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Volumn 9, Issue 9, 2012, Pages 520-528

Cancer treatment according to BRCA1 and BRCA2 mutations

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; CA 125 ANTIGEN; CARBOPLATIN; CISPLATIN; CRIZOTINIB; DACARBAZINE; DASATINIB; DOXORUBICIN; ERLOTINIB; GEFITINIB; GEMCITABINE; IMATINIB; INIPARIB; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NILOTINIB; OLAPARIB; VANDETANIB; VELIPARIB; VEMURAFENIB;

EID: 84865688579     PISSN: 17594774     EISSN: 17594782     Source Type: Journal    
DOI: 10.1038/nrclinonc.2012.123     Document Type: Review
Times cited : (62)

References (103)
  • 1
    • 85203363507 scopus 로고    scopus 로고
    • Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: Patient-level meta-analysis of randomised trials
    • Davies, C. et al. Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet 378, 771-784 (2011).
    • (2011) Lancet. , vol.378 , pp. 771-784
    • Davies, C.1
  • 2
    • 77955551055 scopus 로고    scopus 로고
    • American Society of Clinical Oncology clinical practice guideline: Update on adjuvant endocrine therapy for women with hormone receptor-positive breast cancer
    • Burstein, H. J. et al. American Society of Clinical Oncology clinical practice guideline: update on adjuvant endocrine therapy for women with hormone receptor-positive breast cancer. J. Clin. Oncol. 28, 3784-3796 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 3784-3796
    • Burstein, H.J.1
  • 3
    • 77954162134 scopus 로고    scopus 로고
    • HER2-positive breast cancer: Beyond trastuzumab
    • Murphy, C. G. & Fornier, M. HER2-positive breast cancer: beyond trastuzumab. Oncology (Williston Park) 24, 410-415 (2010).
    • (2010) Oncology (Williston Park) , vol.24 , pp. 410-415
    • Murphy, C.G.1    Fornier, M.2
  • 4
    • 33749023326 scopus 로고    scopus 로고
    • The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability
    • Gudmundsdottir, K. & Ashworth, A. The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability. Oncogene 25, 5864-5874 (2006).
    • (2006) Oncogene , vol.25 , pp. 5864-5874
    • Gudmundsdottir, K.1    Ashworth, A.2
  • 5
    • 77953952646 scopus 로고    scopus 로고
    • BRCA1 and BRCA2: Breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair
    • O'Donovan, P. J. & Livingston, D. M. BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair. Carcinogenesis 31, 961-967 (2010).
    • (2010) Carcinogenesis , vol.31 , pp. 961-967
    • O'Donovan, P.J.1    Livingston, D.M.2
  • 6
    • 0038744296 scopus 로고    scopus 로고
    • Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: A combined analysis of 22 studies
    • Antoniou, A. et al. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies. Am. J. Hum. Genet. 72, 1117-1130 (2003).
    • (2003) Am. J. Hum. Genet. , vol.72 , pp. 1117-1130
    • Antoniou, A.1
  • 7
    • 0033523268 scopus 로고    scopus 로고
    • [No authors listed] Cancer risks in BRCA2 mutation carriers. The Breast Cancer Linkage Consortium
    • [No authors listed] Cancer risks in BRCA2 mutation carriers. The Breast Cancer Linkage Consortium. J. Natl Cancer Inst. 91, 1310-1316 (1999).
    • (1999) J. Natl Cancer Inst. , vol.91 , pp. 1310-1316
  • 8
    • 67649214899 scopus 로고    scopus 로고
    • BRCA1 and BRCA2 mutation carriers in the Breast Cancer Family Registry: An open resource for collaborative research
    • Neuhausen, S. L. et al. BRCA1 and BRCA2 mutation carriers in the Breast Cancer Family Registry: an open resource for collaborative research. Breast Cancer Res. Treat. 116, 379-386 (2009).
    • (2009) Breast Cancer Res. Treat. , vol.116 , pp. 379-386
    • Neuhausen, S.L.1
  • 9
    • 77952982796 scopus 로고    scopus 로고
    • Genetic/familial high-risk assessment: Breast and ovarian
    • Daly, M. B. et al. Genetic/familial high-risk assessment: breast and ovarian. J. Natl Compr. Canc. Netw. 8, 562-594 (2010).
