-
1
-
-
84864623705
-
Personalized medicine and pharmacogenetic biomarkers: Progress in molecular oncology testing
-
Ong FS, Das K, Wang J et al. Personalized medicine and pharmacogenetic biomarkers: progress in molecular oncology testing. Expert Rev. Mol. Diagn. 12(6), 593-602 (2012).
-
(2012)
Expert Rev. Mol. Diagn
, vol.12
, Issue.6
, pp. 593-602
-
-
Ong, F.S.1
Das, K.2
Wang, J.3
-
2
-
-
84865688579
-
Cancer treatment according to BRCA1 and BRCA2 mutations
-
Maxwell KN, Domchek SM. Cancer treatment according to BRCA1 and BRCA2 mutations. Nat. Rev. Clin. Oncol. 9(9), 520-528 (2012).
-
(2012)
Nat. Rev. Clin. Oncol
, vol.9
, Issue.9
, pp. 520-528
-
-
Maxwell, K.N.1
Domchek, S.M.2
-
4
-
-
80053144962
-
A decade of exploring the cancer epigenome-biological and translational implications
-
Baylin SB, Jones PA. A decade of exploring the cancer epigenome-biological and translational implications. Nat. Rev. Cancer 11(10), 726-734 (2011).
-
(2011)
Nat. Rev. Cancer
, vol.11
, Issue.10
, pp. 726-734
-
-
Baylin, S.B.1
Jones, P.A.2
-
5
-
-
40849139208
-
Epigenetics in cancer
-
Esteller M. Epigenetics in cancer. N. Engl. J. Med. 358(11), 1148-1159 (2008).
-
(2008)
N. Engl. J. Med
, vol.358
, Issue.11
, pp. 1148-1159
-
-
Esteller, M.1
-
6
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 100(1), 57-70 (2000).
-
(2000)
Cell
, vol.100
, Issue.1
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
7
-
-
85027954125
-
DNA methylation profiling in the clinic: Applications and challenges
-
Heyn H, Esteller M. DNA methylation profiling in the clinic: applications and challenges. Nat. Rev. Genet. 13(10), 679-692 (2012).
-
(2012)
Nat. Rev. Genet
, vol.13
, Issue.10
, pp. 679-692
-
-
Heyn, H.1
Esteller, M.2
-
8
-
-
79952384705
-
Cancer epigenetics reaches mainstream oncology
-
Rodríguez-Paredes M, Esteller M. Cancer epigenetics reaches mainstream oncology. Nat. Med. 17(3), 330-339 (2011).
-
(2011)
Nat. Med
, vol.17
, Issue.3
, pp. 330-339
-
-
Rodríguez-Paredes, M.1
Esteller, M.2
-
9
-
-
0034626988
-
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
-
Esteller M, Garcia-Foncillas J, Andion E et al. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N. Engl. J. Med. 343(19), 1350-1354 (2000).
-
(2000)
N. Engl. J. Med
, vol.343
, Issue.19
, pp. 1350-1354
-
-
Esteller, M.1
Garcia-Foncillas, J.2
Andion, E.3
-
10
-
-
23044514626
-
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
-
Weber M, Davies JJ, Wittig D et al. Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat. Genet. 37(8), 853-862 (2005).
-
(2005)
Nat. Genet
, vol.37
, Issue.8
, pp. 853-862
-
-
Weber, M.1
Davies, J.J.2
Wittig, D.3
-
11
-
-
34047116826
-
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
-
Weber M, Hellmann I, Stadler MB et al. Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat. Genet. 39(4), 457-466 (2007).
-
(2007)
Nat. Genet
, vol.39
, Issue.4
, pp. 457-466
-
-
Weber, M.1
Hellmann, I.2
Stadler, M.B.3
-
12
-
-
80052937538
-
Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates
-
Molaro A, Hodges E, Fang F et al. Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates. Cell 146(6), 1029-1041 (2011).
