메뉴 건너뛰기




Volumn 61, Issue 11, 2012, Pages 2807-2813

Adipose tissue TCF7L2 Splicing is regulated by weight loss and associates with glucose and fatty acid metabolism

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; MESSENGER RNA; TRANSCRIPTION FACTOR 7 LIKE 2;

EID: 84868035640     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-0239     Document Type: Article
Times cited : (56)

References (26)
  • 1
    • 32544451924 scopus 로고    scopus 로고
    • Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
    • Grant SF, Thorleifsson G, Reynisdottir I, et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006;38:320-323
    • (2006) Nat Genet , vol.38 , pp. 320-323
    • Grant, S.F.1    Thorleifsson, G.2    Reynisdottir, I.3
  • 2
    • 77649086970 scopus 로고    scopus 로고
    • A map of open chromatin in human pancreatic islets
    • Gaulton KJ, Nammo T, Pasquali L, et al. A map of open chromatin in human pancreatic islets. Nat Genet 2010;42:255-259
    • (2010) Nat Genet , vol.42 , pp. 255-259
    • Gaulton, K.J.1    Nammo, T.2    Pasquali, L.3
  • 3
    • 34547702501 scopus 로고    scopus 로고
    • Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes
    • Lyssenko V, Lupi R, Marchetti P, et al. Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 2007;117:2155-2163
    • (2007) J Clin Invest , vol.117 , pp. 2155-2163
    • Lyssenko, V.1    Lupi, R.2    Marchetti, P.3
  • 4
    • 67249096093 scopus 로고    scopus 로고
    • Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function
    • Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function. Hum Mol Genet 2009;18:2388-2399
    • (2009) Hum Mol Genet , vol.18 , pp. 2388-2399
    • Shu, L.1    Matveyenko, A.V.2    Kerr-Conte, J.3    Cho, J.H.4    McIntosh, C.H.5    Maedler, K.6
  • 5
    • 0037443035 scopus 로고    scopus 로고
    • Pre-mRNA splicing and human disease
    • Faustino NA, Cooper TA. Pre-mRNA splicing and human disease. Genes Dev 2003;17:419-437
    • (2003) Genes Dev , vol.17 , pp. 419-437
    • Faustino, N.A.1    Cooper, T.A.2
  • 6
    • 77749239722 scopus 로고    scopus 로고
    • Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans
    • Mondal AK, Das SK, Baldini G, et al. Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans. J Clin Endocrinol Metab 2010;95:1450-1457
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 1450-1457
    • Mondal, A.K.1    Das, S.K.2    Baldini, G.3
  • 8
    • 70349569023 scopus 로고    scopus 로고
    • Tissue-specific alternative splicing of TCF7L2
    • Prokunina-Olsson L, Welch C, Hansson O, et al. Tissue-specific alternative splicing of TCF7L2. Hum Mol Genet 2009;18:3795-3804
    • (2009) Hum Mol Genet , vol.18 , pp. 3795-3804
    • Prokunina-Olsson, L.1    Welch, C.2    Hansson, O.3
  • 9
    • 79955444467 scopus 로고    scopus 로고
    • TCF7L2 splice variants have distinct effects on beta-cell turnover and function
    • Le Bacquer O, Shu L, Marchand M, et al. TCF7L2 splice variants have distinct effects on beta-cell turnover and function. Hum Mol Genet 2011;20: 1906-1915
    • (2011) Hum Mol Genet , vol.20 , pp. 1906-1915
    • Le Bacquer, O.1    Shu, L.2    Marchand, M.3
  • 10
    • 77951233751 scopus 로고    scopus 로고
    • Alternative splicing of tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at wnt/beta-catenin targets
    • Weise A, Bruser K, Elfert S, et al. Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targets. Nucleic Acids Res 2010;38:1964-1981
    • (2010) Nucleic Acids Res , vol.38 , pp. 1964-1981
    • Weise, A.1    Bruser, K.2    Elfert, S.3
  • 11
    • 79960961204 scopus 로고    scopus 로고
    • Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis
    • Pihlajamäki J, Lerin C, Itkonen P, et al. Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis. Cell Metab 2011;14:208-218
    • (2011) Cell Metab , vol.14 , pp. 208-218
    • Pihlajamäki, J.1    Lerin, C.2    Itkonen, P.3
  • 12
    • 0038176278 scopus 로고    scopus 로고
    • The human T-cell factor-4 gene splicing isoforms, wnt signal pathway, and apoptosis in renal cell carcinoma
    • Shiina H, Igawa M, Breault J, et al. The human T-cell factor-4 gene splicing isoforms, Wnt signal pathway, and apoptosis in renal cell carcinoma. Clin Cancer Res 2003;9:2121-2132
    • (2003) Clin Cancer Res , vol.9 , pp. 2121-2132
    • Shiina, H.1    Igawa, M.2    Breault, J.3
  • 13
    • 33745542960 scopus 로고    scopus 로고
    • C-terminal-binding protein directly activates and represses wnt transcriptional targets in drosophila
    • Fang M, Li J, Blauwkamp T, Bhambhani C, Campbell N, Cadigan KM. C-terminal-binding protein directly activates and represses Wnt transcriptional targets in Drosophila. EMBO J 2006;25:2735-2745
    • (2006) EMBO J , vol.25 , pp. 2735-2745
    • Fang, M.1    Li, J.2    Blauwkamp, T.3    Bhambhani, C.4    Campbell, N.5    Cadigan, K.M.6
  • 15
    • 47749089779 scopus 로고    scopus 로고
    • A genomewide RNAi screen for wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer
