Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 296, Issue 3, 2009, Pages

  Blevins, James E ^a,b   Morton, Gregory J ^b   Williams, Diana L ^b   Caldwell, David W ^a   Bastian, Lloyd S ^a   Wisse, Brent E ^b   Schwartz, Michael W ^b   Baskin, Denis G ^a,b  

^a VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Cholecystokinin; Paraventricular nucleus; Retrograde tracer

Indexed keywords

CHOLECYSTOKININ; CHOLECYSTOKININ OCTAPEPTIDE; CHOLERA TOXIN B SUBUNIT; LEPTIN; MELANOCORTIN; MELANOCORTIN 4 RECEPTOR; MESSENGER RNA; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; INTERMEDIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BODY MASS; BRAIN REGION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FEMALE; FOOD INTAKE; FOREBRAIN; HYPOTHALAMUS; LASER CAPTURE MICRODISSECTION; MALE; MOUSE; NEUROANATOMY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHOMBENCEPHALON; SATIETY; SIGNAL TRANSDUCTION; SOLITARY TRACT NUCLEUS; WILD TYPE; ANIMAL; ANTERIOR HYPOTHALAMUS; BIOSYNTHESIS; BRAIN FOURTH VENTRICLE; DRUG EFFECT; EATING; GENETICS; MOUSE MUTANT; PHYSIOLOGY; PSYCHOPHYSIOLOGY; RAT; STEREOTACTIC PROCEDURE; WISTAR RAT;

ANIMALS; EATING; FOURTH VENTRICLE; MALE; MELANOCORTINS; MELANOCYTE-STIMULATING HORMONES; MICE; MICE, KNOCKOUT; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PROSENCEPHALON; RATS; RATS, WISTAR; RECEPTOR, MELANOCORTIN, TYPE 4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHOMBENCEPHALON; RNA, MESSENGER; SATIETY RESPONSE; SIGNAL TRANSDUCTION; SINCALIDE; STEREOTAXIC TECHNIQUES;

EID: 64149130097     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.90544.2008     Document Type: Article

References (53)

1. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS. Role of leptin in the neuroendocrine response to fasting. Nature 382: 250-252, 1996. (Pubitemid 26251358)
2. Aja SM, Sahandy S, Ladenheim EE, Schwartz GJ, Moran TH. Intracerebroventricular CART peptide reduces food intake and alters motor behavior at a hindbrain site. Am J Physiol Regul Integr Comp Physiol 281: R1862-R1867, 2001. (Pubitemid 33776664)
3. Azzara AV, Schuss B, Hong S, Chua SC, Schwartz GJ. Melanocortin 4 receptor (MC4R) knockout mice have increased food intake and meal size, and decreased sensitivity to post-oral nutrient stimulation. Appetite 44: 332, 2005.
4. Azzara AV, Sokolnicki JP, Schwartz GJ. Central melanocortin receptor agonist reduces spontaneous and scheduled meal size but does not augment duodenal preload-induced feeding inhibition. Physiol Behav 77: 411-416, 2002.
5. Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Edelstein E, Choi B, Boss O, Aschkenasi C, Zhang CY, Mountjoy K, Kishi T, Elmquist JK, Lowell BB. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123: 493-505, 2005. (Pubitemid 41546678)
6. Barrachina MD, Martinez V, Wang L, Wei JY, Tache Y. Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc Natl Acad Sci USA 94: 10455-10460, 1997. (Pubitemid 27407063)
7. Benoit SC, Schwartz MW, Lachey JL, Hagan MM, Rushing PA, Blake KA, Yagaloff KA, Kurylko G, Franco L, Danhoo W, Seeley RJ. A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. J Neurosci 20: 3442-3448, 2000. (Pubitemid 30263160)
8. Blevins JE, Dixon KD, Hernandez EJ, Barrett JA, Gietzen DW. Effects of threonine injections in the lateral hypothalamus on intake of amino acid imbalanced diets in rats. Brain Res 879: 65-72, 2000.
9. Blevins JE, Eakin TJ, Murphy JA, Schwartz MW, Baskin DG. Oxytocin innervation of caudal brain stem nuclei activated by cholecystokinin. Brain Res 993: 30-41, 2003.
10. Blevins JE, Schwartz MW, Baskin DG. Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size. Am J Physiol Regul Integr Comp Physiol 287: R87-R96, 2004.
11. Borison HL. History and status of the area postrema. Fed Proc 43: 2937-2940, 1984.
12. Cheung CC, Clifton DK, Steiner RA. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 138: 4489-4492, 1997.
13. Cowley MA, Pronchuk N, Fan W, Dinulescu DM, Colmers WF, Cone RD. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24: 155-163, 1999. (Pubitemid 29466155)
14. Ebihara K, Ogawa Y, Katsuura G, Numata Y, Masuzaki H, Satoh N, Tamaki M, Yoshioka T, Hayase M, Matsuoka N, Aizawa-Abe M, Yoshimasa Y, Nakao K. Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action. Diabetes 48: 2028-2033, 1999. (Pubitemid 29458367)
15. Elias CF, Saper CB, Maratos-Flier E, Tritos NA, Lee C, Kelly J, Tatro JB, Hoffman GE, Ollmann MM, Barsh GS, Sakurai T, Yanagisawa M, Elmquist JK. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol 402: 442-459, 1998. (Pubitemid 29001074)
16. Elmquist JK, Ahima RS, Elias CF, Flier JS, Saper CB. Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc Natl Acad Sci USA 95: 741-746, 1998.
17. Emond M, Ladenheim EE, Schwartz GJ, Moran TH. Leptin amplifies the feeding inhibition and neural activation arising from a gastric nutrient preload. Physiol Behav 72: 123-128, 2001. (Pubitemid 32184801)
18. Emond M, Schwartz GJ, Ladenheim EE, Moran TH. Central leptin modulates behavioral and neural responsivity to CCK. Am J Physiol Regul Integr Comp Physiol 276: R1545-R1549, 1999. (Pubitemid 29249682)
19. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385: 165-168, 1997. (Pubitemid 27034218)
20. Fan W, Ellacott KL, Halatchev IG, Takahashi K, Yu P, Cone RD. Cholecystokinin-mediated suppression of feeding involves the brain stem melanocortin system. Nat Neurosci 7: 335-336, 2004. (Pubitemid 38429170)
21. Farooqi IS, O'Rahilly S. Monogenic human obesity syndromes. Recent Prog Horm Res 59: 409-424, 2004.
22. Hill DR, Campbell NJ, Shaw TM, Woodruff GN. Autoradiographic localization and biochemical characterization of peripheral type CCK receptors in rat CNS using highly selective nonpeptide CCK antagonists. J Neurosci 7: 2967-2976, 1987.
23. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F. Targeted disruption of the melanocortin- 4 receptor results in obesity in mice. Cell 88: 131-141, 1997. (Pubitemid 27180337)
24. Jing X, Ratty AK, Murphy D. Ontogeny of the vasopressin and oxytocin mRNAs in the mouse hypothalamus. Neurosci Res 30: 343-349, 1998. (Pubitemid 28291783)
25. Kirchgessner AL, Sclafani A, Nilaver G. Histochemical identification of a PVN-hindbrain feeding pathway. Physiol Behav 42: 529-543, 1988. (Pubitemid 18105345)
26. Ladenheim EE, Behles R, Bi S, Moran TH. Gastrin-releasing peptide mRNA expression in the hypothalamic paraventricular nucleus is altered by melanocortin receptor stimulation and food deprivation. Endocrinology In press.
27. Lu XY, Barsh GS, Akil H, Watson SJ. Interaction between alpha-melanocyte- stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses. J Neurosci 23: 7863-7872, 2003. (Pubitemid 37052354)