-
(2011)
Cell
, vol.146
, Issue.6
, pp. 1029-1041
-
-
Molaro, A.1
Hodges, E.2
Fang, F.3
-
13
-
-
79960927422
-
Increased methylation variation in epigenetic domains across cancer types
-
Hansen KD, Timp W, Bravo HC et al. Increased methylation variation in epigenetic domains across cancer types. Nat. Genet. 43(8), 768-775 (2011).
-
(2011)
Nat. Genet
, vol.43
, Issue.8
, pp. 768-775
-
-
Hansen, K.D.1
Timp, W.2
Bravo, H.C.3
-
14
-
-
84865369147
-
DNA methylation dynamics during in vivo differentiation of blood and skin stem cells
-
Bock C, Beerman I, Lien WH et al. DNA methylation dynamics during in vivo differentiation of blood and skin stem cells. Mol. Cell 47(4), 633-647 (2012).
-
(2012)
Mol. Cell
, vol.47
, Issue.4
, pp. 633-647
-
-
Bock, C.1
Beerman, I.2
Lien, W.H.3
-
15
-
-
33947315736
-
Cancer epigenomics: DNA methylomes and histone-modification maps
-
Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat. Rev. Genet. 8(4), 286-298 (2007).
-
(2007)
Nat. Rev. Genet
, vol.8
, Issue.4
, pp. 286-298
-
-
Esteller, M.1
-
16
-
-
79956302047
-
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
-
Williams K, Christensen J, Pedersen MT et al. TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature 473(7347), 343-348 (2011).
-
(2011)
Nature
, vol.473
, Issue.7347
, pp. 343-348
-
-
Williams, K.1
Christensen, J.2
Pedersen, M.T.3
-
17
-
-
83855163995
-
Uncovering the role of 5-hydroxymethylcytosine in the epigenome
-
Branco MR, Ficz G, Reik W. Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat. Rev. Genet. 13(1), 7-13 (2012).
-
(2012)
Nat. Rev. Genet
, vol.13
, Issue.1
, pp. 7-13
-
-
Branco, M.R.1
Ficz, G.2
Reik, W.3
-
18
-
-
70450217879
-
Human DNA methylomes at base resolution show widespread epigenomic differences
-
Lister R, Pelizzola M, Dowen RH et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 462(7271), 315-322 (2009).
-
(2009)
Nature
, vol.462
, Issue.7271
, pp. 315-322
-
-
Lister, R.1
Pelizzola, M.2
Dowen, R.H.3
-
19
-
-
84857331867
-
Baseresolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome
-
Xie W, Barr CL, Kim A et al. Baseresolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome. Cell 148(4), 816-831 (2012).
-
(2012)
Cell
, vol.148
, Issue.4
, pp. 816-831
-
-
Xie, W.1
Barr, C.L.2
Kim, A.3
-
20
-
-
84855281409
-
Genomic distribution and inter-sample variation of nonCpG methylation across human cell types
-
Ziller MJ, Müller F, Liao J et al. Genomic distribution and inter-sample variation of nonCpG methylation across human cell types. PLoS Genet. 7(12), e1002389 (2011).
-
(2011)
PLoS Genet
, vol.7
, Issue.12
-
-
Ziller, M.J.1
Müller, F.2
Liao, J.3
-
21
-
-
77957970301
-
Epigenetic modifications and human disease
-
Portela A, Esteller M. Epigenetic modifications and human disease. Nat. Biotechnol. 28(10), 1057-1068 (2010).
-
(2010)
Nat. Biotechnol
, vol.28
, Issue.10
, pp. 1057-1068
-
-
Portela, A.1
Esteller, M.2
-
22
-
-
33646070846
-
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
-
Bernstein BE, Mikkelsen TS, Xie X et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125(2), 315-326 (2006).
-
(2006)
Cell
, vol.125
, Issue.2
, pp. 315-326
-
-
Bernstein, B.E.1
Mikkelsen, T.S.2
Xie, X.3
-
23
-
-
79955583542
-
Mapping and analysis of chromatin state dynamics in nine human cell types
-
Ernst J, Kheradpour P, Mikkelsen TS et al. Mapping and analysis of chromatin state dynamics in nine human cell types. Nature 473(7345), 43-49 (2011).
