Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

Nature Chemical Biology

Volumn 9, Issue 2, 2013, Pages 112-118

  Wang, Adrienne M ^a   Miyata, Yoshinari ^a   Klinedinst, Susan ^a   Peng, Hwei Ming ^a   Chua, Jason P ^a   Komiyama, Tomoko ^a   Li, Xiaokai ^a   Morishima, Yoshihiro ^a   Merry, Diane E ^b   Pratt, William B ^a   Osawa, Yoichi ^a   Collins, Catherine A ^a   Gestwicki, Jason E ^a   Lieberman, Andrew P ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HIP PROTEIN; POLYGLUTAMINE ANDROGEN RECEPTOR; PROTEIN; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CLEARANCE; CONTROLLED STUDY; GENE OVEREXPRESSION; KENNEDY DISEASE; MOLECULAR MECHANICS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN HOMEOSTASIS; PROTEIN METABOLISM; UBIQUITINATION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DROSOPHILA; FEMALE; HEK293 CELLS; HELA CELLS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR CHAPERONES; MUSCULAR DISORDERS, ATROPHIC; NEUROTOXINS; PC12 CELLS; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; PROTEINS; PYRIDINES; RATS; RECEPTORS, ANDROGEN; THIAZOLES; UBIQUITINATION;

EID: 84872680675     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1140     Document Type: Article

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