    • (2010) J. Natl Compr. Canc. Netw. , vol.8 , pp. 562-594
    • Daly, M.B.1
  • 10
    • 77951479651 scopus 로고    scopus 로고
    • Impact of gene patents and licensing practices on access to genetic testing for inherited susceptibility to cancer: Comparing breast and ovarian cancers with colon cancers
    • Cook-Deegan, R. et al. Impact of gene patents and licensing practices on access to genetic testing for inherited susceptibility to cancer: comparing breast and ovarian cancers with colon cancers. Genet. Med. 12(Suppl. 4), 15-38 (2010).
    • (2010) Genet. Med. , vol.12 , Issue.4 SUPPL. , pp. 15-38
    • Cook-Deegan, R.1
  • 11
    • 3343014153 scopus 로고    scopus 로고
    • Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition
    • Kriege, M. et al. Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N. Engl. J. Med. 351, 427-437 (2004).
    • (2004) N. Engl. J. Med. , vol.351 , pp. 427-437
    • Kriege, M.1
  • 12
    • 77951918066 scopus 로고    scopus 로고
    • Prospective multicenter cohort study to refine management recommendations for women at elevated familial risk of breast cancer: The EVA trial
    • Kuhl, C. et al. Prospective multicenter cohort study to refine management recommendations for women at elevated familial risk of breast cancer: the EVA trial. J. Clin. Oncol. 28, 1450-1457 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1450-1457
    • Kuhl, C.1
  • 13
    • 34047137002 scopus 로고    scopus 로고
    • American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography
    • Saslow, D. et al. American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography. CA Cancer J. Clin. 57, 75-89 (2007).
    • (2007) CA Cancer J. Clin. , vol.57 , pp. 75-89
    • Saslow, D.1
  • 14
    • 80052695765 scopus 로고    scopus 로고
    • BRCA in breast cancer: ESMO Clinical Practice Guidelines
    • Balmana, J., Diez, O., Rubio, I. T. & Cardoso, F. BRCA in breast cancer: ESMO Clinical Practice Guidelines. Ann. Oncol. 22(Suppl. 6), 31-34 (2011).
    • (2011) Ann. Oncol. , vol.22 , Issue.6 SUPPL. , pp. 31-34
    • Balmana, J.1    Diez, O.2    Rubio, I.T.3    Cardoso, F.4
  • 16
    • 33645675556 scopus 로고    scopus 로고
    • Tamoxifen and contralateral breast cancer in BRCA1 and BRCA2 carriers: An update
    • Gronwald, J. et al. Tamoxifen and contralateral breast cancer in BRCA1 and BRCA2 carriers: an update. Int. J. Cancer 118, 2281-2284 (2006).
    • (2006) Int. J. Cancer , vol.118 , pp. 2281-2284
    • Gronwald, J.1
  • 17
    • 0035861037 scopus 로고    scopus 로고
    • Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP. P1) Breast Cancer Prevention Trial
    • King, M. C. et al. Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP. P1) Breast Cancer Prevention Trial. JAMA 286, 2251-2256 (2001).
    • (2001) JAMA , vol.286 , pp. 2251-2256
    • King, M.C.1
  • 18
    • 77956193440 scopus 로고    scopus 로고
    • Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality
    • Domchek, S. M. et al. Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality. JAMA 304, 967-975 (2010).
    • (2010) JAMA , vol.304 , pp. 967-975
    • Domchek, S.M.1
  • 19
    • 0037052688 scopus 로고    scopus 로고
    • Loss of heterozygosity analysis at the BRCA loci in tumor samples from patients with familial breast cancer
    • Osorio, A. et al. Loss of heterozygosity analysis at the BRCA loci in tumor samples from patients with familial breast cancer. Int. J. Cancer 99, 305-309 (2002).
    • (2002) Int. J. Cancer , vol.99 , pp. 305-309
    • Osorio, A.1
  • 20
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer, H. et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434, 917-921 (2005).
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1
  • 21
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly (ADP.ribose) polymerase
    • Bryant, H. E. et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly (ADP.ribose) polymerase. Nature 434, 913-917 (2005).
    • (2005) Nature , vol.434 , pp. 913-917
    • Bryant, H.E.1
  • 22
    • 0037169354 scopus 로고    scopus 로고
    • Cancer susceptibility and the functions of BRCA1 and BRCA2
    • Venkitaraman, A. R. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 108, 171-182 (2002).