-
(2011)
Nature
, vol.473
, Issue.7345
, pp. 43-49
-
-
Ernst, J.1
Kheradpour, P.2
Mikkelsen, T.S.3
-
24
-
-
77954659099
-
Relationship between nucleosome positioning and DNA methylation
-
Chodavarapu RK, Feng S, Bernatavichute YV et al. Relationship between nucleosome positioning and DNA methylation. Nature 466(7304), 388-392 (2010).
-
(2010)
Nature
, vol.466
, Issue.7304
, pp. 388-392
-
-
Chodavarapu, R.K.1
Feng, S.2
Bernatavichute, Y.V.3
-
25
-
-
81355142141
-
Noncoding RNAs in human disease
-
Esteller M. Noncoding RNAs in human disease. Nat. Rev. Genet. 12(12), 861-874 (2011).
-
(2011)
Nat. Rev. Genet
, vol.12
, Issue.12
, pp. 861-874
-
-
Esteller, M.1
-
26
-
-
77957932941
-
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications
-
Harris RA, Wang T, Coarfa C et al. Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat. Biotechnol. 28(10), 1097-1105 (2010).
-
(2010)
Nat. Biotechnol
, vol.28
, Issue.10
, pp. 1097-1105
-
-
Harris, R.A.1
Wang, T.2
Coarfa, C.3
-
27
-
-
84868103364
-
Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans
-
Beyan H, Down TA, Ramagopalan SV et al. Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans. Genome Res. 22(11), 2138-2145 (2012).
-
(2012)
Genome Res
, vol.22
, Issue.11
, pp. 2138-2145
-
-
Beyan, H.1
Down, T.A.2
Ramagopalan, S.V.3
-
28
-
-
79952788617
-
Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling
-
Gu H, Smith ZD, Bock C, Boyle P, Gnirke A, Meissner A. Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling. Nat. Protoc. 6(4), 468-481 (2011).
-
(2011)
Nat. Protoc
, vol.6
, Issue.4
, pp. 468-481
-
-
Gu, H.1
Smith, Z.D.2
Bock, C.3
Boyle, P.4
Gnirke, A.5
Meissner, A.6
-
29
-
-
0026546877
-
A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands
-
Frommer M, McDonald LE, Millar DS et al. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc. Natl Acad. Sci. U.S.A. 89(5), 1827-1831 (1992).
-
(1992)
Proc. Natl Acad. Sci. U.S.A
, vol.89
, Issue.5
, pp. 1827-1831
-
-
Frommer, M.1
McDonald, L.E.2
Millar, D.S.3
-
30
-
-
42749087226
-
Highly integrated single-base resolution maps of the epigenome in Arabidopsis
-
Lister R, O'Malley RC, Tonti-Filippini J et al. Highly integrated single-base resolution maps of the epigenome in Arabidopsis. Cell 133(3), 523-536 (2008).
-
(2008)
Cell
, vol.133
, Issue.3
, pp. 523-536
-
-
Lister, R.1
O'Malley, R.C.2
Tonti-Filippini, J.3
-
31
-
-
78649969065
-
The DNA methylome of human peripheral blood mononuclear cells
-
Li Y, Zhu J, Tian G et al. The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol. 8(11), e1000533 (2010).
-
(2010)
PLoS Biol
, vol.8
, Issue.11
-
-
Li, Y.1
Zhu, J.2
Tian, G.3
-
32
-
-
84862979818
-
Distinct DNA methylomes of newborns and centenarians
-
Heyn H, Li N, Ferreira HJ et al. Distinct DNA methylomes of newborns and centenarians. Proc. Natl Acad. Sci. USA 109(26), 10522-10527 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, Issue.26
, pp. 10522-10527
-
-
Heyn, H.1
Li, N.2
Ferreira, H.J.3
-
33
-
-
84856528270
-
Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer
-
Hon GC, Hawkins RD, Caballero OL et al. Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer. Genome Res. 22(2), 246-258 (2011).
