Impact of leucine on energy balance

Journal of Physiology and Biochemistry

Volumn 69, Issue 1, 2013, Pages 155-163

  McAllan, Liam ^a,b   Cotter, Paul D ^a,c   Roche, Helen M ^d   Korpela, Riitta ^e   Nilaweera, Kanishka N ^a  

^a TEAGASC FOOD RESEARCH CENTRE   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c UNIVERSITY COLLEGE CORK   (Ireland)

^d UNIVERSITY COLLEGE DUBLIN   (Ireland)

^e UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Cholecystokinin; Fatty acid synthase; Glucagon like peptide 1; Pro opiomelanocortin

Indexed keywords

LEUCINE;

ADIPOSE TISSUE; BRAIN METABOLISM; CALORIC INTAKE; CELL FUNCTION; ENERGY BALANCE; ENERGY EXPENDITURE; HUMAN; LIPID METABOLISM; NONHUMAN; OBESITY; REVIEW;

ADIPOSE TISSUE; BODY WEIGHT; DIET; ENERGY INTAKE; ENERGY METABOLISM; GASTROINTESTINAL TRACT; HUMANS; HYPOTHALAMUS; LEUCINE; LIPID METABOLISM; LIVER; MUSCLE, SKELETAL; OBESITY;

EID: 84879498662     PISSN: 11387548     EISSN: 18778755     Source Type: Journal    
DOI: 10.1007/s13105-012-0170-2     Document Type: Review

References (74)