    • (2002) Cell , vol.108 , pp. 171-182
    • Venkitaraman, A.R.1
  • 23
    • 79955588797 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate
    • Strom, C. E. et al. Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate. Nucleic Acids Res. 39, 3166-3175 (2011).
    • (2011) Nucleic Acids Res. , vol.39 , pp. 3166-3175
    • Strom, C.E.1
  • 24
    • 80053966336 scopus 로고    scopus 로고
    • The role of PARP in DNA repair and its therapeutic exploitation
    • Javle, M. & Curtin, N. J. The role of PARP in DNA repair and its therapeutic exploitation. Br. J. Cancer 105, 1114-1122 (2011).
    • (2011) Br. J. Cancer , vol.105 , pp. 1114-1122
    • Javle, M.1    Curtin, N.J.2
  • 25
    • 80052168685 scopus 로고    scopus 로고
    • The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings
    • Helleday, T. The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings. Mol. Oncol. 5, 387-393 (2011).
    • (2011) Mol. Oncol. , vol.5 , pp. 387-393
    • Helleday, T.1
  • 26
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly (ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong, P. C. et al. Inhibition of poly (ADP-ribose) polymerase in tumors from BRCA mutation carriers. N. Engl. J. Med. 361, 123-134 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 123-134
    • Fong, P.C.1
  • 27
    • 77954032829 scopus 로고    scopus 로고
    • Poly (ADP)-ribose polymerase inhibition: Frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval
    • Fong, P. C. et al. Poly (ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval. J. Clin. Oncol. 28, 2512-2519 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 2512-2519
    • Fong, P.C.1
  • 28
    • 77955019276 scopus 로고    scopus 로고
    • Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof.of.concept trial
    • Tutt, A. et al. Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof.of.concept trial. Lancet 376, 235-244 (2010).
    • (2010) Lancet , vol.376 , pp. 235-244
    • Tutt, A.1
  • 29
    • 77955039099 scopus 로고    scopus 로고
    • Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof.of.concept trial
    • Audeh, M. W. et al. Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof.of.concept trial. Lancet 376, 245-251 (2010).
    • (2010) Lancet , vol.376 , pp. 245-251
    • Audeh, M.W.1
  • 30
    • 84863010984 scopus 로고    scopus 로고
    • Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase inhibitor, and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer
    • Kaye, S. B. et al. Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase inhibitor, and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer. J. Clin. Oncol. 30, 372-379 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 372-379
    • Kaye, S.B.1
  • 31
    • 0035879099 scopus 로고    scopus 로고
    • Recurrent epithelial ovarian carcinoma: A randomized phase III study of pegylated liposomal doxorubicin versus topotecan
    • Gordon, A. N. et al. Recurrent epithelial ovarian carcinoma: a randomized phase III study of pegylated liposomal doxorubicin versus topotecan. J. Clin. Oncol. 19, 3312-3322 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3312-3322
    • Gordon, A.N.1
  • 32
    • 81155139687 scopus 로고    scopus 로고
    • A high response rate to liposomal doxorubicin is seen among women with BRCA mutations treated for recurrent epithelial ovarian cancer
    • Adams, S. F. et al. A high response rate to liposomal doxorubicin is seen among women with BRCA mutations treated for recurrent epithelial ovarian cancer. Gynecol. Oncol. 123, 486-491 (2011).
    • (2011) Gynecol. Oncol. , vol.123 , pp. 486-491
    • Adams, S.F.1
  • 33
    • 80053950209 scopus 로고    scopus 로고
    • Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer
    • Yang, D. et al. Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer. JAMA 306, 1557-1565 (2011).
    • (2011) JAMA , vol.306 , pp. 1557-1565
    • Yang, D.1
  • 34
    • 79956068235 scopus 로고    scopus 로고
    • Evidence for the efficacy of iniparib, a PARP.1 inhibitor, in BRCA2-associated pancreatic cancer
    • Fogelman, D. R. et al. Evidence for the efficacy of iniparib, a PARP.1 inhibitor, in BRCA2-associated pancreatic cancer. Anticancer Res. 31, 1417-1420 (2011).
