et al. MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell 2, 219-229 (2008).
    • (2008) Cell Stem Cell , vol.2 , pp. 219-229
    • Ivey, K.N.1
  • 46
    • 57749121689 scopus 로고    scopus 로고
    • MicroRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart
    • Liu, N. et al. MicroRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev. 22, 3242-3254 (2008).
    • (2008) Genes Dev. , vol.22 , pp. 3242-3254
    • Liu, N.1
  • 47
    • 77952194808 scopus 로고    scopus 로고
    • The miR-143-adducin3 pathway is essential for cardiac chamber morphogenesis
    • Deacon, D. C. et al. The miR-143-adducin3 pathway is essential for cardiac chamber morphogenesis. Development 137, 1887-1896 (2010).
    • (2010) Development , vol.137 , pp. 1887-1896
    • Deacon, D.C.1
  • 48
    • 56649105278 scopus 로고    scopus 로고
    • MicroRNA-138 modulates cardiac patterning during embryonic development
    • Morton, S. U. et al. MicroRNA-138 modulates cardiac patterning during embryonic development. Proc. Natl Acad. Sci. USA 105, 17830-17835 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 17830-17835
    • Morton, S.U.1
  • 49
    • 34548595368 scopus 로고    scopus 로고
    • EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution
    • Schmidt, M. et al. EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution. Development 134, 2913-2923 (2007).
    • (2007) Development , vol.134 , pp. 2913-2923
    • Schmidt, M.1
  • 50
    • 77951621138 scopus 로고    scopus 로고
    • MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis
    • Nicoli, S. et al. MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis. Nature 464, 1196-1200 (2010).
    • (2010) Nature , vol.464 , pp. 1196-1200
    • Nicoli, S.1
  • 51
    • 60849106298 scopus 로고    scopus 로고
    • Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126
    • Kuhnert, F. et al. Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126. Development 135, 3989-3993 (2008).
    • (2008) Development , vol.135 , pp. 3989-3993
    • Kuhnert, F.1
  • 52
    • 48549106378 scopus 로고    scopus 로고
    • The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis
    • Wang, S. et al. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev. Cell 15, 261-271 (2008).
    • (2008) Dev. Cell , vol.15 , pp. 261-271
    • Wang, S.1
  • 53
    • 48749130187 scopus 로고    scopus 로고
    • MiR-126 regulates angiogenic signalling and vascular integrity
    • Fish, J. E. et al. MiR-126 regulates angiogenic signalling and vascular integrity. Dev. Cell 15, 272-284 (2008).
    • (2008) Dev. Cell , vol.15 , pp. 272-284
    • Fish, J.E.1
  • 54
    • 78650387493 scopus 로고    scopus 로고
    • MicroRNA-218 regulates vascular patterning by modulation of Slit-Robo signaling
    • Small, E. M., Sutherland, L. B., Rajagopalan, R., Wang, S. & Olson, E. N. MicroRNA-218 regulates vascular patterning by modulation of Slit-Robo signaling. Circ. Res. 107, 1336-1344 (2010).
    • (2010) Circ. Res. , vol.107 , pp. 1336-1344
    • Small, E.M.1    Sutherland, L.B.2    Rajagopalan, R.3    Wang, S.4    Olson, E.N.5
  • 55
    • 68449097267 scopus 로고    scopus 로고
    • MiR-145 and miR-143 regulate smooth muscle cell fate and plasticity
    • Cordes, K. R. et al. MiR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature 460, 705-710 (2009).
    • (2009) Nature , vol.460 , pp. 705-710
    • Cordes, K.R.1
  • 56
    • 70449701464 scopus 로고    scopus 로고
    • The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: Correlates with human disease
    • Elia, L. et al. The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease. Cell Death Differ. 16, 1590-1598 (2009).
    • (2009) Cell Death Differ. , vol.16 , pp. 1590-1598
    • Elia, L.1
  • 57
    • 70349213385 scopus 로고    scopus 로고
    • Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster
    • Boettger, T. et al. Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. J. Clin. Invest. 119, 2634-2647 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 2634-2647
    • Boettger, T.1
  • 59
    • 33847304124 scopus 로고    scopus 로고
    • CD34+ hematopoietic stem-progenitor cell microRNA expression and function: A circuit diagram of differentiation control
    • Georgantas, R. W. III et al. CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control. Proc. Natl Acad. Sci. USA 104, 2750-2755 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 2750-2755
    • Georgantas Iii, R.W.1
  • 60
    • 34547955952 scopus 로고    scopus 로고
    • A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway
    • O'Carroll, D. et al. A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway. Genes Dev. 21, 1999-2004 (2007).
