A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator

Journal of the American Chemical Society

Volumn 133, Issue 50, 2011, Pages 20267-20276

  Cho, Hyungseoph J ^a   Gee, Heon Yung ^b   Baek, Kyung Hwa ^a   Ko, Sung Kyun ^a   Park, Jong Moon ^c   Lee, Hookeun ^c   Kim, Nam Doo ^d   Lee, Min Goo ^b   Shin, Injae ^a  

^a Yonsei University   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Gachon University College of Medicine   (South Korea)

^d Daegu Gyeongbuk Medical Innovation Foundation   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANION CHANNELS; ATP-ASE ACTIVITY; ATP-BINDING; ATPASE DOMAIN; BICARBONATE IONS; CELL SURFACES; CHLORIDE CHANNELS; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; LIFE SPAN; LUNG FUNCTION; LUNG INFECTION; MEMBRANE TRAFFICKING; MOLECULAR MODELING STUDIES; PROTEIN LABELING; SMALL MOLECULES; UBIQUITIN-PROTEASOME SYSTEM; UBIQUITINATION;

AFFINITY CHROMATOGRAPHY; AMINO ACIDS; BIOLOGICAL ORGANS; CELL MEMBRANES; CHLORINE COMPOUNDS; PROTEIN FOLDING;

PROTEINS;

ADENOSINE TRIPHOSPHATASE; APOPTOZOLE; CHLORIDE CHANNEL; HEAT SHOCK COGNATE PROTEIN 70; IMIDAZOLE DERIVATIVE; MUTANT PROTEIN; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DRUG INHIBITION; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; UBIQUITINATION;

ADENOSINE TRIPHOSPHATASES; BINDING SITES; CELL LINE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HSC70 HEAT-SHOCK PROTEINS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MUTATION; PROTEIN TRANSPORT; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; UBIQUITINATION;

EID: 83755171532     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja206762p     Document Type: Article

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