    • (2011) Anticancer Res. , vol.31 , pp. 1417-1420
    • Fogelman, D.R.1
  • 35
    • 77958458006 scopus 로고    scopus 로고
    • First.in. human trial of a poly (ADP-ribose) polymerase (PARP) inhibitor MK.4827 in advanced cancer patients (pts) with antitumor activity in BRCA-deficient and sporadic ovarian cancers [abstract]
    • Sandhu, S. et al. First.in. human trial of a poly (ADP-ribose) polymerase (PARP) inhibitor MK.4827 in advanced cancer patients (pts) with antitumor activity in BRCA-deficient and sporadic ovarian cancers [abstract]. J. Clin. Oncol. 28(Suppl. 15), a3001 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.15 SUPPL.
    • Sandhu, S.1
  • 36
    • 84863236347 scopus 로고    scopus 로고
    • A phase I study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas
    • Kummar, S. et al. A phase I study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas. Clin. Cancer Res. 18, 1726-1734 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 1726-1734
    • Kummar, S.1
  • 38
    • 77955886707 scopus 로고    scopus 로고
    • Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer
    • Hennessy, B. T. et al. Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer. J. Clin. Oncol. 28, 3570-3576 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 3570-3576
    • Hennessy, B.T.1
  • 39
    • 80052389761 scopus 로고    scopus 로고
    • Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: A phase 2, multicentre, open-label, non-randomised study
    • Gelmon, K. A. et al. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study. Lancet Oncol. 12, 852-861 (2011).
    • (2011) Lancet Oncol. , vol.12 , pp. 852-861
    • Gelmon, K.A.1
  • 40
    • 80053578082 scopus 로고    scopus 로고
    • A phase II trial of iniparib (BSI.201) in combination with gemcitabine/carboplatin (GC) in patients with platinum-sensitive recurrent ovarian cancer [abstract]
    • Penson, R. T. et al. A phase II trial of iniparib (BSI.201) in combination with gemcitabine/carboplatin (GC) in patients with platinum-sensitive recurrent ovarian cancer [abstract]. J. Clin. Oncol. 29(Suppl.), a5004 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.SUPPL.
    • Penson, R.T.1
  • 41
    • 80053600436 scopus 로고    scopus 로고
    • A phase II trial of iniparib (BSI.201) in combination with gemcitabine/carboplatin (GC) in patients with platinum-resistant recurrent ovarian cancer [abstract]
    • Birrer, M. J. et al. A phase II trial of iniparib (BSI.201) in combination with gemcitabine/carboplatin (GC) in patients with platinum-resistant recurrent ovarian cancer [abstract]. J. Clin. Oncol. 29, a5005 (2011).
    • (2011) J. Clin. Oncol. , vol.29
    • Birrer, M.J.1
  • 42
    • 84859523588 scopus 로고    scopus 로고
    • Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer
    • Ledermann, J. et al. Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer. N. Engl. J. Med. 366, 1382-1392 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 1382-1392
    • Ledermann, J.1
  • 43
    • 77955894453 scopus 로고    scopus 로고
    • Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer
    • Konstantinopoulos, P. A. et al. Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer. J. Clin. Oncol. 28, 3555-3561 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 3555-3561
    • Konstantinopoulos, P.A.1
  • 45
    • 4944229642 scopus 로고    scopus 로고
    • Hallmarks of 'eBRCAness' in sporadic cancers
    • Turner, N., Tutt, A. & Ashworth, A. Hallmarks of 'eBRCAness' in sporadic cancers. Nat. Rev. Cancer 4, 814-819 (2004).
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 814-819
    • Turner, N.1    Tutt, A.2    Ashworth, A.3
  • 46
    • 33847022042 scopus 로고    scopus 로고
    • BRCA1 dysfunction in sporadic basal-like breast cancer
    • Turner, N. C. et al. BRCA1 dysfunction in sporadic basal-like breast cancer. Oncogene 26, 2126-2132 (2007).
    • (2007) Oncogene , vol.26 , pp. 2126-2132
    • Turner, N.C.1
  • 47
    • 77957555168 scopus 로고    scopus 로고
    • Synergistic chemosensitivity of triple-negative breast cancer cell lines to poly (ADP-Ribose) polymerase inhibition, gemcitabine, and cisplatin
    • Hastak, K., Alli, E. & Ford, J. M. Synergistic chemosensitivity of triple-negative breast cancer cell lines to poly (ADP-Ribose) polymerase inhibition, gemcitabine, and cisplatin. Cancer Res. 70, 7970-7980 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 7970-7980
    • Hastak, K.1    Alli, E.2    Ford, J.M.3
  • 48
    • 77953123909 scopus 로고    scopus 로고
    • An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers
    • Natrajan, R. et al. An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers. Breast Cancer Res. Treat. 121, 575-589 (2010).