    • (2007) Genes Dev. , vol.21 , pp. 1999-2004
    • O'Carroll, D.1
  • 61
    • 44449108570 scopus 로고    scopus 로고
    • MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors
    • Lu, J. et al. MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Dev. Cell 14, 843-853 (2008).
    • (2008) Dev. Cell , vol.14 , pp. 843-853
    • Lu, J.1
  • 62
    • 38349146518 scopus 로고    scopus 로고
    • MicroRNA miR-24 inhibits erythropoiesis by targeting activin type i receptor ALK4
    • Wang, Q. et al. MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood 111, 588-595 (2008).
    • (2008) Blood , vol.111 , pp. 588-595
    • Wang, Q.1
  • 63
    • 77954408884 scopus 로고    scopus 로고
    • The miR-144/451 locus is required for erythroid homeostasis
    • Rasmussen, K. D. et al. The miR-144/451 locus is required for erythroid homeostasis. J. Exp. Med. 207, 1351-1358 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1351-1358
    • Rasmussen, K.D.1
  • 64
    • 39849096995 scopus 로고    scopus 로고
    • Regulation of progenitor cell proliferation and granulocyte function by microRNA-223
    • Johnnidis, J. B. et al. Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature 451, 1125-1129 (2008).
    • (2008) Nature , vol.451 , pp. 1125-1129
    • Johnnidis, J.B.1
  • 65
    • 77955890374 scopus 로고    scopus 로고
    • Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3ζ
    • Patrick, D. M. et al. Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3ζ. Genes Dev. 24, 1614-1619 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 1614-1619
    • Patrick, D.M.1
  • 66
    • 77955877430 scopus 로고    scopus 로고
    • MiR-451 protects against erythroid oxidant stress by repressing 14-3-3
    • Yu, D. et al. MiR-451 protects against erythroid oxidant stress by repressing 14-3-3ζ. Genes Dev. 24, 1620-1633 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 1620-1633
    • Yu, D.1
  • 67
    • 70349202176 scopus 로고    scopus 로고
    • MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
    • Callis, T. E. et al. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J. Clin. Invest. 119, 2772-2786 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 2772-2786
    • Callis, T.E.1
  • 68
    • 57749168828 scopus 로고    scopus 로고
    • MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
    • Thum, T. et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 456, 980-984 (2008).
    • (2008) Nature , vol.456 , pp. 980-984
    • Thum, T.1
  • 69
    • 34247589595 scopus 로고    scopus 로고
    • Control of stress-dependent cardiac growth and gene expression by a microRNA
    • Van Rooij, E. et al. Control of stress-dependent cardiac growth and gene expression by a microRNA. Science 316, 575-579 (2007).
    • (2007) Science , vol.316 , pp. 575-579
    • Van Rooij, E.1
  • 70
    • 34249279050 scopus 로고    scopus 로고
    • MicroRNA-133 controls cardiac hypertrophy
    • Care, A. et al. MicroRNA-133 controls cardiac hypertrophy. Nature Med. 13, 613-618 (2007).
    • (2007) Nature Med. , vol.13 , pp. 613-618
    • Care, A.1
  • 71
    • 71549165765 scopus 로고    scopus 로고
    • A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance
    • Van Rooij, E. et al. A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev. Cell 17, 662-673 (2009).
    • (2009) Dev. Cell , vol.17 , pp. 662-673
    • Van Rooij, E.1
  • 72
    • 0032540267 scopus 로고    scopus 로고
    • A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
    • Molkentin, J. D. et al. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93, 215-228 (1998).
    • (1998) Cell , vol.93 , pp. 215-228
    • Molkentin, J.D.1
  • 73
    • 67749106564 scopus 로고    scopus 로고
    • MiR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy
    • Lin, Z. et al. MiR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy. Proc. Natl Acad. Sci. USA 106, 12103-12108 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 12103-12108
    • Lin, Z.1
  • 74
    • 65249185780 scopus 로고    scopus 로고
    • Downregulation of miR-199a derepresses hypoxia-inducible factor-1α and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes
    • Rane, S. et al. Downregulation of miR-199a derepresses hypoxia-inducible factor-1α and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ. Res. 104, 879-886 (2009).
    • (2009) Circ. Res. , vol.104 , pp. 879-886
    • Rane, S.1
  • 75
    • 78049432896 scopus 로고    scopus 로고
    • Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice
    • Patrick, D. M. et al. Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice. J. Clin. Invest. 120, 3912-3916 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 3912-3916
    • Patrick, D.M.1
  • 76
    • 77954758345 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism
    • Fleissner, F. et al. Asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism. Circ. Res. 107, 138-143 (2010).
