Homocysteine induces τ hyperphosphorylation in rats

NeuroReport

Volumn 18, Issue 18, 2007, Pages 2005-2008

  Luo, Yougen ^a   Zhou, Xinwen ^a   Yang, Xifei ^a   Wang, Jianzhi ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

; Alzheimer's disease; Homocysteine; Phosphorylation

Indexed keywords

HOMOCYSTEINE; PHOSPHOPROTEIN PHOSPHATASE 2A;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; CATALYSIS; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LATERAL BRAIN VENTRICLE; MALE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; WESTERN BLOTTING;

ALZHEIMER DISEASE; ANIMALS; BINDING SITES; BRAIN; BRAIN CHEMISTRY; HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA; INJECTIONS, INTRAVENTRICULAR; MALE; NEUROFIBRILLARY TANGLES; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; RATS; RATS, WISTAR; SERINE; TAU PROTEINS; TIME FACTORS;

EID: 36248964572     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e3282f29100     Document Type: Article

References (17)

1. Wenning GK, Jellinger KA. The role of alpha-synuclein and tau in neurodegenerative movement disorders. Curr Opin Neurol 2005; 18:357-362.
2. Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A 1986; 83:4913-4917.
3. Finkelstein JD. The metabolism of Hcy: pathways and regulation. Eur J Pediatr 1998; 157 (Suppl 2):S40-S44.
4. Zhang YD, Ke XY, Shen W, Liu Y. Relationship of Hcy and gene polymorphisms of its related metabolic enzymes with Alzheimer's disease. Chin Med Sci J 2005; 20:247-251.
5. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, et al. Plasma Hcy as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002; 346:476-483.
6. Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998; 55:1449-1455.
7. McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total serum homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998; 13:235-239.
8. Postiglione A, Milan G, Ruocco A, Gallotta G, Guiotto G, Di Minno G. Plasma folate, vitamin B (12), and total Hcy and homozygosity for the C677T mutation of the 5,10-methylene tetrahydrofolate reductase gene in patients with Alzheimer's dementia. A case-control study. Gerontology 2001; 47:324-329.
9. Vafai SB, Stock JB. Protein phosphatase 2A methylation: a link between elevated plasma Hcy and Alzheimer's Disease. FEBS Lett 2002; 518:1-4.
10. Miller AL. The methionine-Hcy cycle and its effects on cognitive diseases. Altern Med Rev 2003; 8:7-19. Review.
11. Iqbal K, Grundke-Iqbal I. Pharmacological approaches of neurofibrillary degeneration. Curr Alzheimer Res 2005; 2:335-341. Review.
12. Brown JC, Rosenquist TH, Monaghan DT. ERK2 activation by Hcy in vascular smooth muscle cells. Biochem Biophys Res Commun 1998; 251:669-676.
13. Zhang CE, Tian Q, Wei W, Peng JH, Liu GP, Zhou XW, et al. Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiol Aging 2007; [Epub ahead of print].
14. Osuna C, Reiter RJ, Garcia JJ, Karbownik M, Tan DX, Calvo JR, Manchester LC. Inhibitory effect of melatonin on Hcy-induced lipid peroxidation in rat brain homogenates. Pharmacol Toxicol 2002; 90:32-37.
15. Baydas G, Kutlu S, Naziroglu M, Canpolat S, Sandal S, Ozcan M, Kelestimur H. Inhibitory effects of melatonin on neural lipid peroxidation induced by intracerebroventricularly administered Hcy. J Pineal Res 2003; 34:36-39.
16. Schweers O, Mandelkow EM, Biernat J, Mandelkow E. Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments. Proc Natl Acad Sci U S A 1995; 92:8463-8467.
17. Li SP, Deng YQ, Wang XC, Wang YP, Wang JZ. Melatonin protects SH-SY5Y neuroblastoma cells from calyculin A-induced neurofilament impairment and neurotoxicity. J Pineal Res 2004; 36:18 6-191.