    • (2010) Breast Cancer Res. Treat. , vol.121 , pp. 575-589
    • Natrajan, R.1
  • 49
    • 78751610848 scopus 로고    scopus 로고
    • Iniparib plus chemotherapy in metastatic triple-negative breast cancer
    • O'Shaughnessy, J. et al. Iniparib plus chemotherapy in metastatic triple-negative breast cancer. N. Engl. J. Med. 364, 205-214 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 205-214
    • O'Shaughnessy, J.1
  • 50
    • 80052330662 scopus 로고    scopus 로고
    • A randomized phase III study of iniparib (BSI.201) in combination with gemcitabine/carboplatin (G/C) in metastatic triple-negative breast cancer (TNBC) [abstract]
    • O'Shaughnessy, J. et al. A randomized phase III study of iniparib (BSI.201) in combination with gemcitabine/carboplatin (G/C) in metastatic triple-negative breast cancer (TNBC) [abstract]. J. Clin. Oncol. 29, a1007 (2011).
    • (2011) J. Clin. Oncol. , vol.29
    • O'Shaughnessy, J.1
  • 51
    • 84862907868 scopus 로고    scopus 로고
    • Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor
    • Liu, X. et al. Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin. Cancer Res. 18, 510-523 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 510-523
    • Liu, X.1
  • 53
    • 33847063053 scopus 로고    scopus 로고
    • The triple negative paradox: Primary tumor chemosensitivity of breast cancer subtypes
    • Carey, L. A. et al. The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes. Clin. Cancer Res. 13, 2329-2334 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , pp. 2329-2334
    • Carey, L.A.1
  • 54
    • 84863994288 scopus 로고    scopus 로고
    • Dissecting the heterogeneity of triple-negative breast cancer
    • Metzger-Filho, O. et al. Dissecting the heterogeneity of triple-negative breast cancer. J. Clin. Oncol. 30, 1879-1887 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 1879-1887
    • Metzger-Filho, O.1
  • 55
    • 56949100951 scopus 로고    scopus 로고
    • Can genetic testing guide treatment in breast cancer?
    • Tutt, A. & Ashworth, A. Can genetic testing guide treatment in breast cancer? Eur. J. Cancer 44, 2774-2780 (2008).
    • (2008) Eur. J. Cancer , vol.44 , pp. 2774-2780
    • Tutt, A.1    Ashworth, A.2
  • 56
    • 39849097680 scopus 로고    scopus 로고
    • Resistance to therapy caused by intragenic deletion in BRCA2
    • Edwards, S. L. et al. Resistance to therapy caused by intragenic deletion in BRCA2. Nature 451, 1111-1115 (2008).
    • (2008) Nature , vol.451 , pp. 1111-1115
    • Edwards, S.L.1
  • 57
    • 42349096328 scopus 로고    scopus 로고
    • Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance
    • Swisher, E. M. et al. Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance. Cancer Res. 68, 2581-2586 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 2581-2586
    • Swisher, E.M.1
  • 58
    • 69249100461 scopus 로고    scopus 로고
    • Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma
    • Sakai, W. et al. Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma. Cancer Res. 69, 6381-6386 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 6381-6386
    • Sakai, W.1
  • 59
    • 80051642095 scopus 로고    scopus 로고
    • Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas
    • Norquist, B. et al. Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas. J. Clin. Oncol. 29, 3008-3015 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 3008-3015
    • Norquist, B.1
  • 60
    • 84857936584 scopus 로고    scopus 로고
    • Advances in using PARP inhibitors to treat cancer
    • Kummar, S. et al. Advances in using PARP inhibitors to treat cancer. BMC Med. 10, 25 (2012).
    • (2012) BMC Med. , vol.10 , pp. 25
    • Kummar, S.1
  • 61
    • 84856396323 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: Clinical impact of BCR-ABL1 mutations and other lesions associated with disease progression
    • Ernst, T. & Hochhaus, A. Chronic myeloid leukemia: clinical impact of BCR-ABL1 mutations and other lesions associated with disease progression. Semin. Oncol. 39, 58-66 (2011).