    • (2010) Circ. Res. , vol.107 , pp. 138-143
    • Fleissner, F.1
  • 77
    • 67649998366 scopus 로고    scopus 로고
    • MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice
    • Bonauer, A. et al. MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science 324, 1710-1713 (2009).
    • (2009) Science , vol.324 , pp. 1710-1713
    • Bonauer, A.1
  • 78
    • 70349333970 scopus 로고    scopus 로고
    • Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis
    • Van Solingen, C. et al. Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis. J. Cell. Mol. Med. 13, 1577-1585 (2009).
    • (2009) J. Cell. Mol. Med. , vol.13 , pp. 1577-1585
    • Van Solingen, C.1
  • 79
    • 77449127999 scopus 로고    scopus 로고
    • Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection3
    • Zernecke, A. et al. Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci. Signal. 2, Ra81 (2009).
    • (2009) Sci. Signal. , vol.2
    • Zernecke, A.1
  • 81
    • 68049083397 scopus 로고    scopus 로고
    • MicroRNA-145, A novel smooth muscle cell phenotypic marker and modulator, Controls vascular neointimal lesion formation
    • Cheng, Y. et al. MicroRNA-145, A novel smooth muscle cell phenotypic marker and modulator, Controls vascular neointimal lesion formation. Circ. Res. 105, 158-166 (2009).
    • (2009) Circ. Res. , vol.105 , pp. 158-166
    • Cheng, Y.1
  • 83
    • 33751520430 scopus 로고    scopus 로고
    • Natural selection on human microRNA binding sites inferred from SNP data
    • Chen, K. & Rajewsky, N. Natural selection on human microRNA binding sites inferred from SNP data. Nature Genet. 38, 1452-1456 (2006).
    • (2006) Nature Genet. , vol.38 , pp. 1452-1456
    • Chen, K.1    Rajewsky, N.2
  • 84
    • 33745577150 scopus 로고    scopus 로고
    • A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep
    • Clop, A. et al. A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep. Nature Genet. 38, 813-818 (2006).
    • (2006) Nature Genet. , vol.38 , pp. 813-818
    • Clop, A.1
  • 85
    • 34547727263 scopus 로고    scopus 로고
    • Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: A mechanism for functional single-nucleotide polymorphisms related to phenotypes
    • Sethupathy, P. et al. Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes. Am. J. Hum. Genet. 81, 405-413 (2007).
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 405-413
    • Sethupathy, P.1
  • 86
    • 57049092842 scopus 로고    scopus 로고
    • Changes in regulatory microRNA expression in myocardium of heart failure patients on left ventricular assist device support
    • Schipper, M. E., Van Kuik, J., De Jonge, N., Dullens, H. F. & de Weger, R. A. Changes in regulatory microRNA expression in myocardium of heart failure patients on left ventricular assist device support. J. Heart Lung Transplant. 27, 1282-1285 (2008).
    • (2008) J. Heart Lung Transplant. , vol.27 , pp. 1282-1285
    • Schipper, M.E.1    Van Kuik, J.2    De Jonge, N.3    Dullens, H.F.4    De Weger, R.A.5
  • 87
    • 77955732822 scopus 로고    scopus 로고
    • MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients
    • Voellenkle, C. et al. MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients. Physiol. Genomics 42, 420-426 (2010).
    • (2010) Physiol. Genomics , vol.42 , pp. 420-426
    • Voellenkle, C.1
  • 88
    • 77957028990 scopus 로고    scopus 로고
    • Circulating microRNAs in patients with coronary artery disease
    • Fichtlscherer, S. et al. Circulating microRNAs in patients with coronary artery disease. Circ. Res. 107, 677-684 (2010).
    • (2010) Circ. Res. , vol.107 , pp. 677-684
    • Fichtlscherer, S.1
  • 89
    • 70449709345 scopus 로고    scopus 로고
    • Plasma miR-208 as a biomarker of myocardial injury
    • Ji, X. et al. Plasma miR-208 as a biomarker of myocardial injury. Clin. Chem. 55, 1944-1949 (2009).
    • (2009) Clin. Chem. , vol.55 , pp. 1944-1949
    • Ji, X.1
  • 90
    • 42249093319 scopus 로고    scopus 로고
    • LNA-mediated microRNA silencing in non-human primates
    • Elmen, J. et al. LNA-mediated microRNA silencing in non-human primates. Nature 452, 896-899 (2008).
    • (2008) Nature , vol.452 , pp. 896-899
    • Elmen, J.1
  • 91
    • 74249112787 scopus 로고    scopus 로고
    • Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
    • Lanford, R. E. et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 327, 198-201 (2010).
    • (2010) Science , vol.327 , pp. 198-201
    • Lanford, R.E.1


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