-
(2011)
Genome Res
, vol.22
, Issue.2
, pp. 246-258
-
-
Hon, G.C.1
Hawkins, R.D.2
Caballero, O.L.3
-
34
-
-
84655162785
-
Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains
-
Berman BP, Weisenberger DJ, Aman JF et al. Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains. Nat. Genet. 44(1), 40-46 (2012).
-
(2012)
Nat. Genet
, vol.44
, Issue.1
, pp. 40-46
-
-
Berman, B.P.1
Weisenberger, D.J.2
Aman, J.F.3
-
35
-
-
84868198427
-
Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
-
Kulis M, Heath S, Bibikova M et al. Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia. Nat. Genet. 44(11), 1236-1242 (2012).
-
(2012)
Nat. Genet
, vol.44
, Issue.11
, pp. 1236-1242
-
-
Kulis, M.1
Heath, S.2
Bibikova, M.3
-
36
-
-
84861920481
-
Wholegenome bisulfite DNA sequencing of a DNMT3B mutant patient
-
Heyn H, Vidal E, Sayols S et al. Wholegenome bisulfite DNA sequencing of a DNMT3B mutant patient. Epigenetics 7(6), 542-550 (2012).
-
(2012)
Epigenetics
, vol.7
, Issue.6
, pp. 542-550
-
-
Heyn, H.1
Vidal, E.2
Sayols, S.3
-
37
-
-
80053304450
-
High density DNA methylation array with single CpG site resolution
-
Bibikova M, Barnes B, Tsan C et al. High density DNA methylation array with single CpG site resolution. Genomics 98(4), 288-295 (2011).
-
(2011)
Genomics
, vol.98
, Issue.4
, pp. 288-295
-
-
Bibikova, M.1
Barnes, B.2
Tsan, C.3
-
38
-
-
61449477534
-
GoldenGate assay for DNA methylation profiling
-
Bibikova M, Fan JB. GoldenGate assay for DNA methylation profiling. Methods Mol. Biol. 507, 149-163 (2009).
-
(2009)
Methods Mol. Biol
, vol.507
, pp. 149-163
-
-
Bibikova, M.1
Fan, J.B.2
-
39
-
-
79958754527
-
Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome
-
Sandoval J, Heyn H, Moran S et al. Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome. Epigenetics 6(6), 692-702 (2011).
-
(2011)
Epigenetics
, vol.6
, Issue.6
, pp. 692-702
-
-
Sandoval, J.1
Heyn, H.2
Moran, S.3
-
40
-
-
84859847507
-
DNA methylation profiling defines clinically relevant biological subsets of non-small cell lung cancer
-
Walter K, Holcomb T, Januario T et al. DNA methylation profiling defines clinically relevant biological subsets of non-small cell lung cancer. Clin. Cancer. Res. 18(8), 2360-2373 (2012).
-
(2012)
Clin. Cancer. Res
, vol.18
, Issue.8
, pp. 2360-2373
-
-
Walter, K.1
Holcomb, T.2
Januario, T.3
-
41
-
-
20044372154
-
MGMT gene silencing and benefit from temozolomide in glioblastoma
-
Hegi ME, Diserens AC, Gorlia T et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N. Engl. J. Med. 352(10), 997-1003 (2005).
-
(2005)
N. Engl. J. Med
, vol.352
, Issue.10
, pp. 997-1003
-
-
Hegi, M.E.1
Diserens, A.C.2
Gorlia, T.3
-
42
-
-
82955233990
-
Prognostic and predictive value of epigenetic silencing of MGMT in patients with high grade gliomas: A systematic review and meta-analysis
-
Olson RA, Brastianos PK, Palma DA. Prognostic and predictive value of epigenetic silencing of MGMT in patients with high grade gliomas: a systematic review and meta-analysis. J. Neurooncol. 105(2), 325-335 (2011).
-
(2011)
J. Neurooncol
, vol.105
, Issue.2
, pp. 325-335
-
-
Olson, R.A.1
Brastianos, P.K.2
Palma, D.A.3
-
43
-
-
0033557903
-
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia
-
Esteller M, Hamilton SR, Burger PC, Baylin SB, Herman JG. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res. 59(4), 793-797 (1999).