28. Marsh DJ, Hollopeter G, Huszar D, Laufer R, Yagaloff KA, Fisher SL, Burn P, Palmiter RD. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet 21: 119-122, 1999. (Pubitemid 29036297)
29. Moran TH, Robinson PH, Goldrich MS, McHugh PR. Two brain cholecystokinin receptors: implications for behavioral actions. Brain Res 362: 175-179, 1986.
30. Morton GJ, Blevins JE, Williams DL, Niswender KD, Gelling RW, Rhodes CJ, Baskin DG, Schwartz MW. Leptin action in the forebrain regulates the hindbrain response to satiety signals. J Clin Invest 115: 703-710, 2005.
31. Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 8: 1298-1308, 1994.
32. Palkovits M, Mezey E, Eskay RL. Pro-opiomelanocortin-derived peptides (ACTH/beta-endorphin/alpha-MSH) in brain stem baroreceptor areas of the rat. Brain Res 436: 323-338, 1987. (Pubitemid 18003571)
33. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. (2nd ed.). Orlando, FL: Academic, 1986.
34. Perez C, Sclafani A. Cholecystokinin conditions flavor preferences in rats. Am J Physiol Regul Integr Comp Physiol 260: R179-R185, 1991.
35. Raposinho PD, Castillo E, d'Alleves V, Broqua P, Pralong FP, Aubert ML. Chronic blockade of the melanocortin 4 receptor subtype leads to obesity independently of neuropeptide Y action, with no adverse effects on the gonadotropic and somatotropic axes. Endocrinology 141: 4419-4427, 2000.
36. Reidelberger RD, Hernandez J, Fritzsch B, Hulce M. Abdominal vagal mediation of the satiety effects of CCK in rats. Am J Physiol Regul Integr Comp Physiol 286: R1005-R1012, 2004. (Pubitemid 38661387)
37. Rinaman L. Oxytocinergic inputs to the nucleus of the solitary tract and dorsal motor nucleus of the vagus in neonatal rats. J Comp Neurol 399: 101-109, 1998. (Pubitemid 28391557)
38. Rossi M, Kim MS, Morgan DG, Small CJ, Edwards CM, Sunter D, Abusnana S, Goldstone AP, Russell SH, Stanley SA, Smith DM, Yagaloff K, Ghatei MA, Bloom SR. A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alphamelanocyte stimulating hormone in vivo. Endocrinology 139: 4428-4431, 1998. (Pubitemid 28513735)
39. Sawchenko PE. Evidence for differential regulation of corticotropin-releasing factor and vasopressin immunoreactivities in parvocellular neurosecretory and autonomic-related projections of the paraventricular nucleus. Brain Res 437: 253-263, 1987.
40. Sawchenko PE, Swanson LW. Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat. J Comp Neurol 205: 260-272, 1982.
41. Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98: 1101-1106, 1996.
42. Schwartz MW, Seeley RJ, Woods SC, Weigle DS, Campfield LA, Burn P, Baskin DG. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46: 2119-2123, 1997.
43. Seeley RJ, Yagaloff KA, Fisher SL, Burn P, Thiele TE, van Dijk G, Baskin DG, Schwartz MW. Melanocortin receptors in leptin effects. Nature 390: 349, 1997. (Pubitemid 28027303)
44. Segal JP, Stallings NR, Lee CE, Zhao L, Socci N, Viale A, Harris TM, Soares MB, Childs G, Elmquist JK, Parker KL, Friedman JM. Use of laser-capture microdissection for the identification of marker genes for the ventromedial hypothalamic nucleus. J Neurosci 25: 4181-4188, 2005. (Pubitemid 40563394)
45. Stanley BG, Lanthier D, Leibowitz SF. Multiple brain sites sensitive to feeding stimulation by opiod agonists: a cannula-mapping study. Pharmacol Biochem Behav 31: 825-832, 1988. (Pubitemid 19274290)
46. Sutton GM, Duos B, Patterson LM, Berthoud HR. Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus. Endocrinology 146: 3739-3747, 2005. (Pubitemid 41175741)
47. Uehara Y, Shimazu T, Ohtani K, Sato N, Mori M. Hypothalamic corticotropin-releasing hormone is a mediator of the anorexigenic effect of leptin. Diabetes 47: 890-893, 1998. (Pubitemid 28255661)
48. Vaughan CH, Haskell-Luevano C, Andreasen A, Rowland NE. Effects of oral preload, CCK or bombesin administration on short term food intake of melanocortin 4-receptor knockout (MC4RKO) mice. Peptides 27: 3226-3233, 2006.
49. Williams DL, Grill HJ, Weiss SM, Baird JP, Kaplan JM. Behavioral processes underlying the intake suppressive effects of melanocortin 3/4 receptor activation in the rat. Psychopharmacology (Berl) 161: 47-53, 2002.
50. Williams DL, Kaplan JM, Grill HJ. The role of the dorsal vagal complex and the vagus nerve in feeding effects of melanocortin-3/4 receptor stimulation. Endocrinology 141: 1332-1337, 2000.
51. Wirth MM, Olszewski PK, Yu C, Levine AS, Giraudo SQ. Paraventricular hypothalamic alpha-melanocyte-stimulating hormone and MTII reduce feeding without causing aversive effects. Peptides 22: 129-134, 2001. (Pubitemid 32146692)
52. Wsniewski H, Olszewski J. Vascular permeability in the area postrema and hypothalamus. A study using iodinated radioactive albumin. Neurology 13: 885-894, 1963.
53. Zheng H, Patterson LM, Pfifer CB, Berthoud HR. Brain stem melanocortinergic modulation of meal size and identification of hypothalamic POMC projections. Am J Physiol Regul Integr Comp Physiol 289: R247-R258, 2005. (Pubitemid 40874981)