Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue

Diabetes

Volumn 59, Issue 1, 2010, Pages 17-25

  Cheng, Ying ^a   Meng, Qingshu ^a   Wang, Chunxia ^a   Li, Houkai ^a   Huang, Zhiying ^a   Chen, Shanghai ^a   Xiao, Fei ^a   Guo, Feifan ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID SYNTHASE; LEUCINE; TRIACYLGLYCEROL LIPASE; UNCOUPLING PROTEIN 1; ADRENALIN; DNA; FATTY ACID; GLUCOCORTICOID; GLYCEROL; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN; RNA;

ABDOMINAL FAT; AMINO ACID DEFICIENCY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY COMPOSITION; BODY WEIGHT; BROWN ADIPOSE TISSUE; CELL VOLUME; CONTROLLED STUDY; ENERGY EXPENDITURE; FATTY ACID OXIDATION; GENE EXPRESSION; LIPID METABOLISM; LIPOLYSIS; MALE; METABOLIC PARAMETERS; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM TEMPERATURE; THERMOGENESIS; UPREGULATION; WHITE ADIPOSE TISSUE; ADIPOSE TISSUE; ANIMAL; BLOOD; C57BL MOUSE; CALORIMETRY; GENETICS; HISTOLOGY; ISOLATION AND PURIFICATION; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADIPOSE TISSUE; ADIPOSE TISSUE, BROWN; ANIMALS; CALORIMETRY, INDIRECT; DNA; EPINEPHRINE; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS, NONESTERIFIED; GLUCOCORTICOIDS; GLYCEROL; ION CHANNELS; LEUCINE; LIPOLYSIS; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIAL PROTEINS; OXYGEN CONSUMPTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; UP-REGULATION;

EID: 77449124765     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-0929     Document Type: Article

References (46)