-
(1999)
Cancer Res
, vol.59
, Issue.4
, pp. 793-797
-
-
Esteller, M.1
Hamilton, S.R.2
Burger, P.C.3
Baylin, S.B.4
Herman, J.G.5
-
44
-
-
0033535612
-
A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer
-
Strathdee G, MacKean MJ, Illand M, Brown R. A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer. Oncogene 18(14), 2335-2341 (1999).
-
(1999)
Oncogene
, vol.18
, Issue.14
, pp. 2335-2341
-
-
Strathdee, G.1
MacKean, M.J.2
Illand, M.3
Brown, R.4
-
45
-
-
0034326784
-
Reversal of drug resistance in human tumor xenografts by 2?-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter
-
Plumb JA, Strathdee G, Sludden J, Kaye SB, Brown R. Reversal of drug resistance in human tumor xenografts by 2?-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter. Cancer Res. 60(21), 6039-6044 (2000).
-
(2000)
Cancer Res
, vol.60
, Issue.21
, pp. 6039-6044
-
-
Plumb, J.A.1
Strathdee, G.2
Sludden, J.3
Kaye, S.B.4
Brown, R.5
-
46
-
-
61749093379
-
Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo
-
Steele N, Finn P, Brown R, Plumb JA. Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo. Br. J. Cancer 100(5), 758-763 (2009).
-
(2009)
Br. J. Cancer
, vol.100
, Issue.5
, pp. 758-763
-
-
Steele, N.1
Finn, P.2
Brown, R.3
Plumb, J.A.4
-
47
-
-
84867743287
-
Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling
-
Zeller C, Dai W, Steele NL et al. Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling. Oncogene 31(42), 4567-4576 (2012).
-
(2012)
Oncogene
, vol.31
, Issue.42
, pp. 4567-4576
-
-
Zeller, C.1
Dai, W.2
Steele, N.L.3
-
48
-
-
84871123307
-
Integrated epigenomics identifies BMP4 as a modulator of cisplatin sensitivity in gastric cancer
-
Ivanova T, Zouridis H, Wu Y et al. Integrated epigenomics identifies BMP4 as a modulator of cisplatin sensitivity in gastric cancer. Gut 62(1), 22-33 (2013).
-
(2013)
Gut
, vol.62
, Issue.1
, pp. 22-33
-
-
Ivanova, T.1
Zouridis, H.2
Wu, Y.3
-
49
-
-
77949654035
-
IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer
-
Ibanez de Caceres I, Cortes-Sempere M, Moratilla C et al. IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer. Oncogene 29(11), 1681-1690 (2010).
-
(2010)
Oncogene
, vol.29
, Issue.11
, pp. 1681-1690
-
-
Ibanez De Caceres, I.1
Cortes-Sempere, M.2
Moratilla, C.3
-
50
-
-
0034607234
-
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors
-
Esteller M, Silva JM, Dominguez G et al. Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J. Natl Cancer Inst. 92(7), 564-569 (2000).
-
(2000)
J. Natl Cancer Inst
, vol.92
, Issue.7
, pp. 564-569
-
-
Esteller, M.1
Silva, J.M.2
Dominguez, G.3
-
51
-
-
84868354895
-
BRCA1 epigenetic inactivation predicts sensitivity to platinum-based chemotherapy in breast and ovarian cancer
-
Stefansson OA, Villanueva A, Vidal A, Martí L, Esteller M. BRCA1 epigenetic inactivation predicts sensitivity to platinum-based chemotherapy in breast and ovarian cancer. Epigenetics 7(11), 1225-1229 (2012).
-
(2012)
Epigenetics
, vol.7
, Issue.11
, pp. 1225-1229
-
-
Stefansson, O.A.1
Villanueva, A.2
Vidal, A.3
Martí, L.4
Esteller, M.5
-
52
-
-
79959838081
-
Integrated genomic analyses of ovarian carcinoma
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature 474(7353), 609-615 (2011).