    • Tang W, Dodge M, Gundapaneni D, Michnoff C, Roth M, Lum L. A genomewide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Proc Natl Acad Sci USA 2008;105:9697-9702
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 9697-9702
    • Tang, W.1    Dodge, M.2    Gundapaneni, D.3    Michnoff, C.4    Roth, M.5    Lum, L.6
  • 16
    • 36849056525 scopus 로고    scopus 로고
    • A unique DNA binding domain converts T-cell factors into strong wnt effectors
    • Atcha FA, Syed A, Wu B, et al. A unique DNA binding domain converts T-cell factors into strong Wnt effectors. Mol Cell Biol 2007;27:8352-8363
    • (2007) Mol Cell Biol , vol.27 , pp. 8352-8363
    • Atcha, F.A.1    Syed, A.2    Wu, B.3
  • 17
    • 84857355693 scopus 로고    scopus 로고
    • Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans
    • Pihlajamäki J, Kuulasmaa T, Kaminska D, et al. Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans. J Hepatol 2012;56:663-670
    • (2012) J Hepatol , vol.56 , pp. 663-670
    • Pihlajamäki, J.1    Kuulasmaa, T.2    Kaminska, D.3
  • 18
    • 65549163338 scopus 로고    scopus 로고
    • Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 finnish men
    • Stancáková A, Javorský M, Kuulasmaa T, Haffner SM, Kuusisto J, Laakso M. Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men. Diabetes 2009;58: 1212-1221
    • (2009) Diabetes , vol.58 , pp. 1212-1221
    • Stancáková, A.1    Javorský, M.2    Kuulasmaa, T.3    Haffner, S.M.4    Kuusisto, J.5    Laakso, M.6
  • 19
    • 11144346107 scopus 로고    scopus 로고
    • Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome
    • Salmenniemi U, Ruotsalainen E, Pihlajamäki J, et al. Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome. Circulation 2004;110:3842-3848
    • (2004) Circulation , vol.110 , pp. 3842-3848
    • Salmenniemi, U.1    Ruotsalainen, E.2    Pihlajamäki, J.3
  • 20
    • 0031963964 scopus 로고    scopus 로고
    • Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited. Metabolic studies on offspring of diabetic probands
    • Vauhkonen I, Niskanen L, Vanninen E, Kainulainen S, Uusitupa M, Laakso M. Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited. Metabolic studies on offspring of diabetic probands. J Clin Invest 1998;101:86-96
    • (1998) J Clin Invest , vol.101 , pp. 86-96
    • Vauhkonen, I.1    Niskanen, L.2    Vanninen, E.3    Kainulainen, S.4    Uusitupa, M.5    Laakso, M.6
  • 21
    • 0035129323 scopus 로고    scopus 로고
    • Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation
    • Wabitsch M, Brenner RE, Melzner I, et al. Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation. Int J Obes Relat Metab Disord 2001;25:8-15
    • (2001) Int J Obes Relat Metab Disord , vol.25 , pp. 8-15
    • Wabitsch, M.1    Brenner, R.E.2    Melzner, I.3
  • 22
    • 70349636577 scopus 로고    scopus 로고
    • Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes
    • Prokunina-Olsson L, Kaplan LM, Schadt EE, Collins FS. Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes. PLoS ONE 2009;4:e7231
    • (2009) PLoS ONE , vol.4
    • Prokunina-Olsson, L.1    Kaplan, L.M.2    Schadt, E.E.3    Collins, F.S.4
  • 23
    • 0035933893 scopus 로고    scopus 로고
    • Insulin regulates alternative splicing of protein kinase C beta II through a phosphatidylinositol 3-kinase-dependent pathway involving the nuclear serine/arginine-rich splicing factor, SRp40, in skeletal muscle cells
    • Patel NA, Chalfant CE, Watson JE, et al. Insulin regulates alternative splicing of protein kinase C beta II through a phosphatidylinositol 3-kinase-dependent pathway involving the nuclear serine/arginine-rich splicing factor, SRp40, in skeletal muscle cells. J Biol Chem 2001;276: 22648-22654
    • (2001) J Biol Chem , vol.276 , pp. 22648-22654
    • Patel, N.A.1    Chalfant, C.E.2    Watson, J.E.3
  • 24
    • 33846596193 scopus 로고    scopus 로고
    • Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
    • Helgason A, Pálsson S, Thorleifsson G, et al. Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet 2007;39:218-225
    • (2007) Nat Genet , vol.39 , pp. 218-225
    • Helgason, A.1    Pálsson, S.2    Thorleifsson, G.3
  • 25
    • 33750602980 scopus 로고    scopus 로고
    • Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk
    • Groves CJ, Zeggini E, Minton J, et al. Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes 2006;55:2640-2644
    • (2006) Diabetes , vol.55 , pp. 2640-2644
    • Groves, C.J.1    Zeggini, E.2    Minton, J.3
  • 26
    • 33746075560 scopus 로고    scopus 로고
    • TCF7L2 polymorphisms and progression to diabetes in the diabetes prevention program
    • Diabetes Prevention Program Research Group
    • Florez JC, Jablonski KA, Bayley N, et al.; Diabetes Prevention Program Research Group. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 2006;355:241-250
    • (2006) N Engl J Med , vol.355 , pp. 241-250
    • Florez, J.C.1    Jablonski, K.A.2    Bayley, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.