    • (2011) Semin. Oncol. , vol.39 , pp. 58-66
    • Ernst, T.1    Hochhaus, A.2
  • 62
    • 81155151836 scopus 로고    scopus 로고
    • Challenges to the development of new agents for molecularly defined patient subsets: Lessons from BRCA1/2.associated breast cancer
    • Domchek, S. M. et al. Challenges to the development of new agents for molecularly defined patient subsets: lessons from BRCA1/2.associated breast cancer. J. Clin. Oncol. 29, 4224-4226 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 4224-4226
    • Domchek, S.M.1
  • 63
    • 37549036689 scopus 로고    scopus 로고
    • Prevalence of pathogenic BRCA1 mutation carriers in 5 US racial/ethnic groups
    • John, E. M. et al. Prevalence of pathogenic BRCA1 mutation carriers in 5 US racial/ethnic groups. JAMA 298, 2869-2876 (2007).
    • (2007) JAMA , vol.298 , pp. 2869-2876
    • John, E.M.1
  • 64
    • 33748092354 scopus 로고    scopus 로고
    • Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years
    • Malone, K. E. et al. Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years. Cancer Res. 66, 8297-8308 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 8297-8308
    • Malone, K.E.1
  • 65
    • 79955478110 scopus 로고    scopus 로고
    • Frequencies of BRCA1 and BRCA2 mutations among 1, 342 unselected patients with invasive ovarian cancer
    • Zhang, S. et al. Frequencies of BRCA1 and BRCA2 mutations among 1, 342 unselected patients with invasive ovarian cancer. Gynecol. Oncol. 121, 353-357 (2011).
    • (2011) Gynecol. Oncol. , vol.121 , pp. 353-357
    • Zhang, S.1
  • 66
    • 0033822151 scopus 로고    scopus 로고
    • Prevalence of BRCA1 in a hospital-based population of Dutch breast cancer patients
    • Papelard, H. et al. Prevalence of BRCA1 in a hospital-based population of Dutch breast cancer patients. Br. J. Cancer 83, 719-724 (2000).
    • (2000) Br. J. Cancer , vol.83 , pp. 719-724
    • Papelard, H.1
  • 67
    • 0035098503 scopus 로고    scopus 로고
    • Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer
    • Risch, H. A. et al. Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer. Am. J. Hum. Genet. 68, 700-710 (2001).
    • (2001) Am. J. Hum. Genet. , vol.68 , pp. 700-710
    • Risch, H.A.1
  • 69
    • 80053595196 scopus 로고    scopus 로고
    • Response to neoadjuvant systemic therapy for breast cancer in BRCA mutation carriers and noncarriers: A single-institution experience
    • Arun, B. et al. Response to neoadjuvant systemic therapy for breast cancer in BRCA mutation carriers and noncarriers: a single-institution experience. J. Clin. Oncol. 29, 3739-3746 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 3739-3746
    • Arun, B.1
  • 70
    • 78149250588 scopus 로고    scopus 로고
    • Familial syndromes associated with thyroid cancer in the era of personalized medicine
    • Richards, M. L. Familial syndromes associated with thyroid cancer in the era of personalized medicine. Thyroid 20, 707-713 (2010).
    • (2010) Thyroid , vol.20 , pp. 707-713
    • Richards, M.L.1
  • 71
    • 77649214078 scopus 로고    scopus 로고
    • Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • Wells, S. A. Jr et al. Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. J. Clin. Oncol. 28, 767-772 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 767-772
    • Wells Jr., S.A.1
  • 72
    • 33645815054 scopus 로고    scopus 로고
    • Medullary thyroid cancer: Options for systemic therapy of metastatic disease?
    • Martins, R. G., Rajendran, J. G., Capell, P., Byrd, D. R. & Mankoff, D. A. Medullary thyroid cancer: options for systemic therapy of metastatic disease? J. Clin. Oncol. 24, 1653-1655 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , pp. 1653-1655
    • Martins, R.G.1    Rajendran, J.G.2    Capell, P.3    Byrd, D.R.4    Mankoff, D.A.5
  • 73
    • 84655175698 scopus 로고    scopus 로고
    • Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: A randomized, double-blind phase III trial
    • Wells, S. A. Jr et al. Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. J. Clin. Oncol. 30, 134-141 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 134-141
    • Wells Jr., S.A.1
  • 74
    • 27844567142 scopus 로고    scopus 로고
    • Distinct sets of genetic alterations in melanoma
    • Curtin, J. A. et al. Distinct sets of genetic alterations in melanoma. N. Engl. J. Med. 353, 2135-2147 (2005).
