The 3D structure of protein phosphatase 2A: New insights into a ubiquitous regulator of cell signalling

ACS Chemical Biology

Volumn 2, Issue 2, 2007, Pages 99-103

  Mumby, Marc ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOGINOSIN LR; HOLOENZYME; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN SUBUNIT; TOXIC SUBSTANCE;

ARTICLE; CANCER; CELL GROWTH; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; GENE MUTATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FUNCTION; PROTEIN METHYLATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING; AMINO ACID SUBSTITUTION; CHEMISTRY; DRUG ANTAGONISM; GENETICS; HUMAN; METHYLATION; NEOPLASM; PROTEIN CONFORMATION; REVIEW; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; CRYSTALLOGRAPHY, X-RAY; HOLOENZYMES; HUMANS; METHYLATION; NEOPLASMS; NOXAE; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN CONFORMATION; PROTEIN SUBUNITS; SIGNAL TRANSDUCTION;

EID: 33947528693     PISSN: 15548929     EISSN: None     Source Type: Journal    
DOI: 10.1021/cb700021z     Document Type: Article

References (21)

1. Virshup, D. M. (2000) Protein phosphatase 2A: a panoply of enzymes, Curr. Opin. Cell Biol. 12, 180-185.
2. Janssens, V., and Goris, J. (2001) Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling, Biochem. J. 353, 417-439.
3. Mumby, M.C. (2003) Protein phosphatase 2A: a multifunctional regulator of cell signaling, in Topics in Current Genetics (Arino, J., and Alexander, D. R., Eds.) 5th ed., pp 45-72, Springer, Berlin/Heidelberg.
4. Xing, Y., Xu, Y., Chen, Y., Jeffrey, P. D., Chao, Y., Lin, Z., Li, Z., Strack, S., Stock, J. B., and Shi, Y. (2006) Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins, Cell 127, 341-353.
5. Cho, U. S., and Xu, W. (2007) Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme, Nature 445, 53-57.
6. Xu, Y., Xing, Y., Chen, Y., Chao, Y., Lin, Z., Fan, E., Yu, J. W., Strack, S., Jeffrey, P. D., and Shi, Y. (2006) Structure of the protein phosphatase 2A holoenzyme, Cell 127, 1239-1251.
7. Dawson, J. F., and Holmes, C. F. (1999) Molecular mechanisms underlying inhibition of protein phosphatases by marine toxins, Front. Biosci. 4, D646-D658.
8. Groves, M. R., Hanlon, N., Turowski, P., Hemmings, B. A., and Barford, D. (1999) The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs, Cell 96, 99-110.
9. Conti, E., Muller, C. W., and Stewart, M. (2006) Karyopherin flexibility in nucleocytoplasmic transport. Curr. Opin. Struct. Biol. 16, 237-244.
10. Ruediger, R., Hentz, M., Fait, J., Mumby, M., and Walter, G. (1994) Molecular model of the A subunit of protein phosphatase 2A interaction with other subunits and tumor antigens, J. Virol. 68, 123-129.
11. Ruediger, R., Fields, K., and Walter, G. (1999) Binding specificity of protein phosphatase 2A cow enzyme for regulatory B subunits and T antigens, J. Virol. 73, 839-842.
12. Ruediger, R., Pham, H. T., and Walter, G. (2001) Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene, Oncogene 20, 1892-1899.
13. Ruediger, R., Pham, H. T., and Walter, G. (2001) Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the Aα subunit gene, Oncogene 12, 10-15.
14. Terrak, M., Kerff, F., Langsetmo, K., Tao, T., and Dominguez, R. (2004) Structural basis of protein phosphatase 1 regulation, Nature 429, 780-784.
15. Janssens, V., Goris, J., and Van, H. C. (2005) PP2A: the expected tumor suppressor, Curr. Opin. Genet. Dev. 15, 34-41.
16. Letoumeux, C., Rocher, G., and Porteu, F. (2006) B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK, EMBO J. 25, 727-738.
17. Kitajima, T. S., Sakuno, T., Ishiguro, K., Iemura, S., Natsume, T., Kawashima, S. A., and Watanabe, Y. (2006) Shugoshin collaborates with protein phosphatase 2A to protect cohesin, Nature 441, 46-52.
18. Seeling, J. M., Miller, J. R., Gil, R., Moon, R. T., White, R., and Virshup, D. M. (1999) Regulation of betacatenin signaling by the B56 subunit of protein phosphatase 2A, Science 283, 2089-2091.
19. Margolis, S. S., Perry, J. A., Forester, C. M., Nutt, L. K., Guo, Y., Jardim, M. J., Thomenius, M. J., Freel, C. D., Darbandi, R., Ahn, J. H., Arroyo, J. D., Wang, X. F., Shenolikar, S., Naim, A. C., Dunphy, W. G., Hahn, W. C., Virshup, D. M., and Kombluth, S. (2006) Role for the PP2A/ B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis, Cell 127, 759-773.
20. Firulli, B. A., Howard, M. J., McDaid, J. R., McIlreavey, L., Dionne, K. M., Centonze, V. E., Cserjesi, P., Virshup, D. M., and Firulli, A. B. (2003) PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation, Mol Cell 12, 1225-1237.
21. Wu, J., Tolstykh, T., Lee, J., Boyd, K., Stock, J. B., and Broach, J. R. (2000) Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo, EMBO J. 19, 5672-5681.