1. Arase K, York DA, Shimizu H et al (1988) Effects of corticotropin- releasing factor on food intake and brown adipose tissue thermogenesis in rats. Am J Physiol 255:E255-E259
2. Azzara AV, Sokolnicki JP, Schwartz GJ (2002) Central melanocortin receptor agonist reduces spontaneous and scheduled meal size but does not augment duodenal preload-induced feeding inhibition. Physiol Behav 77:411-416
3. Backus RC, Howard KA, Rogers QR (1997) The potency of dietary amino acids in elevating plasma cholecystokinin immunoreactivity in cats is related to amino acid hydrophobicity. Regul Pept 72:31-40
4. Balage M, Dardevet D (2010) Long-term effects of leucine supplementation on body composition. Curr Opin Clin Nutr 13:265-270
5. Bartness TJ, Song CK (2007) Brain-adipose tissue neural crosstalk. Physiol Behav 91:343-351
6. Bjorkman MP, Pilvi TK, Kekkonen RA et al (2011) Similar effects of leucine rich and regular dairy products on muscle mass and functions of older polymyalgia rheumatica patients: A randomized crossover trial. J Nutr Health Aging 15:462-467
7. Blevins JE, Morton GJ, Williams DL et al (2009) Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8. Am J Physiol Regul Integr Comp Physiol 296:R476-R484
8. Blouet C, Jo YH, Li X et al (2009) Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit. J Neurosci 29:8302-8311
9. Bong HY, Kim JY, Jeong HI et al (2010) Effects of corn gluten hydrolyzates, branched chain amino acids, and leucine on body weight reduction in obese rats induced by a high fat diet. Nutr Res Pract 4:106-113
10. Bucinskaite V, Tolessa T, Pedersen J et al. (2009) Receptor-mediated activation of gastric vagal afferents by glucagon-like peptide-1 in the rat. Neurogastroent Motil 21
11. Chen Q, Reimer RA (2009) Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro. Nutrition 25:340-349
12. Cheng Y, Meng Q, Wang C et al (2010) Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue. Diabetes 59:17-25
13. Cheng Y, Zhang Q, Meng Q et al (2011) Leucine deprivation stimulates fat loss via increasing CRH expression in the hypothalamus and activating the sympathetic nervous system. Mol Endocrinol 25:1624-1635
14. Cone RD (2005) Anatomy and regulation of the central melanocortin system. Nat Neurosci 8:571-578
15. Cota D, Proulx K, Smith KA et al (2006) Hypothalamic mTOR signaling regulates food intake. Science 312:927-930
16. Cowley MA, Smart JL, Rubinstein M et al (2001) Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411:480-484
17. Cowley MA, Smith RG, Diano S et al (2003) The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37:649-661
18. Cummings DE, Weigle DS, Frayo RS et al (2002) Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 346:1623-1630
19. Date Y, Kojima M, Hosoda H et al (2000) Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141:4255-4261
20. Date Y, Murakami N, Toshinai K et al (2002) The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 123:1120-1128
21. Deschenes RJ, Lorenz LJ, Haun RS et al (1984) Cloning and sequence analysis of a cDNA-encoding rat preprocholecystokinin. P Natl Acad Sci-Biol 81:726-730
22. Devkota S, Layman DK (2010) Protein metabolic roles in treatment of obesity. Curr Opin Clin Nutr 13:403-407
23. Diraison F, Yankah V, Letexier D et al (2003) Differences in the regulation of adipose tissue and liver lipogenesis by carbohydrates in humans. J Lipid Res 44:846-853
24. Donato J Jr, Pedrosa RG, Cruzat VF et al (2006) Effects of leucine supplementation on the body composition and protein status of rats submitted to food restriction. Nutrition 22:520-527
25. Dube MG, Xu B, Crowley WR et al (1994) Evidence that neuropeptide Y is a physiological signal for normal food intake. Brain Res 646:341-344
26. Egecioglu E, Stenstrom B, Pinnock SB et al (2008) Hypothalamic gene expression following ghrelin therapy to gastrectomized rodents. Regul Pept 146:176-182
27. Enriori PJ, Evans AE, Sinnayah P et al (2007) Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons. Cell Metab 5:181-194
28. Fan W, Boston BA, Kesterson RA et al (1997) Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385:165-168
29. Gibbs J, Young RC, Smith GP (1973) Cholecystokinin elicits satiety in rats with open gastric fistulas. Nature 245:323-325
30. Gutzwiller JP, Goke B, Drewe J et al (1999) Glucagon-like peptide-1: a potent regulator of food intake in humans. Gut 44:81-86
31. Hatakeyama Y, Sakata Y, Takakura S et al (2004) Acute and chronic effects of FR-149175, a beta(3)-adrenergic receptor agonist, on energy expenditure in Zucker fatty rats. Am J Physiol-Reg I 287:R336-R341
32. Huang XF, Han M, South T et al (2003) Altered levels of POMC, AgRP and MC4-R mRNA expression in the hypothalamus and other parts of the limbic system of mice prone or resistant to chronic high-energy diet-induced obesity. Brain Res 992:9-19
33. Joseph SA, Michael GJ (1988) Efferent Acth-Ir opiocortin projections from nucleus tractus solitarius - a hypothalamic deafferentation study. Peptides 9:193-201
34. Leenders M, Verdijk LB, van der Hoeven L et al (2011) Prolonged leucine supplementation does not augment muscle mass or affect glycemic control in elderly type 2 diabetic men. J Nutr 141:1070-1076
35. Li FN, Yin YL, Tan B et al (2011) Leucine nutrition in animals and humans: mTOR signaling and beyond. Amino Acids 41:1185-1193
36. Luckman SM, Lawrence CB (2003) Anorectic brainstem peptides: more pieces to the puzzle. Trends Endocrin Met 14:60-65
37. Lynch CJ (2001) Role of leucine in the regulation of mTOR by amino acids: revelations from structure-activity studies. J Nutr 131:861S-865S
