Circumventing Embryonic Lethality with Lcmt1 Deficiency: Generation of Hypomorphic Lcmt1 Mice with Reduced Protein Phosphatase 2A Methyltransferase Expression and Defects in Insulin Signaling

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  MacKay, Kennen B ^a   Tu, Yiping ^a   Young, Stephen G ^a,b   Clarke, Steven G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE CARBOXYL METHYLTRANSFERASE; METHYLTRANSFERASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE 2A METHYLTRANSFERASE; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME SUBSTRATE; ENZYME SUBUNIT; EUKARYOTIC CELL; GENE CASSETTE; GENE INSERTION; IN VIVO STUDY; INSULIN RESISTANCE; INSULIN SIGNALING; INTRON; LETHALITY; LEUCINE CARBOXYL METHYLTRANSFERASE DEFICIENCY; MAMMAL; MOUSE; MOUSE EMBRYO; MOUSE STRAIN; NONHUMAN; PHENOTYPE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN METHYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; STOICHIOMETRY;

ANIMALS; GENE EXPRESSION; GENES, LETHAL; GLUCOSE; HOMOZYGOTE; INSULIN; INSULIN RESISTANCE; MALE; METHYLATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTAGENESIS, INSERTIONAL; PROTEIN O-METHYLTRANSFERASE; PROTEIN PHOSPHATASE 2; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION;

ANIMALIA; EUKARYOTA; MAMMALIA; MUS;

EID: 84879261109     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065967     Document Type: Article

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