    • (2005) N. Engl. J. Med. , vol.353 , pp. 2135-2147
    • Curtin, J.A.1
  • 75
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies, H. et al. Mutations of the BRAF gene in human cancer. Nature 417, 949-954 (2002).
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1
  • 76
    • 77956030786 scopus 로고    scopus 로고
    • Inhibition of mutated, activated BRAF in metastatic melanoma
    • Flaherty, K. T. et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N. Engl. J. Med. 363, 809-819 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 809-819
    • Flaherty, K.T.1
  • 77
    • 84863116743 scopus 로고    scopus 로고
    • Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib
    • Sosman, J. A. et al. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N. Engl. J. Med. 366, 707-714 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 707-714
    • Sosman, J.A.1
  • 78
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman, P. B. et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N. Engl. J. Med. 364, 2507-2516 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2507-2516
    • Chapman, P.B.1
  • 79
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non. small.cell lung cancer to gefitinib
    • Lynch, T. J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non. small.cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129-2139 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2129-2139
    • Lynch, T.J.1
  • 80
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez, J. G. et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304, 1497-1500 (2004).
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1
  • 81
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non. small.cell lung cancer with mutated EGFR
    • Maemondo, M. et al. Gefitinib or chemotherapy for non. small.cell lung cancer with mutated EGFR. N. Engl. J. Med. 362, 2380-2388 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , pp. 2380-2388
    • Maemondo, M.1
  • 82
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non. small.cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
    • Mitsudomi, T. et al. Gefitinib versus cisplatin plus docetaxel in patients with non. small.cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol. 11, 121-128 (2010).
    • (2010) Lancet Oncol. , vol.11 , pp. 121-128
    • Mitsudomi, T.1
  • 83
    • 80053561215 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy (CT) in advanced non-small cell lung cancer (NSCLC) patients (p) with epidermal growth factor receptor (EGFR) mutations: Interim results of the European Erlotinib Versus Chemotherapy (EURTAC) phase III randomized trial [abstract]
    • Rosell, R. et al. Erlotinib versus chemotherapy (CT) in advanced non-small cell lung cancer (NSCLC) patients (p) with epidermal growth factor receptor (EGFR) mutations: Interim results of the European Erlotinib Versus Chemotherapy (EURTAC) phase III randomized trial [abstract]. J. Clin. Oncol. 29, a7503 (2011).
    • (2011) J. Clin. Oncol. , vol.29
    • Rosell, R.1
  • 84
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non. small.cell lung cancer (OPTIMAL, CTONG.0802): A multicentre, open-label, randomised, phase 3 study
    • Zhou, C. et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non. small.cell lung cancer (OPTIMAL, CTONG.0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 12, 735-742 (2011).
    • (2011) Lancet Oncol. , vol.12 , pp. 735-742
    • Zhou, C.1
  • 85
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non. small.cell lung cancer
    • Shepherd, F. A. et al. Erlotinib in previously treated non. small.cell lung cancer. N. Engl. J. Med. 353, 123-132 (2005).
    • (2005) N. Engl. J. Med. , vol.353 , pp. 123-132
    • Shepherd, F.A.1
  • 87
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4-ALK fusion gene in non. small.cell lung cancer
    • Soda, M. et al. Identification of the transforming EML4-ALK fusion gene in non. small.cell lung cancer. Nature 448, 561-566 (2007).
    • (2007) Nature , vol.448 , pp. 561-566
    • Soda, M.1
  • 88
    • 77953291664 scopus 로고    scopus 로고
    • The biology and treatment of EML4. ALK non-small cell lung cancer
    • Sasaki, T., Rodig, S. J., Chirieac, L. R. & Janne, P. A. The biology and treatment of EML4. ALK non-small cell lung cancer. Eur. J. Cancer 46, 1773-1780 (2010).
    • (2010) Eur. J. Cancer , vol.46 , pp. 1773-1780
    • Sasaki, T.1    Rodig, S.J.2    Chirieac, L.R.3    Janne, P.A.4
  • 89
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non. small.cell lung cancer
    • Kwak, E. L. et al. Anaplastic lymphoma kinase inhibition in non. small.cell lung cancer. N. Engl. J. Med. 363, 1693-1703 (2011).