38. Macotela Y, Emanuelli B, Bang AM et al (2011) Dietary leucine - an environmental modifier of insulin resistance acting on multiple levels of metabolism. PLoS One 6:e21187
39. Mano-Otagiri A, Iwasaki-Sekino A, Nemoto T et al (2010) Genetic suppression of ghrelin receptors activates brown adipocyte function and decreases fat storage in rats. Regul Pept 160:81-90
40. Mashiko S, Ishihara A, Iwaasa H et al (2007) A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Mol Pharmacol 71:602-608
41. Mizuno TM, Kleopoulos SP, Bergen HT et al (1998) Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 47:294-297
42. Moran TH, Baldessarini AR, Salorio CF et al (1997) Vagal afferent and efferent contributions to the inhibition of food intake by cholecystokinin. Am J Physiol 272:R1245-R1251
43. Nairizi A, She P, Vary TC et al (2009) Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice. J Nutr 139:715-719
44. Naslund E, Barkeling B, King N et al (1999) Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men. Int J Obes Relat Metab Disord 23:304-311
45. Nilaweera KN, Giblin L, Ross RP (2010) Nutrient regulation of enteroendocrine cellular activity linked to cholecystokinin gene expression and secretion. J Physiol Biochem 66:85-92
46. Noatsch A, Petzke KJ, Millrose MK et al. (2010) Body weight and energy homeostasis was not affected in C57BL/6 mice fed high whey protein or leucine-supplemented low-fat diets. Eur J Nutr
47. Nogueiras R, Perez-Tilve D, Veyrat-Durebex C et al (2009) Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. J Neurosci 29:5916-5925
48. Nogueiras R, Wiedmer P, Perez-Tilve D et al (2007) The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest 117:3475-3488
49. Norton LE, Layman DK, Bunpo P et al (2009) The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats. J Nutr 139:1103-1109
50. Osaka T, Endo M, Yamakawa M et al (2005) Energy expenditure by intravenous administration of glucagon-like peptide-1 mediated by the lower brainstem and sympathoadrenal system. Peptides 26:1623-1631
51. Pankevich DE, Teegarden SL, Hedin AD et al (2010) Caloric restriction experience reprograms stress and orexigenic pathways and promotes binge eating. J Neurosci 30:16399-16407
52. Qin LQ, Xun P, Bujnowski D et al (2011) Higher branched-chain amino acid intake is associated with a lower prevalence of being overweight or obese in middle-aged East Asian and Western adults. J Nutr 141:249-254
53. Raposinho PD, Pierroz DD, Broqua P et al (2001) Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6 J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism. Mol Cell Endocrinol 185:195-204
54. Richard CD, Tolle V, Low MJ (2011) Meal pattern analysis in neural-specific proopiomelanocortin-deficient mice. Eur J Pharmacol 660:131-138
55. Ropelle ER, Pauli JR, Fernandes MF et al (2008) A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss. Diabetes 57:594-605
56. Roseberry AG, Liu H, Jackson AC et al (2004) Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice. Neuron 41:711-722
57. Savastano DM, Covasa M (2005) Adaptation to a high-fat diet leads to hyperphagia and diminished sensitivity to cholecystokinin in rats. J Nutr 135:1953-1959
58. Schelbert KB (2009) Comorbidities of obesity. Prim Care 36:271-285
59. Seo S, Ju S, Chung H et al (2008) Acute effects of glucagon-like peptide-1 on hypothalamic neuropeptide and AMP activated kinase expression in fasted rats. Endocr J 55:867-874
60. Sun X, Zemel MB (2007) Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells. Lipids 42:297-305
61. Suominen AH, Glimm DR, Tedesco D et al (1998) Intestinal nutrient-gene interaction: the effect of feed deprivation and refeeding on cholecystokinin and proglucagon gene expression. J Anim Sci 76:3104-3113
62. Tschop M, Smiley DL, Heiman ML (2000) Ghrelin induces adiposity in rodents. Nature 407:908-913
63. Tucker JD, Dhanvantari S, Brubaker PL (1996) Proglucagon processing in islet and intestinal cell lines. Regul Pept 62:29-35
64. van Loon LJC (2012) Leucine as a pharmaconutrient in health and disease. Curr Opin Clin Nutr 15:71-77
65. Verhoeven S, Vanschoonbeek K, Verdijk LB et al (2009) Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men. Am J Clin Nutr 89:1468-1475
66. Vianna D, Resende GF, Torres-Leal FL et al (2012) Long-term leucine supplementation reduces fat mass gain without changing body protein status of aging rats. Nutrition 28:182-189
67. Walzem RL, Dillard CJ, German JB (2002) Whey components: millennia of evolution create functionalities for mammalian nutrition: what we know and what we may be overlooking. Crit Rev Food Sci Nutr 42:353-375
68. Wren AM, Seal LJ, Cohen MA et al (2001) Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86:5992
69. Xu G, Li Y, An W et al (2009) Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake. Endocrinology 150:3637-3644
70. Yasuda T, Masaki T, Kakuma T et al (2004) Hypothalamic melanocortin system regulates sympathetic nerve activity in brown adipose tissue. Exp Biol Med (Maywood) 229:235-239
71. Yin Y, Yao K, Liu Z et al (2010) Supplementing L-leucine to a low-protein diet increases tissue protein synthesis in weanling pigs. Amino Acids 39:1477-1486
72. Zeanandin G, Balage M, Schneider SM et al (2012) Differential effect of long-term leucine supplementation on skeletal muscle and adipose tissue in old rats: an insulin signaling pathway approach. Age (Dordr) 34:371-387
73. Zhang Y, Guo K, LeBlanc RE et al (2007) Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes 56:1647-1654
74. Zhang YY, Proenca R, Maffei M et al (1994) Positional cloning of the mouse obese gene and its human homolog. Nature 372:425-432