1. Hofbauer KG. Molecular pathways to obesity. Int J Obes Relat Metab Disord 2002;26(Suppl. 2):S18-S27
2. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004;89:2548-2556
3. Fernández-López JA, Remesar X, Foz M, Alemany M. Pharmacological approaches for the treatment of obesity. Drugs 2002;62:915-944
4. Layman DK, Walker DA. Potential importance of leucine in treatment of obesity and the metabolic syndrome. J Nutr 2006;136:319S-323S
5. van Dam RM, Seidell JC. Carbohydrate intake and obesity. Eur J Clin Nutr 2007;61(Suppl. 1):S75-S99
6. Stimson RH, Johnstone AM, Homer NZ, Wake DJ, Morton NM, Andrew R, Lobley GE, Walker BR. Dietary macronutrient content alters cortisol metabolism independently of body weight changes in obese men. J Clin Endocrinol Metab 2007;92:4480-4484 (Pubitemid 350074774)
7. Schutz Y. Macronutrients and energy balance in obesity. Metabolism 1995;44:7-11
8. Layman DK, Shiue H, Sather C, Erickson DJ, Baum J. Increased dietary protein modifies glucose and insulin homeostasis in adult women during weight loss. J Nutr 2003;133:405-410 (Pubitemid 36172891)
9. Guo F, Cavener DR. The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. Cell Metab 2007;5:103-114 (Pubitemid 46172919)
10. Opara EC, Petro A, Tevrizian A, Feinglos MN, Surwit RS. L-glutamine supplementation of a high fat diet reduces body weight and attenuates hyperglycemia and hyperinsulinemia in C57BL/6J mice. J Nutr 1996;126:273-279 (Pubitemid 26030659)
11. Jobgen W, Meininger CJ, Jobgen SC, Li P, Lee MJ, Smith SB, Spencer TE, Fried SK, Wu G. Dietary L-arginine supplementation reduces white fat gain and enhances skeletal muscle and brown fat masses in diet-induced obese rats. J Nutr 2009;139:230-237
12. Fu WJ, Haynes TE, Kohli R, Hu J, Shi W, Spencer TE, Carroll RJ, Meininger CJ, Wu G. Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty rats. J Nutr 2005;135:714-721 (Pubitemid 40464093)
13. Kimball SR, Jefferson LS. Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. J Nutr 2006;136:227S-231S
14. Anthony TG, McDaniel BJ, Byerley RL, McGrath BC, Cavener DR, McNurlan MA, Wek RC. Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. J Biol Chem 2004;279:36553-36561
15. Zhang Y, Guo K, LeBlanc RE, Loh D, Schwartz GJ, Yu YH. Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes 2007;56:1647-1654 (Pubitemid 46842599)
16. Nairizi A, She P, Vary TC, Lynch CJ. Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice. J Nutr 2009;139:715-719
17. Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, Lien LF, Haqq AM, Shah SH, Arlotto M, Slentz CA, Rochon J, Gallup D, Ilkayeva O, Wenner BR, Yancy WS Jr, Eisenson H, Musante G, Surwit RS, Millington DS, Butler MD, Svetkey LP. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab 2009;9:311-326
18. Donato J Jr, Pedrosa RG, Cruzat VF, Pires IS, Tirapegui J. Effects of leucine supplementation on the body composition and protein status of rats submitted to food restriction. Nutrition 2006;22:520-527
19. Matthias A, Ohlson KB, Fredriksson JM, Jacobsson A, Nedergaard J, Cannon B. Thermogenic responses in brown fat cells are fully UCP1-dependent: UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty acid-induced thermogenesis. J Biol Chem 2000;275:25073-25081 (Pubitemid 30658747)
20. Gerin I, Dolinsky VW, Shackman JG, Kennedy RT, Chiang SH, Burant CF, Steffensen KR, Gustafsson JA, MacDougald OA. LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function. J Biol Chem 2005;280:23024-23031 (Pubitemid 40861694)
21. Cariou B, Postic C, Boudou P, Burcelin R, Kahn CR, Girard J, Burnol AF, Mauvais-Jarvis F. Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout mice. Endocrinology 2004;145:1926-1932 (Pubitemid 38402402)
22. Kim IC, Neudahl G, Deal WC Jr. Fatty acid synthase from pig liver. Methods Enzymol 1981;71:79-85
23. Wang SP, Laurin N, Himms-Hagen J, Rudnicki MA, Levy E, Robert MF, Pan L, Oligny L, Mitchell GA. The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice. Obes Res 2001;9:119-128 (Pubitemid 33603838)
24. Watt MJ, Holmes AG, Pinnamaneni SK, Garnham AP, Steinberg GR, Kemp BE, Febbraio MA. Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue. Am J Physiol Endocrinol Metab 2006;290:E500-E508 (Pubitemid 43671697)
25. Brown MS, Goldstein JL. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997;89:331-340 (Pubitemid 27220877)
26. Handschin C, Spiegelman BM. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev 2006;27:728-735 (Pubitemid 44936056)
27. Yubero P, Manchado C, Cassard-Doulcier AM, Mampel T, Viñas O, Iglesias R, Giralt M, Villarroya F. CCAAT/enhancer binding proteins alpha and beta are transcriptional activators of the brown fat uncoupling protein gene promoter. Biochem Biophys Res Commun 1994;198:653-659 (Pubitemid 24178418)
28. Bianco AC, Kim BW. Deiodinases: implications of the local control of thyroid hormone action. J Clin Invest 2006;116:2571-2579
29. de Jesus LA, Carvalho SD, Ribeiro MO, Schneider M, Kim SW, Harney JW, Larsen PR, Bianco AC. The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J Clin Invest 2001;108:1379-1385
30. Lynch CJ, Hutson SM, Patson BJ, Vaval A, Vary TC. Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats. Am J Physiol Endocrinol Metab 2002;283:E824-E835
31. Goldrick RB. Morphological changes in the adipocyte during fat deposition and mobilization. Am J Physiol 1967;212:777-782
32. Lowell BB, Bachman ES. Beta-adrenergic receptors, diet-induced thermogenesis, and obesity. J Biol Chem 2003;278:29385-29388
33. Holm C, Osterlund T, Laurell H, Contreras JA. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Annu Rev Nutr 2000;20:365-393
34. Zhang J, Hupfeld CJ, Taylor SS, Olefsky JM, Tsien RY. Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature 2005;437:569-573
35. Dudek SM, Semenkovich CF. Essential amino acids regulate fatty acid synthase expression through an uncharged transfer RNA-dependent mechanism. J Biol Chem 1995;270:29323-29329
36. Finn PF, Dice JF. Proteolytic and lipolytic responses to starvation. Nutrition 2006;22:830-844
37. Frayn KN, Langin D, Karpe F. Fatty acid-induced mitochondrial uncoupling in adipocytes is not a promising target for treatment of insulin resistance unless adipocyte oxidative capacity is increased. Diabetologia 2008;51:394-397
38. Wolf G. Brown adipose tissue: the molecular mechanism of its formation. Nutr Rev 2009;67:167-171
39. Klingenspor M. Cold-induced recruitment of brown adipose tissue thermogenesis. Exp Physiol 2003;88:141-148
40. Feldmann HM, Golozoubova V, Cannon B, Nedergaard J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 2009;9:203-209
41. Li B, Nolte LA, Ju JS, Han DH, Coleman T, Holloszy JO, Semenkovich CF. Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice. Nat Med 2000;6:1115-1120
42. Dulloo AG, Samec S. Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsidered. Br J Nutr 2001;86:123-139
43. Thomas SA, Palmiter RD. Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline. Nature 1997;387:94-97
44. Lowell BB, Spiegelman BM. Towards a molecular understanding of adaptive thermogenesis. Nature 2000;404:652-660
45. Silva JE. Thermogenic mechanisms and their hormonal regulation. Physiol Rev 2006;86:435-464
46. de Meis L, Arruda AP, Carvalho DP. Role of sarco/endoplasmic reticulum Ca(2+)-ATPase in thermogenesis. Biosci Rep 2005;25:181-190