    • (2011) N. Engl. J. Med. , vol.363 , pp. 1693-1703
    • Kwak, E.L.1
  • 90
    • 80053386829 scopus 로고    scopus 로고
    • Effect of crizotinib on overall survival in patients with advanced non. small.cell lung cancer harbouring ALK gene rearrangement: A retrospective analysis
    • Shaw, A. T. et al. Effect of crizotinib on overall survival in patients with advanced non. small.cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis. Lancet Oncol. 12, 1004-1012 (2011).
    • (2011) Lancet Oncol. , vol.12 , pp. 1004-1012
    • Shaw, A.T.1
  • 91
    • 65249095599 scopus 로고    scopus 로고
    • The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS
    • Wong, D. W. et al. The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS. Cancer 115, 1723-1733 (2009).
    • (2009) Cancer , vol.115 , pp. 1723-1733
    • Wong, D.W.1
  • 92
    • 84861726854 scopus 로고    scopus 로고
    • Clinical Trials.gov online
    • US National Library of Medicine. Clinical Trials.gov [online], http://clinicaltrials.gov/ct2/show/NCT01154140 (2012).
    • (2012) US National Library of Medicine.
  • 93
    • 0037561111 scopus 로고    scopus 로고
    • Inhibitors of epidermal.growth.factor receptors: A review of clinical research with a focus on non. small.cell lung cancer
    • Sridhar, S. S., Seymour, L. & Shepherd, F. A. Inhibitors of epidermal.growth.factor receptors: a review of clinical research with a focus on non. small.cell lung cancer. Lancet Oncol. 4, 397-406 (2003).
    • (2003) Lancet Oncol. , vol.4 , pp. 397-406
    • Sridhar, S.S.1    Seymour, L.2    Shepherd, F.A.3
  • 94
    • 79957492069 scopus 로고    scopus 로고
    • American Society of Clinical Oncology provisional clinical opinion: Epidermal growth factor receptor (EGFR) mutation testing for patients with advanced non. small.cell lung cancer considering first-line EGFR tyrosine kinase inhibitor therapy
    • Keedy, V. L. et al. American Society of Clinical Oncology provisional clinical opinion: epidermal growth factor receptor (EGFR) mutation testing for patients with advanced non. small.cell lung cancer considering first-line EGFR tyrosine kinase inhibitor therapy. J. Clin. Oncol. 29, 2121-2127 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 2121-2127
    • Keedy, V.L.1
  • 95
    • 68949209102 scopus 로고    scopus 로고
    • Overview of molecular testing in non. small.cell lung cancer: Mutational analysis, gene copy number, protein expression and other biomarkers of EGFR for the prediction of response to tyrosine kinase inhibitors
    • John, T., Liu, G. & Tsao, M. S. Overview of molecular testing in non. small.cell lung cancer: mutational analysis, gene copy number, protein expression and other biomarkers of EGFR for the prediction of response to tyrosine kinase inhibitors. Oncogene 28(Suppl. 1), 14-23 (2009).
    • (2009) Oncogene , vol.28 , Issue.1 SUPPL. , pp. 14-23
    • John, T.1    Liu, G.2    Tsao, M.S.3
  • 97
    • 84857232726 scopus 로고    scopus 로고
    • Analytical performance of a real-time PCR-based assay for V600 mutations in the BRAF gene, used as the companion diagnostic test for the novel BRAF inhibitor vemurafenib in metastatic melanoma
    • Halait, H. et al. Analytical performance of a real-time PCR-based assay for V600 mutations in the BRAF gene, used as the companion diagnostic test for the novel BRAF inhibitor vemurafenib in metastatic melanoma. Diagn. Mol. Pathol. 21, 1-8 (2012).
    • (2012) Diagn. Mol. Pathol. , vol.21 , pp. 1-8
    • Halait, H.1
  • 100
    • 84856386750 scopus 로고    scopus 로고
    • BRCA patent dispute may head to US Supreme Court
    • Devi, S. BRCA patent dispute may head to US Supreme Court. Lancet 379, 300 (2012).
    • (2012) Lancet , vol.379 , pp. 300
    • Devi, S.1
  • 103
    • 4344646459 scopus 로고    scopus 로고
    • Determinants of tumor response and survival with erlotinib in patients with non-.small.cell lung cancer
    • Perez-Soler, R. et al. Determinants of tumor response and survival with erlotinib in patients with non-.small.cell lung cancer. J. Clin. Oncol. 22, 3238-3247 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 3238-3247
    • Perez-Soler, R.1


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