-
(2011)
Nature
, vol.474
, Issue.7353
, pp. 609-615
-
-
-
53
-
-
84878444306
-
Promoter methylation of BRCA1 in triple-negative breast cancer predicts sensitivity to adjuvant chemotherapy
-
Epub ahead of print
-
Xu Y, Diao L, Chen Y et al. Promoter methylation of BRCA1 in triple-negative breast cancer predicts sensitivity to adjuvant chemotherapy. Ann. Oncol. PMID:23406733 (2013) (Epub ahead of print).
-
(2013)
Ann. Oncol. PMID:23406733
-
-
Xu, Y.1
Diao, L.2
Chen, Y.3
-
54
-
-
70249125405
-
Utility of gene promoter methylation in prediction of response to platinum-based chemotherapy in epithelial ovarian cancer (EOC)
-
Chaudhry P, Srinivasan R, Patel FD. Utility of gene promoter methylation in prediction of response to platinum-based chemotherapy in epithelial ovarian cancer (EOC). Cancer Invest. 27(8), 877-884 (2009).
-
(2009)
Cancer Invest
, vol.27
, Issue.8
, pp. 877-884
-
-
Chaudhry, P.1
Srinivasan, R.2
Patel, F.D.3
-
55
-
-
0038075462
-
Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors
-
Taniguchi T, Tischkowitz M, Ameziane N et al. Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors. Nat. Med. 9(5), 568-574 (2003).
-
(2003)
Nat. Med
, vol.9
, Issue.5
, pp. 568-574
-
-
Taniguchi, T.1
Tischkowitz, M.2
Ameziane, N.3
-
56
-
-
78751629661
-
BRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitors
-
author reply e565
-
Veeck J, Ropero S, Setien F et al. BRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitors. J. Clin. Oncol. 28(29), e563-564; author reply e565 (2010).
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.29
-
-
Veeck, J.1
Ropero, S.2
Setien, F.3
-
57
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
Farmer H, McCabe N, Lord CJ et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434(7035), 917-921 (2005).
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 917-921
-
-
Farmer, H.1
McCabe, N.2
Lord, C.J.3
-
58
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong PC, Boss DS, Yap TA et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N. Engl. J. Med. 361(2), 123-134 (2009).
-
(2009)
N. Engl. J. Med
, vol.361
, Issue.2
, pp. 123-134
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
-
59
-
-
33745056414
-
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer
-
Agrelo R, Cheng WH, Setien F et al. Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proc. Natl Acad. Sci. USA 103(23), 8822-8827 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, Issue.23
, pp. 8822-8827
-
-
Agrelo, R.1
Cheng, W.H.2
Setien, F.3
-
60
-
-
77949895970
-
Role of ERCC1 promoter hypermethylation in drug resistance to cisplatin in human gliomas
-
Chen HY, Shao CJ, Chen FR, Kwan AL, Chen ZP. Role of ERCC1 promoter hypermethylation in drug resistance to cisplatin in human gliomas. Int. J. Cancer 126(8), 1944-1954 (2010).
-
(2010)
Int. J. Cancer
, vol.126
, Issue.8
, pp. 1944-1954
-
-
Chen, H.Y.1
Shao, C.J.2
Chen, F.R.3
Kwan, A.L.4
Chen, Z.P.5
-
61
-
-
77956893417
-
Down-regulation of the nucleotide excision repair gene XPG as a new mechanism of drug resistance in human and murine cancer cells
-
Sabatino MA, Marabese M, Ganzinelli M, Caiola E, Geroni C, Broggini M. Down-regulation of the nucleotide excision repair gene XPG as a new mechanism of drug resistance in human and murine cancer cells. Mol. Cancer 9, 259 (2010).
-
(2010)
Mol. Cancer
, vol.9
, pp. 259
-
-
Sabatino, M.A.1
Marabese, M.2
Ganzinelli, M.3
Caiola, E.4
Geroni, C.5
Broggini, M.6
-
62
-
-
84862870008
-
The epigenetic promise for prostate cancer diagnosis
-
Van Neste L, Herman JG, Otto G, Bigley JW, Epstein JI, Van Criekinge W. The epigenetic promise for prostate cancer diagnosis. Prostate 72(11), 1248-1261 (2011).
