Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation

ACS Chemical Biology

Volumn 7, Issue 9, 2012, Pages 1556-1564

  Chafekar, Sidhartha M ^a   Wisén, Susanne ^b   Thompson, Andrea D ^b   Echeverria, Analisa ^a   Walter, Gladis M ^b   Evans, Christopher G ^b   Makley, Leah N ^b   Gestwicki, Jason E ^b   Duennwald, Martin L ^a  

^a BOSTON BIOMEDICAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CE 12; ETHYL 4 (2,4 DICHLOROPHENYL) 2,7,7 TRIMETHYL 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 70 INHIBITOR; POLYGLUTAMINE; PROTEIN INHIBITOR; SW 02; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DRUG TARGETING; HYDROLYSIS; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; YEAST CELL;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ANIMALS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; PC12 CELLS; PEPTIDES; PROTEOSTASIS DEFICIENCIES; RATS; SACCHAROMYCES CEREVISIAE; SOLUBILITY;

EID: 84868142926     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb300166p     Document Type: Article

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