-
(2011)
Prostate
, vol.72
, Issue.11
, pp. 1248-1261
-
-
Van Neste, L.1
Herman, J.G.2
Otto, G.3
Bigley, J.W.4
Epstein, J.I.5
Van Criekinge, W.6
-
63
-
-
77952248685
-
DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response
-
Dejeux E, Rønneberg JA, Solvang H et al. DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response. Mol. Cancer 9, 68 (2010).
-
(2010)
Mol. Cancer
, vol.9
, Issue.68
-
-
Dejeux, E.1
Rønneberg, J.A.2
Solvang, H.3
-
64
-
-
84856225906
-
Prognostic significance of gene-specific promoter hypermethylation in breast cancer patients
-
Cho YH, Shen J, Gammon MD et al. Prognostic significance of gene-specific promoter hypermethylation in breast cancer patients. Breast Cancer Res. Treat. 131(1), 197-205 (2012).
-
(2012)
Breast Cancer Res. Treat
, vol.131
, Issue.1
, pp. 197-205
-
-
Cho, Y.H.1
Shen, J.2
Gammon, M.D.3
-
65
-
-
33750364352
-
Association of GSTP1 CpG islands hypermethylation with poor prognosis in human breast cancers
-
Arai T, Miyoshi Y, Kim SJ, Taguchi T, Tamaki Y, Noguchi S. Association of GSTP1 CpG islands hypermethylation with poor prognosis in human breast cancers. Breast Cancer Res. Treat. 100(2), 169-176 (2006).
-
(2006)
Breast Cancer Res. Treat
, vol.100
, Issue.2
, pp. 169-176
-
-
Arai, T.1
Miyoshi, Y.2
Kim, S.J.3
Taguchi, T.4
Tamaki, Y.5
Noguchi, S.6
-
66
-
-
28844468518
-
Role of DNA hypomethylation in the development of the resistance to doxorubicin in human MCF-7 breast adenocarcinoma cells
-
Chekhun VF, Kulik GI, Yurchenko OV et al. Role of DNA hypomethylation in the development of the resistance to doxorubicin in human MCF-7 breast adenocarcinoma cells. Cancer Lett. 231(1), 87-93 (2006).
-
(2006)
Cancer Lett
, vol.231
, Issue.1
, pp. 87-93
-
-
Chekhun, V.F.1
Kulik, G.I.2
Yurchenko, O.V.3
-
67
-
-
37049001640
-
Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel
-
Shen L, Kondo Y, Ahmed S et al. Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel. Cancer Res. 67(23), 11335-11343 (2007).
-
(2007)
Cancer Res
, vol.67
, Issue.23
, pp. 11335-11343
-
-
Shen, L.1
Kondo, Y.2
Ahmed, S.3
-
68
-
-
0035843169
-
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
-
Soengas MS, Capodieci P, Polsky D et al. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature 409(6817), 207-211 (2001).
-
(2001)
Nature
, vol.409
, Issue.6817
, pp. 207-211
-
-
Soengas, M.S.1
Capodieci, P.2
Polsky, D.3
-
69
-
-
38549141939
-
Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer
-
Iorns E, Turner NC, Elliott R et al. Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer. Cancer Cell 13(2), 91-104 (2008).
-
(2008)
Cancer Cell
, vol.13
, Issue.2
, pp. 91-104
-
-
Iorns, E.1
Turner, N.C.2
Elliott, R.3
-
70
-
-
34447262607
-
DNA-methylation of the homeodomain transcription factor PITX2 reliably predicts risk of distant disease recurrence in tamoxifen-treated, nodenegative breast cancer patients-Technical and clinical validation in a multicentre setting in collaboration with the European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group
-
European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group
-
Maier S, Nimmrich I, Koenig T et al.; European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group. DNA-methylation of the homeodomain transcription factor PITX2 reliably predicts risk of distant disease recurrence in tamoxifen-treated, nodenegative breast cancer patients-Technical and clinical validation in a multicentre setting in collaboration with the European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group. Eur. J. Cancer 43(11), 1679-1686 (2007).
-
(2007)
Eur. J. Cancer
, vol.43
, Issue.11
, pp. 1679-1686
-
-
Maier, S.1
Nimmrich, I.2
Koenig, T.3
-
71
-
-
33749316418
-
The epidermal growth factor receptor pathway: A model for targeted therapy
-
Scaltriti M, Baselga J. The epidermal growth factor receptor pathway: a model for targeted therapy. Clin. Cancer Res. 12(18), 5268-5272 (2006).
-
(2006)
Clin. Cancer Res
, vol.12
, Issue.18
, pp. 5268-5272
-
-
Scaltriti, M.1
Baselga, J.2
-
72
-
-
78650728084
-
CHFR hypermethylation and EGFR mutation are mutually exclusive and exhibit contrastive clinical backgrounds and outcomes in non-small cell lung cancer
-
Koga T, Takeshita M, Yano T, Maehara Y, Sueishi K. CHFR hypermethylation and EGFR mutation are mutually exclusive and exhibit contrastive clinical backgrounds and outcomes in non-small cell lung cancer. Int. J. Cancer 128(5), 1009-1017 (2011).
-
(2011)
Int. J. Cancer
, vol.128
, Issue.5
, pp. 1009-1017
-
-
Koga, T.1
Takeshita, M.2
Yano, T.3
Maehara, Y.4
Sueishi, K.5
-
73
-
-
79952194909
-
First-line therapy and methylation status of CHFR in serum influence outcome to chemotherapy versus EGFR tyrosine kinase inhibitors as second-line therapy in stage IV non-small-cell lung cancer patients
-
Salazar F, Molina MA, Sanchez-Ronco M et al. First-line therapy and methylation status of CHFR in serum influence outcome to chemotherapy versus EGFR tyrosine kinase inhibitors as second-line therapy in stage IV non-small-cell lung cancer patients. Lung Cancer 72(1), 84-91 (2011).
-
(2011)
Lung Cancer
, vol.72
, Issue.1
, pp. 84-91
-
-
Salazar, F.1
Molina, M.A.2
Sanchez-Ronco, M.3
-
74
-
-
84856015098
-
Epithelial-mesenchymal transition, cancer stem cells and treatment resistance
-
Dave B, Mittal V, Tan NM, Chang JC. Epithelial-mesenchymal transition, cancer stem cells and treatment resistance. Breast Cancer Res. 14(1), 202 (2012).
-
(2012)
Breast Cancer Res
, vol.14
, Issue.1
, pp. 202
-
-
Dave, B.1
Mittal, V.2
Tan, N.M.3
Chang, J.C.4
-
75
-
-
84859169877
-
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
-
Barretina J, Caponigro G, Stransky N et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483(7391), 603-607 (2012).
-
(2012)
Nature
, vol.483
, Issue.7391
, pp. 603-607
-
-
Barretina, J.1
Caponigro, G.2
Stransky, N.3
-
76
-
-
84859187259
-
Systematic identification of genomic markers of drug sensitivity in cancer cells
-
Garnett MJ, Edelman EJ, Heidorn SJ et al. Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature 483(7391), 570-575 (2012).
-
(2012)
Nature
, vol.483
, Issue.7391
, pp. 570-575
-
-
Garnett, M.J.1
Edelman, E.J.2
Heidorn, S.J.3
-
77
-
-
84858796263
-
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
-
Turcan S, Rohle D, Goenka A et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 483(7390), 479-483 (2012).
-
(2012)
Nature
, vol.483
, Issue.7390
, pp. 479-483
-
-
Turcan, S.1
Rohle, D.2
Goenka, A.3
-
78
-
-
84872607202
-
Genome-wide DNA methylation profiling predicts relapse in childhood B-cell acute lymphoblastic leukaemia
-
Sandoval J, Heyn H, Méndez-González J et al. Genome-wide DNA methylation profiling predicts relapse in childhood B-cell acute lymphoblastic leukaemia. Br. J. Haematol. 160(3), 406-409 (2013).
-
(2013)
Br. J. Haematol
, vol.160
, Issue.3
, pp. 406-409
-
-
Sandoval, J.1
Heyn, H.2
Méndez-González, J.3
|